About the Study : In this randomized clinical trial of elective digestive cancer surgery, a preoperative pulse dose of methylprednisolone did not improve major postoperative outcomes compared with placebo. The findings do not support routine use of high-dose corticosteroids in this setting.
Corresponding Author : Pablo Ortega-Deballon, MD, PhD, Service de Chirurgie Digestive et Cancérologique, Centre Hospitalier Universitaire “François Mitterrand,” 14 Rue Paul Gaffarel, 21079 Dijon Cedex, France ( pablo.ortega-deballon@chu-dijon.fr ).
10.1001/jamasurg.2026.3557
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JAMA Surgery