Articles tagged with Analgesics
Non-Hispanic black and Hispanic women reported higher pain scores compared to white women during the postpartum period. Despite this, they received fewer opioids and were less likely to receive prescriptions at discharge.
Researchers developed a novel nanoparticle delivery method to treat pain, using a non-opioid drug that previously failed clinical trials. The approach successfully treated pain in mice and rats with improved efficacy and duration of action.
Researchers have discovered a class of analgesics in conotoxin peptides, which are found in the venom of marine cone snails. These peptides show exceptional potency and selectivity for ion channels involved in pain transmission, offering new avenues for pain therapy.
A new study at Kellogg Eye Center finds that reducing opioid pills prescribed after cornea surgery doesn't compromise pain control, with most patients using only four pills. The policy change also leads to more responsible pill disposal practices.
A recent NIH-funded study suggests that exposure to acetaminophen during pregnancy may increase the risk of attention deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) in children. The study found that higher levels of acetaminophen exposure were associated with a significantly increased risk of both conditions.
Researchers found an association between aspirin use and decreased intracranial aneurysm growth rate. Growth is crucial as it increases rupture risk. The study suggests that aspirin may exert a protective effect against aneurysm growth and future rupture, but findings are observational and require further interventional studies.
The American Dental Association recommends against prescribing antibiotics for healthy adults with toothaches, citing evidence that they do not alleviate symptoms and can cause harm. In cases where dental treatment is delayed or signs of infection are present, antibiotics may be considered, but only in specific scenarios.
Researchers are examining prescription practices before and after the law took effect to understand how it has shaped healthcare providers' prescribing habits. The study will also investigate the impact on patients, including those with chronic pain, and potential unintended consequences of shorter opioid prescriptions.
A large US study found that 1 in 5 patients was prescribed opioids after having a pacemaker or similar device implanted, with 80 percent having never taken opioids before. The study highlights the importance of improving postoperative pain management following cardiac device procedures to reduce opioid prescriptions.
Researchers have made significant breakthroughs in understanding the role of microglia in neuroinflammation, a hallmark of degenerative brain diseases such as Alzheimer's Disease. Studies show that changes in microglial cells can trigger hyperexcitability in the brain, leading to decreased sociability and motivation.
New research presents alarming findings on ketamine infusion therapy for pain management, revealing that over a third of patients experience hallucinations, visual disturbances, and other adverse effects. The study emphasizes the importance of cautious approach to using ketamine as an opioid alternative.
Studies show nearly 90% of women without opioid use in hospital post-cesarean delivery still receive a prescription for opioids upon discharge. Research highlights the need to reduce opioid use after cesarean delivery using alternative pain medications.
A study found that nearly one-third of children who had tonsillectomy did not need opioids for pain relief during and after surgery. Researchers used non-opioid pain medications instead, with similar postoperative care time in both groups.
A new study published in Science Advances shows that MORE, a mind-body therapy, decreases brain's response to opioid-related cues while increasing its response to natural rewards. Participants reported enhanced joy, less pain, and improved psychological health after treatment.
A McMaster University study found that statin drugs cause muscle pain by releasing glutamate, a potent activator of pain receptors. Administering antioxidants like Vitamin E can help reduce glutamate release.
A study published in Drug and Alcohol Dependence found that combining mindfulness techniques with methadone therapy reduces opioid cravings and improves pain management. Researchers at Rutgers University discovered that mindfulness-based interventions can increase self-awareness, self-control over cravings, and emotional regulation.
Three peptides from Australian fungus Penicillium exhibit unique amino acid structures, leading to development of bilorphin and bilactorphin as novel analgesics acting on opioid receptors. These findings suggest a new pathway for pain management with reduced adverse effects.
A team of researchers from the University of Sydney has made a breakthrough in the search for an opioid alternative, discovering a fungus that produces tetrapeptides mimicking endomophins. The findings, published in PNAS, suggest a new drug could be developed with fewer side-effects and effective pain relief.
Researchers have identified RGS4 as a multifunctional protein that contributes to the transition from acute and sub-acute pain to pathological pain states. Inhibiting RGS4 action disrupts the maintenance of chronic pain, promoting recovery in preclinical models.
A study by TTUHSC researchers suggests that activating certain brain receptors can reduce pain and anxiety associated with arthritis. The compound LY379268 has been shown to produce pain-relieving effects and relieve anxiety, offering potential as a new pain medication.
A new study found that distributing essential medicines at no charge resulted in a 44% increase in adherence to medications. The study also discovered improvements in systolic blood pressure and the likelihood of participants meeting their financial needs.
A study from Nationwide Children's Hospital finds rural areas have a higher rate of reported cases, particularly during school months. Common medications such as OTC analgesics are involved in these incidents, emphasizing the importance of safe storage and supervision.
A randomized clinical trial found that providing free essential medicines increased adherence to treatment among patients who couldn't afford their medications. The study showed a significant improvement in systolic blood pressure, but not in LDL cholesterol levels or diabetes control.
Researchers at UC Davis developed a breath test that can detect opioid drugs in exhaled breath, providing a non-invasive alternative to blood tests. The test was tested on patients receiving pain medications, showing promise in tracking medication usage and detecting potential overdose risk.
Codeine-related poisoning calls and sales in Australia have significantly decreased since the prescription-only change in February 2018. The study found a 50% reduction in monthly rate of codeine-related poisoning calls and halved codeine sales.
Researchers at Technical University of Munich have discovered a specific neuroenzyme responsible for analgesics resistance in chronic pancreatitis. The team found that targeting this enzyme, nNOS, with an existing inhibitor reduces pain perception in animal models, offering new hope for pancreatic patients
New research warns Canadians against taking daily aspirin for primary prevention due to increased risk of major internal bleeding and potential increase in cancer deaths. Experts recommend alternative preventive measures such as smoking cessation, exercise, blood pressure tracking, and considering the Mediterranean diet.
A new study found that hospitals often administer medications based on practical staff scheduling rather than ideal dosing times. This can lead to undertreatment of pain and other medical conditions. Researchers are working to adjust drug administration protocols to better align with patients' needs.
The NIH HEAL Initiative awards $945 million for grants and contracts across 41 states to improve treatments for chronic pain and curb opioid use disorder. The initiative aims to develop non-addictive medications and models of care to balance patient safety with effective pain management.
Researchers found that 2.5% of women and 12.1% of men without established CVD could derive net benefit from aspirin treatment for 5 years. The study used data from a well-characterized web-based decision support program in New Zealand, identifying persons likely to benefit from aspirin treatment based on personalized benefit-harm analy...
Researchers developed a method to categorize drugs based on cellular responses, predicting potential clinical effects and reducing side effects. The approach was validated using opioid analgesics, with potential applications in safer opioids and cannabis product testing.
Researchers at UCalgary and Stanford University have discovered a long-range circuit in the brain that carries pain signals and is altered during chronic pain states. This understanding may lead to new drug therapies and targeted brain stimulation treatments to address chronic nerve pain.
A recent study found that approximately 400 caregivers reported pain medication use by children after common surgeries such as hernia or appendectomy. Most patients received acetaminophen or ibuprofen for pain relief, with only 22% prescribed opioids at hospital discharge.
A study published in JAMA Network Open found that patients in the US and Canada receive opioids at a rate seven times higher than those in Sweden. Nearly half of US patients received high-dose opioid prescriptions within 30 days of discharge, while 25% of Canadian patients did so.
The THEMIS trial found that ticagrelor, when added to aspirin, reduced the risk of cardiovascular death, heart attack, or stroke by 10% in patients with stable coronary artery disease and diabetes. However, patients taking dual antiplatelet therapy also experienced a greater risk of major bleeding.
A sub-group analysis from the ASPREE trial found that daily low-dose aspirin did not prolong disability-free survival in healthy people over 70, even in those at high cardiovascular disease risk. The study suggests that improved risk prediction methods are needed to identify those who could benefit from aspirin therapy.
Researchers found strong evidence that cannabis alleviates pain, with users experiencing a significant drop in pain suffering after consumption. The study highlights the potential of cannabis as a safe and effective alternative to opioids for treating chronic pain.
The study analyzed combined patient-level data from two randomized clinical trials to examine the effectiveness of dual antiplatelet therapy in patients who experienced a minor stroke or transient ischemic attack. The results indicate that treatment with clopidogrel and aspirin can improve outcomes for these patients.
SLU researchers will investigate GPR160, a small molecule that could turn off pain without side effects or addiction. The discovery of new leads for non-addictive pain medications has the potential to significantly improve treatment outcomes for chronic pain patients in the US.
A team of researchers at Scripps Research Institute has discovered an anti-opioid pathway that counteracts the effects of opioids on neuronal firing. The discovery could lead to the development of new pain medications with less potential for abuse and overdose.
Researchers found that DNA methylation patterns can affect the impact of aspirin on mortality in women with breast cancer. Women with certain DNA characteristics who take aspirin before a breast cancer diagnosis may live longer, according to the study published in Cancer journal.
A Brazilian health care system analysis found that women have a 90% increased risk for prescription of pill combinations known to produce reactions requiring medical attention. The study also revealed that one in four older adults over age 55 received drugs with an interaction, reaching one in three for ages 70-79.
A new study suggests that aspirin use can have varying effects on breast cancer patients depending on their DNA methylation profiles. Patients with methylated tumor promoters had a higher mortality risk, while those with unmethylated promoters saw a decrease in breast cancer-specific mortality.
Researchers at Kaiser Permanente discovered that allowing women to eat and move sooner after surgery improves recovery, reduces opioid exposure, and enhances breastfeeding experiences. The study's Enhanced Recovery After Surgery program led to a significant decrease in opioid use without increased pain or hospital stay.
A new study found that NSAIDs contribute to cardiovascular side effects in individuals with osteoarthritis, increasing the risk of heart failure, ischemic heart disease, and stroke by 42%, 17%, and 14% respectively. The study suggests that patients with OA should discuss the risks and benefits of NSAID use with their care providers.
A tiny biodegradable electronic circuit made from magnesium can release controlled amounts of painkillers over several days. The implant degrades safely inside the body after use.
A team of experts from Indiana University and the Karolinska Institutet in Sweden have received a $1.6 million grant to investigate the impact of opioid pain medications prescribed during pregnancy on children's health outcomes. The study aims to identify causal connections between maternal opioid use and adverse childhood outcomes.
A retrospective review of 304 patients found that aspirin therapy improved lab values and overall survival post-TAE for HCC, with lower bilirubin levels at 1 day, 1 month, and 1 year after embolization. Aspirin use was also associated with longer median overall survival period after TAE.
A recent study of over 308,000 women who gave birth from 2008 to 2016 found that nearly half received opioid prescriptions as part of their birth experience, with one in every hundred still filling them a year later. The percentage of women filling opioid prescriptions declined over time, suggesting growing awareness of the national op...
A study by Duke University researchers found that children's common ailments like vomiting and fever require pediatric versions of therapies, which are often lacking in airline first-aid kits. Most incidents were handled by flight crew members, but parents should carry on medications for their children to ensure prompt treatment.
A recent study found that US physicians prescribe opioids more frequently to patients during hospitalization and at discharge compared to peers in other countries. The study adjusted for pain severity and patient illness, but still observed a significant difference.
Researchers uncover how cannabis creates potent pain-relieving molecules, targeting inflammation and offering a non-psychoactive alternative to opioids. The discovery enables the development of naturally derived pain treatments with potentially significant benefits for chronic pain sufferers.
A quarter of adults aged 40+ take daily aspirin for heart disease prevention without physician's advice. Nearly half of adults 70+ report taking aspirin daily due to potential harm outweighing benefits.
Nonprescription antibiotic use is a significant public health concern, with varying prevalence rates across different socioeconomic groups. The study highlights the need for increased awareness and education to prevent unnecessary antibiotic use and its associated adverse events.
A new bariatric surgery protocol has been implemented to reduce postoperative hospital stays and readmissions. The Enhanced Recovery After Surgery (ERAS) protocol, which includes early ambulation and liquid administration, as well as targeted pain management, has been shown to reduce hospital stays by half and readmissions by 38%.
A new study published in the Journal of General Internal Medicine found that online symptom self-management works to decrease pain, anxiety, and depression symptoms. The study also showed that combining online self-management with clinician telecare leads to greater symptom improvement for some individuals.
A clinical trial suggests music can reduce anxiety before peripheral nerve block, with similar effects as midazolam. However, patients in the music group were less satisfied due to limited music choice, and communication was harder.
Researchers found that patients treated with ibuprofen and Percocet used less opioids than those prescribed just Percocet after arthroscopic shoulder instability repair. This study suggests a possible reduction in post-operative narcotics distribution, addressing the public health crisis of opioid abuse.
A computational model simulates how pain is transmitted from a nerve to the spinal cord's dorsal horn, reproducing experimental results on pain sensitivity. The model suggests a potential mechanism for neuropathic pain's flipped sensitivity rhythm: a change from inhibition to excitation in synaptic connections between nerve cells.
Rimegepant, a novel gepant therapy, demonstrates significant relief from acute migraine pain and associated symptoms in a large-scale clinical trial. The study found that rimegepant effectively blocks the CGRP pathway, providing a new option for people with migraine not helped by existing medications.