Quinacrine repurposed with cisplatin synergizes to reduce cancer growth, increasing median time to tumor volume by 12 days; enhances apoptosis and inhibits autophagy in HNSCC cells.
A new study reveals that DFDT, a faster and less toxic insecticide than DDT, was created by German scientists during WWII. The compound kills insects more quickly and in smaller amounts, potentially minimizing its environmental impact.
A new therapy shows promise in reducing liver fat and fibrosis in people with HIV, a form of non-alcoholic fatty liver disease (NAFLD). The study found that tesamorelin reduced liver fat by 37% and slowed the progression of fibrosis in treated subjects.
Researchers found that cold temperatures are associated with luxury and status in products, but not in all categories. The study suggests that marketers can use small adjustments in temperature to influence perceived value and level of luxury for their products.
A USF Health study discovers drugs targeting TAS2R14 can prevent reduced therapeutic effectiveness in poorly controlled asthma. Researchers found that one drug, diphenhydramine, worked better than others to maintain signaling and dilate airways without desensitization.
Researchers found that tesamorelin reduced liver fat and prevented liver fibrosis in people living with HIV. The study showed a 37% relative reduction in liver fat fraction and a significant decrease in blood markers associated with inflammation and liver damage.
A team of researchers, including CeMM PI Joanna Loizou, will study DNA-damage response systems using cutting-edge technologies. The six-year project aims to create integrated genetic and physical maps of DNA repair pathways in human cell types.
Researchers at the University of Dundee develop a blood test to detect desmosine, an amino acid released by diseased aortas into the blood and urine. This test improves diagnosis and monitoring of aortic aneurysms, potentially saving lives by identifying patients at risk.
An international team is working to develop an ethical framework for ancient DNA research, incorporating diverse voices and expertise from Indigenous communities. The project aims to foster better collaboration and address concerns around the use of human genetic material.
The article discusses human-animal chimeras with brains composed of human cells, raising questions about their moral status. The author argues that a standard view, which considers human cognitive capacities morally significant, is mistaken and proposes a better framework for thinking about the moral status of part-human beings.
Researchers at UC San Diego developed soft actuators that can be controlled electrically, making them compatible with small electronic devices and batteries. These actuators enabled the creation of compact, portable and multifunctional soft robots with various applications.
The RESILIENT trial found disease control in 114 out of 126 patients evaluable per protocol and progression-free survival. The study suggests that label-agnostic therapy regimens guided by Encyclopedic Tumor Analysis can offer meaningful clinical benefits for patients with relapsed refractory metastatic malignancies.
Researchers at Argonne National Laboratory have discovered a key property of donut-like nanoparticles called semiconductor quantum rings, which may find application in quantum information storage, communication, and computing. The team achieved coherent directional control over light emission by breaking the symmetry of the ring shape.
Researchers from Forschungszentrum Jülich explore 3D magnetic solitons with potential as information carriers for neuromorphic computing. The €11.8M ERC Synergy Grant will investigate particle-like properties and applications of these structures.
Patient identity management is crucial for accurate health record matching and data quality. Regenstrief research demonstrates that standardizing demographic data can improve health record linkage by up to 8 percent.
A new study finds that obtaining a second opinion from board-certified dermatopathologists improves the accuracy of diagnosing melanoma, reducing misclassification rates. The study's findings suggest that expert second opinions provide value in improving diagnostic reliability, especially for complex cases.
A team of researchers at MIT has developed an 'electroadhesive' stamp that can pick up and place down objects as small as 20 nanometers wide. The stamp uses a sparse forest of ceramic-coated carbon nanotubes to create temporary electrical attraction, allowing it to grasp microscopic structures with precise control.
Researchers have identified RGS4 as a multifunctional protein that contributes to the transition from acute and sub-acute pain to pathological pain states. Inhibiting RGS4 action disrupts the maintenance of chronic pain, promoting recovery in preclinical models.
Typhoon Hagibis has weakened to a typhoon status after being a super typhoon, with NASA-NOAA's Suomi NPP satellite providing visible imagery of the storm. The image showed a cloud-filled eye surrounded by powerful thunderstorms and a large tail of clouds stretching along Japan's east coast.
A new study found that military veterans with post-traumatic stress disorder (PTSD) are more likely to experience a rare sleep disorder called REM sleep behavior disorder (RBD), which is also linked to an increased risk of developing neurodegenerative conditions like Parkinson's disease. Researchers hope that identifying patients with ...
Researchers at West Virginia University are developing an autonomous robotic system to monitor the structural integrity and safety of underground mines. The system will provide high-resolution 3D maps for assessment of pillar and roof damage, enabling a rapid response to detected degradations in stability.
A genetic link has been discovered between Sudden Infant Death Syndrome (SIDS) and a mutation in the HADHA gene, causing infants to die suddenly from cardiac arrest. Researchers hope that this discovery will lead to new treatments and interventions for the disease.
Scientists at Argonne National Laboratory have developed an additive manufacturing method that enables the recycling of more nuclear waste, reducing storage time by almost one thousandfold. The breakthrough uses 3D-printed parts to separate highly radioactive actinide isotopes from rare earth metals.
A new study at Boston Medical Center aims to determine the effectiveness of Mindfulness-Based Stress Reduction (MBSR) in treating chronic lower back pain. The 8-week group mindfulness program may improve patients' physical and psychological function, as well as their likelihood of reducing opioid prescriptions.
Researchers found that altering Sox9 gene expression modifies Alagille syndrome liver disease severity, from mild to severe cases. Increasing Sox9 levels improved biliary duct development without tumor formation.
Subtropical Storm Melissa forms off the New England coast, bringing strong winds and coastal flooding to the mid-Atlantic region. The National Hurricane Center predicts gradual weakening over the next few days, with Melissa expected to lose its subtropical characteristics by Saturday night.
Researchers at UC Riverside discover large-scale winds associated with active black holes in small galaxies suppress star formation, impacting galaxy evolution. The team used the Sloan Digital Sky Survey data to identify 50 dwarf galaxies and found six of them showing signs of winds emanating from their active black holes.
Researchers at UNM's Department of Physics and Astronomy have discovered that decreasing the density of nanoparticles in ordered arrays produces exceptional electric field enhancements. By making particles smaller and farther apart, interactions between nanoparticles are strengthened, resulting in stronger collective responses.
A Norwegian study found that being overweight before age 40 significantly increases the risk of several types of cancer, including endometrial cancer by 70%. Obesity is also linked to an increased risk of postmenopausal breast, renal-cell and colon cancers.
The ONCOMMUN Program aims to improve patient experience and reduce the impact of cancer in Europe. The program combines monitoring of health and emotional status with video-consultations, online education, and social networking to increase quality of life and therapeutic adherence.
The University of Kansas will develop an innovative graduate training program that combines the disciplines of chemistry, chemical engineering, and computer science. The new program aims to make catalysis design more efficient by using artificial intelligence and machine learning.,
Researchers at Kyoto University developed a porous material that selectively captures CO2 molecules with high efficiency, converting them into valuable organic materials. The material can also be recycled without losing its efficiency.
A team of neuroscientists suggests that the sensation of a 'food coma' after eating may be linked to the formation of long-term memories. In a study on brain activity in Aplysia californica, sea slugs, researchers found that insulin-like molecules play a crucial role in both metabolic and neurotropic functions.
A multi-institutional study found that neurofeedback training can alter guilt-related brain connections in patients with Major Depression Disorder, increasing self-esteem. After a single session, participants showed strengthened connectivity between specific brain areas and reported improved self-esteem.
A new analysis reveals that people prioritize attention based on learned associations with danger, influencing how they perceive and learn from stimuli. The study suggests that attention affects how individuals process information about threats.
Researchers discover that koala germ cells recognize and suppress retroviral invasion through a unique 'piRNA response' mechanism. This innate genome immune system can identify viral RNA and block its replication, providing a new understanding of how organisms defend against pathogen invasions.
The Rice reactor produces valuable chemical in desired concentration and high purity, eliminating the need for hazardous transportation and purification. The low-cost carbon black catalyst enables point-of-use production of pure hydrogen peroxide solutions.
Researchers create biofuel precursors from municipal waste and discover unique optical phenomena in moire superlattices. A new model uses cellphone data to improve urban building occupancy estimates, aiming to enhance energy efficiency.
Researchers found that serum neurofilament levels are significantly higher in patients with frontotemporal dementia than those with psychiatric disorders. This biomarker shows promise for differential diagnosis and prognostication of the disease.
Researchers at Georgia State University isolated gut bacteria that can prevent and cure rotavirus infection, the leading cause of severe diarrhea in children worldwide. The discovery may lead to possible treatments and preventive measures for rotavirus infection.
The Noah land surface model with multi-parameterization options (Noah-MP) simulates key hydrological variables across China. The model generally reproduces spatiotemporal patterns of runoff and evapotranspiration, capturing major flood and drought events.
A team from the University of Tsukuba studied volleyball aerodynamics using wind tunnel experiments and found that standard panels create an asymmetric surface, affecting flight patterns. This research may help develop more efficient drones.
Researchers found fairy-wrens start breeding earlier in milder nights and stop breeding later in hot conditions. The study's long-term data on the birds' life history may help scientists understand climate change effects on wild animal populations globally.
A new study suggests that rotavirus infection may trigger the development of type 1 diabetes. Researchers found a significant decrease in the incidence of type 1 diabetes in Australian children under four years old after the introduction of rotavirus vaccination.
The artificial skin developed by Prof. Gordon Cheng and his team enables robots to perceive their surroundings in greater detail and with more sensitivity, making them safer when operating near people. The system combines hexagonal cells with microprocessors and sensors to detect contact, acceleration, proximity, and temperature.
A new study found that 58% of suicide deaths and 45% of non-fatal suicidal behaviors in low- and middle-income countries are linked to psychiatric disorders. The research suggests a wider approach is needed beyond just treating psychiatric illness to prevent suicidal behavior.
Researchers at University of California, Riverside discover that Milky Way is undergoing a massive merger with its largest satellite galaxy, the Large Magellanic Cloud. Several ultrafaint dwarfs and relatively bright satellite galaxies were likely stolen from LMC.
Leo Aerospace's technology has received worldwide attention after participating in TechCrunch's Disrupt SF Startup Battlefield. The team has successfully tested their system and is scaling up efforts with larger payloads. They have also received support from the National Science Foundation and the Air Force through a SBIR grant.
The new material combines liquid metal and shape-morphing rubber, exhibiting adaptability and responsiveness to environmental changes. It also shows resilience and can detect damage, making it suitable for various applications in healthcare, wearables, and robots.
Researchers at the Weizmann Institute of Science and Germany's University of Cologne have identified two antibodies produced by vaccinated individuals that provide long-term immunity against Ebola. These antibodies, which target specific sites on the viral glycoprotein, demonstrate effective protection against the virus.
A team of researchers from the University of Vienna has shown that the widespread food estrogen zearalenone migrates through the placenta and is partially converted to other harmful substances. The study found that even small concentrations could have a greater impact on the embryo than previously assumed.
Researchers at Princeton Plasma Physics Laboratory create simulation framework to fine-tune plasma startup recipes for NSTX-U and MAST-U experiments. The tool enables operators to quickly achieve a balance between electric and magnetic fields, significantly reducing experimentation time.
The study found that almost complete immune capacity in the gut had developed as early as 14 weeks, with cells from both innate and adaptive immune systems present. This discovery could lead to the development of new maternal vaccines and a better understanding of the risk of autoimmune diseases.
A new study by Rice University found that freshly appointed CEOs can improve their job security through strategic social interaction. By ingratiating themselves with their predecessors and engaging in self-promotion, new CEOs can mitigate the negative impact of poor stock market reactions and maintain stability.
Family members and caregivers of young children with atopic dermatitis experience mild to moderate severity anxiety and depression, affecting up to 74%. The study found no association between disease severity and anxiety/depression scores, highlighting the need for holistic management of the condition.
A study from Lancaster University and the University of Hagen found that parties with less stake in an issue tend to adopt extreme policy positions when creating election pledges. This is because they are more likely to pander to voters by offering attractive but potentially radical solutions. In contrast, parties with strong interests...
Research found that offspring of obese rat mothers showed impaired mitochondrial function, leading to early signs of diabetes and increased susceptibility to heart disease. Exercise improved these outcomes, suggesting a potential therapeutic benefit.
A new global database, Forest Observation System (FOS), has been established to share on-site forest aboveground biomass data. This initiative aims to link ecological and remote sensing communities and overcome existing data sharing barriers, providing critical input for climate change mitigation policies.
A new AI model uses citation data to predict which research articles will lead to future clinical applications, accelerating biomedical progress. The 'Approximate Potential to Translate' metric can help researchers and decision-makers focus on promising areas of science.
Scientists found that sunlight can break down polystyrene over a much shorter time scale than previously estimated, degrading it in decades to centuries. The researchers' study suggests that the additive content of polystyrene samples affects its degradation rate.