Articles tagged with Osteocytes
Researchers have successfully mapped the cells and genes that regulate bone formation and loss, revealing blood vessel cells play a critical role in bone health. The discovery has the potential to enable the development of new therapies to reverse bone loss and improve treatments for osteoporosis and other skeletal conditions.
A new study reveals the developmental mechanism of bone marrow formation, identifying septoclasts as early organizers followed by LepR-expressing bone marrow stromal cells. These specialized cell populations work together to build the bone marrow environment through a hardwired process supported by RANKL.
Researchers investigated why bones become less responsive to exercise with age, finding increased mtROS or decreased Atg7-dependent autophagy in osteoblastic cells do not contribute to reduced mechanoresponsiveness. Damage to the bone's osteocyte network also does not prevent a healthy bone-building response.
Scientists have discovered that osteocytes undergo structural and functional changes with age, impairing their ability to maintain bone strength. This discovery could lead to new treatments for osteoporosis and age-related bone loss by targeting senescent cells.
A team of paleontologists has discovered the oldest record of sea turtle DNA in a fossil shell from Panama's Caribbean coast. The findings, published in Journal of Vertebrate Paleontology, date back approximately 6 million years to the upper Miocene Epoch.
Researchers compared zebrafish and medaka bones, finding medaka lacks bone cells but retains water-absorbing Proteoglycans. The study suggests a new explanation for why some bones respond better to stress than others.
Scientists have identified connexin (Cx) 43 hemichannels on the surface of bone cells as a potential new target for medications to treat osteoporosis and other conditions that cause bone loss. The study, published in eLife, reveals how these channels play a crucial role in responding to mechanical stress and building stronger bones.
Researchers have mapped the genetic profile of osteocytes, a type of bone cell that controls skeleton growth and decay. The study identifies novel genes associated with rare and common skeletal diseases, paving the way for new treatments and improved diagnosis.
A researcher is working on a project funded by NASA to understand how the skeleton senses and responds to forces, with the goal of keeping astronauts' bones strong during long periods in space. The study aims to develop strategies to restore healthy bone dynamics, which can be disrupted by disuse and lack of gravity.
Researchers found a connection between estrogen and protein Sema3A in maintaining bone health. As women lose estrogen with age, Sema3A levels drop, leading to osteocytes dying and bones losing support structure.
Scientists have discovered that irisin, a hormone released by muscles during exercise, directly acts on key regulatory cells that control the breakdown and formation of bone. Treating osteocytes with irisin protected them from age-related death and increased their production of sclerostin, a protein that triggers bone remodeling.
Osteocytes are identified as the major source of receptor activator of nuclear factor-κB ligand (RANKL) during orthodontic tooth movement, regulating bone remodeling and osteoclastic differentiation.
Researchers found that osteocytes, tiny bone cells with delicate membranes, experience membrane tears in response to mechanical loading. This tear triggers an increase in calcium levels, leading to bone remodeling and strengthening. The discovery sheds light on how bones adapt to gravity and physical activity.
Researchers have identified a universal mechanism behind bone cell organization, revealing a quantitative framework to assess bone quality. The study shows that different bone types exhibit varying levels of connectivity but similar efficiency in intercellular transport and communication.
A team of researchers confirms ancient protein preservation in dinosaur bone cells using antibodies that target specific proteins found in vertebrate bone cells. This finding further solidifies the case for preservation of cells and possibly DNA in ancient remains.
Researchers have discovered that bone cells' spindly extensions can sense mechanical stimulation, signaling the release of bone-growth factors. This breakthrough could lead to therapies for osteoporosis and bone loss associated with aging.
Researchers, led by Liyun Wang, aim to shed light on how osteocytes sense external stimuli and communicate with surface cells. This study may lead to effective drug therapies for treating debilitating bone diseases.