Articles tagged with Mitosis
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A research team at The University of Osaka has identified a parallel pathway involving CENP-C for centromere specification and function. This process is vital for ensuring chromosomes are structured and genes are expressed appropriately.
Researchers at OIST have discovered that certain cancers can 'lose their sense of time' to avoid cellular stress responses. The study highlights the role of USP28 in stabilizing p53, a known tumor suppressor, and how mutations in this protein can disrupt its function.
A new study reveals how Aurora A ensures smooth dissolution of spindle poles during cell division, allowing the genome to be properly encased in new nuclei. The team identified specific regions and amino acids in NuMA that drive its shift between dynamic and solid states.
Researchers discovered a specialized histone arrangement, called the CENP-A–H4 octasome, in centromeric regions. This unique structure likely contributes to proper kinetochore formation and mitosis.
Researchers at MPI unveiled PLK1's crucial role in replenishing CENP-A proteins per centromere, a process critical for cell division. PLK1 initiates a cascade of events by binding to specific machinery components and inducing phosphorylation changes.
A research collaboration has uncovered a unique mechanism of crosstalk between microtubules and actin cytoskeleton during cell division, revealing characteristics of the previously unexplored protein FAM110A. This breakthrough finding enhances understanding of critical process relevant in developmental disorders and cancer.
Scientists have discovered that different modes of cell division used by animals and fungi may have evolved to support diverse life cycles. A study using Ichthyosporea as a model found that certain species use closed mitosis while others use open mitosis, shedding light on the evolutionary origins of these processes.
The study explores how different cell division strategies have evolved across organisms, finding a link between life cycle stages and mitotic strategies. Species with multinucleate stages tend to use closed mitosis, while those with mononucleate stages employ open mitosis.
A recent study investigated the relationship between RAD51 and FIGNL1, shedding light on the intricacies of homologous recombination. The results reveal that FIGNL1 is essential for proper chromosome separation after replication forks are dismantled, preventing abnormal chromosome bridges that can lead to genetic instability.
Researchers used medaka fish, CRISPR and new imaging techniques to study embryonic mitosis. They discovered unique spindles assemble in early embryos and found Ran-GTP plays a decisive role in spindle formation, which diminishes later in development. The study paves the way for further exploration of embryonic mitosis.
Scientists at the University of California San Diego have identified a biochemical pathway that continually surveils mitosis timing and eliminates potentially problematic cells. The 'stopwatch' mechanism uses protein p53 to track cell division time, labeling sequentially delayed divisions as risky.
Researchers discovered a protein complex that eliminates potentially harmful cells over time by measuring the duration of mitosis. The Mitotic Stopwatch Complex starts forming after prolonged mitosis and triggers cell arrest or death, providing new insights into cancer development.
Research reveals a mechanism by which daughter cells safeguard themselves against UV-damaged RNA inherited from mother cells. DHX9 stress granules, a special type of stress granule, trap and neutralize damaged RNA to prevent harm.
Researchers investigated the impact of senolytic treatments on DNA methylation clocks and epigenetic age. Results showed significant increases in epigenetic age acceleration with Dasatinib and Quercetin treatment, but not with Fisetin addition.
The study reveals that CENP-E binds to protein complexes, forming a scaffold for the fibrous corona's development. This discovery sheds light on errors during cell division and could contribute to cancer treatment strategies.
New study reveals that microtubule poisons effectively treat cancer by causing abnormal cell division, leading to tumor cell death. The findings contradict decades-long assumptions about the mechanism of action of these drugs.
Rensselaer Polytechnic Institute researcher Scott Forth is investigating the mechanical code underlying mitosis to combat cancer. His lab aims to determine how chromosomes are segregated during cell division, with potential insights into new diagnostics and treatments.
A new study published in Aging-US has identified the p53-p16/RB-E2F-DREAM complex as a critical regulator of cellular senescence. The researchers found that this complex represses multiple target genes involved in cell cycle regulation, DNA repair, and chromatin structure, leading to the stability of the senescent arrest.
Scientists at St. Jude Children's Research Hospital discovered that subunits of the SWI/SNF chromatin remodeling complex act as bookmarks to safeguard cell identity during mitosis. This finding provides new insights into how cancers develop and how they can be treated.
A recent study has investigated how cells divide in fibrous environments, revealing the impact of extracellular matrix shape and fiber number on mitotic errors. By re-creating and studying lattice structures, researchers have gained a deeper understanding of cellular dynamics and its connection to disease biology.
Researchers at USTC discovered a dynamic map of chromatin accessibility during mitosis, revealing important bookmarking factors. The study found that certain chromatin regions remained open throughout mitosis and were enriched in rapidly reactivated genes.
A research team led by Dr Gary Ying Wai Chan has uncovered a new mechanism that ensures correct DNA segregation in cell division, preventing cancer development. RIF1 and protein phosphatase 1 play a crucial role in resolving ultrafine DNA bridges, which can lead to DNA damage and genome instability if not properly resolved.
Researchers at Osaka University used cryogenic electron microscopy to study the structural change of the centromere during cell division. The study revealed a complex interaction between proteins involved in cell division, providing new insights into the correct division of chromosomes.
Researchers found that longer chromosomal arms are always thicker throughout eukaryotic species, providing insights into mitotic chromosomal structure. This study challenges current perspectives on mitotic chromosome formation and may lead to new ways to prevent chromosome miscarriage and cancer cell formation.
A new review paper discusses the role of CDK4 in regulating the cell cycle and its involvement in cancer. The study highlights the importance of CDK4/6 inhibitors as treatments for ER+ breast cancer and their potential utility in multiple tumor types.
Researchers studied meiotic cohesin complexes' effect on chromosome structure and genomic integrity in embryonic stem cells. Maintaining adequate levels of REC8 and STAG3 factors ensures chromosomal stabilization and sister chromatid cohesion.
A new mathematical theory explains how cells navigate the risk-speed tradeoff when dividing, balancing risk and speed to ensure survival. The theory applies broadly to all organisms, despite differences between yeast and mammalian cells.
A novel connection between genes involved in mitosis and glucose metabolism was found by researchers at Nagoya University. They demonstrated a gene bypass process using evolutionary repair experiments, suggesting that suppressing both Plk1 and CK1 could be more effective in cancer treatment.
Researchers discovered that moss cells can form mobile spindles during mitosis, moving like animal cells. This unusual process suggests a tug-of-war between microtubules and actin filaments to position the spindle, similar to animal cells.
Researchers have deciphered the structure of the kinetochore corona, a complex protein assembly that plays a pivotal role in chromosome segregation. The study, published in The EMBO Journal, provides new insights into how this critical process is regulated and offers a framework for future studies on cell division.
Researchers at Bielefeld University have identified five key characteristics of mitosis in the microalga Volvox carteri, including a porous nuclear envelope and crucial centrosome function. They used confocal laser scanning microscopy to capture high-resolution images of live cell division and gain insights into the complex process.
A team of researchers has discovered that Naegleria employs three distinct tubulins during mitosis, which could lead to the development of new treatments for brain-eating infections. The study also sheds light on the fundamental rules governing life on earth and the diversity of life.
Researchers discovered that living cell interiors become softer and more fluid during mitosis, a process crucial for life. The findings could help ensure precise separation of cellular structures into daughter cells.
A study published in Nature Chemical Biology revealed that crotonylation of EB1 by TIP60 ensures accurate spindle positioning in mitosis. This mechanism is crucial for cell fate determination and organogenesis, and its disruption can lead to cancer.
Scientists have discovered the mechanism by which plant hormone cytokinin regulates stem cell division, controlling cell proliferation and mitosis. The study reveals that cytokinin activates the transcription factor MYB3R4, promoting its nuclear localization and activating key cell cycle genes.
Researchers from Hiroshima University have identified a mechanism that allows some mutant cells to recover from a displaced nucleus during mitosis, potentially leading to cell death. The study found that microfilaments play a role in pushing the nucleus to safety.
A recent study published in Nature reveals that the protein Ki-67 plays a crucial role in excluding large cytoplasmic components from the nucleus before nuclear envelope reassembly. This exclusion process is essential for maintaining cellular compartmentalization and preventing premature translation of immature RNAs.
Researchers discovered that lysosomes are active during mitosis and selectively degrade specific proteins, leading to a toroidal nucleus morphology that may indicate chromosomal instability. This finding provides a new perspective on the connection between autophagy and cell division in cancer and other diseases.
Autophagy, a cellular recycling process, is repressed during cell division to protect the genome. The researchers identified CDK1 as the key regulator of this repression, decoupling conditional control and halting autophagy until the cell division process is complete.
Researchers have gained new insights into the mechanisms of cell division by examining the function of centrioles. They found that centrioles play a crucial role in promoting mitotic spindle assembly and maintaining centrosome structural integrity. The study's findings help to elucidate the critical functions of centrioles in the process.
Researchers at EMBL have developed an interactive map of proteins involved in human cell division, allowing users to track protein dynamics and identify critical vulnerabilities. The tool has the potential to advance our understanding of cellular processes and disease mechanisms.
Scientists have discovered that mammalian embryos use two spindles to keep parental chromosomes separate during the first cell division. This finding may help explain high error rates in early developmental stages and has potential implications for human infertility treatment.
A University of Tsukuba-centered study reveals that nucleolar integrity during interphase is essential for proper cell cycle progression. The study's findings suggest that the maintenance of nucleolar structure regulates the activity of Cdk1, a kinase that controls mitotic entry.
Researchers at IRB Barcelona have identified the NEK7 protein as a crucial regulator of neuron formation in the hippocampus, a region associated with memory. The study found that NEK7 is essential for dendrite growth and branching, and its deficiency leads to complex phenotypes in mice, suggesting broader roles for this protein.
Researchers at Osaka University have identified distinct factors regulating crossover-type recombination at yeast centromeres and non-centromeres. The study suggests that centromeres are protected from chromosomal rearrangements due to specific proteins, ensuring DNA fidelity.
Researchers find that decapitation of primary cilia, a process linked to cellular duplication, is triggered by the presence of Inpp5e protein, which helps stabilize cilia. The study also reveals that wire-like structures formed in cilia contribute to decapitation, and that this process is essential for full cilia disassembly.
Researchers at Osaka University have found that calcium ions control chromosome condensation during mitosis, preventing misalignment and promoting compaction. This discovery sheds light on the mechanisms behind chromosome structure and organization.
Researchers at the University of Georgia have discovered a drug combination that targets mitotic slippage, allowing for complete cell death and improving chemotherapy's effectiveness. The study focuses on inactivating CRL2-ZYG11, which promotes mitosis, and has potential to treat various cancers.
Researchers at Brown University have discovered a unique interaction among proteins that could be a target for new cancer therapy. Ki-67 and RepoMan bind to PP1 in an unusual way, forming a 'hairpin' shape on the surface of PP1.
Researchers at Rice University used computer simulations to study DNA's twisted-ladder form, finding that chromosomes can emerge with either right- or left-handed superhelices. The discovery could help explain how cells regulate gene expression and cell differentiation.
Researchers found that a gap phase in the cell cycle acts as a switch to mask asynchronous synthesis, enabling a mitotic wave to coordinate with neural tube formation. This study provides insight into the critical stage of animal embryonic development.
Researchers at Duke University found that delayed neural stem cells can cause premature differentiation into neurons and increased cell death, leading to smaller brain development. This study provides new insights into the mechanisms of microcephaly and its potential links to other neurodevelopmental disorders.
Moffitt Cancer Center researchers discovered TBK1 plays a novel role in promoting cell division through interacting with CEP170 and NuMA proteins. Disrupting TBK1 activity prevents chromosome separation and mitosis progression.
Researchers have identified an interaction between proteins that helps organize chromosomes to protect vital genetic information during mitosis. This discovery provides a molecular basis for understanding chromosome segregation and its role in diseases characterized by chromosome instability.
Scientists at the Salk Institute discovered that telomeres play a more central role in a self-destruct program in cells that prevents tumors than previously thought. This process, called crisis, can be exploited to improve cancer therapies by targeting telomeres and making cells more susceptible to chemotherapy.
Researchers have found that Topo 2, an essential enzyme for chromosome separation, needs more time to untangle long chromosomes, which can lead to mutations and cancer. The study suggests that chromosome length affects the enzyme's action and highlights the importance of understanding cell division.
The study reveals that actin is busy forming a stiff cortex in cells during mitosis and cannot be used for endocytosis. By tricking the cell into making actin available, researchers restarted endocytosis in mitotic cells.
Researchers used high-resolution 3D imaging to study the disassembly process of the Golgi apparatus during cell division. The results show that the Golgi apparatus is tightly linked to the endoplasmic reticulum (ER) and redistributes into the ER during mitosis, resolving a basic cellular question.
Researchers at IDIBELL describe the key role of separase protein in regulating mitosis and ensuring correct genetic inheritance. The study identifies two new substrates that contribute to the Hippo tumor suppressor pathway, advancing knowledge of this process.
Researchers have discovered a key role played by TACC3-ch-TOG-clathrin in forming inter-microtubule bridges that stabilise kinetochore fibres during mitosis. Removing this protein team can induce cells to arrest and die, potentially providing a new approach to cancer treatment.