Researchers discovered that LXRs regulate SREBP-1c, a key protein in fat metabolism, allowing animals to store fat when fed high-fat diets with cholesterol. The study also found that LXR's role is crucial in the biochemical pathway that regulates fat storage, suggesting a new target for obesity and heart disease treatments.
A global team of RNA scientists will develop a common vocabulary and scientific concepts to facilitate communication and knowledge-sharing. The project aims to integrate RNA sequence and 3D structure databases to advance understanding of cellular growth and development, key to curing hereditary diseases.
A new study by Vanderbilt researchers has uncovered a crucial role for prostaglandins in early embryonic development, highlighting their potential as molecular targets for cancer prevention therapies. Prostaglandin inhibition led to gastrulation arrest and slowed cell movement in zebrafish embryos.
A study found that ethnic differences in beliefs about health and health management are associated with home remedy use among elderly adults. The researchers analyzed data from the ELDER study, which showed that black and Native American elders were more likely to use home remedies than white elders.
A study found that adolescent daughters of parents with HIV have a high childbearing rate, with 38-67% experiencing pregnancy. Interventions like family-based counseling and academic support reduced the likelihood of early childbearing.
Researchers found that a modest decrease in Mdm2 protein expression prevents tumor formation and does not lead to premature aging. Inhibitors of Mdm2 may delay cancer in young individuals without detrimental side effects.
A unified physics theory explains how animals move by minimizing imperfections in their flows. The constructal law predicts relationships between body mass and speed, stride frequency, and muscle force, showing convergences across different species and environments.
A new study by UT Southwestern researchers found that coaching women to push during labor does not significantly affect the length of labor or long-term pelvic floor problems. However, coached women experienced shorter labors and smaller bladder capacities, with bladder function returning to normal over time.
A report found that large employers are more likely to cover preventive services, while smaller businesses lag behind. However, even among larger employers, coverage is not universal, with many failing to offer services to help employees quit smoking and adopt healthier lifestyles.
Scientists use Chandra to observe the Northern Lights dancing in X-ray light, revealing changing bright arcs of energy above the Earth's surface. The team detects low-energy X-rays generated during auroral activity, expanding our understanding of solar storms and their impact on the planet.
The Office of Naval Research has successfully tested a fast scramjet, reaching speeds of Mach 5.5 and demonstrating the feasibility of low-cost flight test techniques at hypersonic speeds. The engine, powered by liquid fuel, offers a safer alternative to other designs, making it suitable for shipboard use.
Researchers have developed a new approach that boosts the production of TAP, an immune system component, to make smaller vaccine doses more effective, reducing side effects and increasing immunization capacity. This technique has the potential to far-reaching benefits in the field of vaccines.
A recent study found that frequent verbal harassment in middle school is associated with a three-fold increase in alcohol use during high school. The researchers also discovered that peer harassment fuels aggression and antisocial behaviors among boys, particularly those who experience both verbal and physical harassment.
A study by Wake Forest University found that Latino men experiencing family-related ambivalence during migration are more likely to suffer from anxiety. The researchers suggest enhancing communication between migrants and their families could help address mental health needs.
Climate change and human activities are pushing tiny pikas to higher elevations, leaving them with limited habitat options. The animals' distribution has diminished significantly over the past 40,000 years, with many populations now isolated on separated mountain ranges.
A Mayo Clinic study found that vertebroplasty significantly improved back pain and activity levels in patients with vertebral compression fractures. Patients' pain during rest and activity improved an average of seven points one week after treatment and remained improved for up to a year.
The Office of Naval Research has developed a technology that allows binoculars to transmit digital voice over long distances, up to five nautical miles. LightSpeed can also be used for communication between ships at sea and platforms in the air and on the ground.
Scientists have identified two microRNAs, miR-1 and miR-133, that play opposing roles in determining whether myoblasts proliferate or differentiate into mature muscle cells. Increasing miR-1 promotes differentiation, while increasing miR-133 enhances proliferation.
A recent study found that stopping regular blood transfusions in children with sickle cell disease who are at risk for a stroke means their stroke risk likely returns. The study, which involved 41 children, showed that within a few months of halting transfusion, 14 children resumed at-risk status and two had strokes.
J. Virgil Waggoner is being recognized by the Chemical Heritage Foundation for his outstanding contributions to the petrochemical industry, as well as his commitment to education and community service. He will receive the Petrochemical Heritage Award at the opening of the 31st annual NPRA International Petrochemical Conference.
The study found MDCT angiography to be a reliable tool for evaluating the coronary veins prior to pacemaker lead placement and other procedures. It improves diagnosis quality by providing better planning before surgery, making it a valuable alternative to conventional angiography.
Researchers developed a new approach to analyze drug effectiveness data, providing insights into the cost-effectiveness of newer and older anti-epileptic drugs. The study suggests that two older drugs, valproate and carbamazepine, are likely to be more cost-effective for newly diagnosed patients with partial seizures.
The Medicare drug benefit is at risk of causing significant harm to vulnerable populations, including the poor, elderly, and disabled. A narrow six-week transition period to a new formulary may lead to difficulties in accessing essential medications, potentially resulting in health problems.
A high-fat diet suppresses the activity of GnT-4a glycosyltransferase, leading to impaired insulin secretion and type 2 diabetes. The study suggests that people with an inherited predisposition to type 2 diabetes may have variations in the gene for GnT-4a.
Researchers have discovered a gene, PD-1, that causes CD8 T cells to become exhausted in mice with chronic viral infections. By blocking the PD-1/PD-L1 bond, they reactivated the cells' response to infection and reduced viral load.
Researchers at Howard Hughes Medical Institute have determined how P. falciparum parasites can turn on one cloaking gene and keep dozens of others silent until needed. This discovery reveals the mechanism behind the parasite's survival and has implications for developing new therapies to interfere with its immune evasion strategies.
A single gene encoding the enzyme GnT-4a is key to enabling pancreatic beta cells to sense blood glucose levels and produce insulin. In mice fed a high-fat diet, this enzyme's suppression led to type 2 diabetes.
A recent study by Bradley Hospital found that up to twenty percent of adolescents on psychiatric units may be manic-depressive. The study used a mania rating scale and found that these patients were more suicidal and aggressive than those admitted for depression alone.
Pediatric oncologists play a crucial role in guiding patients and their families through complex treatment decisions. Effective communication is key to empowering parents to make informed choices, and clinicians must explore patient values to facilitate better decision-making.
A first published analysis of the FDA's mifepristone reports reveals 607 adverse events, including fatalities from bleeding or septic shock. The authors call for increased research into allergic and fatal septic reactions and propose measures to improve safety monitoring.
A multidisciplinary international consortium of European researchers will study the mechanisms of sleep regulation, combining experimental and clinical research. The project aims to develop new methods to treat sleep disorders and mental health issues, leveraging a large epidemiological study on Finnish population.
The University of Colorado's Student Dust Counter instrument will monitor dust grain density in space as New Horizons approaches Pluto. The team hopes to identify undetected clumps of dust, shedding light on the solar system's formation and other stars' planetary systems.
Researchers believe that analyzing Medicare data will help assess medication use in real-life conditions, improving the nation's ability to understand risks and benefits of drug treatment. This can lead to increased data on whether drugs are used as intended and their potential risks.
A recent trial found that a 13-day perioperative course of oral amiodarone significantly reduced the incidence of atrial tachyarrhythmias after cardiac surgery, particularly in older patients and those undergoing valve surgery. This effective therapy also showed promise in reducing hospital stay and associated healthcare costs.
A recent study by Joanne M. Murabito and colleagues found that having a sibling with cardiovascular disease increases the risk of developing CVD, even after adjusting for traditional risk factors. The research analyzed data from over 4,500 participants and found a 55% increased risk for incident CVD in those with a sibling CVD history.
The study found that flexible drug dosing permitted patients to remain on the medication longer due to fewer side-effects, while also showing a significant clinical advantage in treating patients with epilepsy. This approach balances efficacy and tolerability, providing more realistic data on antiepileptic drugs.
A study by Dana-Farber Cancer Institute found that black lung cancer patients are less likely to undergo surgery, despite equal access to care. The researchers attributed this disparity to a complex 'communications problem' underlying the interaction between doctors and patients.
A newly isolated compound, nostocarboline, has been shown to be a potent inhibitor of cholinesterase, a brain chemical linked to Alzheimer's disease progression. Its potency is comparable to an existing cholinesterase inhibitor, and it holds promise as a potential treatment for mild to moderate forms of the disease.
A significant inverse association was observed for intake of vitamin E, iron, and zinc. An above-median intake of beta carotene, vitamins C and E, and zinc was associated with a reduced risk of AMD.
A study of ancient Egyptian remains and art reveals that dwarfs were highly respected and integrated into society. Elite dwarfs held important positions, while ordinary ones specialized in various occupations, suggesting a positive image of short people in ancient Egypt.
UCSD researchers found a strong association between vitamin D deficiency and higher rates of colon, breast, and ovarian cancers. They recommend increasing the public's intake of vitamin D3 to 1,000 IU/day to reduce cancer incidence, which could lead to thousands of premature deaths annually.
A study of nearly 30,000 patients found that 42 percent received doses outside the recommended range, with excess doses linked to increased risks of bleeding and mortality. The researchers suggest improving dosing accuracy could save lives and reduce healthcare costs.
The Smithsonian Tropical Research Institute presents a comprehensive guide to the marine invertebrates of Bocas del Toro, with over 3000 documented species. The study highlights the region's high diversity and sets the stage for future research and conservation efforts.
A case study highlights the importance of monitoring vitamin B1 deficiency in post-gastric bypass surgery patients due to potential development of Wernicke encephalopathy. The patient experienced symptoms such as nausea, fatigue, and hearing loss, which improved with increased intravenous dose of vitamin B1.
Researchers used gene therapy to introduce a healthy copy of the dystrophin gene into mice with muscular dystrophy, repairing the entire muscle cell. The technique, developed by Michele Calos, has potential for long-term fixes for various genetic diseases.
Researchers found that guppies from high-predation environments reproduce earlier and live longer due to a selective increase in reproductive lifespan. The study supports the hypothesis that natural selection influences only specific segments of an organism's lifespan.
Researchers have found evidence of neuron growth in adult brains, particularly in dendrites, which could lead to new treatments for diseases like paralysis. The study's findings suggest that using neurons can stimulate growth, providing a potential approach to enhancing brain plasticity and improving functional outcomes.
Researchers found that survivors of generations with rampant childhood infection were shorter and died sooner than those from less infected generations. Childhood diseases like respiratory infections and diarrhea reduced growth rates. Improved public health practices led to increased height and longevity.
Researchers discovered that adult interneurons in the visual cortex can dynamically change their branch tips through growth, retraction, and new additions. This finding highlights the complex dynamic properties of cortical neurons, which may underlie observed functional reorganizations.
Researchers found that living in communities with high poverty rates and certain states significantly predict cervical cancer screening failures among black women. The study suggests community outreach programs should target high-poverty neighborhoods to improve screening rates.
Researchers at NIAID identified a specific protein involved in resistance to the TB drug PA-824. By pinpointing this protein, scientists can develop improved versions of PA-824 and accelerate TB drug development.
A new study confirms that evolution selectively influences life history traits affecting fitness, such as age at reproduction and senescence. Guppy populations show no postreproductive lifespan variation, contrary to expectations, suggesting this aspect of life history may be randomly determined.
Researchers at Memorial Sloan Kettering Cancer Center have successfully treated sickle cell disease in human models using stem cell-based gene therapy with RNA interference. The treatment corrected the production of abnormal hemoglobin and restored normal blood flow, offering new hope for patients.
Researchers reconstructed the Indus River's discharge over 30 million years and found a significant change in sediment source five million years ago. The study suggests that rivers were diverted from their original southeasterly flow by uplifted mountain ranges in modern-day Pakistan.
The study reveals that the EBNA3C protein recruits a complex to degrade the retinoblastoma protein (Rb), leading to uncontrollable cell proliferation. This finding holds promise for developing new treatments for EBV-associated B cell lymphomas and other blood cancers.
A new study shows that the net benefits of eating wild Pacific salmon outweigh those of eating farmed Atlantic salmon when considering chemical contaminants. Regional differences in contaminant levels make some farmed salmon safer choices than others.
Researchers at NIST discovered that acetaminophen, a widely used pain reliever, transforms into 11 new toxic compounds when exposed to chlorine disinfection in wastewater. The study highlights the need for environmental scientists to consider downstream reaction products when assessing pharmaceutical impacts on the environment.
A new longitudinal study by Cornell University finds that food insecurity affects the academic development of school-age children, particularly in reading and social skills. Children from food-insecure families tend to develop more slowly academically, with girls facing additional challenges.
Researchers at Duke University used DNA self-assembly to mass-produce grids with infinitesimal patterns, down to nanometers. By specifying the sequence of bases for each DNA strand, they could create trillions of identical grids with specific letter patterns.
Researchers discover precursor miRNAs undergo specific RNA editing, suppressing expression and activity. This finding expands our understanding of the complex process of gene regulation, with implications for embryonic development, cell differentiation, and cancer formation.