Articles tagged with Analgesics
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A recent review of opioid medicines for cancer pain found surprisingly large gaps in evidence regarding their true benefits. Non-steroidal anti-inflammatory drugs (NSAIDs) may be at least as effective as some opioids for background cancer pain, offering potential alternatives to reduce dependence and waning analgesia over time.
A study by the University of Sydney and University of Warwick found large gaps in evidence regarding opioid medicines for cancer pain. Non-opioid medicines, including aspirin, may be as effective as opioids for background cancer pain.
Researchers have identified promising treatment candidates for morphine tolerance and cancer, as well as a biomarker for kidney injury. A monoclonal antibody targeting the mu-opioid receptor has been shown to alleviate morphine tolerance and physical dependence, while inducing excessive mitochondrial fission in tumor cells. Additionall...
Post-surgery pain relief has shifted away from opioids since 2016, with a 36% drop in prescription rates and 46% decrease in average amount of opioids. However, the rate of decline slowed after 2020, suggesting ongoing efforts are needed to right-size prescribing.
A new study will compare two treatment regimens: one using non-opioid medication and another with a low-dose opioid to determine the safest and most effective way to treat pain in adolescents and young adults recovering from common outpatient surgeries. The CARES for Kids study aims to generate evidence-based information on this topic.
Jenny Wilkerson receives $1.94 million grant to develop novel models and investigate antinociceptive profiles of basal sex hormone alterations in patients with chronic post-op pain. The study aims to answer questions about the impact of altered sex hormone levels on recovery times, drug effectiveness, and long-term health.
Researchers have identified a small molecule that reverses four types of chronic pain in animal studies without troublesome side effects. The compound, CBD3063, binds to the inner region of a calcium channel, indirectly regulating its activity and reducing neurotransmitter release.
The ORBITA-2 trial found that stenting improves symptoms compared to a placebo procedure, providing evidence-based treatment for stable chest pain. The study suggests updating guidelines for stable coronary artery disease and offers patients and medical teams two treatment strategies with similar benefits.
A phase 4 clinical trial found that apixaban, an anti-clotting medication, reduced the rate of stroke and blood clots in adults with implanted heart devices experiencing short bouts of asymptomatic, irregular heart rhythms. The study suggests that these individuals may benefit from receiving an anticoagulant.
A recent study found that transmucosal dose of buprenorphine followed by extended-release buprenorphine injection significantly reduced Clinical Opioid Withdrawal Scale scores in individuals using fentanyl. This rapid treatment strategy may be an important potential option for addressing the growing opioid crisis.
A new study shows a significant decline in dental opioid prescriptions, with 45% fewer opioids dispensed between 2016 and 2022. However, progress slowed significantly during the COVID-19 pandemic, which may be attributed to dentists being more cautious due to limited follow-up appointments.
A new study published in JAMA Health Forum shows that implementing a five-day limit on opioid prescriptions for surgery patients did not lead to increased pain levels or decreased satisfaction. However, the amount of opioid pills patients received dropped significantly after the limit went into effect.
A post hoc analysis of 10,678 participants with atherosclerotic cardiovascular disease found no significant difference in heart attack, stroke, or death risk between enteric-coated and uncoated aspirin. Enteric-coated aspirin may offer reduced bleeding risk, but more research is needed to confirm its benefits.
Researchers developed a new technology to test new drugs against liver diseases by recreating the real human liver environment. The model consists of live liver cells in an artificial blood vessel system, allowing for controlled testing and monitoring.
Researchers at University of Chicago identified a new pain relief pathway in the brain that produces powerful analgesic effects without tolerance or addictive risks. Targeting acetylcholine receptors, particularly alpha-7, offers a promising path to developing non-opioid painkillers.
Research presented at the EASD Annual Meeting found that low-dose aspirin among older adults aged 65 and older is associated with a 15% lower risk of developing type 2 diabetes. The study also showed a slower rate of increase in fasting plasma glucose levels among those taking aspirin.
The American Dental Association has released a new clinical practice guideline recommending the use of acetaminophen and/or non-steroidal anti-inflammatory drugs (NSAIDs) as first-line treatments for managing short-term dental pain in children under 12. The guideline has been endorsed by the American Dental Association.
Researchers have deciphered a biochemical mechanism explaining how cortisone preparations mediate inflammation-resolving effects in human immune cells. Cortisone influences enzymes involved in the formation of inflammation-resolving messenger substances, inducing resolvins early but impairing function later.
Chronic pain patients who take opioids need access to gold-standard multi-modal pain care, including physical therapy, cognitive behavioral therapy, and integrative medicine techniques. The experts recommend restructuring insurance models, enhancing provider education, and addressing racial inequities in care.
Most adults commencing treatment with prescription opioids had relatively low and time-limited opioid exposure over a 5-year period. Individuals with sustained or increasing use were older with more comorbidities, reflecting higher pain needs.
A new study published in JAMA Network Open shows that methadone use following surgery in infants can increase hospital stay and delay recovery. Babies who required methadone needed to stay in the hospital an average of 21 days longer after surgery, as well as more days on ventilators and IV nutrition.
The study provides a comprehensive framework for diagnosing and treating acetaminophen poisoning, emphasizing the importance of early detection and aggressive management. Key findings include the need for prompt assessment and treatment with activated charcoal and N-acetylcysteine, as well as the role of monitoring liver function tests.
Researchers have identified a novel therapeutic target for pelvic pain in endometriosis by focusing on the IL-1β pathway and its regulation via the JNK signaling pathway. This study suggests that JNK inhibitors may be effective in reducing neuroinflammation and alleviating symptoms of endometriosis-associated pain.
Researchers at NYU College of Dentistry developed a gene therapy that regulates sodium ion channel activity to alleviate chronic pain. By targeting the specific region where CRMP2 binds to NaV1.7, they were able to reduce sodium influx and quiet down neurons, providing relief from pain in cell and animal studies.
Researchers mapped the 3D structure of kappa opioid receptors, discovering how they change shape to bind to opioid drugs. This finding could lead to the development of next-generation pain relievers that target specific opioid receptors and minimize side effects.
A secondary analysis of a randomized clinical trial found that daily low-dose aspirin increases the risk of intracranial bleeding in healthy older adults, but does not reduce ischemic stroke risk. The study's findings have particular relevance to individuals prone to developing intracranial bleeding after head trauma.
The American Heart Association and the American College of Cardiology recommend a heart-healthy diet and lifestyle to prevent worsening health in people with chronic coronary disease. Clinicians should coordinate care between cardiovascular and primary care professionals, emphasizing team-based approach and social determinants of health.
Researchers have discovered a way to identify pregnant women at risk of preeclampsia by examining lipids in their blood during pregnancy. The approach worked regardless of whether the women were on aspirin therapy, and could predict the risk of preeclampsia with significant accuracy.
A study of commercially insured adults with chronic noncancer pain found that state medical cannabis laws did not lead to a reduction in the use of opioid or nonopioid pain treatments. The researchers also suggested slow implementation and reluctance among healthcare leaders may have contributed to these findings.
A world-first trial by the University of Sydney found that opioids do not alleviate acute back and neck pain, but may cause harm. The researchers recommend updating treatment guidelines to advise against opioid use for this purpose.
The University of Sydney-led guidelines recommend personalized deprescribing plans and gradual dose reduction to minimize withdrawal symptoms. Clinicians should avoid abruptly stopping opioids without support or pain management plans, especially for patients with severe opioid use disorder.
A new patient-guided intervention using telemedicine has been shown to improve symptoms of fatigue, pain, and depression in dialysis patients. The Technology Assisted Stepped Collaborative Care (TĀCcare) trial found significant improvements in energy levels and pain severity that persisted for six months after treatment.
A post-hoc analysis of the ASPREE trial found that low-dose aspirin was associated with a 20% increased incidence of anemia and decline in ferritin levels in healthy older adults. The study recommends periodic monitoring of hemoglobin for patients taking aspirin.
Researchers at UCSF tested a nitroglycerin patch for treating menopausal women experiencing severe hot flashes. The study found short-term improvements, but benefits did not last past 12 weeks, with some side effects reported.
A study suggests that ketamine nasal spray is a convenient alternative to intravenous infusion for treating refractory chronic migraine. The treatment showed promise in reducing daily headaches and improving quality of life, with most participants reporting 'very effective' results.
Researchers at UCL have uncovered the molecular basis of a woman's rare genetic mutation that allows her to live pain-free and heal rapidly. The study found that the mutation in the FAAH-OUT gene turns down FAAH gene expression, affecting other molecular pathways linked to wound healing and mood.
A team of researchers at NYU College of Dentistry has successfully modified an existing anti-nausea drug to target the endosomes within cells, thereby providing a more prolonged analgesic effect. The modified netupitant showed improved pain-relieving properties compared to its original form and other drugs targeting similar receptors.
A team of researchers is exploring the potential of HDAC inhibitors to treat sickle cell disease by reactivating the fetal hemoglobin gene. Early evidence suggests that panobinostat, a specific inhibitor, can increase fetal hemoglobin levels in red blood cells and mouse models.
A Cochrane review found that most antidepressants used to manage chronic pain lack sufficient evidence of their effectiveness, with only duloxetine showing reliable pain relief. The review also revealed that harms from many commonly recommended drugs have not been well studied, posing a global public health concern.
Researchers have observed beta-arrestin molecules directly controlling receptor-mediated signals in living cells using advanced microscopy. The study reveals a new mechanism of how these proteins interact with receptors on the plasma membrane, enabling efficient control of signal flow and desensitization.
Researchers at Washington University School of Medicine have identified a potential mechanism behind hallucinations triggered by kappa opioid receptors, aiming to develop painkillers without these side effects. Targeting specific binding sites on the kappa receptor may relieve pain without inducing euphoria and addiction.
A multicentre registry study found that medicinal cannabis can safely relieve cancer pain while reducing the total number of medications and opioids taken. Products with an equal balance of THC and CBD were particularly effective in reducing pain intensity and symptoms.
Researchers found that spinal cord stimulation reduced pain response in rats with human lung cancer tissue without compromising paclitaxel effectiveness. The study also showed SCS improved antitumor efficacy of paclitaxel, providing evidence for its potential as a companion treatment.
Research finds diclofenac's high variability in metabolism due to UGT2B17, a little-studied enzyme. The study suggests genetic testing and dose adjustments for specific populations can help minimize side effects.
Researchers at UNIGE discovered that natural opioids cannot enter cells, whereas therapeutic opioids can, leading to differences in physiological responses. The study's findings could help develop safer medications with improved efficacy and reduced side effects.
Researchers developed a simple sensor to monitor paracetamol levels in saliva in real-time, enabling personalized treatment and reducing toxic side effects. The device is low-cost, portable, and uses non-invasive collection methods, making it an attractive alternative for therapeutic drug monitoring.
Researchers discovered how aspirin reduces inflammation and its implications for cancer immunotherapies. Aspirin controls transcription factors and influences various inflammatory proteins, potentially paving the way for safer alternatives with fewer side effects.
A statewide effort in Michigan resulted in a 56% reduction in opioid prescriptions after six common operations and a 26% drop in persistent opioid use. The achievement surpassed national trends, driven by voluntary prescribing guidelines and surgical team involvement.
Researchers at Tel Aviv University found that dedicated hyperbaric oxygen therapy is more effective in reducing pain and healing patients with fibromyalgia caused by traumatic brain injury. The treatment resulted in significant improvements in 2 out of 5 patients, including improved pain threshold tests and quality of life indicators.
A systematic review found considerable uncertainty around analgesic effectiveness and safety for acute non-specific low back pain. Clinicians and patients are advised to use analgesics with caution due to limited high-quality evidence.
Researchers have developed a novel 3D covalent organic framework, TUS-64, with the largest pore size and lowest density ever recorded. The material shows promise as a drug nanocarrier vehicle, with high capacity to hold drugs and sustained release rate.
A new study by Weill Cornell Medicine found that the FDA's mandate to limit opioid-acetaminophen combinations resulted in significant reductions in liver injuries. The mandate, implemented in 2014, limited the dosage of acetaminophen in these drugs, leading to a decline in hospitalizations and acute liver failure cases.
A US FDA mandate to limit acetaminophen dosage in pills combining it with opioids significantly reduced hospitalizations and acute liver failure cases. Researchers found a persistent decline in yearly rates of these cases after the mandate was implemented in 2014.
Researchers have discovered a gene mutation that can block chronic pain and provide protection against other stimuli, including heart and brain cells. The TRPV1 receptor mutation, found in avian species, was successfully transplanted into mice, showing reduced pain sensitivity and improved protective effects.
A novel surgical pain management strategy has been developed to reduce opioid use after total knee arthroplasty. The study found that changing prescriptions for opioids at discharge from automatic to upon request dramatically decreased opioid use, with over half of patients recovering without opioid use.
A systematic review of 18 studies found that muscle relaxants and non-steroidal anti-inflammatory drugs (NSAIDs) can effectively reduce symptoms. Combining NSAIDs with paracetamol showed a greater improvement than using NSAIDs alone.
A comprehensive review of antidepressant use in chronic pain found that some classes were effective in treating certain conditions, while others showed unclear or unknown benefits. Serotonin-norepinephrine reuptake inhibitors (SNRIs) like duloxetine demonstrated efficacy for various pain conditions.
Researchers found that while some antidepressants are effective for certain pain conditions, most are either ineffective or the evidence is inconclusive. A more nuanced approach is needed when prescribing antidepressants for pain, say experts.
A new study found that women with pre-pregnancy migraine had greater risks of preterm delivery, gestational hypertension, and preeclampsia. Migraine with aura was associated with a higher risk of preeclampsia than without aura.
A recent review in CMAJ provides comprehensive guidance on diagnosing and managing migraine attacks. It emphasizes a stratified approach to treatment, empowering patients to choose medications tailored to their needs and attack symptoms.