Articles tagged with Internal Medicine
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
A recent study published in JAMA Internal Medicine found that oral semaglutide has a potential benefit in reducing heart failure events among people with type 2 diabetes and existing heart failure. The data support the use of oral semaglutide as a treatment option for these patients.
The American College of Chest Physicians' CHEST Critical Care journal has been added to the Web of Science Core Collection through the Emerging Sources Citation Index. This indexing marks a significant milestone for the journal, increasing access to high-quality research and supporting its commitment to advancing critical care medicine.
The study examines the characterization of the international-born health care workforce in rural US communities. It highlights the Conrad 30 waiver program, which enabled thousands of J-1 visa holders to remain in the US, caring for approximately 44 million patients, and H1-B visas as additional vehicles for immigrant clinicians.
The Ann Arbor Guide provides two algorithms for triaging adults with suspected UTIs, one for non-pregnant women and the other for men. It also emphasizes the importance of accurate testing and treatment to prevent overuse of antibiotics and antibiotic resistance.
A comparative effectiveness study found that SGLT2 inhibitors were associated with a lower risk of chronic kidney disease and acute kidney injury compared to GLP-1 receptor agonists. These findings suggest that SGLT2 inhibitor treatment may be an effective strategy for preventing kidney disease in individuals with type 2 diabetes.
Researchers identify circulating extracellular vesicles produced in diseased kidneys as the culprit behind toxicity in the heart. The discovery could lead to the development of a blood test to identify patients at high risk for serious heart problems and novel treatments to prevent and treat heart failure.
A recent University of Michigan study analyzed over 60 million Medicare participants and found that total visits remained stable or declined slightly through June 2024. Despite widespread adoption of telehealth, overall healthcare visits stayed steady or decreased, contradicting predictions of increased utilization.
Research finds cancer cachexia-related immune cells impair T-cell negative selection, leading to irAEs. This study establishes a critical mechanism connecting cancer cachexia and irAEs, opening new avenues for targeted interventions.
A recent study published in JAMA Internal Medicine found that a significant majority of Americans will experience cost burdens due to healthcare expenses throughout their lives. The study suggests that policies aiming to reduce out-of-pocket costs could potentially improve the well-being of individuals in the US.
The study will select the exact phage that is appropriate for each patient's bacteria, and aims to reduce antibiotic use and healthcare costs. Bacteriophages have been shown to be effective against resistant bacteria causing urinary tract infections.
Researchers have launched a new multimodal medical dataset, Observer, capturing anonymized, real-time interactions between patients and clinicians. The dataset links video, audio, transcripts, and electronic health records to study subtleties like body language and environmental factors affecting care.
A case-crossover study found that air conditioning in nursing homes reduces mortality among older adults during extreme heat. The study suggests that AC provision may be crucial for preventing mortality in congregate care settings.
A study published by Michigan Medicine suggests that AI can help increase the chance of people with risky drinking patterns or signs of alcohol use disorder getting outreach and help. The NLP tool analyzed full text of health records and identified over 47,500 patients with some sign of risky drinking.
A secondary analysis of the WISDOM trial found a substantial number of women with clinically actionable genetic variants, many not qualifying for current guidelines. This study supports broader access to genetic testing for personalized breast cancer risk assessment.
NEJM Clinician curates highly relevant clinical insights from over 150 peer-reviewed journals to give physicians clear guidance without the noise. The weekly publication delivers summaries and commentary in a concise, 30-minute read, helping healthcare providers stay informed and confident in their decisions.
A cohort study found that participation in New York's medical cannabis program was associated with lower rates of opioid prescription during a 18-month follow-up. The study controlled for unregulated cannabis use, suggesting that medical cannabis may be an effective alternative to opioids for managing chronic pain.
Researchers developed a deep learning model to measure adrenal gland volume on existing CT scans, identifying the first imaging biomarker of chronic stress. The AI-derived biomarker correlates with validated stress questionnaires, cortisol levels, and future cardiovascular outcomes.
Withdrawal of tirzepatide after 36-week treatment led to 25% or greater weight regain in most participants within a year, reversing initial cardiometabolic parameter improvements. Continued obesity treatment is crucial for sustained benefits.
Approximately 1 in 30 clinical trials were disrupted due to grant funding terminations, disproportionately affecting infectious disease and prevention studies. The study emphasizes the need for sustainable financial support to ensure trial operations and participant safety.
Researchers identified a 'sweet spot' in clinical decision-making, where presenting two or more appropriate treatment options increases the odds of physicians selecting a high-quality alternative. The study challenges the widely cited status-quo bias theory and suggests that more options can lead to better care decisions.
A 47-year-old man from New Jersey died after consuming beef due to a tick-borne meat allergy caused by the Lone Star tick's alpha-gal sugar. Researchers identified the allergy and its link to fatal anaphylaxis, urging physicians to investigate severe abdominal pain after eating red meat in areas with high Lone Star tick populations.
A new report from Northwestern University offers six practical strategies to improve the doctor-patient bedside encounter in an era dominated by AI. By employing these strategies, clinicians can strengthen patient-physician relationships, combat inequities, and reduce burnout, ultimately leading to better patient outcomes.
Research published in ERJ Open Research suggests that assessing hospital patients' reported shortness of breath could help doctors prioritize care for those at high risk of death. Patients who developed shortness of breath were six times more likely to die than those who did not, with a higher rating indicating greater risk.
A culturally tailored community health worker intervention modestly lowered interdialytic weight gain and improved dialysis adherence among Hispanic and Latino patients with hemodialysis-dependent kidney failure. This study suggests that such interventions can enhance patient outcomes for these vulnerable populations.
The 2024-2025 COVID-19 vaccines demonstrated effective protection against severe disease and similar effectiveness against different subvariants. However, their effectiveness declined over time.
A randomized clinical trial found that an unsupervised online Tai Chi intervention improved knee pain and function compared to the control group at 12 weeks. This free web-based intervention offers a safe, accessible, and scalable option for guideline-recommended osteoarthritis exercise.
Automated external defibrillators (AEDs) in private homes show effectiveness in improving patient outcomes for those with shockable rhythms during cardiac arrest. However, considering the rarity of cardiac arrest at home and current AED pricing, general purchase is not deemed cost-effective.
The FDA has approved elinzanetant for treating hot flashes and night sweats in postmenopausal women. The drug significantly reduces the frequency and severity of symptoms while improving sleep quality and quality of life.
A randomized clinical trial found that colchicine did not improve functional capacity or inflammatory markers in adults with long COVID. Researchers highlight the need for new therapeutic strategies for this condition.
Researchers found that specific bacteria, such as Haemophilus parainfluenzae and Fusobacterium species, are associated with AIG-related neuroendocrine tumors. The study suggests that changes in host metabolism occur before alterations in the gastric microbiota, potentially creating a microenvironment that favors tumor growth.
A new review in Frontiers in Science calls for a fundamental shift in how heart drugs are discovered and tested using AI, omics, and big data. This approach could drive the development of personalized treatments for cardiovascular disease, which currently relies on broad-brush treatments that don't account for individual variability.
The FDA has approved AD-NP1 for human clinical trials, a monoclonal antibody that targets cellular metabolism to promote tissue repair of multiple organs. Funded by the National Institutes of Health and other sources, AD-NP1 has shown efficacy in mice and monkeys, and may benefit various organs beyond the heart after acute injury.
A recent study suggests that the rise in early-onset cancer incidence in the US population may not be as significant as initially thought. Much of the increase is attributed to increased diagnostic scrutiny and over-diagnosis, rather than a genuine rise in clinically meaningful cancer cases.
A large international clinical trial found that elinzanetant significantly reduces hot flashes and night sweats in postmenopausal women by over 73%. The drug also shows secondary benefits such as improved quality of life and reduced sleep disturbances, with no harmful effects on the liver or bone density.
Researchers at Osaka Metropolitan University found that elevated phosphate levels are associated with poor outcomes in canine respiratory disorders. The study used medical records from 133 dogs and identified heart rate, body temperature, and other factors as significant prognostic indicators.
A new study uses GenAI models to extract pathological features for lung adenocarcinoma grading and prognosis, achieving striking accuracy and consistency. The research team discovered 11 key histological features and 4 clinical variables that provide a comprehensive risk assessment for patients.
A study of 22 million urgent care visits found 12.4% of patients received antibiotics, 9.1% glucocorticoids, and 1.3% opioids for generally inappropriate diagnoses. The trends highlight the need for improved clinician knowledge, patient demand, and decision support.
The article provides practical strategies for managing symptoms in patients receiving GLP-1 RAs, focusing on diet and physical activity interventions to support muscle and nutrient preservation. Lifestyle factors remain crucial in GLP-1 RA treatment for effective weight management.
A pilot study evaluated Nutri, a clinical decision support tool for brief diet counseling in safety-net clinics. PCPs found the system usable and satisfactory, while patients effectively engaged with the intervention.
A randomized clinical trial found that cannabidiol (CBD) administration led to liver enzyme level elevations in 5.6% of participants and potential drug-induced liver injury in 4.9%. Hepatic enzymes returned to normal within weeks after discontinuation. Further research is needed on CBD's long-term effects and safety.
Researchers found that combining RFA with anti-PD-1 therapy significantly suppressed non-ablated distant HCC tumor growth and prolonged survival in mice. The treatment remodeled the immune microenvironment, promoting durable immune memory against tumor recurrence.
Dr. Ghosh's expertise combines clinical, social science, and policy research to address the impact of climate change on vulnerable populations. His initiatives focus on developing interventions against heatwaves, hurricanes, and flooding.
Prevalence of current cannabis use rose significantly among adults aged 65+, particularly those with higher incomes. Adults with initial lower cannabis use rates now exhibit the highest prevalence by 2023.
A national survey of internal medicine physicians found that experiencing sacred moments is common among physicians. However, discussing these experiences with colleagues is infrequent, suggesting a potential impact on physician well-being.
New University of Michigan studies find that women primary care physicians are more likely to experience burnout from patient portal messages, but also spend more time managing these messages. Innovative solutions like Patient Asynchronous Care Effort (PACE) slots can help reduce workload and improve physician experiences.
This novel treatment approach yields better weight loss maintenance and cardiovascular risk outcomes compared to standard-of-care treatment. Patient-delivered lifestyle intervention combined with peer support significantly improves weight loss and reduces cardiovascular risk.
The university successfully secured funding for two new clusters, SCALE and CPI, which will focus on understanding cellular architecture and cardiovascular diseases. The clusters aim to pioneer new paths in medicine through innovative research.
A study published in JAMA Health Forum found that patients with female primary care physicians had better diabetes control, more eye exams, and fewer emergency department visits. Women PCPs also earned more than their male colleagues through value-based payment, possibly due to their patients having lower healthcare utilization.
Researchers found that snus cessation led to a clinically significant rise in blood pressure, averaging 3.7 mm Hg, and weight gain of 1.8 kilos in a group of 33 participants. The study suggests that healthcare professionals should monitor blood pressure after snus cessation, especially for individuals with cardiovascular problems.
A study found that US physicians working with an incompletely staffed team experienced significantly greater odds of burnout, intention to reduce clinical work hours, and intention to leave their organization. This highlights the importance of adequate staffing for physician well-being.
UCF students created an AI system, AIMS, to track surgical staples during robotic surgeries, reducing waste and improving sustainability. The technology was developed as part of the college's Senior Design capstone course and has been successfully tested in operating rooms at Orlando Health.
The COVID-19 pandemic led to a substantial increase in depressive symptoms among US adults, with younger individuals being disproportionately affected. Worsening mental health trends were observed across the population.
Researchers found daily increases of 11-24% in asthma-related emergency department visits over the first episode of a wildfire event, continuing up to 6 days after it ended. However, a second period of heavy smoke did not result in an increase in asthma-related ED visits.
New UCLA-led research finds that telemedicine use in 2023 reduced monthly CO2 emissions by the equivalent of 61,000 to 130,000 gas powered vehicles. This modest but noticeable impact on the environment could have policy implications for US healthcare delivery.
A recent meta-analysis found that generative AI's diagnostic accuracy is lower than that of specialist doctors, with an average accuracy of 52.1%. The study suggests that while generative AI has the potential to support non-specialist doctors in diagnostics, further research is needed to improve its capabilities.
A study published in Journal of Proteome Research reveals that inflammation and aging contribute to the development of non-viral liver cancer. Researchers analyzed gene expression and metabolites in normal and affected samples, identifying potential therapeutic targets for chemoprevention.
Researchers compared surgical resection to immunotherapy in HCC patients with pulmonary metastasis, finding surgery provides better long-term prognosis and overall survival. Treatment allocation and hepatic tumor T stage are independent prognostic factors for overall survival.
Current computed tomography (CT) imaging may lead to up to 103,000 future cancers over a patient's lifetime. If practices persist, CT-associated cancer could account for 5% of all new diagnoses annually.
Brienne Miner and Melisa Wong, two emerging investigators, received the Arti Hurria Memorial Award for their work on sleep health and geriatric oncology. Their research aims to improve sleep health and cancer care for older adults.
The American College of Chest Physicians' CHEST Critical Care and CHEST Pulmonary journals have been indexed in Elsevier's Scopus database. This achievement is a testament to the high-quality research published in these journals, which provide open access content in pulmonary and critical care medicine.