Articles tagged with Lipases
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Using science for more animal welfare: Researchers from Max Planck Institute for Polymer Research have developed an alternative to foie gras by mimicking the structure of real foie gras. The new pâté closely mimics the mouthfeel and melt of traditional foie gras, thanks to a treatment process that restructures fat using goose lipases.
Researchers have created a process to replicate foie gras without force-feeding, using the duck's own lipases to treat the fat. The resulting dish has a similar mouthfeel and physical properties to traditional foie gras, with a simple recipe involving liver, fat, and sterilization.
The FDA has issued a Biomarker Letter of Support for four novel biomarkers identifying drug-induced pancreatic injury. These microRNAs will enhance the detection of acute drug-induced pancreatic injury (DIPI) in phase 1 clinical trials, improving safety and accuracy.
A phase 2 study found that ANGPTL3 inhibitor therapy reduced triglycerides by up to 70% in patients with severe hypertriglyceridemia who had previously experienced acute pancreatitis. The treatment, evicanumab-dgnb, also showed potential for cardiovascular prevention by reducing apolipoprotein B levels.
Researchers at Brigham and Women's Hospital have identified LIPE, a lipase that degrades triglycerides, as a promising candidate therapeutic target for Parkinson's disease. Inhibiting LIPE reduced alpha-synuclein inclusions and alleviated neurodegeneration in patient-derived neurons and a C. elegans model of toxicity.
Researchers discovered that inhibiting the breakdown of a neuroprotective molecule called 2-arachidonoylglycerol (2-AG) in astrocytes promotes recovery from traumatic brain injury. The study suggests that targeting this molecule could lead to the development of new therapies for TBI-induced disease.
MUSC researchers discovered blocking an energy pathway for T-cells after hematopoietic stem cell transplant reduces graft-versus-host disease, while maintaining ability to kill leukemia cells. The study uses a lysosomal acid lipase-deficient mouse model, showing promising results with FDA-approved inhibitor orlistat.
A study has overcome a key hurdle to the use of nanorobots powered by lipases, enzymes that play essential roles in digestion. By modulating motor speeds, researchers have broadened the potential biomedical and environmental applications of these devices.
Researchers produce lipase enzyme from mustard seeds by-product, offering a low-cost alternative to commercial enzymes. The enzyme is stable and effective in removing oil stains, making it a prospective additive for laundry detergents.
Researchers have developed biomarkers to detect harmful environmental contaminants in wildlife, enabling faster development of diagnostic tools. Additionally, scientists have created a more sustainable method for producing biodiesel from low-cost cooking oil waste using nanoparticles.
Researchers found that roasting cocoa beans at optimal temperatures can boost polyphenol content and anti-pancreas-lipase activity while maintaining flavor profile. This study challenges previous findings on the negative impact of roasting on health benefits.
Scientists at the University of Bonn have found that ceramide synthase not only produces vital lipids but also regulates gene activity, particularly in response to nutritional status. The enzyme's homeodomain plays a crucial role in adapting gene expression to energy requirements.
Researchers at University of Bristol discovered that enzymes can function without water, enabling the development of thermally robust industrial enzymes for harsh processing conditions. This breakthrough has potential applications in detergent technologies and biofuel production.
Researchers have discovered a bacterial mechanism that prevents MRSA from thriving on human skin. By producing toxic compounds, MRSA inhibits its own growth and persistence on the skin.
Researchers at Arizona State University have developed a novel method that utilizes heat to enhance the yield and reduce costs of high-energy biofuels production. This breakthrough could pave the way for more widespread adoption of renewable energy sources, as the new process is more efficient and cost-effective than previous methods.
Researchers at the University of Copenhagen have discovered an enzymatic ignition key that can be turned on and off, allowing enzymes to work three times harder. This breakthrough has significant implications for understanding and potentially curing diseases such as diabetes, cardiovascular disease, stroke, and acne.
Saskia B. Neher, a UNC School of Medicine assistant professor, is one of 22 promising scientists to receive the 2012 Pew Scholars award, supporting her research on LPL regulation and its implications for cardiovascular disease.
A new study identifies a human genetic link to high levels of 'good' cholesterol, highlighting the role of endothelial lipase enzyme mutations in HDL-C levels. Researchers discovered rare mutated forms of the LIPG gene that significantly increase plasma HDL-C levels.
Researchers found that alternate-day fasting shrinks fat cells and boosts fat breakdown mechanisms. Statin drugs also reduce cholesterol and fats in blood vessels by affecting lipases. Exercise after a high-fat meal stimulates the breakdown of fats in skeletal muscle, making it healthier.
Gene deletion study shows Candida parapsilosis growth and virulence reduced without lipase activity, suggesting enzyme's key role in pathogenicity for immunocompromised individuals and premature infants
Dr. Arthur R. Hand is recognized for his significant work on salivary gland ultrastructure and function, including the role of cyclic-AMP-dependent protein kinase and lingual lipase and amylase. He has made major contributions to our understanding of salivary glands and their various components.
The gene CGI-58 boosts the activity of adipose triglyceride lipase (ATGL) up to 20-fold, solving a puzzle in lipid storage disease CDS. This activation limits lipid accumulation and restores normal fat breakdown.
A study found a significant association between high EL concentrations, low HDL-C levels, and early stages of atherosclerosis. This suggests that EL concentrations may be useful in predicting an individual's risk for atherosclerosis.
GenMAPP organizes gene expression results by biological process, allowing researchers to see coordinated changes in gene expression. The program uses graphical representations of biological pathways to analyze gene expression data, providing a systems approach to interpreting biological data.
The long-term study found that orlistat helped successful dieters keep weight off. The accompanying editorials suggest that orlistat's benefits are modest.
A recent study published by the American Heart Association suggests that sex differences in heart disease risk may be attributed to an enzyme called hepatic lipase. Hepatic lipase activity was found to be higher in men than women, and researchers believe this enzyme plays a crucial role in lipid metabolism.