Articles tagged with Analgesics
Researchers developed a novel gene therapy approach that utilizes acetaminophen to correct disease-causing mutations and make liver cells immune to its toxic effects. This allows treated cells to multiply and reduces the need for liver transplants in treating genetic disorders.
New studies suggest that treating post-surgery pain with non-opioid medications like ibuprofen or acetaminophen can lead to equal short-term outcomes and patient satisfaction as opioids. Researchers analyzed data from over 22,000 patients who had one of seven common operations at 70 hospitals.
A Curtin study reveals that aspirin, a naturally occurring compound found in willow trees, can improve the survival of grass species important for ecological restoration and sustainable pasture. Low concentrations of salicylic acid applied to seeds can boost plant growth and resistance to stress.
Researchers at Medical College of Wisconsin discovered a non-opioid based target to alleviate chronic touch pain and spontaneous pain in mice. The target, TRPC5, is expressed in both mouse and human neurons that send pain signals to the spinal cord.
A two-year study found that providing patients with free access to essential medicines increases adherence by 35% and reduces total health spending by an average of over $1,000 per patient per year. The study, published in PLOS Medicine, tested the effects of free medication on a selected set of medications.
A team of scientists from Pompeu Fabra University has developed a peptide that allows delta-9-tetrahydrocannabinol (THC) to fight pain in mice without cognitive side effects. The peptide, which interrupts the interaction between THC and serotonin receptors, improves memory capacity while providing analgesia.
The HOST-EXAM trial found that patients who received clopidogrel experienced a 30% reduced risk of adverse events compared to those on aspirin. This study confirms the effectiveness of long-term maintenance therapy with clopidogrel as an alternative to aspirin for patients who have completed dual antiplatelet therapy.
Researchers found no significant differences in cardiovascular events or major bleeding between patients taking 81mg or 325mg daily doses of aspirin. Long-term adherence was better among those taking the lower dose.
A study presented at ACC.21 found that low- and high-dose aspirin achieved similar health benefits for those with cardiovascular disease, including reduced death and hospitalization rates. However, the higher dose group was more likely to switch doses and discontinue use due to tolerability concerns.
A new observational study published in The Lancet Rheumatology found that non-steroidal anti-inflammatory drugs (NSAIDs) taken prior to hospital admission for COVID-19 do not increase mortality rates. In fact, the use of NSAIDs was similar among patients who had taken them and those who had not. This large-scale study provides reassura...
A patient support program for people with autoimmune diseases and complex medication regimens can help them avoid using opioids or reduce their use. The study found that patients in the program were 13% less likely to start taking opioid pain medications and 26% less likely to fill two or more opioid prescriptions.
A novel CBD analog, KLS-13019, has been shown to effectively alleviate pain and reverse sensitivity in mice with chemotherapy-induced peripheral neuropathy. The study suggests that KLS-13019 may have an additional mechanism of action beyond pain relief, potentially disrupting opioid-seeking behavior.
A new study found that short-term air pollution exposure can impair cognitive performance, but taking nonsteroidal anti-inflammatory drugs (NSAIDs) like aspirin can reduce these effects. The study used data from the Normative Aging Study and found that elevated PM2.5 exposure over 28 days was associated with declines in global cognitiv...
A new study led by Syracuse University researchers finds that CBD reduces pain intensity while making it less unpleasant. The study reveals a complex interplay between the drug's physical effects and participants' expectations, challenging previous assumptions about pain relief.
A study in cells and mice finds a positive allosteric modulator can boost endorphins' ability to activate the mu-opioid receptor, producing analgesia with reduced side effects. The compound shows promise as an alternative to traditional opioid drugs for pain relief.
A study of over 2,500 hospital patients discharged to hospice care found a decreasing trend of opioid prescriptions and an increase in less powerful non-opioid analgesics. This may lead to undertreated pain in terminally ill patients.
A new study found that nearly one-third of patients prescribed a direct oral anticoagulant were also taking aspirin without a clear reason, leading to an increased risk of bleeding events. The researchers emphasize the importance of consulting with doctors to determine if combination therapy is necessary for individual patients.
The company's Abiprot technology identifies antibody binding sites on native-state, disease-relevant proteins at high resolution. The platform has the potential to bring game-changing benefits to large populations of patients suffering from uncurable diseases.
The pandemic led to a sharp drop in new opioid prescriptions and a decline in buprenorphine treatment for opioid dependency among new patients. This reduced access to treatment may have increased overdose deaths.
A new study reveals a potential mechanism linking traumatic brain injury (TBI) and Alzheimer's disease (AD), as well as a method for preventing nerve cell degeneration after injury. Researchers discovered a blood biomarker of neurodegeneration that could stage severity and progression of TBI-induced nerve cell deterioration.
A study of 940 children found nearly a quarter wanted stronger pain treatment after appendectomies and tonsillectomies, associated with sleep impairments and movement pain. Precautionary administration of non-opioid analgesics may reduce opioid use after surgery.
A new study published in the Journal of Pain found that when male and female patients express the same amount of pain, women's pain is perceived as less intense. The researchers analyzed facial expressions and self-reported pain levels to measure bias, concluding that gender stereotypes play a role in these disparities.
Regular use of baby aspirin before a diagnosis of non-metastatic colorectal cancer is associated with better survival outcomes. The study found that low-dose aspirin use limits the spread of cancerous tumors pre-diagnosis, leading to lower death rates from the disease.
A new study suggests that a stricter definition of high blood pressure during pregnancy could identify more women at risk of developing life-threatening complications. The revised definition would make over 50,000 additional women eligible for aspirin treatment to prevent preeclampsia.
A multicenter study found that aspirin was not equally effective as blood thinners in treating cervical artery dissections. The international study showed a higher risk of problems with aspirin treatment compared to anticoagulation.
Researchers found that ibuprofen inhibits the alternative splicing event generating RAC1B, overexpressed in BRAF-mutated colorectal tumors. Ibuprofen disrupts a WNK1/GSK3β/SRPK1 protein kinase complex, promoting nuclear exclusion of SRPK1 and SRSF1.
Researchers found that low-dose aspirin reduced the need for mechanical ventilation, ICU admission, and in-hospital mortality in hospitalized COVID-19 patients. Aspirin use was associated with a decreased risk of these severe outcomes, including a 44% reduction in mechanical ventilation.
An observational study analyzed data from 10,477 individuals in Israel and found that aspirin use was associated with a 29% lower likelihood of COVID-19 infection. Aspirin treatment was also linked to shorter conversion times for positive to negative PCR test results and reduced disease duration.
Researchers have discovered a new pathway in the brain that provides pain relief and reduces opioid cravings. The study found that transcranial magnetic stimulation (TMS) targeting the motor cortex was significantly more effective at reducing pain and opioid urge than targeting the dorsolateral prefrontal cortex (DLPFC).
A new guideline for reducing opioid use post-surgery has led to a high pain management satisfaction rate of over 90%, with 83% of patients properly disposing of unused pills. The guideline takes into account individual patients' perception of pain, setting expectations and prescribing non-opioid analgesics to minimize opioid use.
Researchers at UT Southwestern Medical Center have discovered that a combination of three decades-old antibiotics can block pain triggered by nerve damage. The finding offers an alternative to opioid-based painkillers and could potentially treat chronic pain caused by damaged nerves.
A study analyzing 11,392 U.S. adults aged 50+ found that many take aspirin despite lack of benefit, while others miss out on statins after cardiovascular events. The authors emphasize the need for healthcare providers to educate patients and promote safer prescribing practices
Researchers at University of California - San Diego will investigate psilocybin's safety and efficacy in treating chronic phantom limb pain. The study aims to elucidate brain mechanisms involved, including possible alterations in brain circuitry.
A recent study from Indiana University found that supply-controlling and harm-reduction policy measures implemented in response to the opioid epidemic may have unintended consequences, including motivating users to switch to alternative illicit substances, leading to higher overdose mortality.
A new study published in The Journal of Thoracic and Cardiovascular Surgery found that aspirin is a safer alternative to warfarin for preventing blood clots in children after Fontan surgery. Patients on aspirin had lower risks of bleeding and poorer bone mineral density compared to those on warfarin.
Researchers found paracetamol alone is superior to high-dose NSAID alone for posttraumatic extremity pain. A study published in Academic Emergency Medicine shows taking paracetamol as a first-line therapy can effectively manage mild to moderate post-traumatic extremity pain after discharge from the emergency department.
Researchers have created an experimental vaccine that has shown promise in blunting the deadly effects of synthetic opioids like fentanyl and carfentanil. In early tests, the vaccine demonstrated significant reduction in fatal respiratory effects, offering hope for a new treatment approach to combat the opioid crisis.
A study published in the journal Pain identifies specialised ion channels involved in transmitting pain signals from the female reproductive tract. The research provides novel findings that could lead to improved treatment options for women experiencing chronic pelvic pain associated with endometriosis and vulvodynia.
A new study suggests that long-term aspirin use before a diagnosis of colorectal cancer may be associated with lower CRC-specific mortality. Preventing distant metastases leads to fewer deaths from colorectal cancer.
A recent study found that over half of primary care clinics in nine states refuse to accept opioid patients due to perceived stigma. Clinics gave more favorable responses when patients mentioned their last doctor had retired, suggesting systemic biases influence decision-making.
Close adherence to low-dose aspirin therapy resulted in 8 more pregnancies, 6 fewer pregnancy losses, and 15 more live births per 100 women. Starting aspirin before or early pregnancy showed stronger benefits than starting after the 6th week.
Researchers found that ACSL1 catalyzes CoA conjugation of propionic acid-class NSAIDs, leading to liver injury through covalent binding with hepatic proteins. This variation in hepatic ACSL1 expression may account for individual susceptibility to toxicities.
A recent study found that daily aspirin use does not reduce the risk of colorectal cancer among adults who start taking it after age 70. However, there may be a potential benefit for those who begin taking aspirin at an earlier age.
A new study by physician-researchers at the University of Texas Health Science Center at Houston found that a modified pain management strategy reduced opioid exposure in trauma patients while maintaining equal levels of pain control. The MAST regimen, a multi-modal analgesic approach using over-the-counter medications, achieved this o...
The study found that a multimodal pain regimen (MMPR) reduced opioid exposure and pain scores in trauma patients. The MMPR, which includes generic medications such as acetaminophen and tramadol, was shown to be an effective alternative to traditional opioid treatments.
A new polymer patch provides controlled release of a drug blocking COX-2 enzyme, driving pain and inflammation. The patch can provide three to four days of localized pain control for critical post-surgical period.
Researchers discover pain and fear are transmitted through different brain regions in mice, with pain mediated by the anterior cingulate cortex to the nucleus accumbens and fear mediated by the ACC to the basolateral amygdala. This study provides insights into empathy and may offer a model for socially-induced pain relief among humans.
A trial found that listening to soothing words and music during surgery reduced postoperative pain levels by 25% and decreased opioid consumption by 16%. This non-invasive technique could offer a safe and inexpensive way to reduce pain and opioid use after surgery.
A new compound has been identified that targets imidazole I2 receptors to reduce neuroinflammation and improve cognition in late-onset Alzheimer's disease. The study also reveals the calcineurin pathway as a key mechanism of action, opening up possibilities for new therapies.
A new study published in Cell Reports found that painkillers such as Aspirin and Ibuprofen interfere with the auxin flow in plants, leading to abnormal root growth. The drugs also suppress the movement and trafficking of substances within plant cells, impairing their ability to develop properly.
A new drug treatment, otilimab, has shown promising results in reducing both inflammation and pain in people with rheumatoid arthritis. In a multicentre trial, patients who received otilimab demonstrated significant improvements in pain scores, while also experiencing reduced tender and swollen joints.
Researchers found that combining ticagrelor and aspirin is more effective than either medication alone in preventing another stroke in patients with heart plaque. The study showed a 27% reduction in stroke risk among these patients, highlighting the potential benefits of this combination therapy.
A one-month treatment of dual anti-platelet therapy is safe and as effective as a longer duration of therapy at preventing cardiac events in patients one year after stent placement. This study evaluated the safety and effectiveness of two durations of dual anti-platelet therapy in patients who had drug-eluting stent placement or polyme...
A single daily pill combining blood pressure and cholesterol medications with or without aspirin reduced cardiovascular disease events in people at intermediate risk for heart disease. The polypill plus aspirin combination lowered cardiovascular disease by 31%, compared to the polypill alone, which reduced it by 21%.
A new study published in BMJ Quality & Safety shows significant reductions in opioid prescribing and consumption after surgery, with no increase in patient pain or satisfaction. The study's findings suggest that team-based approaches to reducing opioid use can lead to sustained success and improved patient outcomes.
A new study suggests that aspirin use is most beneficial for individuals with high coronary calcium scores and a low risk of bleeding. The research found that for patients with CAC scores above 100, aspirin's benefits outweigh its risks, but this effect only applies to those with inherent low bleeding risks.
Researchers at ETH Zurich found a link between the increased availability of high-dose paracetamol tablets and a rise in poisoning cases. The study suggests that limiting pack sizes and promoting lower doses could help minimize accidental overdoses.
Hospitalized COVID-19 patients taking daily low-dose aspirin had lower risk of ICU admission, ventilation, and dying from the virus. The study found a 44% reduction in mechanical ventilator use, 43% decrease in ICU admission, and 47% decrease in hospital death compared to those not taking aspirin.
A new study published in The Journal of Physiology found that administering a low dose of ketamine to healthy individuals does not alter their ability to tolerate simulated major blood loss. This study provides valuable insights for medical personnel when choosing pain medication for serious injuries with accompanying blood loss.
The VOYAGER PAD trial found that drug-coated devices do not increase mortality risk in patients with peripheral artery disease. Rivaroxaban use consistently reduced ischemic limb and cardiovascular outcomes regardless of device type.