About The Study: This comparative effectiveness study found that initiation of sodium-glucose cotransporter-2 inhibitor (SGLT2i) vs glucagon-like peptide-1 receptor agonist (GLP-1RA) treatment in individuals with type 2 diabetes was associated with a lower 5-year risk of chronic kidney disease and a lower 5-year count of acute kidney injury. These findings underscore the potential of SGLT2i treatment for primary prevention of kidney disease in individuals with type 2 diabetes.
Corresponding Author: To contact the corresponding author, Simon K. Jensen, PhD, email skj@clin.au.dk .
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(doi:10.1001/jamainternmed.2025.7409)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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JAMA Internal Medicine