Articles tagged with Analgesics
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
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Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
A new study from the University of California, Davis found that ibuprofen causes significant changes in liver enzymes in laboratory mice. The research highlights marked differences in how males and females metabolize the drug, with potential implications for human health.
A study found that patients who take less opioid pain medication before discharge have lower usage during the four weeks following. Quantifying pre-discharge opioid intake may inform better pain management practices.
A randomized clinical trial found that gabapentin, commonly used for nerve pain, was effective in reducing symptoms of alcohol use disorder. The study suggests that this medication may be beneficial for millions of Americans struggling with problem drinking and a history of withdrawal symptoms.
Researchers at UArizona College of Medicine identified prolactin as a key factor in women's pain sensitivity. The study suggests new therapies targeting the prolactin system could greatly benefit women suffering from functional pain syndromes, such as migraines and fibromyalgia.
Researchers at Charité - Universitätsmedizin Berlin have developed new painkillers that target tissue acidity to reduce the risk of addiction. By fine-tuning the acid dissociation constant (pKa) of opioid molecules, these new drugs can selectively activate opioid receptors in injured tissue, preventing severe side effects.
A new framework for managing chronic pain in older adults emphasizes the importance of combining pharmacologic strategies with nondrug therapies. The 'start low, go slow' approach suggests beginning with low-risk, noninvasive options that involve patients in their own care, while judiciously using higher-risk treatments as needed.
Trials show that Gefapixant can ease the often distressing symptoms of chronic cough with minimal side effects. A dose of 50mg reduced coughing by 67% and another study showed that as little as 30mg was effective in reducing cough frequency.
A study found that over 50% of ED patients with dental-related conditions received antibiotic prescriptions, while 40% received opioid prescriptions. The American Dental Association emphasizes the importance of addressing these issues through education and policy changes.
Researchers at McGill University have discovered a protein called TACAN that plays a crucial role in sensing mechanical pain. The study provides hope for the development of powerful new analgesic drugs to treat chronic pain conditions.
A secondary analysis of the AUGUSTUS trial confirms that apixaban is safer than warfarin in patients with prior stroke or blood clot, while also reducing the risk of bleeding, hospitalization, and death. The study found that a strategy of apixaban plus a P2Y12 inhibitor without aspirin has the most favorable outcomes.
Researchers have identified calcitonin gene-related peptide (CGRP) as a link between traumatic brain injuries and post-concussion headaches. A preclinical study found that administering an anti-CGRP treatment before or after injury significantly reduced pain responses and prevented reactivated headaches.
Research suggests that taking acetaminophen with a tendency to forgive can reduce social pain by influencing pain signaling in the brain. Forgiveness also lessens feelings of stress and anger following experiences of social exclusion. The combination may provide an antidote to the emotional and physical pains of rejection.
Researchers have developed a novel formulation that reduces the toxicity of crotoxin, a toxin from rattlesnake venom, and enhances its analgesic effect. In an animal model of neuropathic pain, the formulation demonstrated promising results, with longer-lasting analgesic effects compared to traditional treatments.
A 'smart' bandage developed by UConn engineers can precisely deliver different medications to chronic wounds, promoting healing and reducing morbidity. The wirelessly-controlled bandage is equipped with miniature needles that can penetrate deeper layers of the wound bed with minimal pain and inflammation.
Researchers reviewed benefits and risks of over-the-counter and prescription pain relievers, including NSAIDs, aspirin, ibuprofen, naproxen, and acetaminophen. The study suggests that healthcare providers and patients should make individual clinical judgements based on the entire risk factor profile to minimize harm.
A UK patient database analysis found tramadol increases hip fracture risk by up to 1.5 new cases per 1000 person-years, compared to other pain medications. The study highlights the need for tramadol's fracture risk to be considered in clinical practice and treatment guidelines.
A study analyzing over 50,000 VA patients found that increasing opioid prescription doses does not improve chronic pain management. Despite higher doses, patients' pain scores showed minimal changes, indicating that clinicians should exercise caution when escalating opioid doses.
A new study suggests that roughly half of opioid prescriptions written by dentists in the US exceed federal guidelines for pain management. Dental procedures like extractions can lead to significant pain, and researchers found that some dentists are overprescribing opioids as a result.
A survey of over 2,700 kratom users found the substance has a lower rate of harm than prescription opioids for treating pain, anxiety, and depression. While self-reporting surveys are not always reliable, the results suggest kratom may have medical applications to explore as an alternative to opioid use.
Researchers found that contaminant concentrations increased during warmer months, with higher risk to fish during spawning stages. The study also discovered that nonpoint sources, such as agricultural runoff, were the primary contributor to contaminant levels in high-flow periods.
APRNs now have full prescriptive authority for opioids in 14 states and autonomous practice in another 10 states. New laws also improve access to care through state prescription drug monitoring programs.
A large clinical trial has found that low-dose aspirin daily from early pregnancy to 36 weeks may lower the risk for preterm birth among first-time mothers by 11%. The study involved over 11,000 women in several low- and middle-income countries and showed a significant reduction in preterm delivery before 37 weeks.
A Houston Methodist study found that using long-acting local anesthetics and scheduled non-narcotic pain medication reduced opioid prescriptions from 87% to 10% after surgery. The program successfully managed pain after surgery using over-the-counter pain medication, decreasing the chance of patients becoming addicted to narcotics.
A study led by McGill University found that anti-inflammatory medications are most effective when taken during the active periods of our biological clocks, promoting post-operative healing and recovery. This discovery suggests a new approach to treating pain and inflammation following surgery.
A new study found that less than 2% of people at risk for an opioid overdose received naloxone, a life-saving drug. The study suggests that there are significant gaps in naloxone prescribing, particularly among high-risk groups such as those who have survived previous overdoses or have a history of opioid use disorder.
City of Hope scientists have found that aspirin appears to reduce tumor growth and inhibit recurrence of colorectal cancer. The right dosage of aspirin is being identified to act as a prophylactic without triggering dangerous side effects.
A new study by Portland State University researchers found racial and ethnic disparities in pain treatment by emergency responders, with Hispanic and Asian patients receiving lower quality care. The study analyzed 25,732 health records and found that odds of pain assessment were 21-31% lower for these groups compared to white patients.
Researchers are developing a non-invasive device that uses transcranial direct current stimulation to desensitize areas tied to knee pain in the brain. Participants wear a cap powered by three AAA batteries and undergo 15, 20-minute sessions over three weeks.
A new US study demonstrates the effectiveness of genicular artery embolization (GAE) in treating osteoarthritis knee pain. The minimally invasive procedure blocks blood flow to certain parts of the knee, providing rapid relief from pain and disability. Results show significant improvement in pain scores, with nearly all patients experi...
A study published by the American Heart Association found that low-dose aspirin did not reduce the risk of a fatal heart attack among African Americans, unlike in white populations. The study used data from over 65,000 participants and suggested genetic differences and poor control of other risk factors may contribute to this result.
A new Boston University School of Public Health study found that the decline in prescriptions of non-opioid analgesics coincided with a marked increase in opioid prescribing. The study suggests that health risks associated with NSAIDs were one factor that led to increased prescribing of opioids.
A new study suggests that taking aspirin daily to prevent a heart attack or stroke may no longer be recommended for adults without a history of these events. The study found that the potential benefits of aspirin are similar to its potential harms for most people, highlighting the need for personalized advice from doctors.
A recent review found that aspirin no longer provides a net benefit for primary prevention of cardiovascular disease and cancer, despite its long history of reducing heart attack risk. Aspirin use has decreased in recent years due to the emergence of statins and improved cancer screening technology.
A new UCLA-led study suggests chronic opioid treatment may raise the risk of post-traumatic stress disorder (PTSD) in individuals who are likely to experience severe emotional stress. Researchers found that mice given morphine before and after a traumatic event showed enhanced fear learning, indicating increased PTSD susceptibility.
Researchers at Harvard Medical School have launched a project to develop preclinical drug candidates that selectively block nociceptor activity, offering an alternative to opioid-based medications. The STOP PAIN consortium combines experimental and AI-driven approaches to address the critical public health need for new pain treatments.
Scientists have discovered the binding mechanism of an important pain receptor, which could lead to the development of new active substances. The current study aimed to find alternatives to opioids used today, as they can be addictive and have life-threatening side effects.
West Virginia University researcher Shane Kaski found that combining nalfurafine with morphine reduces pain while minimizing morphine's addictive potential. This could lead to lower doses of morphine and reduced risk of addiction, combating the opioid epidemic.
In a randomized clinical trial, adults with moderate to severe migraines took either ubrogepant or a placebo. After two hours, participants reported a significant reduction in pain and associated symptoms. The study provides encouraging results for the treatment of migraine pain.
Researchers found yoga and physical therapy significantly improved sleep quality for 52 weeks after 12-week treatment. Participants with early pain improvements were three times more likely to have better sleep outcomes.
Researchers at FEFU developed a method to synthesize biologically active derivatives of fascaplysin, a compound found in sea sponges. The new compounds, including 14-bromoreticulatine and 3,10-dibromofascaplysin, show selective effects on cancer cells, particularly Pseudomonas Aeruginosa bacteria and human prostate cancer cells.
Researchers found a 95% increased risk of frailty among those who self-reported regular use of prescription pain and/or sleep medications. Co-use of multiple prescription medications also increased frailty risk, with effects observed for pain-only and sleep-only prescriptions.
Researchers found small, statistically significant benefits on pain and function with opioids, but no impact on quality of life or depression for patients with osteoarthritis. Strong opioids had consistently worse pain relief benefits and a greater risk of adverse events compared to weak opioids.
Non-Hispanic black and Hispanic women reported higher pain scores compared to white women during the postpartum period. Despite this, they received fewer opioids and were less likely to receive prescriptions at discharge.
Researchers developed a novel nanoparticle delivery method to treat pain, using a non-opioid drug that previously failed clinical trials. The approach successfully treated pain in mice and rats with improved efficacy and duration of action.
Researchers have discovered a class of analgesics in conotoxin peptides, which are found in the venom of marine cone snails. These peptides show exceptional potency and selectivity for ion channels involved in pain transmission, offering new avenues for pain therapy.
A new study at Kellogg Eye Center finds that reducing opioid pills prescribed after cornea surgery doesn't compromise pain control, with most patients using only four pills. The policy change also leads to more responsible pill disposal practices.
A recent NIH-funded study suggests that exposure to acetaminophen during pregnancy may increase the risk of attention deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) in children. The study found that higher levels of acetaminophen exposure were associated with a significantly increased risk of both conditions.
Researchers found an association between aspirin use and decreased intracranial aneurysm growth rate. Growth is crucial as it increases rupture risk. The study suggests that aspirin may exert a protective effect against aneurysm growth and future rupture, but findings are observational and require further interventional studies.
The American Dental Association recommends against prescribing antibiotics for healthy adults with toothaches, citing evidence that they do not alleviate symptoms and can cause harm. In cases where dental treatment is delayed or signs of infection are present, antibiotics may be considered, but only in specific scenarios.
Researchers are examining prescription practices before and after the law took effect to understand how it has shaped healthcare providers' prescribing habits. The study will also investigate the impact on patients, including those with chronic pain, and potential unintended consequences of shorter opioid prescriptions.
Researchers have made significant breakthroughs in understanding the role of microglia in neuroinflammation, a hallmark of degenerative brain diseases such as Alzheimer's Disease. Studies show that changes in microglial cells can trigger hyperexcitability in the brain, leading to decreased sociability and motivation.
New research presents alarming findings on ketamine infusion therapy for pain management, revealing that over a third of patients experience hallucinations, visual disturbances, and other adverse effects. The study emphasizes the importance of cautious approach to using ketamine as an opioid alternative.
A large US study found that 1 in 5 patients was prescribed opioids after having a pacemaker or similar device implanted, with 80 percent having never taken opioids before. The study highlights the importance of improving postoperative pain management following cardiac device procedures to reduce opioid prescriptions.
Studies show nearly 90% of women without opioid use in hospital post-cesarean delivery still receive a prescription for opioids upon discharge. Research highlights the need to reduce opioid use after cesarean delivery using alternative pain medications.
A study found that nearly one-third of children who had tonsillectomy did not need opioids for pain relief during and after surgery. Researchers used non-opioid pain medications instead, with similar postoperative care time in both groups.
A new study published in Science Advances shows that MORE, a mind-body therapy, decreases brain's response to opioid-related cues while increasing its response to natural rewards. Participants reported enhanced joy, less pain, and improved psychological health after treatment.
A McMaster University study found that statin drugs cause muscle pain by releasing glutamate, a potent activator of pain receptors. Administering antioxidants like Vitamin E can help reduce glutamate release.
A study published in Drug and Alcohol Dependence found that combining mindfulness techniques with methadone therapy reduces opioid cravings and improves pain management. Researchers at Rutgers University discovered that mindfulness-based interventions can increase self-awareness, self-control over cravings, and emotional regulation.
A team of researchers from the University of Sydney has made a breakthrough in the search for an opioid alternative, discovering a fungus that produces tetrapeptides mimicking endomophins. The findings, published in PNAS, suggest a new drug could be developed with fewer side-effects and effective pain relief.
Three peptides from Australian fungus Penicillium exhibit unique amino acid structures, leading to development of bilorphin and bilactorphin as novel analgesics acting on opioid receptors. These findings suggest a new pathway for pain management with reduced adverse effects.