Articles tagged with Analgesics
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
A study published in The Journal of Neuroscience found that low-dose aspirin may reduce plaques in the brain by stimulating lysosomes and increasing the activity of TFEB, a protein responsible for waste removal. This could lead to improved treatment options for Alzheimer's disease.
Research suggests that low-dose aspirin regimens could decrease amyloid plaque pathology in mice by stimulating lysosomes. Activating cellular waste removal mechanisms is a promising strategy for slowing disease progression.
Researchers at Johns Hopkins Medicine discovered that combining chemical compounds to activate specific nerve cell receptors may reduce the risk of opioid tolerance and side effects by minimizing the amount of opioids needed. The study used mice models, suggesting that this approach could lead to a lower-risk pain treatment option.
A study by Johns Hopkins Bloomberg School of Public Health found that health insurers have not done enough to combat the opioid epidemic. The researchers analyzed coverage policies for drugs to treat chronic lower-back pain and concluded that these policies missed opportunities to steer patients towards safer treatments.
Researchers have developed a tool that analyzes protein phosphorylation patterns in the brain, revealing changes associated with desired and undesired opioid effects. This study aims to identify potential non-addictive opioids and reduce side effects by interfering with signal cascades.
A study published in Anesthesiology found that IV acetaminophen does not meaningfully decrease opioid use after surgery compared to oral acetaminophen. Researchers suggest that eliminating IV acetaminophen may result in significant cost savings for hospitals.
A new study from LSU Health Sciences Center found that opioids significantly increase the risk of fracture nonunion following acute and chronic administration. The researchers also suggest that certain medications, including Schedule II opioids and prescription NSAIDs, create a greater nonunion risk than non-opioid analgesics.
A recent study found that up to seven percent of patients develop a persistent habit after being prescribed opioids following surgery. To address this issue, experts recommend enhanced care coordination between surgeons and primary care physicians to identify patients at risk of developing opioid addiction.
Researchers discovered that aspirin blocks TIF-IA, a molecule essential for the nucleolus to function, driving tumour formation and dysfunction. Regular use of aspirin may help pinpoint those most likely to benefit from the treatment.
A study led by Stanford researchers found that over 11 million Americans may be prescribed incorrect statins, aspirin, or blood pressure medications due to outdated data. The updated equations improve the accuracy of cardiovascular disease risk estimates.
A study published by the European Society of Anaesthesiology and Intensive Care found that taking aspirin before and after CABG surgery significantly reduced mortality risk. Patients who took aspirin had a 4-year mortality rate of 10.7%, compared to 16.2% in non-aspirin patients.
A new study found that hypnosedation is an effective alternative to general anesthesia for various surgeries, including breast cancer treatments, gynecological procedures, and superficial plastic surgeries. The technique reduces adverse effects, accelerates postoperative rehabilitation, and improves patient comfort.
A national resilience strategy is proposed to reverse mortality trends from drug overdoses, alcohol, and suicides. The strategy includes improved pain management, harm reduction services, and new approaches to suicide prevention.
Research supports recent FDA restrictions on prescription hydrocodone- and codeine-containing cough medicines for children, finding opioids in general should not be prescribed for coughs and colds. The study highlights the risks of opioid-containing cough products outweighing potential benefits in pediatric populations.
A new study published in Anesthesiology found that liposomal bupivacaine, a long-acting local anesthetic, did not reduce opioid prescriptions or complications after total knee replacement surgery. The study included over 88,000 patients and found no significant benefit from adding liposomal bupivacaine to multimodal pain management reg...
A clinical trial involving over 4880 participants found that combining clopidogrel and aspirin reduces the risk of secondary stroke within 90 days. However, it also increases the risk of major bleeding, with most episodes being non-fatal and not brain-related.
A new study published in The New England Journal of Medicine found that combining clopidogrel and aspirin reduces the risk of major stroke within 90 days after a minor stroke or transient ischemic attack (TIA) by 25%. However, this combination also increases the risk of bleeding complications.
A randomized trial of 383 women with uncomplicated urinary tract infections found that taking ibuprofen instead of antibiotics prolonged symptom duration and increased the risk of serious complications. The study concludes that ibuprofen is not a safe alternative to antibiotics for treating uncomplicated UTIs.
A pilot study at Yale University found that reducing IV opioid dosing by 84% and switching to non-IV methods resulted in similar or improved pain scores for hospitalized patients. The study's findings suggest that less is more when it comes to prescription opioids for hospital patients.
Researchers are studying how stress produces pain and developing a potential treatment for stress-related chronic pain conditions. The team, led by Dr. Frank Porreca, will analyze neurons in the amygdala that respond to stress through signaling at the kappa opioid receptor.
A Johns Hopkins study found that physicians' use of stigmatizing language in medical records can lead to negative attitudes towards patients and less aggressive pain management. The study suggests that neutral language in medical records can perpetuate bias among physicians.
Researchers created PainTracker, a pain assessment adaptable to primary care clinics, addressing patient treatment history, goals and expectations, pain intensity and quality-of-life issues. The tool has dramatically transformed doctors' ability to assess and manage chronic pain, with 40-60% of patients having inadequate pain management.
A new study found that daily aspirin use is associated with a nearly double risk of melanoma in men compared to those who do not take aspirin. In contrast, women taking daily aspirin did not have an increased risk of melanoma. Researchers suggest increasing patient education about sun exposure and skin checks for high-risk individuals.
A recent study funded by Morris Animal Foundation found that tramadol is not an effective treatment for osteoarthritis pain in dogs. The research team compared tramadol to placebo and non-steroidal anti-inflammatory drugs, concluding that it was no more effective than a placebo.
A recent study from the University of Michigan found that racial disparities in opioid prescribing have decreased, with blacks and whites now receiving equal numbers of opioid prescriptions. However, blacks are at a higher risk of addiction due to prescription narcotic exposure.
A survey of 138 medical marijuana users aged 61-70 found that most patients significantly reduced their chronic pain and dependence on opioid painkillers. The results suggest that medical marijuana could be an effective solution to curb the opioid epidemic in older adults.
A study published in Kidney Cancer found that non-aspirin NSAID use was associated with shorter overall survival time for patients with metastatic renal cell carcinoma. The use of these medications can cause kidney-specific toxicity, leading to increased blood pressure and decreased renal function.
A network meta-analysis of 53 randomized controlled trials found naproxen most effective in improving both pain and function, followed by cortisone injections and PRP injections. The study suggests naproxen as a relatively safe and low-cost treatment option for knee osteoarthritis.
A new study led by Johns Hopkins researchers found that only a small percentage of patients use nonopioid pain relievers to supplement opioid pain management after spine and joint surgery. Patients also improperly store and dispose of opioids.
Researchers discovered that a multiple sclerosis drug can mitigate the painful side effect of cancer treatment bortezomib. Fingolimod, an approved multiple sclerosis medication, blocks the production of molecules causing nerve damage and alleviates neuropathic pain.
A randomized clinical trial found that combining aspirin with ticagrelor improved patency of grafted saphenous veins in patients undergoing coronary artery bypass grafting. This reduces the risk of vein graft failure and associated worse long-term outcomes.
Scientists tweak an existing diabetes treatment to alter its interaction with cells, leading to increased insulin release and improved efficacy. The new approach could also reduce drug side effects by avoiding internalization of GLP-1 receptors.
Researchers link increased prescribing of opioids to benzodiazepines, a known overdose risk factor, contributing to rising overdose deaths. The US sees a surge in opioid-related fatalities despite a decline in new prescriptions after 2010.
A study by the Hebrew University of Jerusalem found a link between prolonged acetaminophen use during pregnancy and an increased risk of attention deficit hyperactivity disorder (ADHD) and autistic spectrum disorder (ASD). The analysis shows a 30% increase in relative risk for ADHD and a 20% increase in relative risk for ASD.
Researchers have made significant breakthroughs in treating pancreatic, colon and breast cancers, as well as developing new pain treatments for chemotherapy-induced peripheral neuropathy. A new compound has shown promise in targeting cancer cell death pathways, while indomethacin has been found to inhibit colon cancer growth.
A new analysis found that opioid pain medications may pose higher risks of altered mental status, falls, and fractures in patients undergoing hemodialysis. Opioid use was associated with increased risks even at lower doses and with certain types of medication recommended for this population.
A recent study found that celecoxib, an NSAID, had better gastrointestinal safety than ibuprofen or naproxen when co-prescribed with esomeprazole. The medication was associated with infrequent gastrointestinal side effects in arthritis patients, making it a safer option for those taking these medications.
A new study in Journal of Addiction Medicine suggests that people who use medical marijuana are at higher risk for non-medical prescription drug use, including pain relievers. The study analyzed over 57,000 responses and found that medical marijuana users were about 60% more likely to report any prescription drug use.
A systematic review of over 460 studies suggests that ibuprofen and acetaminophen are better options for relieving acute dental pain. The combination of 400mg ibuprofen and 1000mg acetaminophen was found to be superior to any opioid-containing medications.
A substudy of the PRECISION trial found that adding aspirin to celecoxib reduced its cardiovascular safety advantage, while maintaining fewer GI problems and kidney issues compared to ibuprofen. Celecoxib remained associated with better overall outcomes in patients taking aspirin.
Research suggests that taking painkillers during pregnancy could reduce the number of cells in the testes and ovaries, which give rise to sperm and eggs. This could lead to an early menopause in females and affect the fertility of future generations.
A new Consensus Statement provides 16 recommendations to improve safe opioid use in non-cancer hospitalized patients with acute pain. The guidelines emphasize limiting opioid use, using lowest effective doses and immediate-release formulations, and educating patients about non-opioid alternatives.
A new study published in the American Journal of Obstetrics and Gynecology found that an app-based self-care program using acupressure reduced menstrual pain in young women by up to 58% after six months. The app, Luna, was used by participants who received either standard care or a self-acupressure intervention.
Researchers discovered a parasite-derived protein, H-IPSE, with potent therapeutic effects on chemotherapy-induced hemorrhagic cystitis in mice. The study found that H-IPSE alters host cell transcription, suggesting a novel approach to treating bladder pain and injury.
Most older adults (4/5) support allowing medical marijuana if recommended by a physician, while 2/3 advocate for more government-sponsored research on its health effects. The poll also reveals conflicting views on pain management, with prescription medications seen as more effective in controlling dosages.
Researchers at Saint Louis University discovered a method to block chemotherapy-induced neuropathic pain by supplementing a key signaling pathway. The study found that oxaliplatin, a widely used cancer drug, causes debilitating side effects due to increased adenosine kinase expression in astrocytes.
A recent study by the University of Eastern Finland found that initiating opioid analgesics reduces the use of antipsychotics and benzodiazepines in persons with Alzheimer's disease. This decrease was observed without worsening behavioural and psychiatric symptoms.
A nationwide survey found that oral and maxillofacial surgeons prescribed more opioids after hydrocodone-containing products were rescheduled in 2014. The study also showed a significant reduction in phone calls requesting refill authorizations after switching to more potent pain medications.
Researchers at the University of Pennsylvania found that hunger suppresses chronic pain by targeting specific brain cells. The study discovered that activating a group of 300 neurons responsible for prioritizing hunger over pain significantly reduced inflammatory pain responses, while acute pain responses remained intact.
The American Association for Dental Research (AADR) has recognized William Maixner for his outstanding contributions to chronic pain research, a field he considers a 'hidden epidemic'. He is being honored with the $5,000 award for his exceptional research in this area.
Researchers found that generic clopidogrel was as effective as Plavix in reducing mortality and hospitalization rates among heart attack and chest pain patients. The switch to a generic version resulted in significant cost savings for the Canadian health system.
Two studies found that acetaminophen use increases during cold/flu season, with a 24% increase in high-dose intake. Acetaminophen is the most commonly used analgesic in France, but its use can lead to liver harm if not taken correctly.
Acupuncture may be a safe alternative to drugs for chronic pain, with moderate benefit shown in a review of 20,827 patients. However, critics argue that the evidence is insufficient and that it can be linked to better quality of life compared to usual care. Doctors should consider a more flexible approach to guideline development.
A randomized clinical trial found that opioid medications did not improve pain-related function over 12 months compared to nonopioid medications. Nonopioid medications resulted in less intense pain and fewer medication-related symptoms.
A recent study found that a specific manipulation of dopamine receptors impairs chronic pain in male mice but has no effect on females. The researchers suggest that different types of cells drive the development of pain in males and females, leading to the potential for sex-specific pain relief medications.
Two studies showed that pre-operative counseling and non-opioid pain relievers can significantly reduce post-surgery opioid use, resulting in a two-thirds decrease in opioid consumption. Patients who used non-opioids experienced an equivalent pain experience with fewer adverse events compared to those using opioids.
Researchers developed a statistical model to predict hospitalized patients at risk of progressing to chronic opioid therapy. The model correctly identified high-risk patients in 79% of cases and was found to be highly associated with variables such as substance use disorder, benzodiazepine receipt, and surgical procedures during hospit...
Using multiple methods to manage pain during and after joint replacement surgery was associated with a decrease in opioid use, opioid prescriptions, and common complications. Multimodal therapy reduced opioid prescriptions by up to 18.5%, respiratory complications by 19% and gastrointestinal complications by 26%.
A recent study found that thousands of children with oral pain in London are being taken to pharmacies and non-dental health services, resulting in unnecessary use of NHS resources. The study highlights the need for integrated systems and better referral processes to ensure children receive dental treatment as soon as possible.
A study found that aspirin reduces mortality in patients with Type 2 diabetes and heart failure, but increases the risk of nonfatal heart attacks and strokes. The research used data from over 12,000 patients and suggested that aspirin may be beneficial for those living longer due to their age.