Articles tagged with Mitosis
Researchers have discovered a key role played by TACC3-ch-TOG-clathrin in forming inter-microtubule bridges that stabilise kinetochore fibres during mitosis. Removing this protein team can induce cells to arrest and die, potentially providing a new approach to cancer treatment.
Research reveals FAM190A's subtle but crucial role in mitosis, a process commonly disrupted in cancer. Mutations in the gene may contribute to chromosomal instability and cancer development.
A new statistical image analysis method can assist in grading breast cancer by automatically segmenting tumour regions and detecting dividing cells. The method, developed at the University of Warwick, promises to bring objectivity and automation to the cancer grading process.
Researchers from IDIBELL have discovered a new mechanism in cell division regulation through protein Zds1. This finding has significant implications for developing targeted and direct therapies against cancer by understanding the molecular mechanisms of mitosis.
A DNA replication protein called Cdt1 is involved in both DNA replication and mitosis, a later step of the cell cycle. This discovery provides a possible explanation for why many cancers have genomic instability and an abnormal number of chromosomes.
Researchers have discovered that dynein, a motor protein, plays a crucial role in spindle alignment during mitosis. A signal from the chromosomes involving the ras-related nuclear protein (Ran) blocks LGN and dynein from attaching to the cell cortex closest to the chromosomes.
A recent study published in Nature Cell Biology has discovered that bookmarking genes before cell division accelerates their reactivation afterwards. By analyzing the kinetics of gene activation, researchers found that a histone molecule undergoes chemical modification and is preserved during mitosis, allowing for rapid reactivation.
Researchers at Caltech have obtained high-resolution images of a cell with a nucleus undergoing cell division, revealing a surprising twist in the process. The observations suggest that chromosomes may link together to form a bundle that can be segregated by a smaller number of microtubules.
Researchers at UMass Chan Medical School discovered a new function of the cilia protein IFT88 in mitosis, which could contribute to ciliopathies such as primary ciliary dyskinesia and polycystic kidney disease. IFT88 plays a transport role during mitosis, similar to its function in cilia formation.
The Glavy Lab team identified the Werner Helicase Interacting Protein 1 (WHIP), a disease-related protein outside its known range, within nuclear pore complexes. WHIP may play an independent role in maintaining genome stability and detecting genetic damage, offering new avenues for understanding gene repair and expression.
Researchers at Lawrence Berkeley National Laboratory have produced a subnanometer resolution model of human Ndc80, a protein complex essential to mitosis. The study reveals how Ndc80 binds microtubules and self-associates via interactions mediated by the amino-terminal tail.
New research reveals that abnormal huntingtin protein plays a crucial role in neurogenesis, challenging previous understanding of its function in adult neurons. The study demonstrates htt's involvement in cell division and neurogenesis, shedding light on the pathogenic mechanisms underlying Huntington's disease.
Researchers at EMBL identified almost 600 human genes involved in mitosis through high-throughput imaging and computer analysis. The study provides a rich resource for scientists to investigate the molecular workings of cell division.
Researchers found that Aurora B kinase helps regulate XIST's chromatin binding by phosphorylating chromatin proteins during mitosis. This study provides insight into X chromosome silencing and may lead to a better understanding of noncoding RNAs and their role in regulating heterochromatin.
Researchers in France and Austria have created a strain of plant called MiMe, which produces genetically identical pollen and eggs through mitosis instead of meiosis. This breakthrough has the potential to simplify the creation of stable new mutant crops, paving the way for more efficient crop improvement and propagation.
Researchers at the University of Michigan have developed a new understanding of how chromosomes separate during mitosis, a crucial process in cell division. By manipulating chromosome size and observing its effect on movement, they validated the theory that polar ejection forces play a central role in guiding chromosome movements.
Researchers have identified two proteins, dynein and Nudel, as crucial for regulating the assembly of the spindle matrix during mitosis. This finding broadens our understanding of how cells control critical events during division. Understanding spindle assembly is essential to comprehend cell fate choices and development.
Researchers have identified a novel activity, called mitotic checkpoint factor 2 (MCF2), that prevents cells from dividing with improperly separated chromosomes. This finding may help increase the efficiency of cancer drugs and improve our understanding of mitosis.
Researchers at the University of Bath discovered that RASSF7 is crucial for building microtubules during mitosis, a process that allows cells to divide in two. Without this protein, cell division is halted, highlighting its potential as a future cancer treatment target.
Frank Uhlmann, a Cancer Research UK scientist, receives the 2006 EMBO Gold Medal for his decade-long work on understanding the cell cycle. His discoveries have opened new avenues in cancer treatment and diagnosis. Published over 40 papers, including in high-impact journals like Nature and Cell.
Researchers found that broken ends of yeast chromosomes remain associated even after cell division, leading to genomic instability. The association was dependent on the molecular DNA repair machinery, which helps resist pulling forces of the mitotic spindle.
Researchers from Virginia Tech have validated a mathematical model of cell division using experiments on frog egg extracts. They found that the control system is bi-stable and hysteretic, requiring specific levels of cyclin to regulate mitosis.
Researchers found that Clb2 is the real trigger for yeast cell division, contradicting previous findings on Clb5. This discovery has implications for treating cancer, as it reveals a new way to understand the cell cycle mechanism.
A new study reveals that the BRCA2 gene, linked to breast and ovarian cancers, plays a previously unsuspected role in human cell division. Inactivating the BRCA2 protein delays cells' progress through mitosis, suggesting a potential new target for cancer treatment.
Cornell University researchers reveal molecular motor Myo2p's crucial role in guiding the mitotic spindle during cell division. The study sheds light on an essential mechanism in new cell formation and highlights potential consequences of failures in molecular motor function.
Scientists at The Wistar Institute identified a new gene called chfr that establishes a previously unknown checkpoint in mitosis, found in half of human cancer cell lines. This discovery holds promise for predicting patient response to Taxol and developing more effective targeted drugs.
Researchers at Harvard Medical School have identified four human genes critical to cell division, which could lead to more effective cancer treatments. The genes are part of the anaphase-promoting complex (APC) and play a crucial role in regulating mitosis.
Researchers identified a specialized protein that catalyzes conformational change of mitotic proteins, allowing correct exit from mitosis. This finding has significant implications for understanding and developing anti-cancer agents targeting this mechanism.