Articles tagged with Neurology
A Phase I trial evaluated a novel multi-targeted T-cell therapy for children with deadly brain tumors, offering early evidence that the patient's own immune cells can reach and fight tumors while producing fewer severe side effects. The study suggests a safer and more effective approach for pediatric brain cancers.
Research suggests exposure to extreme heat and cold increases risk of emergency department visits among people with dementia. Extreme temperatures accelerate health events that would otherwise occur later, potentially leading to increased healthcare demand.
A new study finds that multiple sclerosis has a substantial impact on social life and work, with 51% of people reporting an effect. The study highlights the need for comprehensive care addressing not only physical health but also daily functioning, employment, and overall wellbeing.
Research presented at the European Academy of Neurology Congress 2026 found that women with Parkinson's disease had significantly greater amyloid plaque burden and neuritic plaque density compared to men. The study suggests that women may be more susceptible to Alzheimer's-related changes in the brain.
A simple bedside eye test may predict recovery of consciousness in patients with severe brain injuries, according to new research. The late light-off response (LOR) phase of the pupil response predicted improvements in consciousness seven days later.
A young woman's quality of life and ability to walk were restored after a specialized procedure at Semmelweis University. The laparoscopic removal of a rare, benign tumor of neurological origin in the lesser pelvis, known as a schwannoma, was performed using intraoperative electrophysiological monitoring.
American Academy of Neurology appoints A. Gordon Smith as the fifth editor-in-chief of Continuum, a leading continuing medical education journal in neurology. Smith aims to ensure educational innovation and make Continuum an essential resource for the entire neurology care community.
A cohort study found that a dietary pattern with lower inflammatory potential was associated with lower dementia risk among individuals with Alzheimer disease pathology. Targeted dietary strategies may help prevent dementia in those already at elevated risk.
A new study has found that changes in a senior dog's gait can be an early warning sign of dementia. The research tracked the stride length of 88 geriatric dogs over time, revealing a significant decrease in front leg stride length with worsening cognitive decline. This change was found to be more pronounced than age-related decline alone.
A new study predicts that genetic testing for amyotrophic lateral sclerosis (ALS) will lead to a significant increase in clinic visits to specialized ALS centers over the next decade. The study estimates that 2,704 people in the US will have a gene-related form of ALS and 10,944 gene carriers by 2026.
Researchers developed zebrafish model that reproduces key features of CADASIL, a hereditary disease causing brain damage and recurrent strokes. The study found progressive decline in cerebral blood flow and impaired learning ability, similar to human patients.
The new section in JMIR Neurotechnology focuses on the responsible and ethical use of neurotechnology. Submissions welcome for original research, case series, theoretical viewpoints, and data-driven analyses on ethics and policy in neurotechnology.
Researchers at UC Riverside link immune signaling to disrupted brain function and cognition after concussion, finding a crucial link between TLR4 and MMP-9. Blocking these pathways may limit changes in brain circuits and improve long-term neurological outcomes.
Baylor College of Medicine researcher Dr. Jimmy Holder and his team will join the ARIA IMPACT Network to accelerate clinical trial readiness and implementation for promising therapies on autism. The collaboration aims to better understand how autism develops and changes over time in children with profound autism.
A study by the American Academy of Neurology found that fewer than one in four people with stroke and one in seven with traumatic brain injury receive inpatient rehabilitation care after hospitalization. The disparities were particularly pronounced across sex, race, insurance coverage, and income level.
Researchers have made major steps toward solving the mystery of how brain aneurysms form by identifying key cell types and genetic pathways involved. The study's findings provide new insights into a clinical paradox: smaller aneurysms can still rupture, and offer opportunities for early intervention to prevent ruptures.
A study published by the American Academy of Neurology found that high blood pressure may be associated with a lower risk of dementia in people with physical frailty. Researchers compared data from over 6,000 participants and found that those with signs of frailty and elevated blood pressure were 32% less likely to develop dementia.
A new study from Northwestern University developed a customized video game to help chronic stroke survivors regain lost arm function. After six weeks of therapy, participants showed significant improvement in arm function and daily activities, with scores improving up to 7.8 times that of the control group.
Advanced Brain is an open access journal dedicated to publishing cutting-edge research across the brain-mind continuum. The journal aims to foster dialogue across life, medical, and behavioral sciences to accelerate fundamental and applied understanding of the human brain.
A study by the American Academy of Neurology found that people with epilepsy living in rural areas had poorer health outcomes, including higher mortality rates, longer hospital stays, and reduced access to specialized care. The study highlights the need for improved access to epilepsy care in rural areas.
Researchers developed a new reference model for the human brain using diffusion MRI scans from over 54,000 people. The model provides growth charts for white matter neural pathways, helping identify subtle changes linked to aging, Alzheimer's, schizophrenia risk and other neurological conditions.
A groundbreaking study created a world's first pure cerebral microbleed model by targeting brain vascular collagen IV using CRISPR/Cas9 gene editing. The research implicated dysfunctional collagen in tiny brain hemorrhages, which are strongly associated with dementia and cognitive decline.
Researchers have developed a new device called Neuropixels Opto that can record and manipulate neuron activity in the brain. The device, published in Nature Methods, integrates electrophysiology and optogenetics to provide unprecedented insight into neural circuits and neurological conditions such as Alzheimer's disease and schizophrenia.
A blood test can identify signs of Alzheimer's Disease decades before symptoms appear, suggesting early detection and potential treatment. A new brain imaging test also detects Alzheimer's Disease biomarkers earlier than the current standard, improving diagnosis and treatment options.
Neuropsychology researchers have identified a unique brain rhythm in the thalamus that distinguishes between different states of consciousness. The discovery, published in Nature Human Behaviour, reveals a rapid oscillation pattern in the frequency range of 20 to 45 Hertz exclusively during waking hours and REM sleep.
Scientists have created a miniature circuit that mimics the brain and spinal cord connection, showing that previously thought irreversible nerve damage can be reversed. The researchers found that blocking specific genes in mature neurons restored axon regrowth ability.
Researchers found that impaired virtual reality path integration was closely tied to brain structure and biomarkers associated with neurodegeneration. This suggests that VR-based navigation errors may reveal hidden changes in the brain long before symptoms arise, making it a promising behavioral marker for preclinical Alzheimer's disease.
A plasma-based staging model using eMTBR-tau243 and %p-tau217 demonstrated strong concordance with positron emission tomography-based staging and clinical severity of Alzheimer disease. This approach may provide a scalable, minimally invasive method for biological stratification and treatment selection.
A new study has identified a group of blood proteins that can flag multiple sclerosis risk years before diagnosis. Researchers found that these proteins are altered in people who develop MS, potentially leading to early intervention and prevention.
A new study published in JAMA Neurology finds ecopipam to be effective in suppressing tics in patients with Tourette syndrome. The medication was well-tolerated and showed no significant adverse effects over a period of up to 24 weeks.
Researchers have discovered that errors in the final step of cell division can cause dramatic changes in developing brain cells, leading to abnormalities such as multiple nuclei and cilia. The study found that a protein called p53 acts as a guardian of brain development by triggering the self-destruction of abnormal cells.
A case-control study found that amateur-level soccer heading is associated with increased blood biomarkers of neural damage, including dose-response relationships. The findings suggest that even low-impact heading may acutely affect neural integrity.
A long-term study of patients treated with flow diversion devices (FDDs) for intracranial aneurysms revealed excellent safety profiles, with no significant differences in outcomes between various FDD platforms. The study found that multiple FDDs were associated with a higher risk of insufficient closure and delayed complications.
Scientists have identified a new drug target for treating Fragile X syndrome by blocking the EPAC2 brain protein, which improves abnormal brain activity and behavioral symptoms. The study uses genetically engineered mice to simulate the condition and finds that EPAC2 levels rise gradually as the brain matures.
Researchers develop tailored revascularization approach for moyamoya disease, improving circulation while minimizing complications. The technique, called STAPC, uses vessel diameter, blood-flow dynamics, and recipient brain arteries to guide surgical decisions.
Researchers developed multiplexed MRI technology, enabling simultaneous imaging of signals from multiple molecules in the brain. The technology provides a comprehensive view of the brain's structure, physiology, and molecular processes, allowing for more precise diagnosis and individualized treatment planning.
A large population-based study found that children with epilepsy have a significantly higher risk of also having autism spectrum disorder. The study highlighted key differences between children with co-occurring conditions, including intellectual disability and age of diagnosis.
Researchers found significant loss of neurons in the locus coeruleus, a second critical region involved in arousal and muscle tone regulation. This finding suggests an immune-mediated process and challenges the prevailing explanation for narcolepsy with cataplexy.
Scientists found that the brain adapts to noise-induced damage within 24 hours by increasing excitability and inhibitory inputs in the superior paraolivary nucleus. This enables the restoration of critical timing information for sound processing, despite diminished sensitivity to quieter sounds.
Researchers discovered that interictal epileptiform discharges (IEDs) occur in a predictable pattern, unfolding sequentially in individual neurons. Nearly 80% of IED-involving neurons are also involved in language and perception, suggesting the brain blips can derail cognition.
A study found that people with commercial insurance plans waited an average of 50 days for their first neurology appointment. Wait times were affected by factors such as sex, race, neurological condition, and insurance type.
Researchers discovered that strokes cause a chain reaction within the brain, leading to neuronal cell death. They found that blocking collagen production can prevent this damage and even restore motor function in paralyzed monkeys. The new drug KDS12025 reduces hydrogen peroxide levels and prevents the entire process from being triggered.
The EBRAINS Roadmap Symposium will bring together the global neuroscience community to shape the EBRAINS 10-Year-Roadmap. A total of 159 submissions from 134 unique contributors across 25 countries have been received, reflecting the momentum of Europe's digital neuroscience landscape.
A global trial involving 1,670 patients with intracerebral haemorrhage found that treatment with a single pill combination of three low-dose blood pressure medicines reduced the risk of another stroke by 39%. The study showed significant benefits in reducing major cardiovascular events and improving blood pressure control.
A new study found that patients experiencing socioeconomic marginalization are more likely to seek initial concussion care in hospital emergency departments, leading to lower follow-up rates. Patients without family physicians were up to 70% less likely to follow up.
A new study by the American Academy of Neurology found that virtual and in-person visits for new neurology patients have no significant difference in follow-up clinic visits or emergency department hospitalizations. However, some conditions like Parkinson's disease and multiple sclerosis showed a higher need for follow-up evaluations a...
A recent study found that nearly 69% of former professional football players may have sleep apnea, with many cases going undiagnosed. Untreated sleep apnea is linked to worse mental, cognitive, and physical health outcomes among former athletes.
Pediatric low-grade gliomas require distinct treatment strategies, with a focus on molecular diagnosis and age-appropriate treatment. The new Chinese guidelines cover imaging, pathology, surgery, radiotherapy, and systemic therapy, aiming to maximize tumor control while protecting neurodevelopment.
Rosa Rademakers' groundbreaking discovery of the C9orf72 hexanucleotide repeat expansion revealed a common genetic origin for ALS and frontotemporal dementia, transforming how scientists study and diagnose these conditions.
A new study reveals that people with Parkinson's disease have a distinct gut microbiome, as do those at genetic risk but without symptoms. This could lead to early detection and potential prevention strategies.
A retrospective study evaluates morphological irregularity parameters in Gamma Knife treatment planning for vestibular schwannoma patients. The analysis revealed strong correlations between these parameters and treatment plan outcomes, suggesting potential improvements in planning strategies.
A new combined surgical strategy outperforms conventional methods in treating spontaneous supratentorial intracerebral hemorrhage by enabling rapid ICP reduction and efficient hematoma clearance. This approach showed improved outcomes in selected patients, but further studies are needed to validate its efficacy.
NYU Langone Health experts present platform talks on practical strategies to counter medical misinformation, phase 3 X-TOLE2 trial results for novel epilepsy treatment, and exploring healthcare accessibility for patients with disabilities. The Department of Neurology features over 80 presentations from faculty members.
Researchers at the University of Waterloo have discovered a safer and more effective way to treat Alzheimer's disease by combining anti-amyloid antibodies with molecules found in grapes, berries, peanuts, and turmeric. This combination approach neutralizes amyloid protein clumping in the brain, leading to better outcomes.
A secondary analysis of the ANGEL-ASPECT trial found EVT to be beneficial for patients with anterior-circulation LVO and a large ischemic core and absent-to-moderate white matter lesions. In contrast, those with severe WMLs showed less pronounced benefits, suggesting uncertainty about EVT's efficacy in this subgroup.
Researchers at Ohio State University developed the first evidence-based guidelines for traumatic brain injury recognition and management in first responders. The guidelines aim to improve care and support for law enforcement officers, firefighters, and others who risk head injuries on the job.