Fanning and Chazin found structural and biochemical evidence for the mechanism of ssDNA break free from its binding protein to allow repair or replication. The researchers developed a working model to answer how RPA gets dislodged, allowing enzymes access to DNA for processing.
Microglial cells are highly dynamic, constantly sampling their environment and interacting with neurons. In response to cerebral hemorrhage, microglial cells rapidly rush to the injured site, shielding it and decomposing damaged tissue.
Researchers discovered that TGFBR1*6A gene variants significantly increase breast cancer risk in women over 50, with a 69% higher risk for those with low TGF-beta activity levels. The findings may help predict breast cancer risk in a large subset of the population and inform genetic testing options.
Molecular Systems Biology is a new journal that publishes papers on complex biological systems using molecular components and their interactions. The journal features innovative technology for formal descriptions of biological systems and sharing of data in widely-used XML-based formats.
Researchers at Michigan State University recreated a rare isotope of nickel called Ni-78, which existed briefly in the chain of events that formed elements. This breakthrough reveals that Ni-78 decays up to three times quicker than expected, changing models of element formation before Earth's creation.
Researchers identify FMRP RNA ligands containing 'kissing complex' motifs, redirecting search for disease targets. The study also reveals a crucial link between FMRP, mRNA translation regulation and neurologic dysfunction in Fragile X syndrome.
A study found that analyzing prostate tissue's metabolic profile can identify the biologic status of the disease, allowing clinicians to make better-informed decisions on treatment. The technique outperformed standard histopathology in differentiating between cancer cells and benign cells.
Researchers found that Brown-headed cowbirds can affect the sex of host offspring, while commercial fishing led to changes in open-ocean fish communities. Additionally, a study on plant defense theory revealed that outbred plants are more resistant to certain insect herbivores.
Researchers have developed a new model to predict the physics of stellar burning, particularly in stars like V4334 Sgr that undergo brief rebirths. The model predicts that V4334 Sgr will become much hotter and then slowly repeat the stellar rebirth cycle, returning to its current temperature in roughly two hundred years.
Researchers found that bacteria's worst enemy in nuclear waste sites may be toxic metals, contradicting conventional wisdom. Actinides are less toxic than other metals, suggesting bioremediation using naturally occurring bacteria can still be effective.
Barron and Monteiro-Riviere's project explores fullerene interactions with skin cells, aiming to develop new nano-biohybrid materials. The researchers will investigate physiochemical properties of fullerenes to predict uptake and activity.
A review of treatments for pulmonary thromboembolism (PTE) in children reveals an acute need for more research into diagnosing the condition. The study found that only four per cent of blood clots in children presented without any risk factors, highlighting the importance of recognizing symptoms.
The Genographic Project is a five-year global study of human migratory history, analyzing genetic samples from indigenous peoples and public participants. Researchers will use markers encoded into DNA to trace lineages, unveiling new aspects of family trees that persist through genes.
A study found that family conferences in ICUs missed opportunities to discuss withholding or withdrawing life-sustaining therapy due to clinicians' failure to listen and respond appropriately. The missed opportunities fell into three categories: listening, acknowledging emotions, and addressing medical ethics principles.
The Lance Armstrong Foundation is supporting a University Hospitals of Cleveland research project exploring the impact of exercise and dietary counseling on obese endometrial cancer patients. Dr. von Gruenigen's study aims to improve quality of life for this high-risk group, which accounts for over 40,000 cases annually in the US.
Research reveals that nitrite is a potent inhibitor of ischemia/reperfusion injury in the liver and heart, limiting cell death and preserving organ function. Additionally, adipocyte-derived collagen VI promotes early tumor growth in breast cancer, while EBV proteins drive immune responses in multiple sclerosis.
Researchers found that popular chemistry textbooks focus on abstract concepts and tools without discussing their application in practice. To address this, they developed a testable framework describing chemists' routine activities, including explaining phenomena, analyzing matter, and synthesizing new substances.
A study on the MSY2 protein found that its absence in mice leads to male and female infertility. The researchers aim to develop new non-hormonal contraceptives using Contrin, a human equivalent of MSY2. This discovery holds promise for targeted fertility treatments and could lead to innovative contraceptive options.
The center aims to provide a national overview of how young adults with disabilities fare after leaving school, collecting and interpreting data to inform program improvements. The grant partners with OSEP, National Dropout Prevention Center, and other organizations to support states in implementing best practices.
A study published by Johns Hopkins Medicine suggests that participating in a variety of physical activities may reduce the risk of Alzheimer's disease in older adults. The research found that individuals who engaged in multiple activities had a lower risk of dementia compared to those who participated in fewer activities.
Mechanical engineers at Purdue University have created micro-channel heat sinks that can cool electronic components, enabling faster performance and better functionality. The devices are being developed to address the growing need for efficient cooling in advanced laser systems, microwave radar, and future computers.
Researchers at Northwestern University show that a magnetic field can be used to increase or decrease the flow of heat through an Andreev interferometer. The findings, published in Physical Review Letters, demonstrate the quantum mechanical nature of heat flow and its relationship with electron charge.
Chronic daily headaches are more prevalent in obese and morbidly obese people than those with normal body weight, the study found. Obese individuals reported severe pain and missed more work days due to headaches.
Leishmaniasis, a fatal disease affecting 1.5 million people worldwide, will be controlled through paromomycin with the goal of delivering treatment for under $10. The Institute for OneWorld Health aims to change generations of families devastated by VL.
A new MS drug, AVP-923, has shown significant improvement in reducing pseudobulbar affect episodes, with 84% of patients reporting betterment compared to 49% on placebo. The treatment also led to overall improvements in quality of life and reduction in pain.
Researchers reassess Martian landslides using recent images and propose alternative gravity-driven explanation. Ocean color tracking reveals 50-year dataset for phytoplankton abundance estimation. Aerosol concentrations in China's atmosphere reduce daily surface solar radiation since 1961, according to Geophysical Research Letters papers.
Hinke Piersma's research explores the interaction between political decision-making and public debate regarding 'the Breda three', four prisoners who became two in 1979. The discussion increasingly focused on integrity, as the Dutch population was criticized for failing to protect Jewish compatriots during WWII.
A study published in Science identifies the master gene grainyhead as essential for wound repair in both fruit flies and mice. The researchers found that grainyhead is required to activate genes involved in cuticle repair, which then regenerate injured patches of skin.
A network of non-profit groups in California is providing critical assistance to low-income consumers struggling with insurance problems, resolving 62% of issues. The Health Consumer Alliance helps consumers choose coverage, navigate public programs, and reduces costs, morbidity, and litigation
A new study assesses the cost-effectiveness of pharmaceuticals in different countries, highlighting the importance of considering location-specific factors. The findings emphasize that economic evaluations are not transferable across borders, requiring repeated studies to determine cost-effectiveness.
A Georgetown University researcher reveals hidden sponsorship of articles and lectures in medical journals, compromising patient care. A public database is needed to disclose conflicts of interest.
Researchers found that nitrite therapy reduces cell death and preserves organ function in mouse models of I/R injury. Nitrite may serve as a therapeutic treatment for I/R disease, particularly in preventing organ dysfunction following surgery or transplantation.
A study by Mayo Clinic investigators found that pessimism and depression are associated with a higher risk of dementia. The research, which analyzed data from over 3,500 individuals, suggests that personality traits may play a role in the development of cognitive impairment 30-40 years later.
A recent study conducted in Norway found that bright Arctic light can trigger migraines in women with aura. The research revealed that nearly half of those with migraine with aura experienced more frequent attacks during the summer light season than during the polar winter season.
A new physical therapy technique, Souchard's global postural re-education, has shown significant improvement in chronic back pain patients. The method involves stretching and strengthening of para-spinal muscles to correct posture and decompress the spinal canal, resulting in pain relief for 92% of participants.
Researchers suggest low atmospheric oxygen levels led to population fragmentation, increasing extinction rates and slowing recovery. Oxygen levels dropped by 20 million years, making breathing at sea level equivalent to summiting a high mountain.
Researchers discovered that the alpha isomer of toxic flame retardant HBCD accumulates in dolphin blubber due to its inability to be metabolized by enzymes. The beta and gamma isomers are broken down by cytochrome P450, leading to their exclusion from fat-rich tissues.
Researchers found significant associations between two SNPs and alcohol dependence in a Russian population, similar to U.S. findings. The study suggests that the GABRA2 gene influences risk for alcoholism regardless of environmental factors.
Researchers developed a classification system to treat thrombotic aneurysms, finding that one-third can be treated surgically with conventional clipping. The study also discovered that bypass and occlusion procedures yield more favorable results for unclippable aneurysms.
Researchers found that palmitate, a saturated fatty acid, can attach to proteins regulating bioelectricity in cells. This attachment affects the transmission of electrical impulses in nerve and heart cells, with potential health implications.
A study found that college students tend to overestimate volumes, over-pour drinks, and under-report levels of consumption. Educational feedback improves students' understanding of standard drink definitions, leading them to report a larger number of beverages consumed.
Researchers have discovered a new treatment that uses a chemical to prevent PARP repair, making recombination essential for cancer cell growth. This approach shows promise as a potential breakthrough for women with hereditary breast cancer.
Dr Christine Thomas has discovered a previously undetected seismic layer near the Earth's core-mantle boundary, allowing researchers to measure internal temperatures and study whole mantle convection. The new layer enables scientists to examine the fate of subducted lithosphere and hot material rising from the core-mantle boundary.
Researchers found that collagen VI from adipocytes stimulates the proliferation and survival of malignant cells in breast tumors. The study suggests a potential link between increased adiposity and breast cancer risk, highlighting the role of extracellular matrix proteins in tumor behavior.
A Northwestern Memorial study finds that smart pump technology alone has limited potential to improve patient safety, but integrating it with EHRs and other technologies can significantly reduce errors. The hospital is developing a robust two-way communication system to verify physician orders in real-time.
A recent editorial in the Journal of General Internal Medicine condemns the practice of ghostwriting in medical journals, citing issues with authorship and financial relationships. The authors highlight the need for transparency and accountability in academic publishing to maintain public trust.
Researchers have discovered two new species of giant amphibians in Africa, which are similar to crocodiles in shape. The findings suggest that climate change over 250 million years ago had a dramatic effect on species survival and evolution.
Pigs can become lethargic in high temperatures, leading to poor growth rates. Providing extra cooling measures such as water baths or misting systems can help reduce heat stress and increase feed intake.
A global study reveals that 172 of the world's largest rivers are regulated by dams, affecting ecosystems globally. The highest impacted regions include temperate forests and savannahs, while Australia has the largest proportion of free-flowing rivers.
A recent study published by the American Academy of Neurology suggests that long-term use of ibuprofen may lower the risk of developing Parkinson's disease. The research found a 35% lower risk among ibuprofen users compared to non-users, with risks decreasing depending on weekly dosage.
Researchers at University College London have discovered how a well-specified bath affects the qubits in a crystal, which behaves as a primitive quantum computer. The study suggests that the effect can be controlled by radio waves and temperature of the bath, paving the way for stable quantum computing.
Researchers have discovered evidence of large fluctuations in sea levels over thousands of years, not just during glacial periods, using a new method of dating corals. This finding suggests that sea levels may be more variable than previously thought, with changes occurring on shorter time scales.
A study of 20 male golfers with and without the yips found that those with yips had abnormal muscle activity in their forearms before impact. Golfers with yips were also older and had higher handicaps than those without yips, who had fewer errors and made more putts.
A new study found that erythropoietin reduced inflammation and cell death, improving functional recovery after hemorrhagic stroke in rats. The treatment also showed decreases in brain water content and increases in behavioral recovery.
Researchers used structural biology to compare viral structures, discovering that some viruses share the same protein structure as the immune system. This finding suggests that viral building blocks may have served as precursors for the evolution of the immune system.
A new study found that low concentrations of sodium nitrite prevent cell death in the hearts and livers of mice undergoing experimental heart attack and liver injury. The potent protective effect reduced dead tissue by 67% compared to control animals given nitrate.
A study published in the American Journal of Clinical Nutrition found that smoking depletes vitamin E levels 13% faster than non-smokers, increasing health risks. The research also reveals an interactive relationship between vitamins C and E, highlighting the importance of adequate levels of both antioxidants to prevent disease.
A recent study by Leonidas Koniaris and colleagues found that lethal injection methods in the US are often inadequate, leading to unnecessary suffering. The study analysed data from executions in Texas and Virginia, as well as autopsy toxicology reports, revealing low concentrations of thiopental in the blood of executed inmates.
Researchers found that small soluble protein clusters called oligomers cause neurotoxicity by increasing membrane permeability. This challenges the long-held idea that insoluble fibrils are responsible for disease symptoms.
A recent study found that women with ischemic stroke are less likely to receive diagnostic tests than men, despite having worse outcomes. Sixty-two percent of all deaths from stroke in the US occur in women, highlighting a need for increased access to tests and education.