About The Study: The findings of this cohort study in Taiwan suggest that positive associations were observed between maternal prenatal acetaminophen prescriptions and offspring’s attention-deficit/hyperactivity disorder (ADHD) or autism spectrum disorders (ASDs) in the full cohort but not in the sibling-matched analyses. A substantial divergence in associations in the sibling bidirectional analyses indicates unaddressed sources of bias and prevents firm conclusions from being drawn using the sibling design.
Corresponding Authors: To contact the corresponding authors, email Pei-Chen Lee, PhD, ( peichenlee@gs.ncku.edu.tw ) and Zeyan Liew, PhD, ( zeyan.liew@yale.edu ).
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(doi:10.1001/jamapediatrics.2026.0071)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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JAMA Pediatrics