Articles tagged with Nucleoli
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Researchers develop novel approach to manipulate nucleolus structure by altering rRNA sequence, revealing dynamic RNA-programmed organelle. This breakthrough enables design and manipulation of entire organelles, bridging atomic structure and cellular organization.
A small protein involved in neurodegeneration leading to Parkinson's disease also drives a type of skin cancer known as melanoma, according to new research. The study suggests new avenues for drug development to reduce the risk of developing both diseases by targeting alpha-synuclein.
Researchers have discovered a nucleolar complex that plays a pivotal role in maintaining cellular health through protein homeostasis, allowing for the dramatic reduction of toxic effects of Alzheimer's-causing proteins. This breakthrough offers hope for new therapies to slow or prevent neurodegenerative diseases, promoting healthy aging.
Researchers at Weill Cornell Medicine discovered that keeping the nucleolus small can delay aging in yeast cells. This finding could lead to new longevity treatments and may also reveal a mortality timer that determines how long a cell has left before it dies.
Researchers discovered that p14<sup>ARF</sup> activates tumor suppression by forming gel-like assemblies in the nucleolus, disrupting ribosome production and cell toxicity. This process contributes to cancer cell death, providing a new mechanism for tumor suppression.
Researchers developed DNA aptamer iSN04 to target vascular smooth muscle cells, reducing plaque formation and promoting stability. The study showed that iSN04 can effectively enter VSMCs without carriers, inducing differentiation and inhibiting angiogenesis.
Researchers identify 'junk proteins' as possible cause of ALS, a degenerative disease characterized by motor neuron death. The accumulation of these proteins is linked to the aging process, suggesting a new hypothesis for understanding ALS.
Scientists have developed a method to measure pH in cell condensates, a crucial step in understanding their physical and chemical properties. The study reveals that nucleolar proteins exhibit distinct acidic profiles, which create a proton motive force facilitating RNA and protein molecule movement.
Researchers discovered an anti-nucleolin DNA aptamer that modulates gene expression and nucleolin localization to determine a cell's lineage during differentiation. The study shows promise as a regenerative therapy for cardiovascular diseases.
Researchers at USTC have made significant discoveries about the composition and regulatory mechanism of nucleolar vacuoles in C. elegans. The study used differential interference contrast microscopy and RNAi screening to reveal that specific ribosomal proteins are required for the formation of these structures.
Researchers found that certain anti-cancer compounds cause distinct nucleolar shapes and stress, which can be measured using a new classification system. This discovery could lead to improved understanding of why some drugs fail in clinical trials, providing a potential tool for identifying promising drug candidates.
Researchers at MIT have discovered a single scaffolding protein, TCOF1, responsible for forming a biomolecular condensate within the nucleolus. The findings suggest that this condensate played a crucial role in the evolutionary shift from a bipartite to a tripartite nucleolus 300 million years ago.
A team of researchers discovered that a mutation in the HMGB1 protein causes a rare disorder with severe malformations, suggesting a link between protein droplets and genetic disease. The study's findings could have implications for understanding congenital malformations, common diseases, and cancer.
Researchers from Tokyo Medical and Dental University found that PQBP5/NOL10 is a core structural element of the nucleolus, forming a meshwork that supports other nucleolar substructures. It remains in the nucleolus under osmotic stress conditions and anchors reassembly of the nucleolar structure.
Researchers have identified a new gene, NUCL-1, in the transparent roundworm C. elegans, which is linked to human neurodegenerative diseases such as ALS and Alzheimer's. The discovery challenges recent theories on the role of nuclear structures in these disorders.
Researchers at MIT discovered how molecular clusters in the nucleus interact with chromosomes, forming small, stable droplets that give the genome a gel-like structure. This interaction helps control gene expression and maintain stable interactions between distant regions of the genome.
African baobab trees can live over a thousand years, providing food, medicine, and resources. The recent study reveals the tree's chromosome count, offering insights into conservation and agricultural applications.
Scientists have found two types of movement in nucleoli that contribute to healthy cellular function and may disrupt disease, including cancer. The research sheds light on the forces responsible for maintaining cellular integrity without membranes.
A team of international researchers has discovered the energy production mechanism of cancerous cells, which drives tumor growth. The study found that cancer cells use Guanosine Triphosphate (GTP) to fuel nucleolus expansion and protein synthesis.
Scientists have used super-resolution microscopy to identify physical connections between five human chromosomes, revealing a shared sequence encoding ribosomal DNA that holds the chromosomes together. The findings suggest that these inter-chromosomal linkages are pervasive in healthy and diseased tissue, and may play a role in chromos...
Researchers found that the most common genetic cause of ALS, C9orf72 mutation, leads to toxic dipeptide repeat polypeptides (DPRs) disrupting nucleolar assembly. Longer DPRs are more toxic to cells, highlighting a potential prognostic value for ALS patients.
Researchers have developed a novel strategy to measure material properties of the cell nucleus and its components using naturally occurring cellular dynamics. The study shows that human nucleoli behave like liquid droplets, which can influence disease progression, such as Alzheimer's and Parkinson's disease.
A synthetic organelle created in a lab modelled membraneless organelles found to drive efficient sugar processing by balancing substrate and enzyme interactions. Researchers at Georgia Institute of Technology used this setup to explore cellular biochemistry, discovering unexpected nuances in organelle chemistry.
A University of Tsukuba-centered study reveals that nucleolar integrity during interphase is essential for proper cell cycle progression. The study's findings suggest that the maintenance of nucleolar structure regulates the activity of Cdk1, a kinase that controls mitotic entry.
Research links nucleolus to age-related pathways, finding that enlarged nucleoli correlate with shorter lifespans and reduced insulin signaling. A small nucleolus may extend lifespan by balancing cellular renewal and repair.
The discovery of nucleophosmin's self-interaction mechanism could advance understanding of ALS and acute myeloid leukemia. Nucleophosmin plays a critical role in regulating the construction of ribosomes, which assemble proteins using RNA genetic code.
Researchers at Cabimer have made significant discoveries about the control of cell division, highlighting the importance of the nucleolus in ensuring accurate chromosome distribution. The study found that precise temporal control of DNA compaction is necessary for equal distribution of chromosomes during mitosis.
Researchers have identified essential aspects of the regulation of the anti-tumor protein p53, with surprising results suggesting that only a few ribosomal proteins are required to maintain nucleolar structure. This discovery has significant implications for cancer research and development of new biomarkers.
The nucleolus, a specialized organelle in cells, behaves like a liquid with complex internal structure, enabling it to control cellular growth and health. Researchers discovered that proteins and RNA spontaneously assemble into three distinct layers, providing insights into the biophysical mechanism of the nucleolus's structure.
The protein NPM1 is revealed as the 'glue' that holds proteins and RNA together in the nucleolus, enabling phase separation and retention of key molecules. This structure makes it ideal for its role in ribosome assembly.
Researchers at Princeton University may have found a key to understanding how cells assemble and grow to the right size. The nucleolus, a part of the cell responsible for making ribosomes, is shown to play a crucial role in regulating cell growth through phase transitions.
Researchers from UPV/EHU applied Game Theory to calculate motorway toll charges, proposing the Nucleolus method for fairness and equity. This method reduces charges for long-distance travelers and allows for more efficient traffic management.
A single protein, NLP, has been identified as crucial for the correct arrangement of chromosome centromeres in the nucleus. The protein binds to the centromere region and causes clustering near the nucleolus, a process that can impact genome stability and potentially contribute to cancer development.
A study has revealed new insights into the 3D organization of the human genome, detailing the spatial location of genes and non-coding sequences within the nucleolus. The research provides a high-resolution sequence map of this nuclear structure, shedding light on how nuclear information is packaged into functional compartments.
Researchers at Washington University in St. Louis have identified a pathway that enables plant cells to silence unwanted genes using short interfering RNAs. The study reveals the roles of eight proteins in this process, which involves DNA methylation and epigenetic regulation.
Researchers at Cold Spring Harbor Laboratory have identified SIRT7 as a key regulator of cellular metabolism and longevity. The study reveals that SIRT7 promotes the activity of key enzymes involved in glucose and lipid metabolism, leading to improved energy balance and lifespan.
U of MN researchers identified proteins FRGY2a and FRGY2b that disassemble nucleoli without other protein help. This discovery may lead to understanding normal cell development and human diseases.