A study published in Journal of the American Academy of Child and Adolescent Psychiatry found that stepwise treatment for pediatric OCD results in excellent long-term stability of treatment gains. Most participants responded well to treatment, with significant improvements in symptoms, psychosocial functioning, and depressive symptoms.
Researchers created a collection of unique songs with manipulated acoustic information, demonstrating the left and right hemispheres handle speech and melody differently. fMRI scans revealed asymmetrical neural activity, with speech content primarily processed in the left auditory cortex and melodic content in the right.
A new phase II trial found a combination of radiation therapy and pembrolizumab to be effective in treating locally advanced head and neck squamous cell carcinoma, particularly for patients ineligible for cisplatin chemotherapy. The treatment showed encouraging survival outcomes and acceptable toxicity.
A recent study published in African Journal of Ecology found that naked mole rats do not disperse according to moon phases. Captured dispersing naked mole rats showed no correlation with full moon or new moon, suggesting cues from the social environment may be triggering this behavior.
Researchers found 31 broad-spectrum antiviral agents that could be used to treat and prevent COVID-19. These existing drugs have already been shown to be safe for human use and may offer a faster alternative to developing new treatments.
A collaborative project led by UCSC aims to develop innovative technology for improving wound healing, funded by up to $16 million from DARPA. The team will use bioelectronic devices, machine learning, and regenerative medicine to control physiological processes involved in wound healing.
Lehigh University MechE professor Hannah Dailey has received a prestigious grant from the National Science Foundation's Faculty Early Career Development (CAREER) Program. Her virtual mechanical test approach holds promise for identifying nonunions, which can lead to depression and opioid abuse, and may enable earlier surgical intervent...
Researchers from the University of Geneva have developed a new technique for tying molecules together, resulting in modified mechanical properties. The method uses fatty molecules that self-assemble into knots without losing material, allowing for analysis of changes in mechanical properties.
Scientists have detected a potential new biomarker for Alzheimer's disease in the Presenilin1 gene, which shows promise for earlier diagnosis and treatment. The study found that changes in DNA methylation of this gene are common in people with Alzheimer's and could be used to monitor environmental triggers and treatment responses.
Researchers found that glacier ice walls block warm seawater, preventing melting and raising global sea levels. The findings provide better tools to predict future water levels and create more accurate climate prognoses.
A study using a cappella recordings revealed that humans have complementary neural systems for speech and music processing. The research found that temporal information is crucial for speech perception, while spectral information is key to music perception. This suggests that hemispheric specialization may be the nervous system's way o...
A new study from the University of Gothenburg shows that structured and preventive care can significantly reduce the risk of recurrent fractures. The study found that patients who received fracture liaison services had an 18% lower risk of having another fracture compared to those without these services. This reduction in risk was attr...
A new Penn study found that imaging techniques, such as MRI, may help identify which glioblastoma patients are best candidates for liquid biopsies. The research showed a correlation between the blood-brain barrier and macrophage density with circulating DNA levels, suggesting the potential for personalized treatment decisions.
A preliminary study by the American Academy of Neurology found that children and teens with epilepsy who were treated with pharmaceutical cannabidiol (CBD) had better seizure control compared to those treated with artisanal CBD. Pharmaceutical CBD was found to have a 39% reduction in seizures, while artisanal CBD resulted in a 70% incr...
A new study by Michigan State University quantifies soil and landscape features and spatial and temporal yield variations in response to climate variability. The research identifies areas within individual fields where yield is unstable, with over one-quarter of corn and soybean cropland in the Midwest experiencing this issue.
Researchers at Hubrecht Institute and Princess Máxima Center found that Escherichia coli bacteria induce unique DNA mutations in human cells, similar to those found in colon cancer patients. The study establishes a direct link between the microbes inhabiting our bodies and genetic alterations that drive cancer development.
Research finds poor connectivity between brain hubs rather than specific regions causes learning difficulties. Children with well-connected hubs have either specific cognitive difficulties or none at all, while poorly connected hubs lead to widespread and severe problems.
Researchers found unique DNA damage patterns in cells lining the gut and bowel cancer tumours, linked to a specific strain of E. coli toxin colibactin. The discovery could enable early detection and prevention of bowel cancer through targeted screening tests.
A new manuscript by Dr. Robert Spengler suggests that all earliest traits of plant domestication are linked to a mutualistic relationship in which plants recruited humans for seed dispersal. This concept, known as seed-dispersal-based evolution, explains why the first traits of domestication in crops were similar across different species.
A new technology developed at Purdue University has shown promise in treating obesity and diabetes by converting bad fat into good fat. The Adipo Therapeutics team is seeking additional funding to further develop their technology and submit it to the FDA.
Researchers developed nanoparticles containing gliadin to treat celiac disease by restoring immune tolerance. In mouse models, these nanoparticles reduced inflammation and tissue damage, inducing gene expression profiles associated with immune tolerance.
Chemists at St Petersburg State University have developed a new method to detect phenols in smoked food samples using vitamin B4, a non-toxic compound. This technique offers advantages such as safety and speed, allowing for analysis to be completed in under half an hour.
A new study led by NYU College of Dentistry researchers found that vaping alters the oral microbiome, making users more prone to inflammation and infection. E-cigarette users were found to have different bacteria in their mouths compared to smokers and non-smokers.
Research at Georgetown University Medical Center found that nicotine increases craving for benzodiazepines, known as benzos, in rats, leading to increased consumption. Boosting a specific protein KCC2 appears to restore normal brain function and decrease benzo consumption.
Researchers at Osaka University discovered that the tadpole-like tunicate Oikopleura dioica uses calcium ion oscillation and right-sided Bmp gene expression to develop left-right asymmetry. Notably, the species lacks the Nodal gene found in other chordates.
Researchers found that omega-3 fatty acid supplementation reduced capsule formation around implants in mice, possibly due to decreased collagen deposits and inflammation. Further clinical studies are needed to confirm the effectiveness of this treatment for preventing capsular contracture in humans.
Researchers developed a nanoparticle delivery method that tags implanted human cancer cells with molecular signals, making them visible to the immune system. The treatment showed promise in mice with melanoma and colon cancer, with some surviving up to 60 days without tumor growth.
Researchers at KAUST found that Middle East dust has a positive cooling effect on the land and Red Sea, with the largest radiative cooling effect in the world. This discovery highlights the complex role of dust aerosols in shaping global climate patterns.
Researchers at the University of Melbourne discovered striking differences in male and female immune systems that may explain why men are more susceptible to obesity. The study found a novel type of stromal cell that communicates with Treg cells and is specific to males, leading to a sex-specific chain of events.
For most people, moderate to vigorous physical activity is beneficial to overall cardiovascular health. However, intense exercise programs like marathons and triathlons can raise the risk of sudden cardiac arrest, atrial fibrillation, or heart attacks, particularly in inactive individuals with known or undiagnosed heart disease.
A new study published in Science Advances shows that freshwater flowing into the North Pacific Ocean triggered widespread changes throughout the northern hemisphere during the last ice age. The researchers used computer modeling and fossil records to track the movement of floodwaters, which mixed with saltwater and altered ocean circul...
Mount Sinai physicians analyzed chest CT scans of Chinese COVID-19 patients, identifying specific patterns in lung disease as it develops over a week and a half. The study could lead to quicker diagnosis and prompt isolation in early stages.
A research team, led by Caroline Krejci, is developing a framework to analyze food, energy, and water systems in the Des Moines area. The project aims to test the impact of different policies on farmer and consumer decisions, with the goal of promoting sustainable cities.
New research challenges traditional models of community ecology, suggesting that mutualism is compatible with stable communities. The balance of mutualism with other types of interactions plays a determinative role in community dynamics and stability.
Physicists have induced and measured nonsymmetrical states in a layered material using circularly polarized mid-infrared light. This phenomenon, known as chirality, can be controlled and enhanced by shining the light beam at specific conditions, demonstrating a new tool for manipulating electronic behavior in materials.
Researchers develop a new health tracking sensor that can monitor vital signs like heart and breathing rates through fur or up to four layers of clothing. The sensor could help owners track their pets' health and improve the work of sniffer dogs used to detect bombs and missing persons.
Researchers characterized the strong nuclear force at extremely short distances, revealing a surprising transition that challenges current understanding. The findings have huge implications for neutron stars and nuclear systems as a whole.
Researchers created a map of molecules in mouse organs, revealing that microbes control bile acid structure. This modification changes how cells communicate and genes are expressed, potentially affecting disease development. Novel microbial-modified bile acids were found in up to 25% of human samples.
Researchers found that patients with rheumatoid arthritis who had adequate folate levels were less likely to die from cardiovascular disease. The study suggests that maintaining optimal folate levels through diet and supplements could help reduce this risk in these patients.
A new ancient DNA study reconstructs the genetic history of Mediterranean islands, showing complex patterns of immigration and trade. The research reveals distinct ancestry profiles for Sicily, Sardinia and the Balearic Islands, tracing migration routes from Africa, Asia and Europe.
A new study reveals that biodiversity increases the efficiency of energy use in grasslands by storing more energy, having greater flow of energy and using energy more efficiently across all trophic levels. Ecosystems with higher plant diversity contain twice as much standing biomass compared to monocultures
In aggressive colorectal cancers, a structural framework called cancer-associated fibroblasts helps tumors evade the immune system by expressing high levels of CD73, an immune checkpoint enzyme. CAFs create a self-serving process that amplifies their own CD73 expression, suppressing immune responses.
Researchers have discovered a molecular pathway that, when silenced, restores immune cells' normal function in people with fatty liver disease. Silencing a microRNA molecule called miR144 increases the endogenous antioxidant response, suggesting a promising therapeutic strategy for treating non-alcoholic steatohepatitis.
Researchers found a stable liquid-gas interface on the Salvinia leaf, enabling drag reduction and anti-corrosion properties. Biomimetic artificial surfaces replicated this effect using 3D printing technology.
The study found that patients whose breast cancer was completely eradicated by chemotherapy had a higher proportion of DNA mutational 'signature 3', indicating defects in DNA repair. This signature is associated with genes like BRCA, which could help doctors predict patient response to neoadjuvant chemotherapy.
A pilot study by researchers at the University of Cincinnati shows that radiation therapy before immunotherapy may increase patient survival for those with brain metastases. The combination therapy was found to be superior to radiation alone, with genes associated with cell death signaling and inflammation present in tissue.
A new study from the University of Bath and Polytechnic University of Milan shows that too much pro-social orientation can be counterproductive on business-focused crowdfunding platforms. Entrepreneurs should strike a moderate balance between social benefits and financial effectiveness to increase funding success.
A new study by KU Leuven and Harvard University found that specific nutrients can inform stem cells which type of cell they should become. Fatty acids signal to stem cells to develop into bone-forming cells when blood vessels are present, while cartilage is formed without them.
A new study reveals that a site in southern Germany's Nordlinger Ries crater may provide insights into Mars' ancient atmosphere. The team used nitrogen isotope ratios to estimate the pH of ancient waters, suggesting high levels of carbon dioxide could have made liquid water possible on the red planet.
Researchers have produced barium titanate ceramics using cold sintering at record low temperatures, achieving high quality without the need for secondary heating. This breakthrough could lead to more efficient manufacturing and reduced environmental impacts.
Researchers at Korea Institute of Energy Research have developed a new separator membrane that significantly reduces gas crossover in water electrolyzers. The membrane exhibits high performance comparable to commercial separators while maintaining low ohmic resistance.
The journal special issue examines how contemporary trends in immigration affect aging populations, with a focus on social ties, filial obligation, and culturally accessible services. Strongest common themes include the importance of social connections for promoting health and well-being.
A recent study found that chest CT imaging has a sensitivity of 98% for detecting COVID-19, compared to RT-PCR's 71%, making it a reliable and practical method for early diagnosis. This is particularly important given the highly contagious nature of the virus.
A recent study from the University of Eastern Finland analyzed data from 1.4 million births and found that quitting smoking during the first trimester reduces low birth weight risk but doesn't fully prevent smaller brain size and body length issues. The study highlights the importance of quitting smoking before pregnancy to minimize lo...
A new study found that widowhood can lead to a sharper cognitive decline in older adults, particularly those with high beta-amyloid levels. This effect was observed even after controlling for other factors such as age, sex, and socioeconomic status.
Research reveals over 8 million to 14 million tonnes of unreported fish catches are traded illicitly annually, costing the legitimate market $9-17 billion. The economic impact is felt heavily in Asia, Africa, and South America, affecting millions' nutritional food security and livelihoods.
A research team led by Dr. Segrey Kasparov has identified a new signaling system in the brain that regulates blood flow, or perfusion, and improves brain function. This discovery opens up new possibilities for regulating blood pressure, particularly in cases where it occurs without an obvious reason.
Researchers evaluated aorta dimensions in older competitive runners and rowers to examine the association between long-term endurance exercise and aorta enlargement. The study found a significant positive correlation between years of endurance exercise and aortic diameter.
A study reveals that the unique architecture of the lip of the suction disc, featuring vertically oriented collagen fibers, provides elasticity for maximizing contact with substrates and maintains adhesive force. The discovery could lead to improved biomimetic suckers with enhanced functionality.
New research from Penn Medicine suggests blocking the Wnt pathway can make chemotherapy more effective against glioblastoma. The study found that targeting stromal cells, which act like stem cells and promote tumor growth, may be an effective way to overcome treatment resistance.