Articles tagged with Kidney
Researchers found that treating severe fetal megacystis with a vesicoamniotic shunt in the first trimester can improve survival rates and kidney function. In the study, 75% of children were born alive and 68% survived their first year of life, with most showing normal or only slightly impaired kidney function.
A new study suggests that using virtual reality (VR) to explain medical procedures can help patients better understand their treatment and reduce anxiety. The research tested VR as part of the consent process for a procedure to treat kidney stones, with patients reporting improved understanding and reduced anxiety after the experience.
A nationwide intervention has led to increased kidney transplants among Black patients, with a 5.3 transplant increase per 1,000 listings. The study found that wait time modifications, required by a national policy, resulted in a 1.7-year gain in priority status for Black candidates.
Researchers identified a drug-and-supplement combination therapy that reduces senescent cells, inflammation, and injury in diabetic kidney disease. The treatment approach involves senolytics, which selectively target senescent cells.
Cancer cell-derived small extracellular vesicles can be excreted into urine, according to researchers who tracked their journey in mouse models. The study reveals that glomerular cells actively transport sEVs across the filtration barrier, supporting their use in emerging urine-based cancer diagnostics.
A study found that COVID-19 infection significantly increases the risk of acute kidney injury, chronic kidney disease, and kidney failure in US adults. The research used machine learning models to analyze data from over three million patients, revealing a 2.3-times higher risk of acute kidney injury compared to influenza.
The study found that increased community disadvantage leads to fewer options for receiving hemodialysis and more likelihood of living without nearby dialysis facilities. Patients with end-stage kidney disease in these areas have limited access to essential care services.
A cohort study of 3,230 kidney transplant recipients found that transplantation reverses declining employment income, enabling meaningful economic recovery. The findings highlight the socioeconomic value of transplantation and inform policies to support patients during pretransplant vulnerability.
A cohort study of patients with chronic kidney disease found that more advanced stages of the condition are associated with a higher incidence of cognitive impairment. The study underscores CKD severity as a key risk factor for cognitive decline across the entire spectrum of CKD.
The Rice lab will produce bioprinted, vascularized kidney tissue that augments renal function in patients with kidney disease. The implantable kidney tissue will be made from a patient's own cells combined with a bioink that supports the long-term viability of the implanted cells.
Researchers discover GPX3 plays a central role in limiting inflammation, oxidative damage, and renal dysfunction following ischemic insult. Restoring GPX3 expression improves renal functional indices, reduces histopathological injury, and alleviates tubular epithelial cell death.
A new study offers hope that kidney transplant patients may one day have a more effective treatment regimen. The Phase 2 pilot study showed improved kidney functioning in all patients who completed the study, with no patients experiencing rejection due to antibodies produced by the immune system.
A UCLA-led team has discovered a novel mechanism of kidney stone formation involving bacteria, challenging the long-held assumption that stones develop solely through chemical and physical processes.
A recent study by King's College London found that diagnosis rates for depression, asthma, and osteoporosis remained lower than expected after the COVID-19 pandemic. The study analyzed data from over 29 million people in England and found that diagnosis rates recovered differently across ethnic and socioeconomic groups.
A comparative effectiveness study found that SGLT2 inhibitors were associated with a lower risk of chronic kidney disease and acute kidney injury compared to GLP-1 receptor agonists. These findings suggest that SGLT2 inhibitor treatment may be an effective strategy for preventing kidney disease in individuals with type 2 diabetes.
Researchers from Institute of Science Tokyo developed 'tubuloids' to capture the slow progression of chronic kidney disease (CKD), replicating key features such as DNA damage, cellular senescence, inflammation, and fibrosis. This realistic platform provides a new way to develop and test treatments for millions globally.
A targeted treatment approach significantly reduces moderate and severe acute kidney injury after major surgery in high-risk patients identified by biomarkers. The study shows that a closely monitored set of clinical measures provides effective protection in the first hours after surgery.
A new study found that chronic kidney disease accelerates cognitive decline through interconnected damage to the heart and brain, with men experiencing greater impairment than women. The research also highlights the need for tailored strategies to prevent progression to neurological disorders.
A recent study published in Neurology found that people with impaired kidney function have higher levels of Alzheimer's biomarkers in their blood. However, the study did not find an increased risk of developing dementia among those with poor kidney health.
Researchers review current evidence on extracellular vesicles' interaction with renal tubular epithelial cells, showing protective effects against damaged tubular cells. However, challenges remain to overcome, such as biodistribution and targeting issues.
Researchers tracked 120 older veterans taking gabapentinoids and loop diuretics, finding that only 4 doctors correctly identified the gabapentinoids as the cause of leg swelling. The study highlights the dangers of 'prescribing cascades' and emphasizes the need for regular monitoring and alternative treatment options.
A study comparing GLP-1 RAs found that all three drugs are relatively safe options for patients with type 2 diabetes, with minimal differences in kidney and cardiovascular risks. Liraglutide had a lower risk of all-cause mortality compared to dulaglutide.
A new electronic medical records-based tool predicts which patients are most at risk of losing a transplanted kidney graft, allowing for timely interventions. The study achieved high predictive accuracy and can be implemented to streamline care of recipients.
Researchers at University of Utah Health have found that AKI is triggered by ceramides, which cause serious injury by damaging kidney mitochondria. Using a backup drug candidate, the team was able to preserve mitochondrial integrity and prevent kidney injury in mice.
A population-based cohort study found that the cumulative incidence of scrotal surgery among male living kidney donors was 1 in 8 after 20 years, compared to 1 in 143 for non-donors. Most males who donate a kidney won't develop this complication, but it's essential to inform past and future donors about the risk and potential symptoms.
This study developed and validated a risk prediction model for CRRT initiation in VV-ECMO patients, incorporating five key predictors. The final model demonstrated strong discrimination with an area under the curve of 0.88 (derivation) and 0.75 (external validation).
The study found CKD affects nearly 800 million worldwide, with diabetes and high blood pressure driving the greatest loss of healthy years. Access to kidney replacement therapies remains limited, highlighting the need for preventive measures and equitable care.
A conservative dialysis approach resulted in faster and more complete kidney function recovery in patients with acute kidney injury. The study's findings suggest that this strategy could be a viable option for treating dialysis-requiring AKI, warranting further investigation.
The study suggests that SGLT2 inhibitors can benefit patients with varying levels of kidney function and albuminuria. Routine use of these medications may lead to improved kidney outcomes across different patient groups.
A study published in JAMA finds that using different methods to estimate glomerular filtration rate (eGFR) can lead to significant discrepancies, particularly for those with chronic kidney disease. The findings suggest that cystatin C-based eGFR may be more accurate in predicting clinical outcomes.
The navigate-kidney study finds that community health workers enhance holistic, patient-centered care through improved patient engagement and emotional wellbeing. This integration into dialysis care teams may lead to better outcomes for patients with kidney failure.
The study found clear absolute benefits of SGLT2 inhibitors on kidney, hospitalization, and mortality outcomes regardless of diabetes status and level of urine albumin to creatinine ratio. This benefit suggests a potential therapeutic approach for patients with kidney disease.
Researchers developed a scalable method to produce human kidney organoids, combining them with pig kidneys outside the body for transplantation. The transplanted organs functioned normally and showed no signs of damage or toxicity.
Researchers analyzed blood samples from dogs in the Dog Aging Project and found that post-translationally modified amino acids are strongly linked to age, suggesting a promising indicator of physiological aging. The study also highlighted an important role of the kidney in the relationship between age and blood metabolites.
Researchers are building an AI-powered database of MRI and CT images to track disease progression and measure patient response to treatments. The database will provide a standardized toolkit for extracting precise imaging biomarkers, enhancing the accuracy of organ measurements and improving treatment choices.
The conference explores how generative AI is reshaping kidney medicine through AI-driven diagnostics, data integration, and omics analysis. Key findings include the use of LLMs to transform diagnostic precision, patient management, and research design.
This study found that GLP-1RAs and SGLT2is offer the greatest cardiovascular benefits for adults with type 2 diabetes. The magnitude of benefit depends on baseline age, atherosclerotic cardiovascular disease, heart failure, and kidney impairment.
A comparative effectiveness study found that liraglutide, semaglutide, and dulaglutide have similar risks for kidney and cardiovascular outcomes in veterans with type 2 diabetes. Head-to-head trials are needed to confirm these findings.
Researchers at UBC have successfully transplanted an enzyme-converted kidney into a brain-dead recipient, showing promise for universal donor organs in transplantation. The breakthrough uses special enzymes to remove blood-type antigens, making it possible to use mismatched organs from deceased donors.
Researchers found that higher SDMA levels, but not ADMA, correlated with weaker blood vessel function in patients with moderate chronic kidney disease. This suggests that measuring SDMA levels may provide a better approach to monitoring vascular function in these patients.
A higher cumulative cardiovascular health score in young adulthood is associated with reduced risk of cardiovascular disease and kidney events in midlife. The study emphasizes the importance of early life prevention efforts.
A binational study found nearly 6 in 10 US adults and 3 in 10 Japanese adults discontinued semaglutide within 12 months of treatment. Patients with established cardiovascular disease and chronic kidney disease had higher discontinuation rates, highlighting the need for alternative treatments.
A study published in Journal of Internal Medicine found that people with moderate to high levels of albumin in their urine have a higher risk of developing dementia. The researchers discovered an association between albuminuria and increased risk of dementia, independent of kidney function.
Researchers found genetic adaptations underlying survival in hot and dry environments, revealing how natural selection enabled the Turkana to thrive in extreme conditions. The study identified key genes, including STC1, that play vital roles in conserving water and protecting kidneys from waste.
A USC Stem Cell-led team has successfully generated lab-grown kidney structures, or organoids, that exhibit kidney-like functions such as blood filtration and urine production. The 'assembloids' achieved maturity levels comparable to newborn mouse kidneys, paving the way for developing new therapies for patients awaiting transplant.
Researchers at the Max Delbrück Center have successfully used base editing to correct mutations that cause autosomal dominant polycystic kidney disease (ADPKD) in human and mouse cells. The technique shows promise in reducing liver cysts, a key symptom of the disease.
Researchers have discovered how lymphatic vessels, the 'plumbing system' of the kidney, undergo dramatic changes during chronic transplant rejection. The vessels become structurally disorganized and spread to unusual parts of the kidney, disrupting immune balance and fuelling inflammation.
A cohort study found GLP-1 RAs offer body mass index-dependent cardiovascular benefits and consistent kidney protection for type 2 diabetes patients. The study suggests BMI stratification is crucial for guiding treatment decisions.
A novel drug target, CD300a, has been identified to suppress immune cell activation and prevent chronic heart and kidney failure after acute tissue injury. The treatment preserves cardiac function and reduces renal fibrosis in mice with genetic deficiency of CD300a.
A retrospective cohort study found system-based disparities in pre-dialysis nephrology care contribute to 1/3 of incident vascular access disparities among Hispanics. Targeted policies are needed to improve timely identification and referrals for equitable improvements in kidney failure outcomes.
USC Stem Cell scientists have developed a blueprint for generating specific kidney cell types on demand, holding immense value for preclinical studies of new therapeutics and congenital kidney diseases. The team successfully created lab-grown proximal tubule cells that can absorb sugar and protein, respond to chemotherapy drugs, and pr...
A clinical trial led by Tohoku University has found that lubiprostone can prevent the decline of renal function in patients with chronic kidney disease. The study evaluated the effects of lubiprostone on kidney function and found that it improves mitochondrial function, which exerts a renoprotective effect.
Researchers successfully created functional ureter tissue from pluripotent stem cells, bringing them closer to developing transplantable kidneys that can produce and expel urine. The achievement is a significant step toward next-generation regenerative therapies.
Researchers used human stem cell-derived kidney organoids to test the safety of gene editing delivered by AAV, a common tool in clinical trials. The study found that AAV2 caused significant harm to kidney cells through the NFκB pathway, but an existing drug was able to prevent this damage without interfering with gene delivery.
Researchers at Penn Medicine and Wharton have developed AI tools, CellSpectra and SISKA, to analyze kidney disease at the cellular level, matching effective treatments. The tools offer clues to better treatments for kidney disease and beyond.
Researchers have identified biomarkers that can predict and manage chronic kidney disease (CKD), offering a more nuanced understanding of patient disease progression and mortality risk. A combination of biomarkers, including sTNFR1 and hs-cTnT, were found to be comparable in predicting kidney failure and all-cause mortality.
The interleukin family is involved in the development of acute kidney injury through inflammatory and fibrotic mechanisms. Protective ILs like IL-2, IL-10, and IL-37 mitigate injury, while pro-inflammatory ILs such as IL-1α and IL-18 exacerbate damage.
A new study found that two simple blood markers—eGFRdiff and GDF-15 levels—can independently predict kidney disease progression and mortality in people with diabetes. Patients with lower eGFRdiff values faced a higher risk of chronic kidney disease, while those with elevated GDF-15 levels were at increased risk of death.
The American Heart Association has launched a nationwide initiative to tackle cardiovascular disease, focusing on 15 regions across the US. The Cardiovascular-Kidney-Metabolic Health Initiative aims to improve treatment of interconnected conditions leading to heart disease and stroke.
A new study identifies a biomarker that can detect kidney accumulation of uranium, a common contaminant in drinking water, potentially leading to chronic kidney disease. The research suggests a non-invasive way to monitor kidney health and prevent damage from low-level uranium exposure.