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Science News for January 31, 2023


Medical cannabis for chronic pain may help patients on long-term opioid treatment reduce dosages

A study found that receiving medical cannabis for thirty days or more can lead to a significant reduction in prescription opioid dosages among patients on long-term opioid therapy. Patients who were on higher baseline dosages of prescription opioids experienced larger reductions in opioid dosages.

Deer carry SARS-CoV-2 variants that are extinct in humans

A study found white-tailed deer are harboring SARS-CoV-2 variants that were once widely circulated but no longer found in humans. The deer may have become infected through contact with humans, and the virus has adapted to the deer population, potentially making it more transmissible between them.

SourceCornell University·JournalProceedings of the National Academy of Sciences·DateJan 31, 2023

Powering neutron science

Researchers at Osaka University developed a laser-driven neutron source, enabling extremely rapid elemental analysis. The study found that increasing laser intensity yields neutrons proportional to the fourth power, allowing for faster identification of elements in samples.

SourceOsaka University·JournalPhysical Review X·TypeExperimental study·DateJan 31, 2023

Transforming the way cancer vaccines are designed and made

Researchers developed a new way to increase vaccine potency by changing the structural location of antigens and adjuvants. This approach, called 'rational vaccinology,' allows for precise dosing and tailored presentation of vaccine components, leading to improved immune response and cancer cell targeting.

SourceNorthwestern University·JournalNature Biomedical Engineering·TypeExperimental study·DateJan 31, 2023

How sound waves trigger immune responses to cancer in mice

Researchers at the University of Michigan have developed a new technique called histotripsy, which uses sound waves to break apart tumors and trigger an immune response in mice. This approach has shown promising results in preventing tumor growth and recurrence, and could potentially offer a new treatment option for patients with cancer.

SourceUniversity of Michigan·JournalFrontiers in Immunology·DateJan 31, 2023

THE LANCET: Planting more trees could decrease deaths from higher summer temperatures in cities by a third, modelling study suggests

A modelling study suggests that increasing urban tree cover to 30% could decrease deaths from higher summer temperatures by a third. The study found that tree cover reduced urban temperatures by an average of 0.4 degrees during the summer, resulting in 6,700 premature deaths attributable to hotter urban temperatures.

SourceThe Lancet·JournalThe Lancet·TypeComputational simulation/modeling·DateJan 31, 2023

Hospitality sector customer perceptions improve when commercial organisations are seen to be employing the houseless

Employing individuals experiencing houselessness leads to more positive perceptions from customers, resulting in improved feelings towards the company and its responsible actions. This study highlights the potential win-win for all involved, as organisations can improve customer trust while helping those in need.

SourceUniversity of Surrey·JournalInternational Journal of Contemporary Hospitality Management·DateJan 31, 2023

An action plan to prevent Alzheimer’s disease

An international task force led by UNIGE and HUG has developed a preventive protocol to address the growing number of people affected by Alzheimer's disease. The guidelines focus on four pillars: risk assessment, risk communication, risk reduction, and cognitive enhancement.

SourceUniversité de Genève·JournalThe Lancet Regional Health - Europe·TypeNews article·DateJan 31, 2023

Pusan National University researchers uncover novel gene that regulates leukemia development and progression

Pusan National University researchers have identified a novel gene, SURF4, that regulates cell death and differentiation in acute myeloid leukemia (AML). The study found that suppressing SURF4 expression increases cell differentiation, cell death, and accumulation of ROS, leading to arrested tumor growth in mice.

SourcePusan National University·JournalCancer Communications·TypeExperimental study·DateJan 31, 2023

Bioengineered skin grafts that fit like a glove

Researchers at Columbia University Irving Medical Center have developed a method to grow engineered skin in complex, three-dimensional shapes, making it possible to construct seamless 'glove' of skin cells that can be easily slipped onto a severely burned hand. The new skin grafts have better mechanical and functional properties than c...

SourceColumbia University Irving Medical Center·JournalScience Advances·TypeExperimental study·DateJan 31, 2023

Focused ultrasound technique leads to release of neurodegenerative disorders biomarkers

Researchers at Washington University in St. Louis have developed a non-invasive method called sonobiopsy that uses focused ultrasound to release neurodegenerative biomarkers into the blood, facilitating diagnosis of conditions like Alzheimer’s disease. The technique has shown promising results in releasing tau proteins and another biom...

SourceWashington University in St. Louis·JournalRadiology·TypeExperimental study·DateJan 31, 2023

Genomic methods aid study of Seattle 2017-2022 Shigella outbreak

A genomic study of the Seattle 2017-2022 Shigella outbreak revealed its origin as international travelers from areas where Shigella was common. The study also found that multi-drug resistant Shigella has become a growing global health concern, primarily affecting men who have sex with men and those experiencing homelessness.

SourceUniversity of Washington School of Medicine/UW Medicine·JournalThe Lancet Infectious Diseases·TypeObservational study·DateJan 31, 2023

Recreating the natural light-harvesting nanorings in photosynthetic bacteria

Researchers at Ritsumeikan University have successfully synthesized ring-shaped nanostructures via the self-assembly of chlorophyll derivatives, mimicking the arrangement of chlorophyll pigments observed in nature. This discovery enables efficient sunlight absorption and could lead to novel smart materials with tunable properties.

SourceRitsumeikan University·JournalChemical Communications·TypeExperimental study·DateJan 31, 2023

Catching the wrongdoers in the act: HKU chemists develop a novel tool to decipher bacterial infections in real time

A research team led by Professor Xiang David LI has developed a novel chemical tool called photo-ANA to investigate bacterial interactions with the host in real-time. This approach enables scientists to comprehensively profile host–bacteria protein interactions during infection, revealing known and newly discovered interactions.

SourceThe University of Hong Kong·JournalNature Chemical Biology·TypeExperimental study·DateJan 31, 2023

S1416 trial results show PARP inhibitor benefit in “BRCA-like” breast cancer

The SWOG S1416 clinical trial demonstrated the efficacy of PARP inhibitor veliparib in patients with triple-negative breast cancer and a 'BRCA-like' phenotype. Patients treated with veliparib experienced longer progression-free survival times compared to those receiving chemotherapy alone, with median PFS of 5.9 months versus 4.2 months.

SourceSWOG Cancer Research Network·JournalThe Lancet Oncology·TypeRandomized controlled/clinical trial·DateJan 31, 2023

‘Racial uplifts’ aid Asian American well-being

A new study by Cornell University researchers has discovered the benefits of positive everyday racial encounters for Asian Americans. The study found that experiencing 'racial uplifts' - such as bonding over ethnic music or food, or sharing culture with others - reduces negative feelings and increases positive feelings and self-esteem.

SourceCornell University·JournalAmerican Psychologist·DateJan 31, 2023

Eggshells of large, flightless birds evolved along different tracks

A new study analyzes the microstructure of eggshells from living and extinct flightless birds, shedding light on their evolutionary history. The research finds that wedge-like microstructures in rhea eggs evolved from ancient ancestors, while prism-like structures in ostrich and tinamous eggs likely developed independently.

SourceeLife·JournaleLife·DateJan 31, 2023

Moderate and intense physical activity favors good sleep

A recent study conducted in Japan found that moderate and intense physical activity favors good sleep in middle-aged Japanese women. The research used an isotemporal substitution approach and replaced sedentary behavior with moderate-to-vigorous physical activity, resulting in improved sleep quality. Interestingly, this association was...

Β-blocker use associated with lower rates of violence

A study of 1.4 million individuals found β-blocker use associated with a 13% lower risk of violent crime and an 8% lower risk of hospitalization due to psychiatric disorders. The findings suggest that β-blockers may be considered as a way to manage aggression and hostility in individuals with psychiatric conditions.

SourcePLOS·JournalPLOS Medicine·TypeObservational study·DateJan 31, 2023

Central pain mechanisms and other peripheral pain sources contribute to post-knee replacement pain

A new study found that central pain mechanisms and peripheral pain sources contribute to post-knee replacement pain, suggesting a need for targeted pain management strategies. The research suggests that managing other sites of pain may be important in ameliorating persistent knee pain.

SourceBoston University School of Medicine·JournalOsteoarthritis and Cartilage Open·TypeData/statistical analysis·DateJan 31, 2023

Self-help metacognitive therapy – which aims to reduce rumination – significantly reduces anxiety and depression symptoms in recovering heart disease patients, according to new randomized controlled trial

A new randomized controlled trial found that self-help metacognitive therapy significantly reduces anxiety and depression symptoms in recovering heart disease patients. The study suggests this treatment approach may be beneficial for individuals with cardiovascular disease who struggle with rumination.

SourcePLOS·JournalPLOS Medicine·TypeRandomized controlled/clinical trial·DateJan 31, 2023

AI technologies have even more exaggerated biases in perception of facial age than humans

A recent study found that AI technologies exhibit more pronounced biases in facial age perception than humans, with exaggeration of smiling faces' aging effect and decreased accuracy for older adults. The research suggests these biases stem from visual cues rather than preconceptions.

SourceBen-Gurion University of the Negev·JournalScientific Reports·TypeComputational simulation/modeling·DateJan 31, 2023

Study finds large gap in breast cancer treatment recommendations for patients aged 70 vs 69

Researchers analyzed over 500,000 patient records and found that patients diagnosed at age 70 were nearly twice as likely to be passed over for post-surgical radiation therapy. This significant gap in treatment recommendations suggests that cognitive heuristics play a major role in physician decision-making.

SourceAmerican Society for Radiation Oncology·JournalInternational Journal of Radiation Oncology*Biology*Physics·DateJan 31, 2023

Scientists document two separate reservoirs of latent HIV in patients

Researchers have identified a distinct latent reservoir of HIV-infected CD4+ T cells in the central nervous system (CNS), separate from the latent reservoir in blood and lymph tissue. This finding highlights a new challenge in creating a cure for HIV, as any curative therapy would need to activate both dormant reservoirs.

SourceUniversity of North Carolina Health Care·JournalNature Microbiology·TypeObservational study·DateJan 31, 2023

Bot gives nonnative speakers the floor in videoconferencing

A new study at Cornell University introduced an automated participant that periodically interrupts the conversation to give nonnative speakers a chance to speak. The AI bot increased participation from 12% to 17% of all words spoken, with nonnative speakers feeling valued and appreciated for their perspectives.

SourceCornell University·JournalProceedings of the ACM on Human-Computer Interaction·DateJan 31, 2023

Seawater split to produce green hydrogen

A team of researchers has successfully produced green hydrogen from seawater without pre-treatment, achieving nearly 100% efficiency. This breakthrough uses a non-precious and cheap catalyst in a commercial electrolyser, offering a solution to directly utilize seawater for hydrogen production.

SourceUniversity of Adelaide·JournalNature Energy·DateJan 31, 2023

The social code—deciphering the genetic basis of hymenopteran social behavior

A study published in Genome Biology and Evolution found a core genetic toolkit for reproductive division of labor in rudimentary insect societies. The authors identified common genes associated with fundamental social divisions in bees and wasps, suggesting a universal molecular 'theme' for cooperation across species.

SourceSMBE Journals (Molecular Biology and Evolution and Genome Biology and Evolution)·JournalGenome Biology and Evolution·TypeExperimental study·DateJan 31, 2023

Elucidation of electrolyte decomposition behavior in all-solid-state lithium-sulfur batteries

Researchers at Toyohashi University of Technology elucidated the decomposition behavior of electrolytes in cathode composites of all-solid-state lithium-sulfur batteries. The sulfide solid electrolytes convert to thiophosphates with long-chain cross-linked sulfur during charging and discharging cycles, governing battery performance.

SourceToyohashi University of Technology (TUT)·JournalChemistry of Materials·TypeExperimental study·DateJan 31, 2023

When bugs swipe left

Researchers discovered a single protein called Gr8a that plays an inhibitory role in mating decision-making, helping flies avoid inter-breeding with the wrong partner. The findings provide insight into how signal production and perception are tied together, shedding light on pheromone communication.

SourceWashington University in St. Louis·JournaliScience·TypeExperimental study·DateJan 31, 2023

Measuring changes in brain tissue oxygenation for personalized cancer radiotherapy

Researchers developed a method to measure individual biological response to therapy using functional near-infrared spectroscopy, enabling real-time evaluation of radiotherapy's impact on patients. This technique allows for tailored radiation doses to optimize treatment and improve outcomes.

SourceSPIE--International Society for Optics and Photonics·JournalJournal of Biomedical Optics·TypeExperimental study·DateJan 31, 2023

With rapidly increasing heat and drought, can plants adapt?

A new study by University of California, Berkeley researchers suggests that iconic desert plants came preadapted to stresses of arid living. The rock daisy study found these pioneers developed adaptations on dry, exposed rock outcrops within older areas, making it easier for them to thrive in expanding deserts.

SourceUniversity of California - Berkeley·JournalProceedings of the National Academy of Sciences·TypeSurvey·DateJan 31, 2023

Can a computer teach babies to count?

A two-year study by Rutgers researcher Jinjing Jenny Wang found that babies between 14 and 19 months old benefit from watching counting videos, engaging them with real-life scenarios. The study's findings suggest these videos could reduce disparities in children who may not receive enough counting exposure from caregivers.

SourceRutgers University·JournalDevelopmental Psychology·DateJan 31, 2023

Google's and Apple's tightrope walk between enforcement and oversight as distributors and developers for health apps

The EU's Medical Devices Regulation and Digital Markets Act pose challenges for Google and Apple, which must balance enforcement and oversight with their interests as distributors and developers. New regulations aim to improve app store models and ensure safe provision of digital health applications.

SourceTechnische Universität Dresden·Journalnpj Digital Medicine·DateJan 31, 2023

SwRI investigations reveal more evidence that Mimas is a stealth ocean world

Numerical simulations suggest that Mimas' Herschel impact basin is compatible with a thinning ice shell and geologically young ocean. The results imply that the present-day ocean within Mimas must have been warming and expanding since its formation, potentially making it an emerging ocean world.

SourceSouthwest Research Institute·JournalGeophysical Research Letters·TypeComputational simulation/modeling·DateJan 31, 2023

Kobe University and AGC successfully convert dry cleaning solvent into useful chemical compounds

Researchers developed a new photo-oxidation method to efficiently synthesize pharmaceutical intermediates and polyurethane from perchloroethylene, a common dry cleaning solvent. The method yields high-quality compounds with minimal environmental impact, offering a promising alternative for sustainable chemical recycling.

SourceKobe University·JournalACS Omega·TypeExperimental study·DateJan 31, 2023

‘Ghostly mirrors’ for high-power lasers

Researchers have developed a new way to produce mirrors that can withstand extremely high powers, enabling the creation of small footprint, ultra-high-power laser systems. This breakthrough has significant implications for various fields such as medicine, biology, and physics.

SourceUniversity of Strathclyde·JournalCommunications Physics·TypeExperimental study·DateJan 31, 2023

Study suggests side-effects and costs are biggest concerns for users of HIV pre-exposure prophylaxis

Men who would use PrEP prefer long-acting injectable medications due to lower cost and reduced side effects. The survey found that respondents ranked costs and potential side effects as the most important factors in considering whether to take PrEP, with a preference for lower-cost options.

SourceJohns Hopkins Bloomberg School of Public Health·JournalAIDS and Behavior·TypeSurvey·DateJan 31, 2023

Ancient fossils shed new light on evolution of sea worm

Fossils of a type of sea worm, Iotuba chengjiangensis, have provided new insights into the evolution of annelid worms. The discovery suggests that these worms diversified into different lineages around 515 million years ago, during the Cambrian explosion.

SourceDurham University·JournalProceedings of the Royal Society B Biological Sciences·TypeObservational study·DateJan 31, 2023

Deer browsing is just one of many factors shaping North American forests

A recent study published in Forest Ecology and Management found that deer browsing had relatively little long-term impact on two tree species in a northern forest. Researchers discovered that seedling survival and growth were more greatly influenced by light availability, soil nitrogen, and size attained before gaps were created.

SourcePenn State·JournalForest Ecology and Management·TypeObservational study·DateJan 31, 2023