The researchers have identified a new protein, called renalase. Renalase is secreted by the kidney into the blood and regulates heart rate and blood pressure. Interestingly, renalase levels are markedly reduced in patients with end-stage kidney disease as compared to healthy subjects. Therefore, there may be a causal link between reduced renalase and the increased cardiovascular risk that is often seen in patients with renal disease
The identification of renalase not only provides a more complete understanding of renal and cardiovascular physiology, but could also lead to the development of novel therapies for patients with chronic kidney disease.
TITLE: Renalase: a novel, soluble monoamine oxidase that regulates cardiac function and blood pressure
AUTHOR CONTACT:
Jianchao Xu
Yale University School of Medicine, New Haven, CT USA
Phone: (203) 932-5711, extension 2542; Fax: (203) 785-4904; E-mail: jianchao.xu@yale.edu
View the PDF of this article at: https://www.the-jci.org/article.php?id=24066
Journal of Clinical Investigation