Researchers found that blocking the nerve receptor EP1 significantly reduced brain damage in mice following stroke. The study suggests an alternative to COX inhibitors, which have lethal side effects.
Researchers at UW-Madison report that transplanted stem cells can develop into heart muscle and blood vessels in damaged hearts, improving function. The study's results demonstrate the therapeutic potential of embryonic stem cells for treating heart disease.
A study of over 9,400 men found a strong association between erectile dysfunction and subsequent cardiovascular disease, including angina, myocardial infarction, stroke, and transient ischemic attack. Men with erectile dysfunction were found to have a 25-45% increased risk of cardiovascular events compared to those without the condition.
Researchers Matthias Weber, David Hoffman, and Michael Wolf discovered a genus one helicoid, a minimal surface with an extra feature: a handle. This finding has implications for understanding the properties of surfaces at the nanoscale and could lead to new applications in structures and materials science.
Researchers found that nonmelanoma skin cancers are strongly associated with UVB radiation, but melanoma patients have a different response. The study suggests that melanoma may be resistant to UVB-induced chromosomal breaks, increasing the risk of more serious cancer.
Research by Iris Van Gulik found that pupils who learned proofs in plane geometry through the history of non-Euclidean geometry gained a deeper understanding. The method also led to higher motivation among pupils. In contrast, teaching methods focused on historical development were less successful.
Research reveals that pertussis toxin is responsible for prolonging the infection period in immune and vaccinated hosts. The study found that antibodies produced by vaccines are effective only seven days after administration, allowing the bacteria to grow and spread before the body can mount an effective response.
Scientists at Vrije Universiteit in Amsterdam developed a new type of valve producing its own vocal sound by a small silicone rubber flap acting as an artificial vocal chord. Female patients with weak voices benefit from this prosthesis, regaining a natural female pitch.
Researchers found that age has little predictive value for postoperative performance with cochlear implants in elderly patients. Instead, residual hearing capacity and language abilities appear to be key determinants of success.
Researchers found that marbled murrelets in the past fed on more nutritious prey, such as sardines and squid, while modern-day birds rely on lower-value food sources like krill. This shift in diet affects the birds' energy levels, reproductive success, and nesting patterns.
Dr. Raz examines inconsistencies in antidepressant data for treating child and adolescent depression, highlighting the need for stronger evidence and questioning the safety of SSRIs for this age group.
Research by Corbett et al. reveals that islet cells are susceptible to necrosis when exposed to interleukin-1, a cytokine that triggers b-cell release of HMGB1. This process contributes to the development of diabetes.
Researchers at Rutgers University have discovered two key fertility genes in the roundworm Caenorhabditis elegans, which are essential for successful fertilization. The study's findings have significant implications for understanding human infertility and may lead to new treatments.
A UCF-led study successfully grew a safe and effective anthrax vaccine in tobacco plants, producing potent doses without bacterial toxins. The breakthrough method could help alleviate supply shortages and make vaccines more accessible worldwide.
Scientists have developed a new method to catalogue and examine the differences between individual cases of prion diseases. Applying this assay to 50 postmortem samples from patients with sCJD reveals substantial differences in molecular pathology, which could help understand this mysterious disease.
Elderly people in developing countries face significant health challenges, including infectious and non-communicable diseases. Nutritional interventions such as supplementation, food fortification, or development of nutrient-rich crops may help reduce the disease burden.
A year-long randomized trial involving 32 emergency departments in Connecticut and southwestern Pennsylvania showed that moderate- and high-intensity quality improvement strategies safely increased outpatient treatment for low-risk patients. The study also found effective implementation of guideline recommendations among practitioners.
Researchers found that newborn screening for SCID could be cost-effective due to the benefits of early diagnosis and the potential to save lives. A two-tiered strategy combining existing tests has been shown to improve accuracy without increasing costs, making it a promising approach for nationwide screening programs.
Researchers from University of Toronto found that environmental cues, such as portion size, palatability, and social norms, dominate eating decisions rather than physical or nutritional needs. This 'zone of biological indifference' makes individuals vulnerable to socially-based influences, leading to overeating.
A recent study found a connection between childhood sexual abuse and eating disorders in college-age women, emphasizing the role of psychological distress and alexithymia. The research suggests that addressing these underlying emotional factors can help prevent the development of eating disorders.
Researchers identified 17 cases of hypersensitivity reactions caused by drug-eluting stents, with symptoms including rash and difficulty breathing. The study concludes that the polymer coating on the stent is the most probable cause of these reactions.
A cross-sectional study found that smoking was associated with increased risk of more severe psoriasis among adults. Cigarette-years significantly increased the risk of clinically more severe psoriasis, with stronger effects observed in women than men.
A novel partnership between Indian institutions and the government aims to document the causes of death in rural and urban areas. The Verbal Autopsy method has already demonstrated reliable measurement of deaths in young and middle-aged individuals, and will be expanded to collect physical measurements and blood samples.
The revised International Health Regulations require detailed reporting from countries, but regional governments may withhold data due to economic and federalism concerns. This 'federalism dilemma' poses a challenge for global pandemic planning and response.
The percentage of US households classified as food insecure rose from 11.2 percent in 2003 to 11.9 percent in 2004, surpassing the official goal of six percent by 2010. Household food insecurity is influenced by unobserved hardships such as medical emergencies, which can divert income normally used for food.
A UCSF study found that living in lower-income areas worsens health and quality of life due to poorer air quality. Neighborhoods with high traffic flow and industrial pollution also linked to reduced lung function, while larger backyards with allergenic plants may play a role.
Selective serotonin reuptake inhibitors (SSRIs) increase nerve impulse-carrying axon density in the frontal and parietal lobes, controlling emotions and motivation. This growth may explain why antidepressants take time to work, with effects seen within hours but clinically meaningful results taking weeks.
A new EPA rule requires manufacturers to reduce motorcycle emissions by 60% by 2010, reducing pollution by 54,000 tons and saving 12 million gallons of fuel annually. Motorcycles produce more harmful exhaust emissions per mile than cars or sports utility vehicles.
Researchers at Children's Hospital of Philadelphia developed a novel technique to attach therapeutic genes to bare metal stents, reducing inflammation and restenosis. The study used animal models and found significantly lower restenosis with the new stents compared to conventional ones.
A Group Health study found that yoga was more effective than traditional exercise and education for treating back pain. After 12-26 weeks, patients in the yoga group showed significant improvements in daily activities, back-related function, and pain levels.
Researchers introduce a modified form of ChR2 in C. elegans neurons and muscle cells, allowing blue-light activation to trigger strong contraction and backing behavior. Electrophysiological experiments confirm the effects are due to ion flow caused by light exposure.
A 12-year-old girl from rural Hunan, China died of acute respiratory distress syndrome after developing fever and cough. Her 9-year-old brother recovered after treatment with antiviral medication. The investigation highlights the need for improved infection control measures in backyard farming settings.
Researchers found that artemisinin reduced breast tumors by 39% and inhibited tumor growth. The study suggests artemisinin's anti-malarial properties may also target cancer cells due to their high iron uptake.
A recent study by Columbia Climate School researchers found two genetically distinct populations of Asian elephants in northeast India, separated by the Brahmaputra River. This discovery is significant for future conservation planning, highlighting the importance of preserving genetic diversity to protect the endangered species.
Research suggests that low-dose carbon monoxide can act as an anti-inflammatory agent, reducing the production of interleukin-12 and short-circuiting disease-causing inflammation in ulcerative colitis. Non-smokers with inflammatory bowel disease should not rely on smoking to alleviate symptoms.
A study at Rush University Medical Center found that 96% of patients underwent minimally invasive knee replacement surgery could be discharged the same day without any complications. The key to this success was a comprehensive team approach, including pre-surgical education, optimized care pathways, and post-operative rehabilitation.
Researchers found genetic markers for albinism in two cave-dwelling fish populations appeared in the same location, suggesting a common mutation. The Oca2 gene was identified as responsible for pigmentation and the deletion of a specific exon produced albinism.
Scientists have identified 570 genes associated with Parkinson's disease, which could lead to the development of new treatments. The study analyzed brains from 23 patients and found that limiting the activity of these genes may help control or even stop the progression of the disease.
The revised International Health Regulations require countries to report public health emergencies within 24 hours, but regional governments may resist disclosure due to economic concerns and federal scrutiny. This 'federalism dilemma' poses a challenge for successful implementation of the new regulations.
A novel enzyme, JHDM1A, has been discovered to remove methyl groups from histones, a finding with diverse implications for understanding gene regulation and its role in diseases. The study suggests that many proteins containing a similar domain may also be involved in histone demethylation.
A study found a significant association between high EL concentrations, low HDL-C levels, and early stages of atherosclerosis. This suggests that EL concentrations may be useful in predicting an individual's risk for atherosclerosis.
The study proposes a novel model of neural circuitry that fine-tunes behavior through feedback inhibition, potentially explaining regulatory mechanisms like temperature control and satiety. This framework provides a new tool for exploring working memory complexities and understanding mental health and disease.
The Children's Hospital of Philadelphia has received a four-year, $6.7 million grant to study novel HIV therapy targeting neurokinin-1 receptors. The program aims to block the virus from immune cells, improve innate immune function, and reduce symptoms of depression associated with the disease.
A study found that current use of proton pump inhibitors was associated with nearly 3 times the rate of CDAD; use of H2-receptor antagonists was associated with twice the rate of CDAD. The rates and severity of nosocomial CDAD are increasing, posing a significant public health concern.
Researchers found that passive smoking significantly increases the risk of age-related macular degeneration, with pack years of cigarette smoke being a major determinant. Regularly smoking for 40 years or more can almost triple this risk compared to non-smokers.
A new study published in Cancer Research found that artificial light at night can stimulate the growth of human breast cancer cells in laboratory mice. The researchers discovered that melatonin, a hormone produced by the brain, plays a key role in regulating tumor growth and development.
Between 1998 and 2002, laparoscopic bariatric surgery operations increased from 2.1% to 17.9% of total procedures, while Roux-en-Y gastric bypass rose from 78% to 92%. This growth is attributed to surgeons' increased use of the minimally invasive technique and patients' greater acceptance of the procedure.
A study by Saskia van Vuren reveals that changes in the riverbed elevation can cause high-water problems, flooding, droughts, erosion, and affect discharge distribution. The researcher argues that future high-water level predictions must consider morphological dynamics.
A study predicts that up to 90% of the Northern Hemisphere's permafrost will thaw by 2100, threatening ecosystems and climate change. Permafrost holds significant carbon emissions, which could accelerate climate change.
A new study by Michael Gurven examines food exchanges in small-scale societies to understand the evolution of conditional cooperation among humans. The research finds that people share more with those who give more, but families struggling to produce food receive more support from close kin and neighbors.
Researchers found that dark chocolate improved arterial flow and reduced platelet activity, benefiting vascular health in smokers. A daily treat of 40g dark chocolate improved smoothness of arterial flow for eight hours.
Researchers found that a structured psychoeducational intervention improved caregiver quality of life and reduced distress for those caring for terminally ill cancer patients. The study suggests expanding end-of-life care studies to include other populations.
A study published in Annals of Internal Medicine found that yoga, specifically Viniyoga, significantly improved back function and reduced pain in patients with lower back pain. Regular home practice and supervised instruction were essential for successful treatment.
Researchers found that plants trigger the elimination of a genomic island in bacteria to prevent infection, but this process can also drive the evolution of more virulent strains. The study reveals a molecular mechanism for how plant defenses can lead to the emergence of new bacterial pathogens.
Researchers have successfully sequenced the DNA of a woolly mammoth, comparing it to African and Indian elephant genomes. The study provides unprecedented insight into the evolution and extinction of the species.
A new Israeli study found that vaccinating all children against hepatitis A at 18 and 24 months reduced overall incidence of the disease for all ages by 95%. The study also showed a significant decrease in reported incidents among one- to four-year-olds, a demographic historically susceptible to infection.
Researchers analyzed genes and developed new statistical technique to estimate divergence time. They found that humans and chimpanzees likely shared a common ancestor between 5-7 million years ago, with a maximum limit of approximately 7 million years ago.
A study of 574 women who underwent postmastectomy breast reconstruction found that 31% developed at least one adverse event, with common complications including infection, blood clotting, and seroma. Additional surgery was required for 21%, while reimplantations also showed similar rates of complications.
Researchers found that two doses of inactivated polio vaccine (IPV) provided similar immunity to one dose of the live virus vaccine. However, IPV's mucosal immunity was less effective than OPV's. The study suggests that HPV-immunized communities are partially protected from poliovirus spread.
A new software system, GRIP, was implemented in a 12-bed ICU and monitored 179 patients over four months. The results showed that 61% of the patients had correct glucose levels more than 75% of the time they were being monitored by GRIP.