Articles tagged with Analgesics
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
A four-week rest period was nearly as effective as an experimental drug in reducing discomfort and regaining function after injury from repeated moderate-strain activity. The study suggests that rest may be a good first treatment choice for common musculoskeletal disorders, with exercises and pain reducers used to aid recovery.
Researchers found that combining cannabinoids with morphine did not increase impulsivity or memory impairment in rhesus monkeys, suggesting a safe way to cut opioid dosage for pain sufferers. The study's findings support the notion that opioid-cannabinoid mixtures can be effective for treating pain without greater adverse effects.
A new Ohio University study shows that taking acetaminophen limits a person's positive empathetic feelings towards others. The study, conducted on 114 participants, found no effect of acetaminophen on perceptions of pleasure and positivity.
A new study suggests that increasing thrombospondin-1 levels may aid liver recovery after acetaminophen overdose. Mice with higher thrombospondin-1 levels showed improved liver function and reduced cell death compared to those without the protein.
The opioid epidemic is driving a surge in infectious diseases such as HIV/AIDS, hepatitis, heart infections, and skin and soft tissue infections. Comprehensive treatment that addresses both substance use disorder and underlying infections can improve outcomes for patients.
Researchers found that acetaminophen use was associated with a slightly higher risk of stroke in people with diabetes. In contrast, the medication did not increase the risk of heart attacks or overall deaths. The study suggests that older adults with diabetes should exercise caution when taking acetaminophen.
A new study suggests that giving surgery patients disposal bags to safely dispose of leftover opioids can double the percentage of patients who properly dispose of their unneeded pills within six weeks. The study showed that providing only an informational brochure had a much smaller effect on safe disposal rates.
Researchers discovered a novel gene mutation that reduces activity of the FAAH gene, which is involved in pain sensation and anxiety. The mutation is associated with enhanced wound healing, reduced anxiety, and fearlessness, potentially leading to new treatments for post-surgical pain and anxiety.
Researchers at the University of Utah Health found that pairing music with pain medications improved analgesic outcomes by up to 90% in mouse models. The study showed significant reductions in inflammation and pain responses, suggesting a potential therapeutic strategy for managing pain.
James Bray, a UTSA psychologist, is training first responders in Houston to recognize prescription opioid overdoses and administer naloxone. This project aims to provide treatment services for overdose victims through the Houston Recovery Center.
Patients who stopped taking aspirin and continued clopidogrel fared significantly better after one year, with a reduced risk of bleeding and no increase in clot-related events. The study suggests that stopping DAPT after one month may be a good option for patients after drug-eluting stent implantation.
Patients who stopped taking aspirin three months after receiving a stent had a significantly lower rate of bleeding and no higher rate of death from any cause, heart attack, or stroke compared to those following standard therapy. The study's results balance ischemic and bleeding risks in patients undergoing PCI.
The new guideline provides comprehensive recommendations for preventing cardiovascular disease through lifestyle changes, such as a balanced diet, regular exercise, and maintaining a healthy weight. It also emphasizes the importance of identifying and addressing personal or social barriers to adopting these habits.
Patients treated with apixaban and a P2Y12 inhibitor had lower rates of bleeding and no increase in heart attacks or strokes compared to those receiving warfarin and aspirin. The combination reduced the risk of major bleeding by up to 47% without increasing mortality or hospitalization.
A study of nearly 500,000 women found that taking paracetamol or other painkillers during pregnancy increases the risk of asthma in children, but the risk is similar when other types of painkillers are used. The research suggests that another factor linked to painkiller use and asthma risk may be chronic pain and stress.
The opioid crisis is expanding globally, with Norway, Sweden, and Denmark reporting a surge in prescription opioid prescriptions for chronic non-cancer pain. The study highlights the need to curtail the use of strong painkillers like oxycodone, which can lead to overdose deaths.
HSS has developed a pain management pathway that combines multimodal analgesia and alternative treatments, resulting in a significant decrease in opioid use without sacrificing pain control. The initiative involves surgeons, anesthesiologists, nurses, and other care team members.
A study published in the Journal of Arthroplasty found that intravenous and oral acetaminophen work equally well to manage post-surgery pain after hip replacement. The researchers tested both forms as part of a multimodal analgesia protocol, with patients showing low pain scores and minimal side effects.
Researchers at Hiroshima University discovered a potential new target for chronic pain treatment by activating the REV-ERBs receptor. This discovery could lead to more effective drugs for various types of chronic pain, including sciatica, cancer, and rheumatoid arthritis.
A nationwide cohort study of Danish children found no link between MMR vaccination and autism. The study included 657,461 children and analyzed their risk for autism after vaccination. No increased risk was observed in susceptible subgroups or during specified time periods.
A Michigan Medicine study reveals that combining aspirin with warfarin increases the risk of major bleeding events. The study found that nearly 2,500 patients were taking both medications without a clear reason, and that clinicians should review medical history to determine if it's necessary.
Researchers developed a machine learning tool to classify children with arthritis into seven distinct groups based on joint patterns. This allowed them to predict which children will go into remission faster or develop more severe disease, enabling doctors to tailor treatment and spare patients unnecessary medication side effects.
Researchers at the University of New Mexico found that THC content is more important for symptom relief than previously thought. The study analyzed real-time measurements of cannabis effects using a mobile app and found that patients experienced an average symptom improvement of 3.5 points on a 0-10 scale.
Researchers developed a cell model to investigate anti-inflammatory drug efficacy in both acute and resolving phases of chronic inflammation. The model reveals that conventional drugs can impair the resolution phase, leading to prolonged inflammation.
A study of 1.7 million Chinese adults found 10% at high heart disease risk, yet only 3% taking statins or aspirin for prevention. The low uptake is attributed to a lack of awareness among patients and providers in China.
A study published in JAMA found that intravenous acetaminophen reduced postoperative delirium incidence by 70% and ICU length of stay by 25%. Acetaminophen also reduced opioid use, suggesting effective pain control without increasing delirium risk.
Researchers at Indiana University School of Medicine have made a breakthrough in developing a blood test that can objectively determine the severity of pain in patients. The test, led by psychiatrist Alexander Niculescu, uses biomarkers found in the blood to match with potential treatment options.
Researchers have developed a new nano-painkiller that bypasses the blood-brain barrier and has been shown to be effective in treating intense pain without severe side effects. The new approach uses Leu-enkephalin-based nanoparticles that target peripherally located opioid receptors with lower abuse potential than morphine.
A case report describes a patient who developed cardiac events after consuming potent marijuana edibles, emphasizing the importance of understanding THC's effects on the cardiovascular system. The study highlights the need for healthcare providers to educate patients with cardiovascular disease about cannabis use and its complications.
A new study found that combining cilostazol with aspirin or clopidogrel reduced the risk of ischemic stroke recurrence in high-risk patients. The dual antiplatelet therapy approach showed similar major bleeding risks compared to monotherapy.
A Stanford University School of Medicine investigation discovered that common opioids are less effective for patients taking selective serotonin reuptake inhibitors (SSRIs) for depression. This interaction may lead to reduced pain relief and increased risk of opioid abuse.
A federally funded study of nearly 400 patients found that compounded topical pain creams and gels offer no statistically significant difference in pain relief compared to placebos. The researchers concluded that people using these creams are being taken advantage of, as the scientific evidence supporting their benefits is lacking.
Researchers found compounded pain creams ineffective in relieving localized pain, with small benefits attributed to peripheral nervous system drugs. The treatment's lack of efficacy and high cost make it less suitable than FDA-approved compounds.
Molecular vibrations in aspirin cause electron motions visible in real time for the first time through x-ray experiments. Electron distributions shift by 10,000 times larger than atomic displacements, demonstrating hybrid modes in crystal structures.
Patients on SSRIs are 40% more likely to develop severe GI bleeding when taking NSAIDs, according to a review in the Journal of the American Osteopathic Association. Physicians should educate patients on recognizing symptoms and monitor for bleeding risks during SSRI therapy.
A study suggests that regular use of aspirin or other NSAIDs can improve the survival of patients with head and neck squamous cell carcinoma (HNSCC) who have mutations in the PIK3CA gene. This is due to the reduction of prostaglandin E2, an inflammatory molecule that promotes tumor growth.
Regular use of NSAIDs, such as aspirin and ibuprofen, significantly improves overall five-year survival rate from 25% to 78% for patients with head and neck cancer containing the mutated PIK3CA gene. This is the first study to show a strong clinical advantage of regular NSAID use in this specific case.
The study found that benzodiazepine prescriptions for anxiety increased from 3.8% to 7.4% over the 12-year period, with primary care physicians accounting for half of all visits. The growing use of benzodiazepines has led to an increase in overdose deaths, prompting a need for addressing prescribing patterns.
A new study found that regular aspirin use after delivery erases the increased risk of stroke associated with a history of preeclampsia in women under 60. Women in this age group who took aspirin had the same stroke risk as those without a history of preeclampsia, whereas those who did not take aspirin had a 50% greater risk.
A meta-analysis of 13 clinical trials involving over 164,000 participants found that aspirin use was associated with a lower risk of cardiovascular events, including death, heart attack, and stroke. However, it also increased the risk of major bleeding in people without pre-existing cardiovascular disease.
A new study published in JAMA found that frequent aspirin use can lead to a 50% increase in major bleeding episodes. While aspirin reduces cardiovascular event risks, it increases the risk of major bleeding, making its use for initial prevention uncertain.
A new study published in Sleep found a 250% increase in Americans taking opioids with benzodiazepines or Z-drugs between 1999 and 2014. This alarming trend is associated with increased risks of serious adverse outcomes, including breathing problems and death.
CHOP surgeons found that opioids were often overprescribed for children's elbow fractures, with patients using less than 25% of the prescribed amount. Most patients stopped taking opioid medication after a short period, with some opting for over-the-counter pain relievers instead.
A study reveals GPs in poorer areas prescribe more opioids for pain, with smoking, obesity, and depression linked to increased prescribing. Chronic pain management is a challenge, with limited capacity for counseling and potential risks outweighing benefits.
A Canadian population study tracked back pain patterns over 16 years, identifying four trajectories: persistent, developing, recovery, and occasional. The persistent and developing groups had more pain and disability, while the recovery group increased opioid use.
Pharmacogenetic testing, which maps a person's genetic makeup, can ensure patients receive effective and safe medications. This technology has the potential to deliver an economic benefit of $12 billion over five years to the national health system in Australia.
New research suggests that taking non-steroidal anti-inflammatory drugs (NSAIDs) for pain can increase the risk of severe Clostridium difficile infections. The study found that brief exposure to an NSAID prior to infection worsened infection severity and shortened survival in mice.
A Rutgers study found that Gabapentin reduces pain and improves sexual desire and satisfaction in women with vulvodynia, a condition characterized by stinging, burning, or itching at the vaginal entry point.
A new study analyzed combined results of 47 randomized clinical trials, lasting at least 12 months, involving 22,000 patients with knee osteoarthritis. The research found uncertainty around long-term effectiveness of medications in controlling pain, highlighting the need for large randomized clinical trials.
A study combining 96 randomized clinical trials found that opioids had small improvements in pain and physical functioning compared to placebo, but also an increased risk of vomiting. Nonopioid alternative pain medications showed similar benefits with lower risks.
A new study by Stanford Medicine and Duke University finds that early physical therapy can reduce the risk of long-term opioid use by 7-16% for patients with musculoskeletal pain. Physical therapy is also associated with a 5-10% reduction in opioid dosage for those who do use them.
Researchers are developing a nonopioid drug, ML351, to treat certain types of chronic pain. The drug targets a novel signaling pathway responsible for chronic pain development and has shown promise in preclinical studies.
A recent study found that opioids like methadone and buprenorphine can impair cognitive tasks and increase sleepiness, with four participants stopping their tests due to drowsiness. The study's results indicate that patients should be informed about the potential driving impairment caused by these medications.
Medication administration errors are a significant concern, with omissions being the most common cause, particularly among elderly patients. The study highlights the need for vigilant attention to safe dosing practices, especially in older adults.
A new study from the University of Eastern Finland found that strong opioids increase the risk of hip fractures in people with Alzheimer's disease. The risk was highest in the first two months of opioid use, and was significantly higher for moderate to strong opioids.
Researchers found that a fractional dose of the 17D yellow fever virus vaccine provided protective levels of antibodies for over 10 years after vaccination. This finding supports the use of fractional doses in mass vaccination campaigns before outbreaks and eliminates the need for booster shots.
A clinical trial found that aspirin reduced the number of polyps overall, including on the right side, while EPA reduced polyps on the left side. Both compounds had preventative effects by reducing specific types of polyps.
Researchers discovered that BH4 regulates T cell activity, suppressing inflammation in autoimmune conditions and enhancing responses in cancer. A new therapeutic approach targets the same pathway to treat a range of diseases.
A study published in Human Reproduction found that women fed soy-based formula milk as babies are 40% more likely to have used hormonal contraception for menstrual pain relief. The research also showed a 50% increased risk of moderate or severe menstrual discomfort between ages 18-22.
A new study found that surgery patients often take less than half of the prescribed opioid pain medications, with prescription size being the most important factor. The study suggests that surgeons can reduce opioid prescriptions and improve patient safety by considering individual factors such as pain scores and operation intensity.