Articles tagged with Analgesics
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
A new study found that MET signaling plays a critical protective role in acetaminophen-induced acute liver failure by reducing liver damage and accelerating regeneration. The findings suggest targeting MET signaling could become a game-changer for treating drug-induced ALF, potentially reducing the need for emergency liver transplants.
A recent study found that low-dose aspirin use was not associated with incident cancer incidence in older adults, contrary to previous findings. However, the study revealed a significant elevation in cancer mortality risk during the randomized clinical trial period, which did not persist after the trial ended.
Research suggests that blocking growth factor receptor signaling using cancer drugs may overcome two challenges: managing oral cancer pain and preventing opioid tolerance. This approach could control cancer while addressing pain through a non-opioid, biologically rational approach.
A new study used deep learning and large-scale computer simulations to identify structural differences in synthetic cannabinoid molecules that cause them to bind to human brain receptors differently from classical cannabinoids. Researchers found that these substances often trigger the beta arrestin pathway, leading to more severe psych...
Researchers found that abstinent smokers have altered brain activity linked to increased pain sensitivity and a need for more postoperative pain relief. The study suggests that nicotine withdrawal affects specific brain regions, leading to higher requirements for pain management in surgery.
Headache disorders affect nearly one in every three people, causing significant disability and health loss. Migraine and medication overuse drive most of the global burden, emphasizing the need for improved prevention, management, and access to care.
Research finds existing evidence on paracetamol use during pregnancy does not clearly link it to autism or ADHD in children; studies suggest shared genetic and environmental factors within families may explain the observed risk. Women can be advised to take paracetamol when needed for pain and fever during pregnancy.
A new study by Rutgers University found that over-the-counter pain medications are as effective as opioids in reducing pain after tooth extraction for both men and women. The study's results confirm the analgesic effect of non-opioid medications, which were superior to opioids in terms of sleep quality and daily activity interference.
A comprehensive systematic review and meta-analysis published in the Journal of the American Academy of Child & Adolescent Psychiatry found no association between prenatal acetaminophen exposure and the risk of neurodevelopmental disorders, including autism and ADHD. The study offers reassurance for pregnant women, public health agenci...
Researchers discovered a new enzyme produced by Bacteroides fragilis that activates pain signaling. The enzyme is targeted with nanoparticles to develop treatments for gut pain in inflammatory bowel disease and irritable bowel syndrome. The studies aim to restore balance between good and bad bacteria to reduce symptoms.
A pooled data analysis found tramadol to be ineffective in easing chronic pain, with a small and clinically insignificant effect. The use of tramadol was also associated with an increased risk of serious side effects, including heart disease and certain cancers.
A new study suggests that low-dose aspirin can prevent cancer in older adults based on individual characteristics. The analysis found varying treatment effects among participants, highlighting the need for personalized approaches to cancer prevention.
Scientists at NYU Pain Research Center identified the EP2 receptor as the main cause of inflammatory pain but not inflammation. Blocking this receptor silenced pain responses without affecting inflammation, offering a new strategy for treating prostaglandin-mediated pain.
Inflammasome activation plays a key role in acetaminophen-induced hepatotoxicity, triggering oxidative stress, mitochondrial dysfunction, and inflammation. Targeting inflammasome signaling offers promising therapeutic approaches, including NLRP3 inhibitors, caspase-1 inhibitors, and anti-inflammatory agents.
Researchers have identified two key brainstem regions involved in pain relief, with distinct patterns of activity depending on the location of pain. This discovery may pave the way for safer, more targeted treatments for chronic pain without relying on opioids.
Research from the University of South Australia finds that ibuprofen and paracetamol drive antibiotic resistance when used individually, but amplifying it when combined. The study also reveals that common bacteria like E. coli become highly resistant to antibiotics and multiple other medications.
A new Cochrane review has found no clear evidence of benefit for ketamine in treating chronic pain conditions. The review identified an increased risk of adverse effects such as delusions and vomiting. High-quality trials are needed to determine the role of ketamine in chronic pain care.
A parasitic worm has evolved to suppress neurons in the skin to evade detection, reducing its own survival. Researchers discovered that the worm produces molecules blocking TRPV1+ activity, essential for pain sensation and immune responses, allowing it to infect the skin undetected.
Researchers have discovered a way to distinguish identical medicines at the molecular level, allowing for the tracing of counterfeit or stolen medicine. The technology focuses on variants of chemical elements such as isotopes of carbon, hydrogen, and oxygen.
Researchers at Kyoto University have discovered a novel analgesic called ADRIANA, which targets the α2B-adrenoceptor and exerts its effect without causing cardiovascular instability. The compound has shown highly promising results in non-clinical studies and early clinical trials.
Researchers found that injecting botox directly into the TMJ alleviated TMD-related pain, hypersensitivity, and neural activity, while preserving movement abilities. The study suggests avoiding muscle tissue to overcome botox side effects and offers new hope for treating jaw disorders.
Researchers found that external cues alleviated pain for all participants but only half reported less pain with placebo treatment. Predictive cues were less impactful when patients received placebo treatment. The study suggests cue-based expectations have more consistent effects than treatment-based expectations.
Researchers discovered a new pathway to boost immunity against parasitic infections, suggesting that NSAIDs like ibuprofen could be repurposed as anti-parasitic treatments. Gasdermin C plays a crucial role in this process, targeting and penetrating Rab7-positive vesicles to reduce prostaglandin d2 levels.
A large medical record study found that receiving six or more gabapentin prescriptions for low back pain significantly increases the risk of developing dementia (29% higher) and mild cognitive impairment (85% higher). Risks are particularly high among 18-64 year olds, with no age group considered safe from increased risks.
A study of over 2,500 adults aged 50-80 found that nearly 1 in 6 take aspirin for cardiovascular protection without a history of heart disease. Despite revised guidelines reducing aspirin use for primary prevention after age 70, many patients are unaware of the increased risk of bleeding.
A new study found that Black emergency department patients are less likely to be treated with opioids, but when their preferences are not met, they are at a higher risk of misusing opioids three months later. Patients who were satisfied with their pain care had lower rates of opioid misuse.
Researchers identified a key brain region, the ventrolateral periaqueductal gray matter (vIPAG), that modulates pain and emotional responses in threatening situations. By inhibiting specific cells within this region, scientists discovered a potential pathway for better pain relief.
The UT Health San Antonio Multispecialty and Research Hospital is the first in Texas to approve use of suzetrigine, a new non-opioid medication for post-surgical pain. This medication targets the peripheral nervous system, avoiding opioid-related side effects.
A new book by Professor Aldrin Gomes details the benefits and risks of ibuprofen, including its interaction with over 400 prescription drugs and impact on cardiovascular health. The comprehensive guide aims to educate readers about responsible painkiller use and natural alternatives.
A study published in The Journal of Pain found that nature exposure can help people with chronic lower back pain by providing a sense of escapism, social connection, and physical exercise. Researchers recommend incorporating accessible design features into natural spaces to improve inclusivity.
SBI-810, a non-opioid treatment, activates a specific pain-relief pathway that avoids the euphoric high linked to addiction. The compound effectively relieved pain from surgical incisions and nerve injuries better than some existing painkillers.
Researchers at State University of Campinas found that physical exercise prevents the transition from acute to chronic muscle pain by activating an anti-inflammatory signaling pathway in immune cells. This can lead to the development of new treatments for muscle pain, potentially reducing opioid consumption.
Scientists at the University of Southern California have developed a wearable lactation pad that monitors breast milk for safe levels of acetaminophen. The device provides real-time information, enabling parents to make informed decisions about breastfeeding and medication use, and may also be adapted to detect other drugs and biomarkers.
A synthetic peptide derived from neurotoxin GsMTx4 has been found to alleviate mechanical hyperalgesia and neuropathic pain through the TRPV4 channel. The peptide's analgesic effects are comparable to those of morphine, but without any side effects.
A new study found that both employed people with obesity and employer representatives acknowledge the impact of obesity on future health problems and perceive lifestyle change alongside anti-obesity medications as the most effective approach for maintaining weight-loss reduction. Cost of medication coverage remains a significant barrie...
A team of scientists at the University of Florida has developed a new drug compound that selectively targets delta opioid receptors, providing pain relief without the dangerous side effects associated with opioids. The study's findings offer a promising approach to developing safer pain treatments, which could also be applied to treati...
Researchers discovered a mechanism that harnesses immune cells to produce opioids, potentially alleviating chronic pain. Estrogen and progesterone drive this process, which could lead to more effective treatments for women experiencing pain after menopause.
Patients prescribed medicinal cannabis in Australia showed long-term improvements in overall health-related quality of life, fatigue, and sleep disturbance. The study, which recruited over 2,300 participants, also found improvements in anxiety, depression, insomnia, and pain for those with corresponding conditions.
Scientists at ISTA create a new brain organoid model that incorporates microglia to study viral infections, such as Rubella, and test the effectiveness of ibuprofen. The results show that microglia play a crucial role in inflammatory reactions and that ibuprofen exerts its protective effects by inhibiting two inflammatory enzymes.
Researchers from Florida Atlantic University challenge the current aspirin guidelines based on a flawed trial, advocating for healthcare providers to make individual clinical judgments about prescribing aspirin. They stress that patients should consult their primary care provider to balance the benefits of clot prevention against bleed...
Scientists at the University of South Australia have developed a phospholipid complex to improve cannabidiol's effectiveness in treating epilepsy, multiple sclerosis, and other neurodegenerative diseases. The new formula increases cannabidiol's solubility by up to six times and improves its absorption in the gastrointestinal tract.
The ASCOLT trial found that aspirin does not statistically improve disease-free survival for all patients but demonstrates a consistent trend of improving overall and disease-free survival. Aspirin taken for up to 3 years is efficacious in patients with PIK3CA mutation, reducing recurrence by over 50%.
A new study suggests that statins can reduce chest muscle loss in smokers, while aspirin may contribute to increased muscle loss. The study examined data from 4,191 participants and found that statins protected pectoralis muscle area and density, whereas aspirin led to decreased muscle mass.
A new study found that viewing nature can help ease how people experience pain by reducing the brain activity linked to pain perception. The research suggests that the pain-relieving effect of nature is genuine and could provide an alternative way to relieve pain, potentially used in conjunction with medication.
A new study by Boston University School of Public Health refutes claims that Medicaid expansion increases misuse of prescription opioids and benzodiazepines. Despite initial concerns, the study found no association between Medicaid expansion and non-prescribed opioid use among people who inject drugs.
Researchers are conducting a clinical trial to find the optimal combination of pain management tools for patients undergoing mastectomy procedures. The study will enroll approximately 100 patients and examine various combinations of pectoralis nerve blocks, non-opioid analgesics, and administration methods.
Researchers found that aspirin prevents cancers from spreading by decreasing a clotting factor called thromboxane A2 and releasing T cells from suppression. This discovery could lead to the development of targeted treatments to prevent cancer metastasis, making aspirin potentially less expensive than antibody-based therapies.
People who took over-the-counter pain relievers after a concussion recovered faster than those who did not take pain relievers. Those who took pain relievers were cleared to return to activities with no restrictions an average of two days faster at 50% recovery and seven days faster at 90% recovery.
A NIH-funded research team has engineered a medication that targets the body's cannabinoid receptor type 1 (CB1), which shows promise in treating acute and chronic pain. The new drug, VIP36, is more 'peripherally restricted' compared to previous drugs, reducing unwanted side effects.
Research reveals nearly 10% of individuals with disabilities misused prescription drugs in the past year, compared to 4.4% without disabilities. Young adults and those with cognitive disabilities are particularly vulnerable to prescription drug misuse.
The FDA has approved a new treatment for Parkinson's disease that can adjust to the individual's brain activity, providing precise stimulation. This technology, known as adaptive deep brain stimulation (aDBS), detects patterns of brain activity and delivers tailored electric pulses to reduce symptoms.
A rare case report highlights the association between systemic mastocytosis and severe osteoporosis in a young adult patient, emphasizing the importance of early diagnosis and consideration of SM as an underlying cause. The study aims to raise awareness about this underrecognized condition and its potential impact on bone health.
Researchers at Tokyo University of Science have found that opioid delta-receptor agonists can alleviate stress-induced IBS symptoms in a validated mouse model by targeting the central nervous system. The study suggests that these drugs could provide a more definitive solution for IBS with minimal adverse effects.
A new survey by the Annenberg Public Policy Center finds that nearly half of US adults incorrectly think taking a daily low-dose aspirin reduces heart attack and stroke risk. The survey reveals significant gaps in understanding about aspirin use among older adults, with younger respondents more likely to correctly assess the risks.
Non-white communities had significantly less access to opioid medications, despite declines in prescription use across the US. Communities of color may be especially vulnerable to the unintended consequences of efforts to reduce opioid analgesics.
Despite decreased aspirin use among adults with low and higher ASCVD risk, many patients with limited benefit to treatment continue taking aspirin. The study highlights the need for better understanding of individual risk factors to improve treatment decisions.
Researchers at UT Health San Antonio and The University of Texas at San Antonio have won the 2025 Hill Prizes for their groundbreaking work on non-opioid painkillers and emergency airway management. The $500,000 prize funding will support the development of novel analgesics and a new design for endotracheal tubes.
Researchers will analyze tissue samples from 100 patients over three years to understand why some respond better than others to biologic and targeted therapies. The study aims to improve matching of treatments to individual patients, reducing the guesswork and cost associated with ineffective treatment.
A Rutgers University study found that a combination of acetaminophen and ibuprofen controls pain after wisdom tooth removal better than opioids. Patients who received the non-opioid medication experienced less pain, better sleep, and higher satisfaction compared to those receiving hydrocodone with acetaminophen.
Researchers found that methanolic extract and palmatine from Annona squamosa leaves exhibit analgesic, anti-inflammatory, and anti-hyperalgesic properties. Palmatine may be responsible for the plant's anti-arthritic effects. Further studies are needed to confirm these findings and assess their therapeutic potential.