Researchers found that semaglutide and tirzepatide led to significant weight loss (9.1% and 21.4%, respectively) and improved blood sugar control in patients with type 1 diabetes. Weight loss was associated with reduced insulin dose, indicating improved insulin resistance.
A new study found that adults with type 1 diabetes are hesitant to exercise due to fear of hypoglycaemia, a concern exacerbated by limited understanding of insulin dose adjustments and carbohydrate intake for physical activity. Education on exercise safety and dialogue within clinics can help break down barriers.
A new hybrid closed-loop technology has been shown to enable people with type 1 diabetes to run marathons with excellent glucose control. The technology, called AID system, automates insulin delivery based on sensor glucose values, allowing for safer and healthier lives.
The SURPASS-4 trial found that tirzepatide improved blood glucose control and weight loss in adults with type 2 diabetes. Higher doses of tirzepatide and female patients were associated with better long-term outcomes, including reduced risk of cardiovascular events.
The study found that semaglutide was effective in preventing heart attacks and other major adverse cardiovascular events as well as death in adults with impaired kidney function. The results showed a significant reduction in cardiovascular disease risk with semaglutide, even among those with poor kidney function.
A new US study found that rapidly controlling blood sugar levels in women with gestational diabetes can significantly reduce the risk of their children developing obesity. The study analyzed data from over 258,000 women and their children, revealing a strong correlation between maternal blood sugar control and childhood obesity risk.
A post-hoc analysis of the SURMOUNT trials found that tirzepatide consistently reduced body weight in both males and females, but women experienced greater weight loss with up to 24.6% reduction compared to 18.1% for men. The safety profile was broadly similar by sex, but females were more likely to experience nausea and vomiting.
A large-scale population analysis confirms tirzepatide's similar gastrointestinal tolerability to other GLP-1 medications without increased risk of diabetic retinopathy, medullary thyroid cancer, or pancreatitis. Researchers analyzed real-world evidence from the FDA adverse event reporting system database and found that tirzepatide has...
A new class of weekly insulin, efsitora alfa, has been shown to be non-inferior to daily injections in managing blood sugar levels in patients with type 1 diabetes. However, the study found higher rates of hypoglycaemia, highlighting the need for vigilance in dose initiation and optimization.
A new study published in the New England Journal of Medicine found that liraglutide is safe and effective in reducing BMI by 7.4% in children aged 6 to under 12, as well as improving blood pressure and blood sugar control. The treatment was well-tolerated with no new safety concerns.
A phase 1 trial found that a new oral weight loss drug, Amycretin, resulted in significant weight loss of up to 13% over three months. The drug targets both amylin and glucagon-like peptide-1 (GLP-1) biology, leading to appetite regulation and reduced hunger.
A new class of once-weekly insulin, efsitora, is noninferior to daily insulin injections in controlling high blood sugar levels. The study found that efsitora reduced Hb1Ac by 1.26% and was associated with a lower rate of hypoglycaemia compared to daily insulin.
A randomized crossover trial found that restricting eating to an 8-hour window improved daily time spent in normal blood glucose range and reduced fluctuations in blood glucose levels. The benefits were evident within three days, even without restricting calories.
A Danish study published in The Journal of Dental Research found that individuals with diabetes complications are at higher risk of gum disease. Periodontitis was more common among those with microvascular complications such as retinopathy and neuropathy.
Research links impaired circadian heart rate fluctuations to microvascular disease and increased long-term risk of cardiovascular mortality in people with diabetes. Disrupted daily heart rate variations are associated with a doubled risk of dying from cardiovascular causes.
A study of 17 million individuals reveals a reciprocal relationship between asthma and type 2 diabetes, with asthma increasing T2D risk by 83% and T2D increasing asthma risk by 28%. Shared factors like hypertension and dyslipidaemia are associated with both conditions.
Researchers developed an AI model using 25 seconds of a person's voice to detect type 2 diabetes, distinguishing between individuals with high accuracy. The model showed strong performance, especially in females aged 60 or older and those with hypertension, aligning with the American Diabetes Association risk score.
A Dutch study found that night owls are more likely to develop type 2 diabetes due to a disrupted circadian rhythm. Participants with late chronotypes had a 46% higher risk of T2D and increased body fat, including visceral and liver fat.
A new UK study found that patients receiving systemic glucocorticoids are more than twice as likely to develop diabetes. The study, conducted by researchers at the University of Oxford, involved over 451,000 adults and revealed a significant link between steroid treatment and new-onset diabetes.
Research suggests that eating fruit, oats, and rye in childhood increases the risk of developing type 1 diabetes, but consuming berries may lower this risk. The study followed thousands of children in Finland from birth to age six and found associations between specific foods and an increased or decreased risk of islet autoimmunity.
Researchers found that altitude changes during flights may cause slight increases and decreases in insulin delivery, potentially leading to blood glucose fluctuations. Individuals using insulin pumps should be aware of these effects and consider temporarily disconnecting their pumps before take-off.
Researchers have developed a semaglutide hydrogel that could reduce diabetes shots to once a month, improving drug adherence and quality of life. The hydrogel's slow release of semaglutide over one month was found to be well-tolerated in laboratory rats with no inflammatory reactions.
A study of 500,000 UK participants found insulin resistance associated with higher risk of 26 conditions, such as sleep disorders and pancreatitis, and lower risk of five diseases, including anaemia and Parkinson's disease. Insulin resistance also linked to increased mortality risk in women.
A new study found that higher BMI is associated with hospitalization for severe bacterial and viral infections. Conversely, mild hyperglycemia was not linked to increased risk of severe infections.
A simple blood test could identify individuals with type 2 diabetes who are at a higher risk of certain cancers. The study found that higher levels of pro-inflammatory cytokine interleukin-6 were associated with an increased risk of obesity-related cancers.
A new study found that females' and males' muscles handle glucose and fatty acids differently, but regular physical activity cancels out these differences and triggers similar beneficial metabolic changes in both sexes. This research has important implications for preventing type 2 diabetes.
A large Danish study published in Diabetologia found no association between gestational diabetes and an increased risk of breast cancer. The study included over 708,000 women and followed them for a median of 11.9 years to examine the link between the two conditions.
Research suggests that exposure to type 1 diabetes in the womb confers long-term protection against the condition in children with affected mothers, but not fathers. The study found a relative risk of 1.8 for children diagnosed with T1D if their father has the condition compared to those with affected mothers.
A study found that both short and long sleep durations are associated with a higher risk of microvascular disease in individuals recently diagnosed with type 2 diabetes. Short sleep duration, especially among older adults, was linked to a significantly increased risk of blood vessel damage.
Research links low birthweight (<2.5 kg/5 lbs 8oz) to increased risk of early type 2 diabetes (59 years or younger) when combined with overweight at aged 20 years, with a 10 times greater risk compared to normal weight peers.
Participants with diabetes remission had a 33% lower rate of CKD and a 40% lower rate of CVD compared to those without remission. The magnitude of risk reduction was greatest for participants with longer-term remission.
Research reveals that low muscle mass is associated with a two-fold risk of death from cardiovascular disease in individuals with diabetes. The study found that body composition, not just weight loss, plays a crucial role in managing weight in people with diabetes.
Research suggests that trans men and women have a higher risk of cardiovascular disease, while the link to diabetes remains uncertain. Testosterone therapy may contribute to increased cardiovascular risk in trans men, whereas hormone treatments for trans women do not explain this association.
A new study published in Diabetologia found that hybrid closed-loop technology improved maternal blood sugars during pregnancy complicated by type 1 diabetes. The technology, which adjusts insulin doses every 10-12 minutes, helped reduce maternal blood sugar levels and weight gain, while also improving baby health outcomes.
A recent study demonstrated that lasting remission of type 2 diabetes is feasible in the real-world setting through a low-calorie diet and weight loss maintenance. The DiRECT trial showed significant weight loss and remission rates, even after five years, with participants who maintained their weight losing type 2 diabetes permanently.
Researchers found tirzepatide equally effective in treating young-onset and late-onset type 2 diabetes, improving HbA1c levels and weight. The drug also showed similar benefits in cardiometabolic markers such as waist circumference and blood pressure.
The Second International Consensus Report on Precision Diabetes Medicine addresses the need for personalized approaches in diabetes care. The report highlights the potential of precision medicine to improve prevention and treatment outcomes by accounting for disease heterogeneity.
Researchers analyzed UK data to identify patterns of illnesses in individuals leading up to a type 2 diabetes diagnosis. High blood pressure, respiratory tract infections, heart conditions, and asthma were commonly observed, suggesting earlier diagnosis may be possible.
A new study has identified commonly prescribed antibiotic, antipsychotic and prokinetic drugs as being associated with a higher risk of sudden cardiac arrest (SCA) in individuals with type 2 diabetes. Low fasting blood sugar levels are also linked to SCA, a leading cause of death.
A phase 1/2 study shows that a stem cell-derived islet therapy has improved blood sugar control in all six adult patients with type 1 diabetes. Three patients achieved insulin independence and showed sustained improvements in blood glucose levels.
A UK study found that emergency department screening for type 2 diabetes could identify tens of thousands of previously undiagnosed cases every year. The study used the glycated haemoglobin test to screen 1,388 patients, yielding an additional 9% of type 2 diabetes cases and 30% of prediabetes cases.
Studies show that people with metabolically healthy obesity (MHO) have a 50% increased risk of coronary heart disease, despite not exhibiting metabolic complications. This raises questions about the validity of the MHO concept.
New research finds that cigarette smoking increases the risk of developing type 2 diabetes by affecting various metabolites in the bloodstream. A unique metabolic signature, identified through analysis of over 93,000 UK Biobank participants, can predict which smokers are more likely to develop the condition.
Research suggests that universal screening for type 1 diabetes at two ages could predict most cases of T1D by age 15. Dr. Emily K. Sims emphasizes the importance of identifying individuals with early, presymptomatic stages of disease to prevent life-threatening episodes and improve outcomes.
A worldwide audit of testosterone deficiency in men with type 2 diabetes found that testosterone replacement therapy improves glycaemic control for up to 2 years. The study suggests that the ongoing effect of testosterone on insulin resistance and fat reduction contributes to the improvement in blood sugar levels.
A real-world study of over 23,000 adults with type 2 diabetes found that semaglutide significantly improved blood sugar control and weight loss for up to 3 years. The study showed that patients who had never taken a GLP-1 RA or those with higher adherence achieved more pronounced reductions in blood sugar levels and weight loss.
A 10-year study found that even low doses of radiation may contribute to an increased risk of diabetes among emergency workers at the Fukushima nuclear power plant. Researchers analyzed data from over 6,000 workers and found a significant association between low-dose radiation exposure and a higher risk of developing diabetes.
A study published in Diabetologia found that daily dark tea drinkers had a 53% lower risk of prediabetes and a 47% reduced risk of type 2 diabetes compared to non-drinkers. Drinking dark tea may help improve blood sugar control by increasing glucose excretion in urine and reducing insulin resistance.
A new study published in Diabetologia found that breastfeeding for six months or longer is associated with lower levels of body fat at the age of nine. Infants who were not given soda before 18 months also had a lower fat mass at this age. The study suggests that infant feeding patterns, including breastfeeding duration and early intro...
A recent US study has found that food insecurity significantly increases the risk of severe hypoglycaemia in adults with diabetes. The study, which analyzed data from over 1,000 participants, revealed that those experiencing food insecurity were nearly twice as likely to experience severe hypoglycaemic events.