Articles tagged with Protein Secretion
A Kobe University team identified the cause of pollutant accumulation in pumpkins and their relatives, discovering that specific proteins bind to pollutants and transport them through the plant. By controlling these proteins' behavior, safer crops can be created and polluted soils can be cleaned.
Researchers developed a novel label-free biosensing platform to monitor cellular secretion of monoclonal antibodies in real-time. This approach enables rapid clone selection and cost-effective manufacturing of life-saving immunotherapies.
Researchers found that tumor cell secreted DNA in extracellular vesicles acts as a 'danger' signal to activate an anti-tumor response in the liver, reducing liver metastasis risk. The discovery improves understanding of cancer progression and anticancer immunity.
Scientists at UChicago developed a new approach to study snoRNAs, uncovering thousands of previously unknown targets in human cells and mouse brain tissues. These discoveries suggest that snoRNAs may have a broader range of functions beyond guiding RNA modifications.
Researchers analyzed young and aged dermal fibroblasts, finding a significant decrease in protein secretion with age. The study also revealed an increase of over 60% in cytoplasmic protein accumulation, highlighting the cytoskeleton's crucial role in skin aging.
Researchers genetically engineered Toxoplasma gondii to produce and release therapeutic proteins in the human brain, bypassing the blood-brain barrier. The method has potential implications for treating diseases caused by protein deficiencies or abnormal expression.
Researchers investigated molecular changes in aging mouse sweat glands, finding 171 mRNAs enriched in secretory cells. Altered mRNA and protein abundance were associated with age-related declines in sweat gland function.
Researchers at MIT and University of Helsinki discovered a protein in human sweat that can protect against Lyme disease. A genetic variant of this protein is associated with increased susceptibility to the disease.
Scientists have discovered an additional source of genetic mutations that cause rare conditions like Huntington's disease. Expanded CAG repeat RNA can form aggregates that reduce global protein synthesis and lead to neurotoxicity.
Researchers successfully created stem-cell derived organoids from human stem cells that secrete three essential enamel proteins. These proteins form a matrix that undergoes mineralization to create a hardened enamel structure. The breakthrough offers hope for developing novel treatments to repair and regenerate teeth.
Researchers have identified KIAA0930 as a key factor causing muscle atrophy in cancer cells, which could lead to the development of new anti-cachexia therapies. The study found that KIAA0930 knockdown cells showed increased muscle mass and weight compared to control cells.
Researchers at the University of Helsinki discovered a small molecule that inhibits cytokine protein formation, alleviating rheumatoid arthritis symptoms in mice. This breakthrough enables the rational design of novel molecules for disease prevention and treatment.
Researchers at the Sainsbury Laboratory, Cambridge University have discovered that symbiotic and pathogenic fungi use a similar group of proteins to interact with and live within plants. This finding suggests that both pathogens and symbionts are using universal mechanisms to colonise plant cells.
Researchers developed a novel optical imaging approach to observe cell secretions in space and time, revealing key heterogeneity and potential for pharmaceutical development. The method has tremendous potential for high-throughput screening of individual cells and studying delicate antibody-secreting human donor B-cells.
Research at IRB Barcelona reveals CPEB4's essential role in T lymphocytes' adaptation to chronic cellular stress. By overcoming this stress, these cells can exert their antitumour function and halt tumour growth.
Researchers from Harvard University developed an efficient method to make large numbers of C4-secreting human astrocytes from stem cells. A small group of about 20 drugs were identified that reduced C4 secretion, effective in both healthy and Schizophrenia patients' astrocytes.
Researchers from University of Cologne and Technical University of Munich discovered that the signal peptidase complex plays a crucial role in quality control of membrane proteins. The complex cleaves faulty membrane proteins to initiate their degradation, maintaining cellular function. This discovery has important implications for und...
A study characterizes secreted proteins from Candidatus Liberibacter solanacearum, a newly emerging pathogen of tomato and potato. The proteins, called effectors, offer clues into the manipulation tactics used by the bacterium to subdue its plant host.
Researchers found that knockdown of secreted frizzled-related protein 4 (SFRP4) suppresses SASP and improves age-related skin phenotypes. This suggests a potential candidate for the development of new skin rejuvenation therapies.
A study by Osaka University researchers has revealed the molecular details of how Vibrio cholerae secretes its colonization factor TcpF. The mechanism involves the Toxin-coregulated pilus (TCP) system, which allows the bacterium to colonize the human intestine and initiate infection.
Researchers at NUS have developed a method to produce cell-based meat using magnetic pulses, reducing reliance on animal products and increasing efficiency. This technology has the potential to revolutionize the food industry and improve regenerative medicine by stimulating the growth of healthy cells.
Scientists have developed a new model to track protein signals that enable organ-to-organ communication, which could help understand disease onset and progression. The technology has the potential to identify novel secreted proteins and develop targeted treatments for diseases such as cancer and obesity.
Researchers created genetically edited mice to label and study secretome proteins, facilitating studies of inter-organ communication. The transgenic mice enable scientists to identify specific cell types and organs, providing a valuable resource for mapping and profiling the secretome.
Researchers developed a novel method to visualize proteins secreted by cells with high resolution, using plasmonic-fluor technology. The FluoroDOT assay is versatile, low-cost and adaptable, providing a more comprehensive look at these proteins.
Researchers found an autism-associated mutation in the Hevin protein results in its retention in the endoplasmic reticulum, activating the unfolded protein response in cells. This disrupts normal brain function, contributing to autism pathogenesis.
Researchers at Kobe University have successfully identified and disrupted genes in Pichia pastoris yeast to increase its secretory production of useful proteins. Through a series of processes, they developed new host strains that can produce high yields of proteins for industrial enzymes and biomedical antibodies.
Scientists at UC Berkeley developed a new structure prediction method that modeled 500 secreted proteins in fungal pathogen Magnaporthe oryzae. The method revealed novel sequence-unrelated effectors and common folds among plant pathogens.
A team of scientists from NTU Singapore has developed a plant-based emulsifier that is rich in protein and antioxidants, allowing it to replace eggs or dairy in food staples. The emulsifier is made by fermenting brewers' spent grain and can help cut down on food waste, reducing greenhouse gas emissions.
Researchers at the University of Alabama at Birmingham discovered the mechanism of secretion and trafficking of Mycobacterium tuberculosis' toxin TNT, which kills over 1 million people annually. The ESX-4 type VII secretion system plays a crucial role in transporting TNT across cell membranes.
Scientists have identified tube-forming proteins in mycobacterial outer envelope that enable protein secretion. The discovery, using x-ray crystallography and cryo-electron microscopy, reveals a novel method for studying substance transport mechanisms in pathogenic mycobacteria.
Defective ACLP protein causes cellular stress and induces fibrosis in multiple organs, including lungs, livers, and adipose tissues. The study identifies a novel variant of EDS-causing mutations and reveals the protein's role in maintaining connective tissue integrity.
A new method detects trace proteins secreted by embryos using microfluidic droplets and multicolor fluorescence, predicting developmental potential with high accuracy. The technique improves upon conventional morphological scoring, reducing variability among embryologists.
Researchers at McMaster University found that metformin induces the expression and secretion of protein GDF15, which suppresses appetite and may contribute to weight loss. The study opens new avenues for research into the potential effects of metformin on aging and diseases.
Researchers at the University of Copenhagen have mapped proteins secreted by adult human brown and white fat cells, revealing they send distinct signals to the rest of the body. Brown fat plays a key role in regulating the cellular immune system, while white fat promotes tissue plasticity.
Researchers discovered a blood marker that can predict the risk of bone fractures in postmenopausal women, independent of other measures. High levels of periostin protein fragments were found to be associated with an increased risk of fractures, suggesting they reflect additional bone properties.
A team of researchers at Osaka University has discovered a novel autophagy-dependent secretory system that facilitates the secretion of inflammatory cytokines like interleukin-1 beta and leaderless proteins such as ferritin. This finding opens new therapeutic avenues for diseases related to autophagy.
Researchers identified HMGB2 as a critical regulator of cytokine and chemokine expression during senescence, which may have detrimental effects on tumor growth. Silencing HMGB2 suppresses the expression of pro-tumorigenic factors, suggesting potential therapeutic strategies to mitigate negative side effects of senescence.
Researchers discovered a soy-based protein called soy-ghretropin that increases blood levels of ghrelin, an appetite-stimulating hormone. The findings suggest this protein may be developed to help elderly people or anorexic patients with reduced ghrelin levels and food intake.
Researchers at Washington University School of Medicine have discovered a potential target for malaria drug development by identifying a key protein involved in the parasite's protein secretion process. Disrupting this protein, heat shock protein 101 (HSP101), prevents the parasite from secreting its proteins into the red blood cell.
Researchers have identified twenty specific proteins secreted by primary effusion lymphoma cell lines, which may explain the cancer's peculiar behavior. These proteins are involved in inflammation, immune response, and cell growth, and their presence in tumor cells could lead to more personalized treatment approaches.
Researchers at University of Bristol have successfully mapped the molecular gateway across cellular membranes, revealing the mechanism responsible for protein secretion. The study, published in Cell Reports, provides a major breakthrough in cell biology, shedding light on how proteins are transported across membranes.
Bacteria Pseudomonas aeruginosa employs a unique secretion system to break down its opponents' cell walls, causing their breakdown. The bacteria protects itself from this attack by using immunity proteins that counteract the effects of toxic proteins it secretes.
Researchers at University of Louisville identified a protein sorting mechanism used by the salivary gland, which could lead to advanced therapies for patients with damaged or non-functioning salivary glands. The study found that a specific lipid molecule, PtdIns(3,4)P2, plays a crucial role in sorting proteins into vesicles for secretion.
Researchers have identified a roundworm protein that can suppress systemic inflammation caused by sepsis, providing new potential treatment options. The protein, ES-62, triggers autophagy, a process that clears damage and promotes cell survival during stress situations.
Researchers at the University of Michigan found that bacteria spend more on internal proteins than external ones, conserving resources and improving their competitiveness. This thrifty behavior is linked to protein location and cost, with cheaper amino acids used in internal proteins.
A study found that a specific gene variation linked to a protein hormone secreted by fat cells is associated with a lower risk of colorectal cancer. The discovery suggests that the adiponectin axis may play an important role in modifying colorectal cancer risk.
Researchers discovered a strong association between elevated fetuin-A levels and the development of type 2 diabetes in older adults. The study found that higher fetuin-A levels were associated with a significantly increased risk of diabetes, with the strongest association seen in the third highest quartile of fetuin-A levels.
Researchers identified a new protein called renalase, which regulates heart rate and blood pressure. Reduced levels of renalase have been linked to increased cardiovascular risk in patients with end-stage kidney disease.
Dr. Castle's work elucidates the mechanism of secretion from exocrine cells, particularly salivary glands, through analysis of secretory granules and membrane components. His discovery of SCAMPs and demonstration of four pathways of secretion in parotid cells contribute to a deeper understanding of membrane trafficking and exocytosis.
The US Navy is developing new antifouling hull coatings inspired by nature, using complex nanometer-scale patterns to prevent barnacles from attaching. These coatings have shown exceptional low settlement rates in early experiments, promising a reduction in fuel costs and frequent cleaning needs for Navy ships.
A new study found that the secretory path's activity is closely tied to the nucleus' structure and functions, with disruptions impacting gene expression and cellular growth. This research may hold key to developing molecular therapies for these genetic diseases.