Researchers found that changes in deep-water circulation occurred around 7,000 years ago, influencing CO2 levels in the atmosphere. This discovery highlights the importance of studying past climate change and suggests future climate change could lead to increased CO2 release from Southern Ocean.
A study on pectoral fin rays of ancient fish species uncovers key structural changes enabling fins to give rise to limbs. The transformation is marked by the appearance of digits, reducing dermal fin rays and fin webs.
Researchers have identified a possible buried impact crater in southern Laos as the origin of ancient tektites found across one-tenth of Earth's surface. The crater is believed to have formed approximately 790,000 years ago, with geochemical analysis and dating techniques supporting this claim.
A study found that tropical conditions, rather than the Arctic stratosphere, influence three out of four main winter weather patterns in North America. This discovery provides forecasters with an additional tool to predict high-impact weather during winter.
NASA analyzed Tropical Storm Sarai's cloud top temperatures to determine its strength and identify areas of heavy rain potential. The analysis showed coldest cloud top temperatures as cold as -81 degrees Celsius, indicating strong storms capable of creating heavy rain.
Researchers discovered that DHCR7 inhibitors and intermediate cholesterol metabolite 7-DHC promote IFN-I production and an antiviral response by activating AKT3 and IRF3. This may aid in the development of new drugs to treat viral infections.
A recent NIH-funded study analyzing data from 366 identical twin pairs found significant variability in autism symptom severity among those with ASD. The researchers estimated that only 9% of the cause of trait variation was attributed to genetic factors.
A research team from HKU developed a novel deep learning approach to predict disease-associated mutations in metal-binding sites. The approach uses spatial features and physicochemical sequential features to train a model, achieving an AUC of 0.90 and accuracy of 0.82.
A new study reveals that one dose of the HPV vaccine may prevent infection from the potential cancer-causing virus, with implications for reducing global cancer burden. The current two- or three-dose series may be replaced by a single dose regimen if ongoing clinical trials provide sustained benefits.
A new study by researchers at Linköping University found that a diet rich in sugar can rapidly affect sperm motility and quality. After two weeks of consumption, the sperm motility of all participants became normal, suggesting a close link between diet and fertility.
A study published in JAMA Oncology found that proton therapy is just as effective as X-ray radiation therapy in treating cancer, but causes fewer side effects and lower hospitalization rates. This could lead to improved quality of life for patients and reduced healthcare costs.
A study found that nitroglycerin infusion triggers abnormal cardiovascular responses in migraine patients, including higher heart rates and reduced stroke volume. The findings suggest a systemic susceptibility to the vasodilatory effects of nitroglycerin, possibly due to enhanced sensitivity to nitric oxide.
A new study supports the idea that hydrogen played a crucial role in the emergence of eukaryotes, the first nucleated cells. The research suggests that the Lokiarchaeota, an enigmatic group of microorganisms, use hydrogen for metabolism, providing evidence for the 'hydrogen hypothesis' of eukaryote evolution.
A population study by the Finnish Institute for Health and Welfare found that preterm children are at least one and a half times more likely to be placed outside the home than full-term counterparts. The likelihood of placement is highest during early childhood, with no difference observed after age 5.
A study by the University of Pittsburgh School of Medicine found that teenage boys who witness their peers abusing women and girls are more likely to bully and fight with others. In contrast, those with equitable gender attitudes had lower odds of reporting violent behaviors.
Researchers have identified a key protein, Importin-11, that transports the cancer-causing protein βcatenin into the nucleus of colon cancer cells. Inhibiting this transport step could block the growth of most colorectal cancers caused by elevated βcatenin levels.
Phanfone is weakening due to dry air and vertical wind shear, leading to its elongation. The storm's maximum sustained winds have dropped to 50 knots, with forecasters expecting it to dissipate by Dec. 29.
Researchers discovered that thiol redox switches play a central role in enabling energy release efficiently during seed germination. These molecular switches kick-start mitochondrial energy metabolism, allowing seeds to conserve stored energy reserves for years or even centuries.
A global study found that attitudes towards gay men and lesbian women vary greatly across countries, with gay men consistently rated more negatively. The researchers identified three exceptions where negative attitudes were not correlated with gender norms, including China, India, and South Korea.
NASA's Terra satellite captured images of Tropical Storm Phanfone, revealing maintained circular shape and thunderstorm bands. The storm is forecast to weaken and move toward Hainan Island, China.
Scientists at Max Planck Florida Institute for Neuroscience have developed novel biosensors to study CREB dynamics in living brains. They found that sensory experiences shape CREB activity over hours to days after a stimulus, and this effect can be observed even when visual stimuli are absent.
A randomized controlled study found that Transcendental Meditation prevents abnormal enlargement of the heart and reduces chronic heart failure in African Americans. The study tested 85 hypertensive participants who practiced TM or received health education controls, with significant reductions in cardiovascular mortality and morbidity.
Researchers found proton therapy significantly lowers the risk of severe side effects such as hospitalization, while maintaining similar cure rates and effectiveness compared to traditional photon radiation. The study suggests proton therapy offers a way to reduce serious side effects without sacrificing treatment efficacy.
Researchers have developed glioblastoma organoids from patient tissue, allowing them to rapidly test personalized treatment strategies. The models retain features from the primary tumor and can be used to explore ways to attack it.
A study investigated eye changes in astronauts during long space missions and those experiencing simulated weightlessness from 30 days of bed rest. The results showed similarities between the two conditions, providing new insights into spaceflight's effects on vision.
Researchers at Tokyo Institute of Technology developed a novel strategy to exploit spin-related phenomena in topological materials, achieving a giant unidirectional spin Hall magnetoresistance ratio of over 1%. This breakthrough could lead to the development of spintronics and outperform current storage devices with improved power cons...
Researchers have developed a custom artificial neural network that can analyze molecular signals controlling gene function, enabling biologists to understand complex mechanisms of gene regulation. This breakthrough enables the creation of machine learning algorithms that reflect common concepts in biology.
Researchers discovered that the brain can integrate artificial and natural vision, allowing for partial visual restoration in AMD patients. This breakthrough has implications for future retinal prosthetic devices and brain-machine interfaces.
Scientists have developed Y2O3-MgO nanocomposite ceramics with uniform distribution of two phases, microhardness over 11 GPa, and average grain size of 250 nm. The new material can transmit over 70% of IR-range light with wavelength up to 6,000 nm.
Researchers found that patients with high body mass index (BMI) responded better to atezolizumab, a common immunotherapy treatment for non-small-cell lung cancer (NSCLC). This unexpected result may lead to further investigation into the potential link between BMI and inflammation in cancer treatment outcomes.
Despite a slight increase in physical activity among Russian men and women, the country's working population remains under European health standards. Most people engage in exercise or sports for less than 30 minutes, three times a week, with financial constraints and laziness being major barriers. The study also found that city dweller...
A new study found that people who went into the movie with low expectations actually had lower overall enjoyment, contrary to those who expected less but were pleasantly surprised. Researchers surveyed 441 participants before and after seeing The Last Jedi and found that negative bias can drag down even positive reactions.
Tropical Storm Sarai has formed near Fiji, with maximum sustained winds near 35 knots (40 mph/65 kph) and a band of thunderstorms wrapping into its low-level center. The cyclone is expected to intensify as it passes southwest of Fiji, with the Joint Typhoon Warning Center predicting steady intensification to 65 knots.
Researchers found that specific patterns of brain connectivity were associated with the development of attention-deficit/hyperactivity disorder (ADHD) and major depressive disorder. By examining brain architecture at age 7, the study identified potential links between brain development and later mental health symptoms in children.
The new membrane separates water from various oily substances with high efficiency, rejecting 99.9% of oil droplets. It also shows great tolerance to acidic, alkaline, solvent, and salt solutions.
Researchers at Osaka University discovered that ESAM, a surface marker for hematopoietic stem cells and vascular endothelial cells, is crucial for the development of definitive hematopoiesis, especially adult-type erythropoiesis. The study found that ESAM-deficient mice had impaired hematopoiesis-supporting ability.
A pooled analysis of nine studies involving over 750,000 adults found that recommended amounts of leisure-time physical activity were linked to a lower risk for seven cancers. The study suggests that people should aim for moderate- or vigorous-intensity activities for at least 2.5 to 5 hours/week to reduce cancer risk.
A study by Kobe University found that group apologies perceived as more genuine when costly to the organization, similar to individual apologies. The research used fMRI brain scans and participant ratings to determine that costly apologies activated key brain regions associated with cognitive empathy and intention processing.
Researchers propose a new computational analysis method that uses keystroke time series data to detect early stages of Parkinson's disease. The method, based on fuzzy recurrence plots, is less physically demanding than traditional testing methods and shows encouraging results.
Research in mice reveals the motor cortex needs continuous feedback to generate dexterous movements, unlike other neural circuits that can operate with sustained input. The study found blocking incoming signals or disrupting rhythmic patterns impaired grasping skills, highlighting the importance of precise timing and signal processing.
Researchers at Liverpool School of Tropical Medicine identified a new mechanism by which mosquitoes become resistant to insecticides. The SAP2 binding protein in the legs plays a key role in this process.
The East Asia VLBI Network observed the afterglow of TeV Gamma-Ray Burst 190114C, providing unique opportunities to study its progenitor and pre-burst medium. The non-detection results place strong upper limits on parameters extracted from different theoretical models of GRBs.
A comprehensive interaction network map reveals how Plasmodium falciparum traffics between human host cells, transforming red blood cells into rigid forms that hinder oxygen transportation. This understanding paves the way for further study and discussion on the molecular mechanism of severe malaria.
Researchers at Princeton University have successfully established a long-distance relationship between two silicon quantum bits, paving the way for more complex calculations and potentially cheaper quantum computers. The breakthrough uses light-based communication to transmit messages between qubits on a computer chip.
The study found that H2A.Z promotes H4K20me2 deposition, recruiting ORC1 to license and activate early DNA replication origins. H2A.Z-regulated origins have higher firing efficiency and earlier replication timing compared to other origins.
A review article published in The New England Journal of Medicine suggests that intermittent fasting can improve blood sugar regulation, increase resistance to stress, and suppress inflammation. Studies have shown that this adaptation may trigger a slower metabolic process, which can lead to weight loss and reduced belly fat.
A research team created a neuromorphic network composed of metallic nanowires, exhibiting electrical characteristics similar to human brain functions. The team found that the network's fluctuation-based functionalities mimic memorization, learning, and forgetting processes.
Scientists in China successfully induced granulosa cells to transform into functional oocytes in mice, which were then fertilized to produce healthy offspring. The chemical reprogramming method appears to offer a promising approach for preserving fertility and endocrine function.
Researchers have discovered a new species of goby, Larsonella pumilus, off the coast of Okinawa, revealing insights into its habitat and relationships with other deep-sea fish. The discovery was made at a depth of 214 meters, making it the deepest recorded finding of the species.
Certain bacteria, such as Shigella, use lipopolysaccharides to block caspases and prevent apoptosis, allowing them to multiply intracellularly. This strategy is essential for their survival and spread within the human body.
Researchers at Washington University School of Medicine found that T cells play a critical role in protecting against staph infections. The study suggests activating untapped immune cells and immunizing infants before birth to block toxin effects. This new approach shows promise for developing an effective staph vaccine.
The IKBFU scientists proposed a new theory suggesting that the 'Dark Energy' is not a mysterious entity but rather a manifestation of the universe's boundaries. They draw an analogy with the Earth, where we experience attraction due to gravity but also have no physical boundaries.
A cohort study found that preoperative N-terminal pro-B-type natriuretic peptide (NT-proBNP) concentrations were independently associated with vascular death or myocardial injury at 30 days after surgery. Preoperative NT-proBNP thresholds improved discrimination and risk stratification for patients undergoing noncardiac surgery.
Scientists at Scripps Research Institute have developed a molecular switch that enables precise control of gene therapy doses. The technique involves embedding an RNA molecule called a hammerhead ribozyme into the genes used in gene therapies, allowing doctors to regulate the dosing level.
Researchers found that younger patients with stomach cancer often present with more aggressive disease, a worse prognosis, and reduced effectiveness of traditional chemotherapy treatments. The study highlights the importance of increased awareness and early detection for this increasingly prevalent form of stomach cancer.
Scientists at La Jolla Institute for Immunology found no evidence linking CD4 T cells to severe dengue hemorrhagic fever. Instead, they discovered a novel T cell response that may help counteract inflammation, suggesting a new direction for developing effective vaccines.
Researchers have developed a noncontact laser ultrasound technique that generates and detects sound waves on the skin surface using eye- and skin-safe lasers. This method produces images with centimeter depths, comparable to clinical ultrasound, and shows sensitivity to tissue features currently detected by conventional ultrasound.
Researchers created a molecular 3D-map of nerve cells targeted by opioids in striatum, dividing it into subregions with spatiomolecular code. This knowledge may contribute to an increased understanding of normal reward processes and the effects of addictive substances on decision-making.
Researchers analyzed animal bones from Navan Fort to discover that communities in Iron Age Ireland were highly mobile and engaged in large-scale feasting events. The study found evidence of pigs, cattle, and sheep being brought from across Ireland, including as far as Galway, Donegal, and Antrim.
Researchers developed a system to accurately detect space debris in Earth's orbit using laser ranging telescopes and neural networks. The new algorithm significantly improves the success rate of space debris detection, allowing for safer spacecraft maneuvers.