Articles tagged with Analgesics
A new study by Weill Cornell Medicine found that the FDA's mandate to limit opioid-acetaminophen combinations resulted in significant reductions in liver injuries. The mandate, implemented in 2014, limited the dosage of acetaminophen in these drugs, leading to a decline in hospitalizations and acute liver failure cases.
Researchers have discovered a gene mutation that can block chronic pain and provide protection against other stimuli, including heart and brain cells. The TRPV1 receptor mutation, found in avian species, was successfully transplanted into mice, showing reduced pain sensitivity and improved protective effects.
A novel surgical pain management strategy has been developed to reduce opioid use after total knee arthroplasty. The study found that changing prescriptions for opioids at discharge from automatic to upon request dramatically decreased opioid use, with over half of patients recovering without opioid use.
A systematic review of 18 studies found that muscle relaxants and non-steroidal anti-inflammatory drugs (NSAIDs) can effectively reduce symptoms. Combining NSAIDs with paracetamol showed a greater improvement than using NSAIDs alone.
Researchers found that while some antidepressants are effective for certain pain conditions, most are either ineffective or the evidence is inconclusive. A more nuanced approach is needed when prescribing antidepressants for pain, say experts.
A comprehensive review of antidepressant use in chronic pain found that some classes were effective in treating certain conditions, while others showed unclear or unknown benefits. Serotonin-norepinephrine reuptake inhibitors (SNRIs) like duloxetine demonstrated efficacy for various pain conditions.
A new study found that women with pre-pregnancy migraine had greater risks of preterm delivery, gestational hypertension, and preeclampsia. Migraine with aura was associated with a higher risk of preeclampsia than without aura.
A recent review in CMAJ provides comprehensive guidance on diagnosing and managing migraine attacks. It emphasizes a stratified approach to treatment, empowering patients to choose medications tailored to their needs and attack symptoms.
A study found a link between pain and indigestion medication purchases and ovarian cancer diagnoses, suggesting earlier symptom recognition. The research suggests that loyalty card data can be used to identify potential ovarian cancer cases.
A new study shows that Medasense's NOL monitoring during major abdominal surgery can significantly reduce the proportion of patients with severe post-operative pain. The study found that intraoperative opioid dosing based on the NOL index reduced PACU pain scores by a median of 1.5 points at 90 minutes post-surgery. This technology use...
A new clinical trial of over 12,000 patients found that inexpensive aspirin is just as effective as injectable blood thinners in preventing life-threatening blood clots and other complications. The study suggests that surgeons may change their practice to administer aspirin to patients hospitalized with bone fractures.
Researchers found that dendritic cells in meninges produce mediators causing pain hypersensitivity after nerve injury. The kynurenine pathway, primarily driven by IDO1, is involved in pain production.
A new study found that nearly a third of patients with chronic pain use cannabis to manage their symptoms, leading to decreased use of pain medications. The study suggests that further research is needed to understand the benefits and risks of using cannabis for chronic pain management.
Research found that common anti-inflammatory drugs taken by children can alter the formation of dental enamel, leading to defects. The study's authors suggest potential harm from widespread use of these medications and plan to conduct a clinical trial to confirm findings in humans.
A study published in Addiction journal found a significant decrease in codeine consumption across Australia after the country's most misused legal opioid was switched to a prescription-only medicine. The switch led to a 37% overall drop in codeine consumption, with smaller decreases observed in regional areas.
A new review paper aims to educate medical professionals on diagnosing and treating rat lungworm disease, which is expected to spread globally due to climate change. Early diagnosis and treatment are critical in reducing the risk of complications such as long-term disability.
Researchers at Tokyo University of Science have developed a unique 3D COF with scu-c topology, exhibiting efficient gas adsorption and drug delivery capabilities. The material has been shown to exhibit excellent hydrogen and methane adsorption properties.
A new study found that taking NSAIDs for osteoarthritis pain and inflammation may worsen joint inflammation and cartilage quality over time. Researchers used MRI-based structural biomarkers to analyze the association between NSAID use and synovitis in patients with knee osteoarthritis.
A new study published in PLOS Global Public Health found that 70% of ayahuasca users experienced physical health adverse effects, while 55% reported mental health concerns. Most adverse events were reported as mild and temporary, with only 2.3% requiring medical attention.
A study found that 16.5% of American adults with diabetes ration their insulin, with younger adults and the uninsured being most affected. Insulin rationing is often linked to cost concerns, with many patients delaying purchases or taking less insulin than needed.
A US cohort study suggests that maternal acetaminophen use during pregnancy may be associated with increased risk of sleep and attentional problems in offspring at age 3. The study found a potential link between acetaminophen exposure and neurobehavioral issues in children.
A new study found that medical cannabis users reported significant improvements in pain management, social functioning, and overall health. The majority of participants were able to stop or reduce their opioid use, with some experiencing a five-fold decrease in hydrocodone prescriptions.
Patients undergoing virtual reality immersion during hand surgery required significantly less anesthetic to manage pain, suggesting its potential as a non-pharmacologic distraction method. The study compared VR immersion to monitored anesthesia care and found no significant differences in post-operative pain or anxiety levels.
Researchers at UC Davis aim to develop monoclonal antibodies that can bind to specific ion channels in nerve cells, inhibiting pain signal transmission. The goal is to create a monthly, non-addictive pain medication to replace opioids, which can lead to addiction.
A new poll reveals that nearly half of people over 50 experience joint pain, and many turn to prescription-based treatments despite potential health risks. The poll's authors stress the need for healthcare providers to discuss medication interactions and non-drug options with patients.
A new randomized, controlled trial demonstrates that Medasense's NOL monitoring during major abdominal surgery can reduce postoperative pain by 30% compared to standard care. The study found that personalized fentanyl dosing with NOL guidance leads to lower sympathetic activation and surgical stress, resulting in reduced PACU pain scores.
A newly identified link between chronic pain and lung cancer in mice suggests that old drugs such as clonidine, capsaicin, and fluphenazine may offer new treatments for chronic pain. The study found that blocking the BH4 pathway reduced pain sensitivity and decreased tumor growth in mouse models of KRAS-driven lung cancer.
A University of the Basque Country team has successfully produced starch-based pharmaceutical tablets using 3D printing technology. The tablets display varying release properties depending on the type of starch used, offering promising solutions for personalized medicine and tailored drug delivery.
A new study explores how active parent participation can improve neonatal health and reduce parental stress. The study found that cultural attitudes, collaboration between medical staff and parents, and availability of equipment are key factors in enabling parent-infant closeness.
A new University of Rochester study compares two groups of patients with dental extractions, finding that a combination of non-opioid pain medications and gabapentin can minimize or eliminate opioids for dental pain. The results show promise for reducing opioid use during the COVID-19 pandemic.
Researchers studied the impact of withholding nitrous oxide on labor pain and found no adverse outcomes for mothers or children. Opioid use increased significantly but no change in other measures such as epidural use or Caesarean section rates were observed.
Researchers at The University of Queensland are working on a new treatment to reduce pain and debilitating side effects from chemotherapy in children. Dr Hana Starobova's research aims to prevent damage from cancer treatments, reducing the impact on children's quality of life. By studying Acute lymphoblastic leukaemia, the team hopes t...
A recent study published in PLOS ONE found that opioid prescriptions declined for US patients with both cancer and non-cancer pain between 2012 and 2019. The proportion of people receiving any opioid prescription dropped from 49.7% to 30.5% for non-cancer pain and from 86.0% to 78.7% for cancer pain.
A new analysis shows that combining two anti-platelet drugs can reduce the risk of graft failure after coronary artery bypass surgery, but also increase the risk of bleeding. The study found a significant reduction in graft failure rates with dual therapy, but more bleeding events requiring medical attention.
Researchers at Okayama University discovered EPA's molecular target, which blocks purinergic chemical transmission and reduces pain perception. The study suggests EPA can be used as a therapeutic strategy for managing chronic pain with fewer side effects.
A recent study from the University of Geneva suggests that ketamine's therapeutic use may be safe due to its limited impact on dopamine levels and neuronal communication. The research found that ketamine triggers a short increase in dopamine, but also inhibits a specific receptor that prevents addiction progression.
A Michigan Medicine study found that patients who received preoperative education on opioid risks and nonopioid pain management options consumed significantly less oxycodone, with only 16 doses used despite similar pain scores. The results suggest a multimodal approach to managing pain can reduce harm and prevent substance use disorders.
A multidisciplinary team at UVA Health will use deep brain stimulation to treat refractory neuropathic pain, aiming to modulate pain signals from the insula. The study may shed light on the fundamental nature of pain and identify biological indicators for effective treatment.
A team of scientists has discovered a potent and selective analgesic called BnOCPA, which is non-addictive and potentially opens a new pipeline for the development of new analgesic drugs. The research provides an alternative to commonly used pain killers with fewer side effects.
The 2016 CDC guideline aimed to reduce opioid-related overdose deaths by encouraging clinicians to weigh the benefits and risks of prescribing opioids. Researchers found a significant increase in nonopioid pain medication prescribing rates, coinciding with a drop in opioid prescribing.
Researchers found that prescribing smaller quantities of opioid medication after knee surgery is just as effective as higher quantities in controlling postoperative pain. The study showed no significant differences in pain levels, opioid consumption, or patient satisfaction between the three groups, suggesting a potential benefit in li...
A new study found that opioids like morphine can cause gastric inflammation due to increased acid secretion and delayed gastric emptying. Treatment with naloxone or proton pump inhibitors like omeprazole may provide gastroprotection, improving pain management and reducing side effects.
A new study found that hospitals can reduce excessive opioid prescribing by implementing an evidence-based default setting for opioid prescriptions written in electronic health records. The study showed that patients who received a standard prescription size with a lower default dose of opioids had similar pain control, but took home f...
Experts outline a framework for treating cancer pain in patients with opioid use disorder or prescription opioid misuse. The study highlights the need for better integration of addiction treatment in cancer care, particularly prescribing methadone and buprenorphine.
New research finds that acetaminophen is safe for spine-related pain in older adults, while non-steroidal anti-inflammatories may be more effective. Medications should be coupled with physical therapy, exercise programs, and treatment of underlying degenerative disease processes and medical illnesses.
A new study published in PNAS found that physicians prescribe less pain medication during night shifts than during the day. Researchers attribute this discrepancy to reduced empathy among doctors on night shifts. The study analyzed data from 13,482 discharge letters and found a significant bias towards prescribing fewer painkillers at ...
A new study found that doctors working overnight shifts are less likely to prescribe pain relievers due to decreased empathy for patient pain. This bias can lead to under-prescription of analgesics, especially at night shifts, highlighting the need for more structured guidelines and education.
Researchers found that 27.8% of drugs with high abuse potential successfully completed development compared to 4.7% for low-abuse potential drugs. Funding is needed to improve understanding of pain mechanisms and develop non-addictive treatments.
A study published in the British Journal of Anaesthesia found that fentanyl can induce changes similar to autism-like behaviors in young male and female mice. The research team discovered that fentanyl induces autism-like behaviors via activating the mu-opioid receptor in the anterior cingulate cortex.
A randomized controlled trial found that spinal anesthesia was associated with worse pain immediately after surgery, but differences diminished over time. Researchers also found higher rates of pain reliever prescriptions at 60 days in the spinal anesthesia group.
A recent study published in Annals of Internal Medicine found that patients who underwent spinal anesthesia for hip fracture surgery experienced more pain and were more likely to use prescription painkillers compared to those who received general anesthesia. The researchers hope to improve pain care by increasing the use of peripheral ...
A study found that intense training schedules are associated with a heightened risk of non-allergic asthma in competitive cross-country skiers. Skiers with high-performance levels and intense training hours were more likely to develop non-allergic asthma, which was linked to airway damage caused by cold air.
Researchers at Johns Hopkins Medicine have designed nanobodies derived from llama antibodies to target specific sodium ion channels in human muscle cells. This breakthrough could lead to safer and more efficient treatments for pain during surgery and irregular heart rhythms, as well as seizure control.
Researchers from McGill University and Italy found that blocking neutrophils can prolong pain, even with anti-inflammatory drugs. The study suggests reconsidering acute pain treatment, and findings are supported by a large UK analysis.
A study by researchers at the University of Pennsylvania School of Medicine found that mailing opioid disposal kits doubled the rate of safe disposal among patients who received them. The kits were provided to 235 patients after orthopedic or urologic procedures and resulted in the safe disposal of 480 unused tablets.
A study at the University of Helsinki found that a strong saline solution can quadruple morphine concentration in the spinal cord, intensifying pain relief. The glymphatic system enables faster drug delivery when administered with hypertonic solutions.
The USPSTF recommends against initiating low-dose aspirin use for primary prevention of CVD in adults 60+, but suggests its use for those with a 10% or greater 10-year CVD risk. The net benefit is small, and those willing to take daily aspirin are more likely to benefit.
Researchers found no evidence that early selective treatment with ibuprofen reduces death or moderate to severe bronchopulmonary dysplasia in extreme preterm infants. However, treatment reduced the risk of an open patent ductus arteriosus and surgical treatment for a symptomatic PDA.
Researchers found that NSAID use negates the bone-protective effects of bisphosphonate clodronate on preventing osteoporotic fractures. The study suggests caution in extrapolating these data to more widely used bisphosphonates, as concomitant usage may lead to reduced fracture risk.
A Canadian study of over 12,000 hospital admissions found that updated product label changes did not reduce rates of accidental acetaminophen overdose. The study suggests additional measures are needed to prevent these episodes beyond just labeling changes.