About The Study: In this multicenter randomized clinical trial among older adults with family history of dementia and/or self-reported subjective cognitive decline, exercise, intensive pharmacological reduction of cardiovascular risk factors, or both did not result in statistically significant differences in improvements in cognitive function over 24 months.
Corresponding Author: To contact the corresponding author, Rong Zhang, PhD, email rongzhang@texashealth.org .
To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/
(doi:10.1001/jamaneurol.2026.0359)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
# # #
Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamaneurology/fullarticle/10.1001/jamaneurol.2026.0359?guestAccessKey=d68dfe57-c1fb-41e0-8fb5-be67d1f15b04&utm_source=for_the_media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=032326
JAMA Neurology