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Science News Archive 2005 - Page 2


Page 2 of 165

Role of microRNA identified in thyroid cancer

Researchers have identified 23 microRNAs that are significantly altered in the cancerous tissue compared to normal samples, with three miRs dramatically overexpressed and forming a signature that predicts the presence of malignant tissue. The study provides evidence for the regulatory role of microRNA in thyroid cancer development.

SourceOhio State University Wexner Medical Center·JournalProceedings of the National Academy of Sciences·DateDec 22, 2005

A little telomerase isn't enough

Researchers found that mice with half the normal amount of telomerase can't maintain their stem cells' chromosome ends, leading to early demise. The study suggests that inherited disease may be caused by inherited telomere length, not the status of the telomerase gene.

SourceJohns Hopkins Medicine·JournalCell·DateDec 22, 2005

Researchers know what you were about to say; fMRI used to detect memory storage and retrieval

A study by Sean Polyn and colleagues used fMRI to track brain activity during memory retrieval, finding the 'bootstrapping' effect where recalling a part of a memory triggers associated memories. This technique could help treat brain disorders like Alzheimer's disease and guide creation of more self-sufficient artificial neural networks.

SourceUniversity of Pennsylvania·JournalScience·DateDec 22, 2005

Cedars-Sinai researchers demonstrate a new way to switch therapeutic genes 'on' and 'off'

Cedars-Sinai researchers have developed a new delivery system that can effectively regulate therapeutic gene expression, overcoming obstacles in bringing genetic therapies to humans. The system allows for the flexibility to turn gene expression on or off, even in the presence of an immune response, making it a critical tool for treatin...

SourceCedars-Sinai Medical Center·JournalJournal of Virology·DateDec 22, 2005

Study demonstrates safety of oral contraceptives in women with lupus

A study of 183 women with inactive or stable lupus found that taking oral contraceptives had no statistically significant difference in the occurrence of flares compared to those taking a placebo. Mild-to-moderate flares and disease complications were also similar between the two groups over a 12-month follow-up.

Woolly mammoth genome comes to life

Researchers at McMaster University have successfully sequenced the woolly mammoth genome, providing a new understanding of evolution and allowing for the potential recreation of extinct hybrid animals. The discovery has significant implications for fields such as conservation and genetics.

SourceMcMaster University·JournalScience·DateDec 22, 2005

Why Christmas trees are not extinct

Conifers like Christmas trees survive due to efficient microscopic valves that allow water flow as easily as in flowering trees. The study found resistance to water flow was only 1.2 times greater in conifers, enabling them to dominate forests despite their shorter pipes.

SourceUniversity of Utah·JournalScience·DateDec 22, 2005

JCI table of contents: December 22, 2005

Researchers found that expressing active MMP-9 in macrophages within atherosclerotic plaques leads to their rupture, causing blood clots and reduced blood flow. Additionally, the inactivation of focal adhesion kinase in cardiomyocytes promotes eccentric cardiac hypertrophy and fibrosis in mice.

SourceJCI Journals·JournalJournal of Clinical Investigation·DateDec 22, 2005

Light-sensing cells in retina develop before vision

Researchers discovered that light-sensing retinal ganglion cells are active and functioning at birth, surprising the developmental timeline of the mouse retina. The cells react to light in two ways, sending messages to parts of the brain controlling circadian rhythms and visual development.

SourceWashU Medicine·JournalNeuron·DateDec 21, 2005

Fear of death may factor into who we vote for

Researchers found that participants who were primed with thoughts of death were more likely to vote for John Kerry, while those who thought about their own mortality were more likely to support George W. Bush. The study suggests that mortality salience can influence political preference and worldview defense mechanisms.

SourceBlackwell Publishing Ltd.·JournalAnalyses of Social Issues and Public Policy·DateDec 21, 2005

State board-disciplined physicians more likely to have shown unprofessional behavior in med school

A study by UCSF researchers found that medical students with early warning signs of unprofessional behavior were nearly nine times more likely to be disciplined as practicing physicians. The study recommends reviewing medical school admissions and graduation standards to include explicit language about professional behavior.

SourceUniversity of California - San Francisco·JournalNew England Journal of Medicine·DateDec 21, 2005

Infectious agent thwarts typical defense mechanisms; Sheds light on immune system function

Researchers discovered that Francisella tularensis can bypass the immune system's sensors and only triggers a response once inside a monocyte. This finding may lead to better treatments for diseases like tuberculosis and the plague. Understanding how the human immune system reacts to F. tularensis could provide new avenues for treatment.

SourceOhio State University·JournalProceedings of the National Academy of Sciences·DateDec 21, 2005

Novel strategies needed to boost cancer clinical trial participation among blacks and Asians

A study found that informational campaigns alone may not be enough to increase participation in cancer clinical trials among black and Asian American patients. Lack of awareness about trial costs being covered by insurance is a significant barrier to participation, especially among those with lower incomes and education levels.

SourceUniversity of California - Davis Health·JournalJournal of Clinical Oncology·DateDec 21, 2005