Research on kidney function and disease. Covers kidney-failure prevention, gestational diabetes links, environmental risks, and gum-kidney connections.
Researchers analyzed blood samples from dogs in the Dog Aging Project and found that post-translationally modified amino acids are strongly linked to age, suggesting a promising indicator of physiological aging. The study also highlighted an important role of the kidney in the relationship between age and blood metabolites.
Researchers are building an AI-powered database of MRI and CT images to track disease progression and measure patient response to treatments. The database will provide a standardized toolkit for extracting precise imaging biomarkers, enhancing the accuracy of organ measurements and improving treatment choices.
The conference explores how generative AI is reshaping kidney medicine through AI-driven diagnostics, data integration, and omics analysis. Key findings include the use of LLMs to transform diagnostic precision, patient management, and research design.
This study found that GLP-1RAs and SGLT2is offer the greatest cardiovascular benefits for adults with type 2 diabetes. The magnitude of benefit depends on baseline age, atherosclerotic cardiovascular disease, heart failure, and kidney impairment.
A comparative effectiveness study found that liraglutide, semaglutide, and dulaglutide have similar risks for kidney and cardiovascular outcomes in veterans with type 2 diabetes. Head-to-head trials are needed to confirm these findings.
Researchers at UBC have successfully transplanted an enzyme-converted kidney into a brain-dead recipient, showing promise for universal donor organs in transplantation. The breakthrough uses special enzymes to remove blood-type antigens, making it possible to use mismatched organs from deceased donors.
Researchers found that higher SDMA levels, but not ADMA, correlated with weaker blood vessel function in patients with moderate chronic kidney disease. This suggests that measuring SDMA levels may provide a better approach to monitoring vascular function in these patients.
A higher cumulative cardiovascular health score in young adulthood is associated with reduced risk of cardiovascular disease and kidney events in midlife. The study emphasizes the importance of early life prevention efforts.
A binational study found nearly 6 in 10 US adults and 3 in 10 Japanese adults discontinued semaglutide within 12 months of treatment. Patients with established cardiovascular disease and chronic kidney disease had higher discontinuation rates, highlighting the need for alternative treatments.
A study published in Journal of Internal Medicine found that people with moderate to high levels of albumin in their urine have a higher risk of developing dementia. The researchers discovered an association between albuminuria and increased risk of dementia, independent of kidney function.
Researchers found genetic adaptations underlying survival in hot and dry environments, revealing how natural selection enabled the Turkana to thrive in extreme conditions. The study identified key genes, including STC1, that play vital roles in conserving water and protecting kidneys from waste.
Researchers at the Max Delbrück Center have successfully used base editing to correct mutations that cause autosomal dominant polycystic kidney disease (ADPKD) in human and mouse cells. The technique shows promise in reducing liver cysts, a key symptom of the disease.
A USC Stem Cell-led team has successfully generated lab-grown kidney structures, or organoids, that exhibit kidney-like functions such as blood filtration and urine production. The 'assembloids' achieved maturity levels comparable to newborn mouse kidneys, paving the way for developing new therapies for patients awaiting transplant.
Researchers have discovered how lymphatic vessels, the 'plumbing system' of the kidney, undergo dramatic changes during chronic transplant rejection. The vessels become structurally disorganized and spread to unusual parts of the kidney, disrupting immune balance and fuelling inflammation.
A cohort study found GLP-1 RAs offer body mass index-dependent cardiovascular benefits and consistent kidney protection for type 2 diabetes patients. The study suggests BMI stratification is crucial for guiding treatment decisions.
A novel drug target, CD300a, has been identified to suppress immune cell activation and prevent chronic heart and kidney failure after acute tissue injury. The treatment preserves cardiac function and reduces renal fibrosis in mice with genetic deficiency of CD300a.
A retrospective cohort study found system-based disparities in pre-dialysis nephrology care contribute to 1/3 of incident vascular access disparities among Hispanics. Targeted policies are needed to improve timely identification and referrals for equitable improvements in kidney failure outcomes.
USC Stem Cell scientists have developed a blueprint for generating specific kidney cell types on demand, holding immense value for preclinical studies of new therapeutics and congenital kidney diseases. The team successfully created lab-grown proximal tubule cells that can absorb sugar and protein, respond to chemotherapy drugs, and pr...
A clinical trial led by Tohoku University has found that lubiprostone can prevent the decline of renal function in patients with chronic kidney disease. The study evaluated the effects of lubiprostone on kidney function and found that it improves mitochondrial function, which exerts a renoprotective effect.
Researchers successfully created functional ureter tissue from pluripotent stem cells, bringing them closer to developing transplantable kidneys that can produce and expel urine. The achievement is a significant step toward next-generation regenerative therapies.
Researchers used human stem cell-derived kidney organoids to test the safety of gene editing delivered by AAV, a common tool in clinical trials. The study found that AAV2 caused significant harm to kidney cells through the NFκB pathway, but an existing drug was able to prevent this damage without interfering with gene delivery.
Researchers at Penn Medicine and Wharton have developed AI tools, CellSpectra and SISKA, to analyze kidney disease at the cellular level, matching effective treatments. The tools offer clues to better treatments for kidney disease and beyond.
Researchers have identified biomarkers that can predict and manage chronic kidney disease (CKD), offering a more nuanced understanding of patient disease progression and mortality risk. A combination of biomarkers, including sTNFR1 and hs-cTnT, were found to be comparable in predicting kidney failure and all-cause mortality.
The interleukin family is involved in the development of acute kidney injury through inflammatory and fibrotic mechanisms. Protective ILs like IL-2, IL-10, and IL-37 mitigate injury, while pro-inflammatory ILs such as IL-1α and IL-18 exacerbate damage.
A new study found that two simple blood markers—eGFRdiff and GDF-15 levels—can independently predict kidney disease progression and mortality in people with diabetes. Patients with lower eGFRdiff values faced a higher risk of chronic kidney disease, while those with elevated GDF-15 levels were at increased risk of death.
The American Heart Association has launched a nationwide initiative to tackle cardiovascular disease, focusing on 15 regions across the US. The Cardiovascular-Kidney-Metabolic Health Initiative aims to improve treatment of interconnected conditions leading to heart disease and stroke.
A new study identifies a biomarker that can detect kidney accumulation of uranium, a common contaminant in drinking water, potentially leading to chronic kidney disease. The research suggests a non-invasive way to monitor kidney health and prevent damage from low-level uranium exposure.
Researchers developed a serum proteomics-based prediction model to identify biomarkers involved in ADPKD progression. The study identified 29 proteins linked to immune system, fat transport, and metabolism, which can predict kidney function decline rate. This breakthrough could lead to more accurate and earlier diagnosis of ADPKD.
Researchers at the University of Pittsburgh have discovered a novel tool to help stratify rejection risk in kidney transplantation. They found that mismatching SIRP-alpha between donors and recipients contributes to worse rejection, scarring, and graft failure in humans, suggesting improved transplant outcomes.
A major international study found that deceased-donor kidney transplantation offers a consistent survival advantage with standard-criteria kidneys, but the benefit plateaus in older and high-risk recipients. The study used a robust target trial emulation framework to compare long-term survival between transplant patients and those on d...
Surgeons at Mount Sinai performed the world's first heart-liver-kidney triple organ transplants in New York State, with two patients making full recoveries after the surgeries. The procedures were led by Anelechi Anyanwu and Sander S. Florman and represent a significant milestone in complex organ transplantation.
A global study found that pentoxifylline has no mortality benefit in patients with severe alcohol-associated hepatitis and acute kidney injury. The study, which included 525 patients across 20 centers from eight countries, reaffirmed previous findings that cast doubt on the efficacy of pentoxifylline in alcoholic hepatitis.
Women are at high risk for cardiovascular disease, with nearly 45% living with some form of cardiovascular disease. Regular screening for kidney health is crucial due to its connection with high blood pressure and diabetes. Pregnancy complications and menopause can also impact heart and metabolic health.
A modified surgical face mask can detect chronic kidney disease by analyzing the wearer's breath, showing high sensitivity for CKD-related metabolites. The sensor accurately identifies patients with CKD 84% of the time and those without 88% of the time.
The FAVOR III China Trial showed that machine learning-based approach identify top 10 prognostic factors for predicting 2-year major adverse cardiovascular events (MACE) after Quantitative Flow Ratio (QFR)-guided Percutaneous Coronary Intervention (PCI). Patients with pre-random PCI strategy changed, Left Circumflex artery (LCX) lesion...
Researchers at TUM developed an AI-powered algorithm to predict kidney damage in prostate cancer patients undergoing lutetium-177 PSMA therapy. Early detection could enable personalized treatment adjustments to prevent organ damage.
Long COVID can result in significant health risks for young people, including chronic kidney disease, gastrointestinal symptoms, and cardiovascular conditions. Studies found that children with COVID-19 face elevated risks of developing these conditions, even years after the initial infection.
The American Heart Association funds research teams to investigate how risk factors for cardiovascular and kidney diseases impact women differently. The project aims to understand the biological significance of certain life cycles and societal factors on disease development.
This study investigates the protective effect of N-acetylcysteine (NAC) on acyclovir (ACV)-induced nephrotoxicity in adult Wistar rats. The results show that NAC supplementation significantly reduces kidney damage caused by ACV, restoring normal kidney function.
The study finds that the current transplant system is a net positive for patients, producing an additional 9.29 life-years from transplantation. However, the optimal structure of the matching system could potentially raise this figure to as high as 14.08 life-years.
A new inpatient onconephrology service has been established to care for patients with cancer and kidney disease, resulting in improved kidney recovery rates. The study found that patients treated by the dedicated service were more likely to have kidney recovery at discharge compared to those treated by general nephrology services.
A large US cohort study found SARS-CoV-2 infection associated with adverse postacute kidney outcomes in children and adolescents, especially those with chronic or acute kidney disease. Long-term monitoring is recommended for these patients.
Researchers have identified a potential precision medicine approach to prevent chronic kidney disease progression by targeting type 5 collagen, a minor component of scar tissue. A repurposed anti-cancer drug, Cilengitide, has been shown to slow kidney scarring and disease progression in high-risk individuals.
Researchers at Seoul National University have developed a compact peritoneal dialysis device that can be used as a wearable artificial kidney, offering an alternative to traditional hemodialysis. The device uses nanoelectrokinetic technology to continuously regenerate peritoneal dialysate and remove waste products from the body.
The SUMMIT trial shows tirzepatide reduces the risk of cardiovascular death or worsening heart failure in patients with obesity, chronic kidney disease, and heart failure, while improving kidney function. Researchers found significant improvements in both patient groups with and without chronic kidney disease.
Researchers have identified six promising biomarkers that can detect drug-induced kidney injury earlier than traditional markers, enabling more timely monitoring during drug development. These biomarkers could lead to the development of safer medications and improve patient outcomes.
A study by Medical University of Vienna reveals high blood pressure can cause abnormalities in podocytes, specialized cells in the renal filter, before other conditions like diabetes. Early detection and treatment are crucial to prevent kidney damage.
Chronic kidney disease rates increased by 24% globally from 1990 to 2021, linked to higher cardiovascular disease risk. Collaborative care and screening for cardiovascular-kidney-metabolic syndrome can reduce mortality and improve patient lives.
A new 'concierge' approach called the Kidney Transplant Fast Track enables more people to receive transplants and erases racial disparities. This streamlined process coordinates testing onsite and often performed by the transplant center, increasing patient suitability and reducing wait times.
A new study suggests that paricalcitol may help manage chronic kidney disease (CKD) in dogs by reducing renal secondary hyperparathyroidism and proteinuria. The treatment showed promise in stabilizing proteinuria, but raised questions about potential long-term effects on CKD progression.
A new study suggests that a low creatinine-to-cystatin C ratio may be associated with lower muscle volumes and poorer gait speeds in midlife women. Researchers found that this biomarker was linked to an increased risk of developing sarcopenia, which can lead to immobility and related health problems.
A study published by HKUMed has found that C-reactive protein (CRP) can worsen inflammation in diabetic kidney disease through the Smad3-NLRP3 inflammasome-dependent mechanism. The research suggests that targeting CRP or the Smad3-NLRP3 pathway may provide new treatment options for patients with DKD.
Researchers at the University of Oklahoma are using a new $2 million grant to study the mechanisms of polycystic kidney disease (PKD), a family of genetic disorders causing clusters of cysts on the kidney. By identifying genes and proteins responsible for PKD, they aim to develop novel therapies.
Long non-coding RNAs (lncRNAs) have been identified as crucial regulators of kidney injury and repair, influencing inflammation, fibrosis, and apoptosis. LncRNA signatures in exosomes show promise as minimally invasive biomarkers for early detection, paving the way for precision medicine applications.
Researchers identified GPR107 as a key regulator of COL4 levels in the kidney, finding that reduced GPR107 contributes to harmful COL4 accumulation and kidney damage. Strategies aimed at restoring or enhancing GPR107 function could represent a novel approach to preventing diabetic nephropathy progression.
Researchers identified 19 metabolites and found that levels of certain compounds correlated with increased blood pressure, worse obstetric outcomes, and poorer end-organ function. The study expands scientific knowledge of preeclampsia and its mechanisms, paving the way for future therapeutic strategies.
A new method combines traditional histopathology with spatial transcriptomics data to improve understanding of chronic kidney disease lesions at the cellular and molecular levels. This approach has the potential to identify new biomarkers and therapeutic strategies for patients.
Research found that community-dwelling older adults with advanced age, frailty, or multiple prescription medications had greater net benefits from intensive blood pressure lowering. However, this approach can increase treatment-related harms in these groups.
The American Heart Association has chosen five US regions to implement a new preventive health initiative aimed at improving care for people with cardiovascular-kidney-metabolic (CKM) syndrome. The initiative will increase awareness and screening for CKM syndrome and facilitate collaboration among healthcare professionals.
A study found that DNA methylation clocks used in forensic science and epigenetics are less reliable when applied to non-blood tissues, such as lungs, colon, and kidneys. The researchers suggest that organ-specific epigenetic clocks may be needed to improve biological age prediction.