The AFT-70 NAVIGATE trial tests a novel molecular residual disease-guided treatment strategy for ER-positive/HER2-negative breast cancer patients. The trial pairs giredestrant with longitudinal Signatera Genome MRD monitoring to identify patients who may benefit from treatment escalation with a CDK4/6 inhibitor.
Allergen immunotherapy (AIT) is showing promising results in reducing clinical symptoms and severity of allergic diseases, including asthma and allergic rhinitis. The latest advances in AIT include innovative technologies and biomarkers that predict and monitor treatment response.
A phase Ib/II trial evaluated the triple combination of famitinib, dalpiciclib, and fulvestrant in HR+/HER2− breast cancer, meeting initial efficacy targets with a confirmed objective response rate of 51.9%. However, the regimen showed no superiority over standard first-line treatments and was terminated early due to safety concerns.
A randomized trial found that five-treatment stereotactic body radiation therapy (SBRT) provided excellent long-term cancer control and better urinary continence and sexual function compared to surgery. SBRT offered clear advantages for urinary continence and sexual function, with 91% of patients remaining free from biochemical or clin...
Patients with small cell lung cancer and brain metastases lived 17.4 months with radiosurgery, compared to 8.6 months with whole brain treatment. Radiosurgery was associated with a 40% lower risk of death. The study challenges the long-standing reliance on whole brain treatment for SCLC brain metastases.
A randomized phase 2 trial found that five treatments of stereotactic body radiation therapy (SBRT) better preserved physical function and reduced fatigue compared to 28 treatments of conventional radiation therapy with chemotherapy. Rates of cancer remaining in lymph nodes did not differ significantly between the groups.
A phase 3 trial found that delivering focused radiation therapy over three to five sessions after surgery for a large brain metastasis reduced cancer recurrence and improved survival. Patients who received multi-session treatment lived nine months longer than those treated in a single session without significantly increasing side effects.
A systematic review and meta-analysis found that approximately 40% of patients with chronic pancreatitis worldwide develop exocrine pancreatic insufficiency, a condition that can lead to malabsorption, weight loss, and deficiencies in fat-soluble vitamins. Smoking emerged as a significant modifiable risk factor, emphasizing the need fo...
Researchers at Ohio State University are testing psilocybin-assisted therapy to reduce depression and emotional distress in patients with advanced lung cancer. The trial aims to determine whether this approach can address the unique psychological challenges faced by lung cancer patients.
A multi-institutional trial found that ultra-low-dose radiation therapy relieved painful bone lesions from multiple myeloma for most patients, with 81% achieving pain control without additional radiation. Treatment side effects were limited to low-grade fatigue.
Low-dose radiation therapy may slow the progression of knee osteoarthritis, with sustained improvements in pain, physical function, and quality of life. The therapy was associated with a 67% lower adjusted hazard of government-certified disability due to knee osteoarthritis, particularly in patients with grade 2 disease.
A digital therapeutic intervention CT-155 has shown promising results in improving motivation and pleasure negative symptoms of schizophrenia with a small-to-moderate effect size comparable to psychosocial interventions and pharmacologic treatment. CT-155 is a scalable and accessible option for improving schizophrenia negative symptoms.
Studies on hypofractionated postmastectomy radiotherapy, proton therapy for hepatocellular carcinoma, and stereotactic body radiation therapy for Ewing sarcoma showcase improved patient outcomes. The findings also suggest potential benefits for short-course radiation therapy access and patient navigation in cancer centers.
A new tool, INSPECT-SR, has been developed to assess the trustworthiness of randomized controlled trials (RCTs) and identify problematic studies. This tool, which has been endorsed by the Cochrane community, provides a rigorous and transparent method for reviewers to evaluate the integrity of trial data.
A new trial will determine whether chemotherapy provides additional benefit for patients with high anatomic risk but low genomic risk. The RxFINE-Low trial will enroll 2,000 postmenopausal women and men with high anatomic risk breast cancer and low genomic risk, and follow them for up to 10 years.
Virtual reality may help patients with cancer experience less pain and anxiety in the short term, according to a systematic review and meta-analysis. The research found that VR was associated with reduced pain and anxiety in patients, with effects being more consistent among pediatric patients.
Researchers have found that an oral medication called Danegaptide can protect against vision-threatening damage in Non-Proliferative Diabetic Retinopathy (NPDR), a leading cause of blindness in working-age adults. The study highlights a new therapeutic approach that could replace or complement frequent, invasive eye injections for mill...
A randomized clinical trial found that 200-mg/d DNL343 did not slow disease progression in ALS patients, suggesting the need for alternative therapeutic approaches. The study highlights the importance of exploring new treatment options for ALS, a devastating neurological disease.
A new treatment for chagas disease has been found to be safer and more practical with once-daily dosing, reducing side effects by nearly 40% and improving treatment adherence. The 30-day benznidazole regimen is as effective as the standard 60-day treatment and has the potential to increase treatment completion rates.
A 30-day course of benznidazole taken once a day has been shown to significantly reduce side effects and improve treatment adherence for people with chronic chagas disease. The treatment, which is less toxic and easier to follow than the current standard regimen, was found to be non-inferior to the 60-day standard regimen.
A phase 2 clinical trial found that vitamin C supplements reduced the frequency of anemia, pneumonia, and internal bleeding in patients with pre-cancer blood disorders. The study suggests that vitamin C may improve outcomes in these patients, warranting further investigation in a phase 3 trial.
A phase 2 trial found that vitamin C may benefit people with pre-cancer blood disorders by altering inflammatory signaling molecules and reducing adverse events. The study suggests that vitamin C may help regulate inflammatory pathways associated with growth and progression of pre-cancerous blood cells.
A multicenter randomized clinical trial of 370 nulliparous individuals found that intrauterine mepivacaine instillation significantly reduced pain and improved tolerability during IUD placement compared to placebo saline. The study supports mepivacaine instillation as a simple approach to improve the IUD placement experience.
A new AI-powered test, IICM+, has been developed to predict breast cancer recurrence risk more accurately than the widely used 21-gene Recurrence Score. IICM+ uses clinical, molecular, and histopathology data to provide reliable prognostic information, distinguishing between patients at different risks of recurrence.
A clinical trial found that long-acting antibodies can suppress HIV for months and even years, with participants' natural immune response working alongside the treatment. The discovery could bring an end to lifelong daily medication for HIV patients.
Young people with HIV who receive injections every eight weeks manage their condition better than those taking daily tablets, according to a study published in The Lancet. The injections suppressed the virus more effectively, with only 1% of participants experiencing viral rebound, compared to 6% on daily tablets.
Researchers identified a distinct risk profile for young adults with early-onset fatty liver disease, associated with genetic factors and metabolic conditions like type 2 diabetes. The study highlights the need for more accurate liver screening and assessment for individuals at greatest risk.
Researchers propose using carefully designed combinations of approved drugs to create a more convincing placebo, limiting participant disclosure, and rigorous testing to ensure effective masking. This approach, called UMBRAA, aims to overcome the challenge of distinguishing between psychedelic effects and the power of expectation.
The use of azithromycin for emergency c-sections significantly increased after trial results publication, with a corresponding decrease in postpartum infection rates. Postpartum infection rates declined from 9.2% to 8.0%, a 20% relative risk reduction.
Researchers at Texas Tech University Health Sciences Center are conducting a clinical trial to examine the potential benefits of pecans on brain health in older adults with mild cognitive impairment. The study aims to investigate whether daily consumption of pecans can delay or mitigate mild cognitive symptoms and improve brain health.
A randomized trial found that brain MRI surveillance alone preserves cognitive function without a difference in survival, supporting MRI surveillance as the standard of care for patients with small cell lung cancer. No apparent difference was observed in overall survival and progression-free survival between the groups.
Child cancer groups are urging a concerted effort to tackle pediatric sarcomas, a rare and aggressive form of childhood cancer. The groups propose three key priorities to improve collaboration, data sharing, and clinical infrastructure to translate discoveries into effective treatments.
The study confirms the durability of benefit for pembrolizumab plus chemotherapy as a first-line standard-of-care option for recurrent and metastatic cervical cancer. This treatment regimen has been shown to provide a significant advantage over traditional chemotherapy in patients with this type of cancer.
A first-in-human study at UCI Health uses laser light to target and destroy pancreatic tumors, showing a high success rate in patients with localized cancer. The treatment, known as vascular targeted photodynamic therapy, uses a light-sensitive drug to break down the tumor's network of blood vessels, ultimately destroying the tumor.
SourceUCI Health·JournalJournal of Vascular and Interventional Radiology·TypeRandomized controlled/clinical trial·DateSep 10, 2026
Researchers at USC developed an algorithmic tool to improve screening of patients for Alzheimer's clinical trials, reducing unnecessary PET scans by over half. The tool uses blood plasma biomarkers to identify patients at risk of Alzheimer's disease, enabling faster and more efficient recruitment for trials like AHEAD 3-45.
A Phase 3 clinical trial showed tozorakimab reduced moderate-to-severe COPD exacerbations by 29-34% compared to placebo, impacting a broad COPD population. The therapy's safety profile was generally comparable to placebo, with injection-site reactions being more frequent.
A clinical trial shows that laughter therapy can reduce breathing difficulties and is as effective as traditional breathing exercises in COPD patients. Patients who underwent laughter therapy had less difficulty breathing and better overall health compared to those who received traditional breathing exercises or no treatment.
The Starr Healthspan Innovation Alliance will bridge the gap between scientific discovery and life-changing treatments for age-related diseases. The partnership will expand clinical trials and support groundbreaking laboratory research to extend healthy lifespan.
Lurie Children's hospital is launching a clinical trial for a new radiation therapy that spares healthy tissue, offering hope to children with brain tumors. The trial will use a novel technology to deliver higher doses of radiation while minimizing exposure to surrounding healthy tissue.
A phase 2 clinical trial found that a less-intensive combination of azacitidine and venetoclax was more effective in treating acute myeloid leukemia, with patients tolerating treatment better and spending less time in the hospital. The combination also led to more patients reaching stem cell transplantation.
A crossover randomized clinical trial found that cannabis edibles impaired simulated driving performance at blood THC concentrations below per se thresholds. The study's findings suggest that even low doses of THC can have significant effects on driving ability.
High-risk patients taking evolocumab had a 20% lower risk of death compared to those on placebo, according to a Mass General Brigham study. The study found that intensive LDL-C lowering with evolocumab was associated with lower risk of heart attack and stroke, as well as improved survival in high-risk patients without a prior CV event.
Prostate cancer affects 1 in 8 men, with 60% diagnosed in men 65 and older. Clinical trials like Alliance's help improve early detection and treatment, reducing mortality rates by half since 1993. These trials also explore new treatments and survivorship strategies.
A clinical trial funded by NIH found that PAXLOVID does not improve Long COVID symptoms, but its extended duration did not cause serious side effects. The study recruited 959 patients and monitored symptoms over six months.
A clinical trial found that AZD5462, a new oral medication, was well-tolerated and improved cardiac remodeling and blood flow in patients with heart failure. The results suggest that AZD5462 may be a promising treatment option for patients with chronic heart failure.
A prospective multicenter study found the EAP regimen delivered outstanding mobilization effects, achieving 90.8% optimal mobilization in patients. The regimen showed good clinical tolerability, with most hematological toxicities well managed, and presented a practical alternative to conventional mobilization strategies.
PCORI awards funding for new patient-centered comparative clinical effectiveness research, addressing key healthcare questions and generating evidence for better-informed decisions. The projects will focus on emergency, hospital, and surgical care, as well as mental and behavioral health, to improve health outcomes.
Dr. Georg Aue, a nationally recognized blood cancer expert, has been named the inaugural director of the Stem Cell Transplant and Cellular Therapy Program at UT Health San Antonio. The program aims to increase access to new therapeutic approaches for patients across South Texas, with a focus on clinical excellence, research innovation,...
A new Cochrane map has identified significant gaps in dengue prevention research, with most studies lacking synthesis into reliable reviews that policymakers can use. The map highlights areas such as vaccine implementation, adult mosquito control, and environmental interventions, which require more evidence to inform effective dengue c...
SourceCochrane·JournalCochrane Database of Systematic Reviews·TypeSystematic review·DateAug 23, 2026
The RACER-Knee trial found that robotic-assisted knee replacement surgery resulted in similar patient outcomes as traditional surgery, including recovery, mobility, and pain levels. Despite increased precision, the technology did not translate to improved patient outcomes within the first year after surgery.
The study aimed to determine the proportion of eligible patients consenting to either thyroid lobectomy or total thyroidectomy. It found that 93.5% of patients who would consent to randomization completed the assigned surgery. The results provide valuable insights for targeting enrollment in future multicenter trials.
A meta-analysis of randomized clinical trials found that mindfulness-based cognitive therapy is associated with worsening symptoms of depression. The study examined individual participant data from over 13,000 participants, providing evidence for the potential negative effects of this therapy on depression.
A comparative study of 11,681 US cancer clinical trials reveals that industry-sponsored trials focus on single-agent drug therapies, while federally sponsored trials evaluate nontreatment interventions and rare cancer therapies. The study highlights the differences in trial design and objectives between industry and federal funding.
This randomized clinical trial found spectacle lenses with highly aspherical lenslets reduced myopia progression and axial elongation in children over 24 months. The study supports the use of these lenses as a safe and effective myopia control intervention.
A randomized clinical trial found that preoperative high-dose corticosteroids did not improve major postoperative outcomes in elective digestive cancer surgery. The study suggests that routine use of high-dose corticosteroids in this setting is not justified
A randomized clinical trial found that daily zinc supplementation at 20 mg reduced all-cause infections in children with sickle cell anemia over 6 months compared to placebo. No adverse events were observed in the study, suggesting zinc supplementation may be a useful preventive measure for these children.
A new study suggests that a video game designed to raise teens' awareness of mental health issues can reduce symptoms of depression on par with in-school programs. The game, PlaySmart, was played by 269 students for up to six weeks, with significant reductions in symptoms reported after only six weeks.
A clinical trial found that refrigerated platelets stored for up to 21 days are just as effective as room-temperature platelets in treating bleeding patients. This discovery could extend the lifespan of platelets by nearly 4-fold, reducing waste and improving access to lifesaving therapy.
The RadiCaL study, the first randomized trial of a radiopharmaceutical in kidney cancer, found that adding radium-223 to the standard of care does not improve skeletal event-free survival. Patients who received the combination treatment lived a median of 28.3 months, compared with 19.7 months for those who received cabozantinib alone.
A post hoc analysis of a cluster randomized clinical trial found that the Real-time Prescription Benefit Tool (RTPB) increased fill rates for high-cost medications, especially among patients from low-income communities. However, the tool's recommendations were only made for a small proportion of orders, limiting the study's applicability.