HOUSTON – (June 11, 2026) – Dr. Jimmy Holder, associate professor in pediatrics at Baylor College of Medicine and Principal investigator at the Jan and Dan Duncan Neurological Research Institute at Texas Children’s Hospital, and his team have received a grant for up to $17.25 million from Aligning Research to Impact Autism (ARIA) to become a part of the Innovative Medicine and Precision Approaches to Clinical Trials (IMPACT) Network .
As part of the IMPACT Network, Holder and his team will serve as one of an initial 12 collaborative sites around the world designed to accelerate clinical trial readiness and implementation to find promising therapies for different forms of autism, including both those related to a rare genetic mutation and those without an identified genetic cause.
“The ARIA initiative’s support could not come at a better time, as our understanding of autism has advanced so that we now stand at an exciting precipice, ready to translate that progress into clinical trials and life-changing treatments for patients and families,” said Holder. “Joining the ARIA IMPACT Network will allow Baylor and Texas Children’s Hospital to accelerate our breakthrough work to bring effective therapies to people with autism those with related neurodevelopmental disorders.”
The selection of the Duncan Neurological Research Institute at Texas Children’s and Baylor reflects the organizations’ many years of investment in autism research and clinical care. Since the institute’s creation in 2010, Duncan NRI researchers have discovered or co-discovered the genetic basis of numerous neurological and developmental disorders, including Rett syndrome, an autism spectrum disorder.
An international leader in genetics, neuroscience, and pediatrics with an emphasis on multidisciplinary collaboration, the Duncan NRI is well-positioned to contribute to the ARIA initiative’s scientific discovery. As part of this network, Baylor and Texas Children’s will contribute to a short-term natural history and clinical endpoint study, which aims to better understand how autism and related neurodevelopmental conditions develop and change over time in children with profound autism.
Holder’s own research lab focuses on the SHANK3 and SYNGAP1 genes, which cause severe neurodevelopmental disorders, such as autism spectrum disorders and intellectual disabilities, when mutations occur. By identifying these mutations and the processes they affect, his team is working to find therapeutic targets for these disorders.
ARIA is an initiative that connects emerging research, insights, and promising technologies from across scientific fields with the goal of advancing scientific discovery and creating more therapeutic opportunities for people with profound autism and people on the spectrum.
“The ARIA IMPACT Network was built on the premise that no single institution can generate the scale and quality of evidence this field needs on its own," said Ekemini Riley, PhD, managing director of ARIA. "The team at Texas Children’s Hospital brings the expertise and dedication that make this kind of coordinated science possible, and we are glad to have them as partners in advancing therapeutic opportunities for autistic people and related neurodevelopmental conditions."
Collaborators who will be joining Holder on this project include:
About Texas Children’s Hospital
Texas Children’s, a nonprofit health care organization, is committed to creating a healthier future for children and women throughout the global community by leading in patient care, education and research. Consistently ranked as the best children’s hospital in Texas and among the top in the nation, Texas Children’s has garnered widespread recognition for its expertise and breakthroughs in pediatric and women’s health. The system includes the Texas Children’s Duncan NRI; the Feigin Tower for pediatric research; Texas Children’s Pavilion for Women, a comprehensive obstetrics/gynecology facility focusing on high-risk births; Texas Children’s Hospital West Campus, a community hospital in suburban West Houston; Texas Children’s Hospital The Woodlands, the first hospital devoted to children’s care for communities north of Houston and Texas Children’s Hospital North Austin, the new state-of-the-art facility providing world-class pediatric and maternal care to Austin families. The organization also created Texas Children’s Health Plan, the nation’s first HMO focused on children; Texas Children’s Pediatrics, the largest pediatric primary care network in the country; Texas Children’s Urgent Care clinics that specialize in after-hours care tailored specifically for children; and a global health program that is channeling care to children and women all over the world. Texas Children’s Hospital is affiliated with Baylor College of Medicine. For more information, visit www.texaschildrens.org .