About The Study: During a press conference on September 22, 2025, President Trump and top health officials endorsed use of leucovorin, a generic drug formulated from folinic acid, for treatment of autism, and urged against acetaminophen use during pregnancy, stating concerns about its risk for development of autism in children. The White House announcement was associated with large increases in internet searches over the subsequent 2 weeks, including more than 1 million additional searches for leucovorin ; nearly 81,000 additional purchasing interest searches for leucovorin , folinic acid , or folate ; and more than 4 million additional searches for acetaminophen with pregnancy or autism .
Corresponding Author: To contact the corresponding author, Joseph S. Ross, MD, MHS, email joseph.ross@yale.edu .
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(doi:10.1001/jamanetworkopen.2026.17910)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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