A recent study from Scripps Research found that proof-of-concept HIV vaccines generate off-target antibodies that degrade the vaccine's payload, hindering protection. The research provides critical insights for improving HIV subunit trimer vaccines and offers a promising avenue for design improvements.
Researchers have identified a recurring trend of elevated blood glucose levels among those with severe Covid-19, which impairs lung immune defense and facilitates cytokine storm. Tight control and management of glycemia may be crucial for better outcomes, and metformin shows potential as a treatment option.
The World Health Organization has fired 500 staff on the polio programme, potentially ending a multibillion-dollar crusade. Despite reducing cases by 99.99%, polio efforts have been stagnant for years, raising questions about the effectiveness of funding and integration with routine immunization services.
Researchers analyzed data from Kīlauea's caldera collapse to characterize friction at a large scale. The study confirms the role of slip-weakening distance in earthquake mechanics and provides insights into the physics governing caldera collapses.
A new study finds that youth-onset type 2 diabetes increases the risk of developing serious complications by young adulthood. Within 15 years of diagnosis, nearly a third of participants had two or more complications, including heart disease, kidney disease, and eye disease.
Researchers at Children's Hospital of Philadelphia have developed a system that can fine-tune protein expression from gene therapy vectors, addressing the need for controlled dosing. The 'dimmer switch' uses alternative RNA splicing and an orally available small molecule to adjust levels of expression up or down as needed.
A survey of hospital employees in Switzerland found that self-protection is the main motivation for wearing masks, while younger employees also prioritize protecting others due to their perceived risk aversion, according to researchers.
Researchers from Skoltech and their colleagues developed a neural network that can efficiently generate IUPAC names for organic compounds in accordance with the IUPAC nomenclature system. The network, trained using the Transformer architecture, achieved an accuracy of nearly 99%, outperforming traditional rule-based solutions.
Researchers created a new indicator, CPRS, to measure overall cancer risk based on an individual's unique combination of DNA changes. A healthy lifestyle is associated with decreased cancer incidence in people with a high genetic risk.
Researchers at MUSC Health found that children with underlying mental illnesses are more likely to suffer from additional mental disorders after a nonfatal gunshot wound. The study also highlights the importance of addressing mental health needs in children who have suffered firearm-related injuries.
A pilot study from North Carolina State University found that a gene associated with autism spectrum disorder and pain hypersensitivity may decrease itch response. Contactin-associated protein 2 (CNTNAP2) is expressed in sensory neurons responsible for transmitting sensations of both pain and itch.
Scientists have found evidence of hydrohematite, an iron oxide mineral containing water, in Martian rocks. This discovery suggests that Mars may have once had a watery environment and could hold a significant water reserve.
A study published in Nature Communications suggests that a county's moral values, particularly binding values, can predict the prevalence of hate groups and extreme behavioral expressions of prejudice. The research used geospatial modeling and psychological experimentation to analyze data from over 3,100 US counties.
Researchers found that cardiometabolic abnormality, such as hypertension and high cholesterol, were more strongly associated with cognitive function and decline than obesity alone. Individuals with obesity and cardiometabolic abnormality had lower performance results on testing and greater cognitive decline.
Researchers at Princeton University and GFDL found that the Earth's energy balance sheet is out of equilibrium, leading to rising temperatures and extreme weather events. The study suggests that human activities are responsible for the observed changes in the energy imbalance.
The poor are unlikely to obey strict lockdowns due to lack of nutrition, economic opportunities, and infrastructure. African policymakers need to prioritize social and economic measures over stringent lockdowns to slow the spread of COVID-19 and future pandemics.
A Yale study finds that pandemic-induced paranoia was particularly acute in states with low mask mandate adherence and increased acceptance of conspiracy theories. Increased feelings of paranoia were associated with erratic choice behavior and a higher likelihood of endorsing conspiracy theories.
Researchers produce aqueous solution with metallic properties for the first time by dropping a tiny droplet of liquid alkali metal alloy into water. The resulting 'metallic water' exhibits characteristic spectroscopic properties, including a golden glow and conduction band.
Researchers have discovered a new paradigm in superconductivity, where the 'strange metal' phase plays a crucial role in understanding high-temperature superconductivity. The study found that exotic carriers undergo maximal dissipation in the metallic state, leading to a far cry from the original theory of superconductivity.
Researchers found that levels of REG3G, a natural antimicrobial molecule, fluctuate on a circadian rhythm prompted by resident gut bacteria. This cycling has significant consequences for the ability to fight off infection, with higher bacterial burdens and rates of death when exposed at sunset.
Scientists developed new AI-based tools to identify and study materials exhibiting a metal-insulator transition (MIT), which could lead to faster and more energy-efficient microelectronic devices. The tools provide a freely available database, online classifier, and new features for characterizing these materials.
Researchers at UCF have developed a new nanoscale material that can efficiently split seawater into oxygen and clean energy fuel - hydrogen. The material offers the high performance and stability needed for industrial-scale electrolysis.
Researchers successfully tested gene drive technology to control malaria-carrying mosquitoes in large cages mimicking natural environments. The technology, which spreads a genetic modification blocking female reproduction, worked as expected and showed significant population decline within one year.
A 2 MWel power plant will be built in Saudi Arabia, combining CSP and desalination techniques to achieve unprecedented efficiencies. The DESOLINATION project aims to provide low-cost renewable electricity and fresh water for the GCC region.
The study found that people's willingness to exert effort fluctuates moment by moment but gradually declines over time due to fatigue. Two types of fatigue were detected in distinct parts of the brain, with one short-term and another long-term effect, affecting motivation to work.
Researchers at the University of Texas at Austin have discovered a new method to improve oxygen reduction in fuel cells using iron-based single-atom catalysts. This breakthrough could unlock a level of efficiency never before realized, enabling large-scale deployment of fuel cells and their nearly limitless potential applications.
A multidisciplinary team of scientists developed a method to dispose wastewater safely, reducing the danger of triggering earthquakes. The approach was tested in Italy's largest onshore oil field and found to be sustainable.
The Patient-Centered Outcomes Research Institute (PCORI) has awarded $254 million to fund 28 new research studies aimed at reducing health disparities in maternal morbidity, preventing youth suicide, and improving behavioral health outcomes. Four studies will assess interventions to improve prenatal care for Black women and their child...
A new study suggests that small single-celled organisms may have formed larger multicellular life forms to better navigate icy waters. This shift in size allowed for increased propulsion and access to a wider range of food sources, giving early organisms an ecological advantage.
A recent study found that 25% of cancer patients lacked adequate protective antibodies against measles virus and 38% lacked adequate antibodies against mumps virus. The study suggests that increasing immunity at the community level is crucial to protect vulnerable populations, particularly young adults and stem cell transplant recipients.
Deep Longevity has adapted its blood aging clock to work with saliva samples, improving accuracy from 20.9 years to 4.7 years. The company's solution uses cell-type deconvolution to separate the composition of saliva samples.
A team of researchers has successfully synthesized polycarbonate diols from carbon dioxide and diol at atmospheric pressure using a CeO2 catalyst. This process eliminates the need for dehydrating agents, producing only water as a by-product, making it an attractive alternative to existing methods.
The study aims to compare two interventions: Intensive Tailored Telehealth Management (ITTM) and Intensive Clinic Management (ICM). Researchers hope to answer how to effectively manage blood pressure among stroke survivors and whether telehealth is the most effective strategy.
EPFL researchers have mapped the genetic and developmental trajectories of embryonic cells towards their fate in the maturing brain. They analyzed gene expression profiles from mouse embryos every day from day 7 to birth, revealing diversity in neuronal progenitors and organizer radial glial cells that guide cell development.
A new study found that eating a diet rich in flavonoids may lower the risk of cognitive decline. Flavonoid-rich foods like fruits, vegetables, and spices may have a protective effect on brain health.
A study published in Science Translational Medicine identified a common cellular defect in ALS that can be treated with an antisense oligonucleotide drug. Researchers found that the accumulation of CHMP7 protein in the nucleus leads to nuclear pore injury and TDP-43 mislocalization, ultimately causing cell death.
A study analyzing ancient DNA has uncovered new information on the blood types of Neanderthals and Denisovans. The analysis reveals consistent African origins and increased vulnerability to diseases affecting fetuses and newborns, confirming previous evidence of low genetic diversity leading to eventual demise.
Research suggests cats can help understand human genetic 'dark matter' and aid in precision medicine for genetic diseases like polycystic kidney disease. By studying the cat genome, scientists may uncover new insights into human genetics and develop more targeted treatments.
A new study suggests that dancing can lower cholesterol levels, improve physical fitness and body composition in postmenopausal women. Additionally, dance practice has been shown to enhance self-image and self-esteem, contributing to overall mental health.
Researchers created a 3D view of diseased lung tissue using microCT to reveal that TB granulomas are complex and branched, with unique connections to airways. This has significant implications for treatment, including the potential for aerosolized drug delivery to reduce treatment times.
A new tool helps assess barriers and facilitators to strategic responses, highlighting the impact of COVID-19 on sociological, ecological, and industry domains. The study suggests improving pandemic decision-making through more comprehensive and effective assessments.
Researchers create detailed map of Andromeda's disk, identifying region where new stars are born. The study sheds light on thermal and non-thermal emission components in the galaxy.
Göttingen researchers have developed mini-antibodies that efficiently block the coronavirus SARS-CoV-2 and its new variants. The nanobodies bind and neutralize the virus with extreme stability, making them promising agents to treat COVID-19.
A significant minority of people in Kentucky's indoor public areas fail to wear masks correctly during the pandemic. The study found higher compliance rates in larger stores and affluent city districts. Men aged 40-60 are most likely to be unmasked or incorrectly masked.
Researchers found a steady decline in blood glucose control over 15 years, with certain participants developing multiple complications. Minority groups and those with high blood pressure and dyslipidemia were at higher risk for developing complications.
A new study published in Journal of the American Heart Association found a correlation between high cell-free DNA concentrations and markers of preeclampsia severity. Increasing amounts of circulating cell-free DNA were associated with earlier gestational age at delivery, worse systolic blood pressure, and maternal tissue injury.
Exciton-polaritons exhibit non-linear effects, including Bose-Einstein condensation and polariton lasing without occupation inversion. The study reveals energy-degenerate parametric scattering of polaritons and opens up new avenues for research on multi-level polariton systems.
Researchers use X-rays to activate opsins in neurons, allowing for remote control of neural function and behavior. Scintillators emit visible light in response to X-ray irradiation, enabling the technique without tissue damage.
A new study found that higher testosterone levels are linked to socioeconomic position in men but not women. In contrast, lower testosterone was associated with poorer health and risk-taking behavior in women. The research suggests that testosterone may be less important than previously thought in determining success.
Researchers discovered that double-stranded RNA (dsRNA) is substantially more chemically stable than single-stranded RNA (ssRNA), which has implications for its use in pesticides and understanding of viral behavior. The findings suggest storing dsRNA in high pH environments can provide extra protection against degradation.
A team led by Professor Monique Lacroix at INRS has demonstrated that fermenting drinks fortified with pea and rice proteins yields the same quality of protein as casein. The study found that plant proteins can be predigested by lactic acid bacteria, facilitating their absorption during digestion.
Scientists at Charité - Universitätsmedizin Berlin have identified a crucial communication pathway between peripheral circadian clocks, enabling tissue-level synchrony. Disrupting this pathway can lead to timing disruptions and increase the risk of metabolic disorders.
A new study recommends making methadone more widely available through office-based visits with primary care physicians to improve access and convenience for patients with opioid use disorder. This could reduce transportation costs and enhance treatment retention rates, but further research is needed to confirm its effectiveness.
A new study from Oregon State University found that climate conditions significantly affect the reproductive success of mature female Antarctic krill. The researchers discovered a relationship between the condition of these females during spawning season and the proportion of juvenile krill in the population the following year.
Research reveals that transgender and gender nonbinary adults experience higher rates of subjective cognitive decline, depression, and functional limitations compared to cisgender adults. The findings highlight the need for culturally competent healthcare services to address the unique needs of aging transgender individuals.
Research reveals significant differences in gut microbiomes worldwide, impacting immune responses and susceptibility to infections. The study found that microbial composition alone can impact immune resilience, with Guatemala's microbiome proving most resistant.
Researchers discovered gastric balloons as a cost-effective and health-improving solution for obesity treatment. The procedure, non-invasively placed in the stomach, shows promise as a substitute or complement to bariatric surgery.
A study published in Trends in Genetics reveals that the cat genome is remarkably similar to the human genome, with similarities found even in mice and dogs. This discovery holds promise for understanding genetic diseases in cats and humans, including polycystic kidney disease and hypertrophic cardiomyopathy.
A Cornell University study found no evidence that environmental stresses increase THC concentrations or CBD ratios in hemp. The research suggests genetics play a key role in determining THC content and CBD ratios.
Children of parents who regularly use marijuana may experience more viral respiratory infections than those whose parents do not. The study highlights the potential risks of second-hand marijuana smoke exposure on young children's health and suggests targeting public health messaging to raise awareness about these issues.