When cells run out of fuel
Parkinson-associated genes PINK1 and Parkin functionally interact to maintain mitochondrial function, impairing neuron loss
Mitochondrial Function
Articles tagged with Mitochondrial Function
STAT3 protein found to play a key role in cancer
A recent study published in Science found that the STAT3 protein plays a key role in converting normal cells to cancerous cells by regulating gene expression in both the cell nucleus and mitochondria. This discovery may lead to the development of targeted cancer therapies.
Protein regulates movement of mitochondria in brain cells
Scientists identified a protein that regulates mitochondrial movement in brain cells, shedding light on how the brain recovers from stroke. Understanding this mechanism may help identify novel approaches for preventing and treating neurological disorders.
Role for CISD2 gene in human disease and lifespan control
Researchers have developed a mouse model of Wolfram Syndrome, linking CISD2 gene function to mitochondrial integrity and aging. CISD2-deficient mice display premature aging, decreased body weight, and degeneration of optic and muscular tissues.
Scientists identify protein with a crucial role in cell death
Researchers discovered that PARL plays a key role in initiating apoptosis in mitochondria, leading to faster cell death and increased risk of diseases like Parkinson's. The study used 'knock-out' mice that lacked PARL, showing that the protein is essential for protecting cells from controlled cell death.
First direct mechanical communication of mitochondria, cardiomyocyte nucleus shown
Researchers found substances increasing mitochondrial size also boost cardiac contractility. This effect isn't related to energy production; instead, it suggests a form of mechanical signaling between organelles in cardiac cells. The study opens possibilities for developing drugs that enhance heart function.
Alzheimer's study first to explain death of brain cells
Researchers discover that excessive amyloid-beta toxicity leads to functional heme deficiency, causing mitochondrial decay and oxidative damage. A new class of targeted drugs could soon be developed to address this underlying mechanism.
A human parasite with a streamlined mitochondrion
The Entamoeba mitosome, a human parasite's organelle, contains a single type of protein that imports and exports chemicals. This streamlined organelle may represent the simplest mitochondrion yet described, offering insights into eukaryotic cell function.
Preliminary study shows high-dose coenzyme Q10 slows functional decline in Parkinson's patients
A national clinical trial with 80 Parkinson's patients showed that high-dose coenzyme Q10 slowed functional decline by 44%, particularly in everyday activities. The therapy needs to be tested in a larger trial before it can be recommended.
Compounds rejuvenate rats, may aid humans
A combination of two compounds, acetyl-l-carnitine and alpha-lipoic acid, have been shown to improve physical and mental function in older rats. The study suggests that these compounds may have therapeutic potential for humans, with the goal of improving quality of life and health.