Kidney
Articles tagged with Kidney
Clinical decision support for chronic kidney disease in primary care
Creatine is claimed to benefit our body and mind. Here’s what the latest science does – and doesn’t – tell us
Creatine supplementation has been shown to increase muscle energy and improve cognitive function, particularly in populations with lower baseline creatine levels. Emerging evidence also explores its potential therapeutic applications for conditions like Parkinson's disease and menopause-related muscle loss.
Can birth weight influence endurance limits?
A study published in Frontiers in Ecology and Evolution found that optimal birth weight for minimal kidney damage during extreme endurance events is around eight pounds. Individuals with lower or higher birth weights may face a greater risk of kidney stress or damage.
Mayo Clinic research supports targeted therapy to manage kidney complications, potentially enabling continuation of lifesaving immunotherapy
A Mayo Clinic study provides preclinical evidence for a targeted approach to managing immune-related kidney inflammation triggered by immunotherapy. The findings suggest that TNF-alpha blockade may improve markers of kidney injury and could be explored as a preventive measure.
Blood test predicts kidney failure risk to Black Americans years before onset
A new blood test identifies African Americans carrying high-risk APOL1 variants at risk of developing kidney failure years before clinical symptoms appear. The test uses circulating protein markers linked to kidney injury and fibrosis, outperforming existing clinical prediction tools.
Epigenetic suppression of RASAL1 by HDAC3 and cofactor YY1 promotes fibroblast-myofibroblast transition and renal fibrosis
This study reveals that HDAC3 epigenetically represses RASAL1, a key antifibrotic regulator, leading to enhanced fibroblast activation and extracellular matrix deposition in renal fibrosis. Restoring RASAL1 expression or inhibiting HDAC3 activity attenuates renal fibrosis.
Integration of single-cell multiomics data allows a more precise identification of rare cell types and states
Researchers developed an interpretable machine learning algorithm, scOMM, to classify cell types consistently across different single-cell methods. The integration strategies and scOMM establish a robust approach for cell atlas generation in complex tissues, leading to the discovery of previously undetected rare cell types.
Cardiorenal outcomes with tirzepatide compared with dulaglutide in patients with diabetes and cardiovascular disease
A post hoc analysis found that tirzepatide was associated with a lower incidence of a broad composite cardiovascular and kidney endpoint. The study compared tirzepatide with dulaglutide in patients with diabetes and established cardiovascular disease.
Early intervention in severe fetal megacystis can increase survival rate and kidney function
Researchers found that treating severe fetal megacystis with a vesicoamniotic shunt in the first trimester can improve survival rates and kidney function. In the study, 75% of children were born alive and 68% survived their first year of life, with most showing normal or only slightly impaired kidney function.
VR could reduce anxiety for people undergoing medical procedures
A new study suggests that using virtual reality (VR) to explain medical procedures can help patients better understand their treatment and reduce anxiety. The research tested VR as part of the consent process for a procedure to treat kidney stones, with patients reporting improved understanding and reduced anxiety after the experience.
National policy to remedy harms of race-based kidney function estimation associated with increased transplants for Black patients
A nationwide intervention has led to increased kidney transplants among Black patients, with a 5.3 transplant increase per 1,000 listings. The study found that wait time modifications, required by a national policy, resulted in a 1.7-year gain in priority status for Black candidates.
Mayo Clinic researchers find combination therapy reduces effects of ‘zombie cells’ in diabetic kidney disease
Researchers identified a drug-and-supplement combination therapy that reduces senescent cells, inflammation, and injury in diabetic kidney disease. The treatment approach involves senolytics, which selectively target senescent cells.
Understanding how extracellular vesicles from cancer cells end up in urine
Cancer cell-derived small extracellular vesicles can be excreted into urine, according to researchers who tracked their journey in mouse models. The study reveals that glomerular cells actively transport sEVs across the filtration barrier, supporting their use in emerging urine-based cancer diagnostics.
COVID-19 infection predicts higher risk of kidney disease, study finds
A study found that COVID-19 infection significantly increases the risk of acute kidney injury, chronic kidney disease, and kidney failure in US adults. The research used machine learning models to analyze data from over three million patients, revealing a 2.3-times higher risk of acute kidney injury compared to influenza.
Access to dialysis facilities in socioeconomically advantaged and disadvantaged communities
The study found that increased community disadvantage leads to fewer options for receiving hemodialysis and more likelihood of living without nearby dialysis facilities. Patients with end-stage kidney disease in these areas have limited access to essential care services.
Transplantation and employment earnings in kidney transplant recipients
A cohort study of 3,230 kidney transplant recipients found that transplantation reverses declining employment income, enabling meaningful economic recovery. The findings highlight the socioeconomic value of transplantation and inform policies to support patients during pretransplant vulnerability.
Chronic kidney disease severity and risk of cognitive impairment
A cohort study of patients with chronic kidney disease found that more advanced stages of the condition are associated with a higher incidence of cognitive impairment. The study underscores CKD severity as a key risk factor for cognitive decline across the entire spectrum of CKD.
Rice lab to help develop bioprinted kidneys as part of ARPA-H PRINT program award
The Rice lab will produce bioprinted, vascularized kidney tissue that augments renal function in patients with kidney disease. The implantable kidney tissue will be made from a patient's own cells combined with a bioink that supports the long-term viability of the implanted cells.
GPX3: A protective regulator of inflammation and oxidative stress in renal ischemia–reperfusion injury
Researchers discover GPX3 plays a central role in limiting inflammation, oxidative damage, and renal dysfunction following ischemic insult. Restoring GPX3 expression improves renal functional indices, reduces histopathological injury, and alleviates tubular epithelial cell death.
New therapy could make life better for kidney transplant patients
A new study offers hope that kidney transplant patients may one day have a more effective treatment regimen. The Phase 2 pilot study showed improved kidney functioning in all patients who completed the study, with no patients experiencing rejection due to antibodies produced by the immune system.
Researchers discover a previously unknown bacterial component in kidney stone formation
A UCLA-led team has discovered a novel mechanism of kidney stone formation involving bacteria, challenging the long-held assumption that stones develop solely through chemical and physical processes.
Diagnoses of major conditions failing to recover since the pandemic
A recent study by King's College London found that diagnosis rates for depression, asthma, and osteoporosis remained lower than expected after the COVID-19 pandemic. The study analyzed data from over 29 million people in England and found that diagnosis rates recovered differently across ethnic and socioeconomic groups.
SGLT2 inhibitors vs GLP-1 receptor agonists for kidney outcomes in individuals with type 2 diabetes
A comparative effectiveness study found that SGLT2 inhibitors were associated with a lower risk of chronic kidney disease and acute kidney injury compared to GLP-1 receptor agonists. These findings suggest that SGLT2 inhibitor treatment may be an effective strategy for preventing kidney disease in individuals with type 2 diabetes.
‘Tubuloids’ offer a realistic platform for modeling chronic kidney disease
Researchers from Institute of Science Tokyo developed 'tubuloids' to capture the slow progression of chronic kidney disease (CKD), replicating key features such as DNA damage, cellular senescence, inflammation, and fibrosis. This realistic platform provides a new way to develop and test treatments for millions globally.
Prevention reduces the incidence of severe acute kidney injury after major surgery
A targeted treatment approach significantly reduces moderate and severe acute kidney injury after major surgery in high-risk patients identified by biomarkers. The study shows that a closely monitored set of clinical measures provides effective protection in the first hours after surgery.
Study highlights underrecognized link between kidney disease and cognitive decline
A new study found that chronic kidney disease accelerates cognitive decline through interconnected damage to the heart and brain, with men experiencing greater impairment than women. The research also highlights the need for tailored strategies to prevent progression to neurological disorders.
Poor kidney health linked to higher levels of Alzheimer’s biomarkers in blood
A recent study published in Neurology found that people with impaired kidney function have higher levels of Alzheimer's biomarkers in their blood. However, the study did not find an increased risk of developing dementia among those with poor kidney health.
New evidence on the therapeutic potential of extracellular vesicles in kidney injury
Researchers review current evidence on extracellular vesicles' interaction with renal tubular epithelial cells, showing protective effects against damaged tubular cells. However, challenges remain to overcome, such as biodistribution and targeting issues.
Your pain meds' side effects may be masquerading as heart failure
Researchers tracked 120 older veterans taking gabapentinoids and loop diuretics, finding that only 4 doctors correctly identified the gabapentinoids as the cause of leg swelling. The study highlights the dangers of 'prescribing cascades' and emphasizes the need for regular monitoring and alternative treatment options.
Research compares how GLP-1s impact the heart, kidneys of veterans with type 2 diabetes
A study comparing GLP-1 RAs found that all three drugs are relatively safe options for patients with type 2 diabetes, with minimal differences in kidney and cardiovascular risks. Liraglutide had a lower risk of all-cause mortality compared to dulaglutide.
New tool predicts graft failure after kidney transplant
A new electronic medical records-based tool predicts which patients are most at risk of losing a transplanted kidney graft, allowing for timely interventions. The study achieved high predictive accuracy and can be implemented to streamline care of recipients.
New drug protects mitochondria and prevents kidney injury in mice
Researchers at University of Utah Health have found that AKI is triggered by ceramides, which cause serious injury by damaging kidney mitochondria. Using a backup drug candidate, the team was able to preserve mitochondrial integrity and prevent kidney injury in mice.
1 in 8 males undergo scrotal surgery 20 years after kidney donation
A population-based cohort study found that the cumulative incidence of scrotal surgery among male living kidney donors was 1 in 8 after 20 years, compared to 1 in 143 for non-donors. Most males who donate a kidney won't develop this complication, but it's essential to inform past and future donors about the risk and potential symptoms.
Development and validation of a predictive model for continuous renal replacement therapy in patients undergoing venovenous extracorporeal membrane oxygenation
This study developed and validated a risk prediction model for CRRT initiation in VV-ECMO patients, incorporating five key predictors. The final model demonstrated strong discrimination with an area under the curve of 0.88 (derivation) and 0.75 (external validation).
Chronic kidney disease has more than doubled since 1990, now affecting nearly 800 million people worldwide
The study found CKD affects nearly 800 million worldwide, with diabetes and high blood pressure driving the greatest loss of healthy years. Access to kidney replacement therapies remains limited, highlighting the need for preventive measures and equitable care.
A conservative dialysis strategy and kidney function recovery in dialysis-requiring acute kidney injury
A conservative dialysis approach resulted in faster and more complete kidney function recovery in patients with acute kidney injury. The study's findings suggest that this strategy could be a viable option for treating dialysis-requiring AKI, warranting further investigation.
SGLT2 inhibitors and kidney outcomes by glomerular filtration rate and albuminuria
The study suggests that SGLT2 inhibitors can benefit patients with varying levels of kidney function and albuminuria. Routine use of these medications may lead to improved kidney outcomes across different patient groups.
Discordance in creatinine- and cystatin C–based eGFR and clinical outcomes
A study published in JAMA finds that using different methods to estimate glomerular filtration rate (eGFR) can lead to significant discrepancies, particularly for those with chronic kidney disease. The findings suggest that cystatin C-based eGFR may be more accurate in predicting clinical outcomes.
Participant experiences in a kidney failure care intervention in the navigate-kidney study
The navigate-kidney study finds that community health workers enhance holistic, patient-centered care through improved patient engagement and emotional wellbeing. This integration into dialysis care teams may lead to better outcomes for patients with kidney failure.
Effects of sodium glucose cotransporter 2 inhibitors by diabetes status and level of albuminuria
The study found clear absolute benefits of SGLT2 inhibitors on kidney, hospitalization, and mortality outcomes regardless of diabetes status and level of urine albumin to creatinine ratio. This benefit suggests a potential therapeutic approach for patients with kidney disease.
First transplant in pigs of modified porcine kidneys with human renal organoids
Researchers developed a scalable method to produce human kidney organoids, combining them with pig kidneys outside the body for transplantation. The transplanted organs functioned normally and showed no signs of damage or toxicity.
Can blood analyses in dogs provide insights into human aging?
Researchers analyzed blood samples from dogs in the Dog Aging Project and found that post-translationally modified amino acids are strongly linked to age, suggesting a promising indicator of physiological aging. The study also highlighted an important role of the kidney in the relationship between age and blood metabolites.
Grant to build AI imaging database for polycystic kidney disease
Researchers are building an AI-powered database of MRI and CT images to track disease progression and measure patient response to treatments. The database will provide a standardized toolkit for extracting precise imaging biomarkers, enhancing the accuracy of organ measurements and improving treatment choices.
Generative AI enters nephrology: Towards an augmented medicine
The conference explores how generative AI is reshaping kidney medicine through AI-driven diagnostics, data integration, and omics analysis. Key findings include the use of LLMs to transform diagnostic precision, patient management, and research design.
Glucose-lowering medication classes and cardiovascular outcomes in patients with type 2 diabetes
This study found that GLP-1RAs and SGLT2is offer the greatest cardiovascular benefits for adults with type 2 diabetes. The magnitude of benefit depends on baseline age, atherosclerotic cardiovascular disease, heart failure, and kidney impairment.
Liraglutide vs semaglutide vs dulaglutide in veterans with type 2 diabetes
A comparative effectiveness study found that liraglutide, semaglutide, and dulaglutide have similar risks for kidney and cardiovascular outcomes in veterans with type 2 diabetes. Head-to-head trials are needed to confirm these findings.
UBC enzyme technology clears first human test toward universal donor organs for transplantation
Researchers at UBC have successfully transplanted an enzyme-converted kidney into a brain-dead recipient, showing promise for universal donor organs in transplantation. The breakthrough uses special enzymes to remove blood-type antigens, making it possible to use mismatched organs from deceased donors.
Kidney disease study reveals unexpected marker
Researchers found that higher SDMA levels, but not ADMA, correlated with weaker blood vessel function in patients with moderate chronic kidney disease. This suggests that measuring SDMA levels may provide a better approach to monitoring vascular function in these patients.
Cumulative cardiovascular health score through young adulthood and cardiovascular and kidney outcomes in midlife
A higher cumulative cardiovascular health score in young adulthood is associated with reduced risk of cardiovascular disease and kidney events in midlife. The study emphasizes the importance of early life prevention efforts.
Discontinuation of semaglutide among older adults with diabetes in the US and Japan
A binational study found nearly 6 in 10 US adults and 3 in 10 Japanese adults discontinued semaglutide within 12 months of treatment. Patients with established cardiovascular disease and chronic kidney disease had higher discontinuation rates, highlighting the need for alternative treatments.
Protein in urine can predict risk of dementia
A study published in Journal of Internal Medicine found that people with moderate to high levels of albumin in their urine have a higher risk of developing dementia. The researchers discovered an association between albuminuria and increased risk of dementia, independent of kidney function.
Partnership with Kenya's Turkana community helps scientists discover genes involved in adaptation to desert living
Researchers found genetic adaptations underlying survival in hot and dry environments, revealing how natural selection enabled the Turkana to thrive in extreme conditions. The study identified key genes, including STC1, that play vital roles in conserving water and protecting kidneys from waste.
Gene editing to treat inherited kidney disease
Researchers at the Max Delbrück Center have successfully used base editing to correct mutations that cause autosomal dominant polycystic kidney disease (ADPKD) in human and mouse cells. The technique shows promise in reducing liver cysts, a key symptom of the disease.
USC Stem Cell-led team makes major advance toward building a synthetic kidney
A USC Stem Cell-led team has successfully generated lab-grown kidney structures, or organoids, that exhibit kidney-like functions such as blood filtration and urine production. The 'assembloids' achieved maturity levels comparable to newborn mouse kidneys, paving the way for developing new therapies for patients awaiting transplant.
Kidney transplant rejection associated with changes in lymphatic vessels, new research shows
Researchers have discovered how lymphatic vessels, the 'plumbing system' of the kidney, undergo dramatic changes during chronic transplant rejection. The vessels become structurally disorganized and spread to unusual parts of the kidney, disrupting immune balance and fuelling inflammation.
GLP-1 RAs and cardiovascular and kidney outcomes by body mass index in type 2 diabetes
A cohort study found GLP-1 RAs offer body mass index-dependent cardiovascular benefits and consistent kidney protection for type 2 diabetes patients. The study suggests BMI stratification is crucial for guiding treatment decisions.
Developing a novel drug for acute myocardial infarction, acute kidney injury, and subsequent chronic organ failure
A novel drug target, CD300a, has been identified to suppress immune cell activation and prevent chronic heart and kidney failure after acute tissue injury. The treatment preserves cardiac function and reduces renal fibrosis in mice with genetic deficiency of CD300a.
Pre-dialysis nephrology care disparities and incident vascular access among Hispanic individuals
A retrospective cohort study found system-based disparities in pre-dialysis nephrology care contribute to 1/3 of incident vascular access disparities among Hispanics. Targeted policies are needed to improve timely identification and referrals for equitable improvements in kidney failure outcomes.
USC Stem Cell scientists unlock blueprint for lab-grown kidney cells with preclinical value
USC Stem Cell scientists have developed a blueprint for generating specific kidney cell types on demand, holding immense value for preclinical studies of new therapeutics and congenital kidney diseases. The team successfully created lab-grown proximal tubule cells that can absorb sugar and protein, respond to chemotherapy drugs, and pr...