Articles tagged with Liposomes
Researchers at Boston Children's Hospital developed a slow-release injectable drug delivery system that achieved pain-numbing anesthetic effects lasting two to three weeks in rats. The system uses liposomes with multiple compartments, allowing for ultra-slow release of hydrophilic drugs.
By localizing peptides at the membrane interface or within the liposome interior, researchers can promote branched structures or spherical nanoparticles, respectively. This approach offers a new strategy for controlling nanoscale reaction environments in nanoparticle synthesis.
Cancer cell-derived small extracellular vesicles can be excreted into urine, according to researchers who tracked their journey in mouse models. The study reveals that glomerular cells actively transport sEVs across the filtration barrier, supporting their use in emerging urine-based cancer diagnostics.
Researchers are formulating and evaluating an intranasal oxytocin delivery system to treat post-traumatic stress disorder (PTSD). The project aims to enhance the efficacy and palatability of existing treatments, expanding on prior research that explored using oxytocin to treat alcoholism.
Researchers at IBEC created an artificial cell that migrates towards specific substances like living cells do. The study demonstrates how microscopic bubbles can be programmed to follow chemical trails and explores the core principles behind chemotaxis.
Researchers have developed a novel immunotheraphy targeting macrophages to induce tolerance in type 1 diabetes, demonstrating its potential as a curative treatment. The therapy also shows promise for other autoimmune diseases, with results suggesting no impact on the immune system's ability to capture and process liposomes.
Researchers investigate nanoparticles for cancer treatment, hoping to reduce side effects and improve efficacy. La-Beck's lab aims to understand the body's interaction with nanoparticles and their impact on tumor growth and immune responses.
Researchers used solid-state NMR to study the Fluc channel protein and discovered a new fluoride ion permeation model. The findings provide insights into the gating mechanisms in the Fluc channel, shedding light on its functionality.
The Bioaction project leverages bacteria as allies in promoting tissue regeneration, offering a paradigm shift in addressing infections. By developing functional bio-hydrogels, the project aims to accelerate healing and stimulate bone growth, reducing reliance on extended antibiotic therapies.
A new liposome-based method aims to kill periodontitis-causing leukotoxin while protecting immune cells, providing an alternative treatment for aggressive gum infections. The approach has potential applications against a range of bacteria and could help combat antibiotic resistance.
Researchers at Pusan National University have created a portable molecular sensor that detects biogenic amines released from spoiled food using polydiacetylene-based beads. The sensor, which changes color to red upon binding with BAs, can be used for rapid visual detection of spoiled food during storage and distribution.
Researchers at Hokkaido University developed a novel branched ionizable lipid that significantly increases the efficiency of mRNA delivery by LNPs. The new lipid, CL4F 8-6, was found to enhance protein expression in mice and achieve stable formulations.
Researchers have developed bacteria-based biohybrid microrobots that can navigate through viscous tissues and deliver chemotherapy directly to tumors. The microrobots use near-infrared light to melt liposomes containing drugs, triggering release in acidic environments.
Researchers at University of Texas at Austin create first-ever biologically authentic computer model of HIV-1 virus liposome, shedding light on replication and infectivity. The study reveals key characteristics of the liposome's asymmetry and its role in shaping macroscopic properties.
Scientists at UC Riverside and UCLA have engineered nanoparticles to serve as 'molecular traps' that bind to SARS-CoV-2, preventing it from attacking macrophages and inducing inflammation. The findings suggest potential therapeutic strategies for treating COVID-19-associated diseases.
Researchers at Lehigh University are working on a project funded by the Good Food Institute grant to adapt human tissue engineering techniques for growing meat in the lab. The team is developing a scaffold for meat cells to grow on and using electrochemistry, nanomaterial design, and liposomal delivery vehicles to promote fibrous growth.
Researchers at University at Buffalo successfully freeze-dried a liposome-based liquid vaccine formula, offering a thermostable solution for future COVID-19 vaccines. The freeze-dried product showed stability at elevated temperatures and induced effective antibody responses in mice.
The study utilizes gas-phase electrophoresis (GEMMA) to separate nanovesicles from proteins in natural samples. This allows for accurate attribution of effects to transport vesicles, crucial for understanding cellular communication and metabolism. The method has significant implications for extracellular vesicle research and its releva...
Researchers at UNSW and University of Sydney develop DNA 'nanostructures' to effectively manipulate synthetic liposomes, leading to potential applications in biosensing and mRNA vaccines. The study also explores the creation of 'mini biological computers' that can sense their environment and respond to signals.
Researchers studied the mechanism of liposome accumulation in tumors using fluorescent microscopy and imaging. They found that different lipids have varying abilities to accumulate in tumors, with one lipid type showing remarkable extravasation and reaching immune and tumor cells.
Protein corona formation affects cationic liposome interactions with cells, altering internalization pathways and cargo distribution. Energy-dependent endocytosis replaces initial membrane fusion.
Scientists have developed a method to create crystalline exoskeletons around delicate liposomes and lipid nanoparticles, stabilizing them at room temperature for up to two months. This breakthrough could help address the need for COVID-19 vaccines to be kept at below-freezing temperatures during transport and storage.
Researchers have developed a safer, more targeted way to deliver CRISPR gene therapy using light-activated liposomes. The new method uses spherical nanostructures of fat molecules to carry CRISPR molecules to specific sites in the body.
Researchers have developed a new method to stabilize liposomes using nanobowls, which improves the delivery of chemotherapy drugs to cancer cells. The nanobowl-stabilized liposomes showed reduced leakage and increased efficacy in treating metastatic breast tumors in mice.
Researchers developed a new type of liposome called a sterosome, which successfully activated bone regeneration on its own in mice with bone defects. The sterosomes were found to stimulate cells to develop into bone-forming cells and reduced defect size by an average of 50% in a six-week study.
Research at the University of Manchester shows that tiny vesicles called liposomes can potentially transport life-saving drugs across the brain's blood-brain barrier following a stroke. This breakthrough offers a new way to get vital drugs to the lesions and stop further damage.
Researchers have developed nanovectors that can transport two drugs with different properties, improving their efficacy and delivery. The strategy targets the sexual phase of the parasite, reducing the emergence of antimalarial resistance.
Researchers have modified cotton fabric to emit a lemony citronella aroma when sweat comes into contact. The fragrance release strategy uses either an odorant-binding protein or liposomes, resulting in quick and controlled scent emission.
A new study demonstrates how ankyrin repeat and KH domain-containing protein 1 (ANKHD1) forms the early endosome, enabling cellular transport. The ARD of ANKHD1 contains 25 ankyrin repeats that have different roles in vesiculation and dimerization.
Liposomes, small artificial structures with lipids and aqueous cores, have been engineered to transmit light or electrical signals. By incorporating magnetic nanoparticles and fluorescent molecules, the vesicles can be controlled by magnets and used for Boolean logic operations, enabling on/off signal transmission.
Researchers developed dual-complementary liposomes loaded with doxorubicin to target ICAM1 and EGFR receptors, achieving 40% reduction in tumor growth and no lung metastasis development. The treatment showed significantly improved survival without liver or kidney toxicity.
Nano-droplets play a crucial role in controlling the formation of membranes, a process that can be manipulated to create new nanomedicines. This discovery has significant implications for the development of targeted cancer treatments by encapsulating medicines in liposomes.
Scientists have developed a new technique to extract biomolecules from blood samples, which could lead to early diagnosis, drug discovery and personalized medicines. The method uses liposomes to detect a wide variety of biomolecules, overcoming the challenge of amplifying cancer signals in the presence of noise.
Researchers have developed liposomal nanoparticles that can deliver collagenase enzymes to remodel teeth in the mouth without surgery. This technology has shown promising results in pre-clinical studies, potentially leading to faster and less painful orthodontic procedures.
A study published in ACS Nano describes the real-time visualization of liposomes escaping from blood vessels into surrounding skin cells in living mice. Researchers found that liposomes can invade skin cells within five minutes of injection and remain there for up to seven days.
Researchers have developed a new test that can provide results in just hours for diagnosing bacterial infections like Strep throat. The test uses lipid vesicles to detect beta-hemolytic bacteria with 100% accuracy on plates and 99% accuracy in liquid broth.
Researchers at Boston Children's Hospital developed a novel system using ultrasound to trigger the release of nerve-blocking agents, providing on-demand pain relief. The system, using ultrasound-triggered liposomes, has potential for replacing addictive opioids and short-lasting local anesthetics.
Scientists at Tokyo Institute of Technology create liposomes with a DNA-based skeletal support, allowing them to withstand osmotic pressure and maintain their structure. This innovation enables controlled release of entrapped compounds and opens up new possibilities for drug delivery and cosmetics.
Researchers found that smaller liposomes elicited higher levels of IgG and IgA antibodies in mice, while larger liposomes produced lower antibody titers. The study suggests that a mix of different liposome sizes can achieve similar results as the smallest liposomes.
MIT researchers have developed a technique to isolate genetic circuits within individual synthetic cells, preventing interference and enabling controlled communication. This approach allows for the design of complex products or sensors that respond to environmental changes.
Scientists have created a potential nerve agent antidote that can be taken before an attack, offering hope for soldiers and others exposed to these molecular weapons. The enzyme-based antidote was encapsulated in a porous metal-organic framework, enhancing its staying power and effectiveness.
Researchers have developed a high-throughput method for creating stable vesicles of controlled size using microfluidics. The approach works for both liposomes and polymersomes, enabling applications in synthetic biology such as encapsulation of biological agents and creation of artificial cell membranes.
Scientists have repurposed portable glucose monitors to detect diseases using enzymes and liposomes. The method accurately detects thrombin levels, corresponding to restricted blood flow or heart disease. This approach could be used to detect other disease-associated proteins.
Scientists have created cellular backpacks that can be loaded with therapeutic compounds and unloaded, targeting specific disease locations. These backpacks use immune cells as carriers, minimizing the impact on healthy cells and potentially treating a range of diseases including cancer and Parkinson's.
Researchers from University of Southern Denmark found that liposomes cannot penetrate the human skin barrier intact. The study used a nanoscope to directly observe individual molecules and liposomes, revealing no penetration without breaking down. This challenges previous assumptions about liposome efficacy in skincare and medicine.
Researchers have successfully used microbe S. islandicus to construct nano-capsules that can transport drugs safely through the stomach, offering a potential solution for oral drug delivery. The liposomes, made from cell membrane molecules of S. islandicus, survived in acidic environments, retaining their content and showing promise fo...
Computational models suggest a new design for nanoparticles used in targeted drug delivery. The researchers proposed making more stable liposomes by incorporating a nanoparticle core and polymer tethers, which acts as a hub-and-spoke-like scaffold that helps the liposome to weather stresses and strains.
The review highlights the major achievements in liposome technology, including modern synthesis methods, drug delivery systems, and their use in disease diagnosis. Liposomes are being explored as a potential solution to improve treatment outcomes and reduce side effects for various diseases, including cancer and inflammatory conditions.
Researchers have developed a novel approach using liposomes to prevent the onset of Type 1 Diabetes in mice, offering a promising candidate for human vaccination. The technique avoids damaging insulin-producing pancreatic cells and induces immunological tolerance, providing a potential solution for this incurable disease.
Researchers at the University of Texas Health Science Center at San Antonio have launched a groundbreaking clinical trial using tiny radioactive liposomes to treat brain cancer. The technology has shown promising results with minimal side effects in the first patient, and the team expects to start the second patient soon.
Researchers at the University of Manchester developed heat-activated liposomes with antibody targeting capabilities, showing improved drug delivery to tumour tissue in mice. The combination approach resulted in a moderate improvement in animal survival, offering potential for novel targeted drug delivery strategies.
Researchers have developed a new technique to wrap chemotherapy drugs in fatty covers called liposomes, reducing heart damage and improving cardiac function. The study found that the group receiving Myocet had better diastolic and systolic function compared to conventional doxorubicin, with less fibrosis development.
Researchers at the University of Illinois have designed a new nanoparticle that combines weak chemical forces to improve MRI imaging. The innovation, inspired by cell membranes, has led to clearer images and paved the way for better diagnostic tools.
A new 3D capillary device has been developed to improve the manufacture of high-quality liposomes, a crucial step in delivering drugs directly to cancer cells. The device increases production threefold while reducing costs, offering a significant breakthrough for the field.
Researchers developed a novel anti-cancer drug delivery method using lipid-based nanocapsules to deliver drugs directly to cancer cells. The technique triggers the release of the drug, leading to cell death in breast cancer tumors. This efficient and fast-acting approach may improve treatment outcomes for cancer patients.
Researchers have made a breakthrough in packaging insulin into tiny sacs that can be absorbed through the gut, overcoming digestive enzyme hurdles. The new delivery system has shown promising results in rats, with blood glucose levels lowered almost as much as injected insulin.
Scientists have made breakthroughs in delivering medicines to the brain via the nose, with improved liposomes and polymers allowing for more efficient transport of active substances. The new method could lead to reduced side effects and improved treatment outcomes for patients with neurological diseases.
Researchers at the University of Cincinnati have discovered a novel delivery method for the enzyme plasmin, which is more effective at dissolving blood clots than the standard treatment rt-PA. The new technique uses liposomes and ultrasound waves to target plasmin directly to the clot.
Researchers from University of Southern Denmark used RICS technique to investigate liposome movement on skin. They found that liposomes are destroyed before entering the skin and spilling their cargo of active ingredients. The study advises against trusting claims about liposomes carrying active ingredients into the skin.
Researchers at Children's Hospital Boston developed liposomes that can prevent HIV infection, providing a potential solution for women in resource-poor settings. The innovative technology shows great promise as a safe and effective form of prevention.