About The Study: In this population-based cohort study, a sibling-matched analysis found no evidence of an association between prenatal paracetamol (acetaminophen) exposure and the risk of autism spectrum disorder or attention-deficit/hyperactivity disorder (ADHD) in offspring. The positive signals observed in conventional studies are likely attributable to residual familial confounding. These findings provide important reassurance regarding the safety of indicated paracetamol use during pregnancy.
Corresponding Authors: To contact the corresponding authors, email Eric Yuk Fai Wan, PhD, ( yfwan@hku.hk ) and Ian Chi Kei Wong, PhD, ( i.wong1@aston.ac.uk ).
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(doi:10.1001/jamainternmed.2026.2215)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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JAMA Internal Medicine