In a study of over 800 patients, Badellino and colleagues now found a link between high EL concentrations in the blood, low levels of HDL-C, and early stages of atherosclerosis. This suggests that EL concentrations influence the development of atherosclerosis in humans as well and might be useful to predict an individual's risk.
Citation: Badellino KO, Wolfe ML, Reilly MP, Rader DJ (2006) Endothelial lipase concentrations are increased in metabolic syndrome and associated with coronary atherosclerosis. PLoS Med 3(2): e22.
CONTACT:
Dr. Karen Badellino
University of Pennsylvania
Institute for Experimental Medicine and Therapeutics
Room 646 BRB II/III
421 Curie Blvd
Philadelphia, PA USA 19104
+1-215-898-5909
+1-215-573-8606 (fax)
kbadelli@mail.med.upenn.edu
PLEASE MENTION PLoS MEDICINE ( www.plosmedicine.org ) AS THE SOURCE FOR THESE ARTICLES. THANK YOU.
All works published in PLoS Medicine are open access. Everything is immediately available without cost to anyone, anywhere--to read, download, redistribute, include in databases, and otherwise use--subject only to the condition that the original authorship is properly attributed. Copyright is retained by the authors. The Public Library of Science uses the Creative Commons Attribution License.
PLOS Medicine