About the Study : In a randomized clinical trial of 100 children younger than 5 years with sickle cell anemia in Uganda, daily zinc supplementation at 20 mg reduced all-cause infections over 6 months compared with placebo. No adverse events requiring discontinuation of the study intervention were observed, although the authors note that multisite trials are needed to validate the findings.
Corresponding Author : Chandy C. John, MD, Ryan White Center for Pediatric Infectious Diseases and Global Health, Indiana University School of Medicine, 705 Riley Hospital Dr, RI5900, Indianapolis, IN 46202 ( chjohn@iu.edu ).
10.1001/jama.2026.14190
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