Articles tagged with Cancer
A novel method for monitoring on-treatment disease burden in high-grade serous ovarian cancer uses tumor-informed breakpoints-spanning ddPCR, detecting superior sensitivity and specificity compared to real-time PCR. The approach may enable sensitive and specific detection of minimal residual disease and early relapse detection.
Researchers engineered supercharged T cells that can recognize and kill prostate cancer cells more effectively. By fine-tuning how they physically interact with tumor cells, the T cells form a stronger bond, allowing them to deliver a targeted immune response without damaging healthy tissue.
Public awareness of the link between drinking alcohol and elevated cancer risk has remained unchanged since February 2025, with over half of Americans acknowledging that regular consumption increases cancer risk. The new US dietary guidelines do not mention this link, sparking criticism from health experts.
A Mayo Clinic study shows that delivering chemotherapy at home is safe and feasible, reducing physical, emotional, and financial burdens associated with cancer treatment. Patients experienced fewer disruptions to daily life while maintaining a continuous connection with their care team through virtual visits and remote monitoring.
The Society for Maternal-Fetal Medicine has released the first evidence-based clinical guidance for cancer diagnosis and treatment during pregnancy. The guidance aims to support both maternal health and pregnancy goals, while also prioritizing effective cancer therapy and fetal well-being.
A study led by Dr. Marco Milán identified mitochondria as a key player in a rare disease causing microcephaly, a condition where the brain develops to a smaller size. The researchers found that mitochondria dysfunction leads to proteotoxic stress, causing cells to accumulate errors in chromosome distribution, resulting in microcephaly.
Researchers at the University of Pennsylvania developed lipid nanoparticles that modify immune metabolism to strengthen mRNA vaccines and reduce common side effects. The new lipid boosts the metabolism of immune cells, providing energy for the body's defenses while dialing down inflammatory signals.
Dr. Aliesha O’Raw, Principal Investigator at TIBI and Co-Founder of OnVagus, has been selected for the 2026 ACS BrightEdge Entrepreneurs Program. The program provides mentorship, entrepreneur training, and early-stage investment support to advance cancer diagnostic and therapeutic solutions.
A new clinical trial will investigate whether adding the oral medication vorasidenib to standard chemotherapy improves progression-free survival for people with newly-diagnosed, grade 3 IDH-mutant astrocytoma. The study aims to recruit 400 individuals with this type of brain cancer and evaluate the safety and side-effect profile of the...
A phase 3 clinical trial found romiplostim significantly reduced chemotherapy dose delays and improved platelet counts in patients with gastrointestinal cancers who developed persistent low platelet counts during treatment. The therapy enables patients to maintain chemotherapy intensity, potentially preserving the integrity of cancer c...
Researchers developed a targeted genetic therapy using milk-derived nanoparticles to attack cancer cells while sparing healthy tissue. The approach shows promise in treating aggressive bile duct cancer with limited treatment options.
A novel drug delivery system developed by Osaka Metropolitan University improves Paclitaxel absorption by binding to the lipocalin-type prostaglandin D synthase enzyme, enabling selective delivery to cancer tissues. The system demonstrates significant tumor suppression effects even after administration cessation.
Researchers from Institute of Science Tokyo reveal the SPP1–CD44–Hedgehog signaling pathway as a key driver of fibrosis in liver tumors, hinting at its potential as a therapeutic target. The study provides valuable insights into how liver tumors actively shape their surroundings, driving the onset and progression of fibrosis.
Researchers at UCLA have developed a novel immunotherapy that uses CAR-NKT cell therapy to fight endometrial cancer. The therapy achieved complete tumor elimination and prolonged survival in mouse models, outperforming conventional CAR-T cell therapies.
A new study found that A&E patients with visible blood in their urine who receive a scan within 48 hours are 2.5% less likely to die within three months. The study also showed that patients with cancer are diagnosed significantly faster when they receive prompt investigation.
Researchers compare prostate cancer screening to breast cancer screening, finding similarities in identifying significant cancers and reducing mortality. The study suggests that prostate cancer screening should be reconsidered, offering benefits over harms, and highlights the need for further analysis on costs.
A new study found that bilingual consent forms significantly improve cancer treatment understanding among people with limited English, with understanding rising from 35% to 60%. The study, published in Supportive Care in Cancer, examined the impact of different translation approaches on cancer treatment understanding among Bengali- and...
Researchers at Duke University have developed a technique using microbubbles and ultrasound to deliver large cancer drugs into cells, causing them to self-destruct. The technology, called SonoPIN, shows promise in precisely delivering therapeutics to cancer cells with minimal off-target effects.
Recent discoveries have shed light on gene expression control in tumor growth, revealing the critical role of epigenetic marks and genomic imprinting. The findings have significant implications for cancer treatment, as they suggest that disrupting the tumor's access to neural signaling may halt its growth.
Researchers at Albert Einstein College of Medicine have developed a new strategy to engineer immune cells that prolong their effectiveness, addressing a major limitation of current treatments. The new method generates longer-lasting immune cells that provide more sustained control of human blood cancers and suppression of HIV-infection.
A new study suggests that exercise can improve mental sharpness and reduce cognitive decline in cancer patients undergoing chemotherapy. Researchers found that patients who exercised while on chemotherapy maintained their daily step goals and reported improved mental clarity, while those who did not exercise experienced significant dec...
A preclinical study reveals a new topical cream that activates the skin's immune defenses and suppresses tumor growth in two models of cutaneous squamous cell carcinoma. The cream works by blocking LSD1, an enzyme that suppresses immune-activating pathways in the skin, prompting immune cells to attack tumors.
Researchers at UCSF have discovered a new therapeutic target, SRC, present on up to half of all tumors, which can be targeted with antibody drugs. The enzyme, normally hidden inside cells, is exposed on the surface of tumor cells due to an overactive disposal system, making it an easy target for cancer-killing antibodies.
Recent advances in photonic nanomaterials and healthcare devices have led to the development of wearable and implantable medical devices. These devices utilize light for precise manipulation of cells and tissues, offering new possibilities for early disease detection, light-based therapies, and personalized precision medicine.
The NRG-LU005 trial found that immunotherapy atezolizumab did not improve survival for patients with limited-stage small cell lung cancer when added to chemoradiation. Twice-daily radiation therapy, however, was associated with improved survival in this population.
Scientists have developed a new method to measure the editing process that fuels cancer growth and survival. By analyzing RNA sequencing data, researchers found two distinct cellular editing programs in cancer, one accelerating and the other decelerating tumour growth. This breakthrough may lead to new therapeutic targets and treatment...
Researchers found that a small region of the PRC2 complex, called the SBD, is crucial for its function and can be targeted by cancer inhibitors. The SBD's absence halts the growth of aggressive lymphomas and normalizes gene expression, mimicking the effects of powerful clinical cancer inhibitors.
Researchers developed an experimental therapy to target microscopic precancerous lesions in the pancreas, which nearly doubled survival in mouse models of pancreatic ductal adenocarcinoma. Long-term treatment with the therapy tripled median overall survival time compared to untreated mice.
A new study by UCLA researchers shows that a personalized counseling program, called Motivation and Problem-Solving (MAPS), can help cervical cancer survivors quit smoking, with twice as many women quitting compared to standard support. The program's cost-effectiveness is also demonstrated, with the probability of being cost-effective ...
Researchers identified structural variants as a key driver of childhood cancer, with RAG-mediated recombination found in nearly all subtypes of acute lymphoblastic leukemias. The analysis highlights the importance of structural variants in pediatric blood cancers and provides new insights into the mechanisms driving these diseases.
Researchers developed GluBs to target ASCT2 in aggressive cancers, bypassing the LAT1 route. The agents showed efficacy in limiting tumor growth and demonstrating potential to treat cancers with limited LAT1 expression.
Researchers found that patients who followed an exercise prescription while receiving chemotherapy reported fewer problems with thinking and memory and felt less mentally tired. The study suggests that exercise may help people with cancer stay mentally sharp and better able to handle daily tasks.
The Alliance trial explores the combination of zanubrutinib and sonrotoclax for CLL treatment, aiming to send cancer into remission and allow patients to stop treatment earlier. The study has the potential to be life-changing for patients and their families, reducing the burden of ongoing therapy and improving quality of life.
A large Australian study of over 417,000 women found that fertility treatments were not linked to higher overall cancer rates, but some cancers were slightly more common, while others were less common. Women who received fertility treatment were more likely to develop uterine and ovarian cancer, as well as melanoma, but the overall ris...
A recent survey highlights the importance of Clinical Practice Guidelines in managing rare cancers, with strong overall uptake but inconsistent use for diagnosis and research purposes. High guideline adherence is linked to tangible survival benefits, such as reduced mortality and improved outcomes in various rare tumour types.
Researchers at the University of Gothenburg have identified a protein, ATF4, linked to increased metastasis and recurrence in lung cancer. The study reveals that older individuals' tumors are smaller and grow more slowly, yet more likely to have spread when detected.
Severe COVID-19 and influenza infections can prime the lungs for cancer development, according to new research. Vaccination, however, largely prevents these changes, suggesting a reduced risk of lung cancer.
Researchers discovered yaku'amide B induces CD9 degradation, a cancer stem cell-related protein, in addition to inhibiting ATP synthase, leading to cellular energy depletion and cancer cell suppression. This natural compound has potential as a new therapeutic approach for cancer treatment.
A positive feedback loop between UBE2V1 and HIF-1α drives HCC progression by facilitating tumor growth and metastasis. UBE2V1 promotes HCC progression by competing with HIF-1α for VHL protein binding, leading to sustained HIF-1α stabilization.
A new study found that MYC amplification in metastatic prostate cancer is associated with reduced tumor immunogenicity, making it harder for the immune system to detect and attack the tumor. This reduction in immunogenicity was linked to poorer progression-free survival outcomes in patients with MYC-amplified tumors.
Patients with type 2 diabetes and brain metastases who used GLP-1 receptor agonists showed a significant reduction in all-cause mortality. The use of these medications was associated with reduced neuroinflammation, preservation of the blood-brain barrier, and lowered oxidative stress and mitochondrial dysfunction.
Researchers will investigate how a common dietary nutrient controls a hidden layer of gene regulation in cancer cells. The study aims to understand how changes in RNA modifications and methionine availability impact cancer cell behavior, with potential therapeutic implications.
A population-level cohort study of 20 low-mortality countries found that females aged 35-60 have higher cancer mortality rates than males, despite similar treatment and diagnostic pathways. The study highlights the need for targeted action to improve the prevention, early detection, and treatment of female reproductive cancers.
Researchers found that depleting fibrinogen, a clotting protein, slows down pancreatic cancer by shrinking tumors and reducing liver metastasis. Fibrinogen contributes to tumor growth and environment, and its depletion changes tumor cells to alter behavior and aggressiveness.
Researchers have developed a novel approach to fight colorectal cancer using modified Listeria bacteria as a courier to deliver potent cancer-killing proteins into tumor cells. This method has shown significant anti-tumor activity and could potentially lead to the development of a safe and effective oral treatment.
Singapore's breast cancer incidence is rising, but mortality rates are falling, mirroring global trends. The country's strong healthcare system and high-screening participation have contributed to improved survival rates.
The Alliance for Clinical Trials in Oncology is spotlighting new trials for colorectal cancer in March, focusing on early detection methods and treatments for treatment delays and loss of appetite. The trials aim to improve patient outcomes, with several enrolling patients with newly diagnosed colon or rectal cancer.
Peter WT Pisters, MD, receives the prestigious Charles M. Balch, MD, Distinguished Service Award for his substantial contributions to surgical oncology through service, research, and leadership. He is recognized as a renowned cancer surgeon, researcher, and hospital administrator.
Researchers discover enzyme ANKIB1 crucial for innate immune signalling, driving type I and type III interferon induction. This finding solves a long-standing puzzle in innate immunity and provides opportunities for new therapies for devastating diseases.
A study published in Nature Communications reveals that human DNA is crowded with metabolic enzymes, which interact with DNA and play a crucial role in cancer cell growth and response to treatment. The unique pattern of enzymes differs by cancer type and tissue, providing new clues for understanding cancer biology.
A new clinical study aims to improve communication between patients and families about genetic risks of colorectal cancer. The trial will compare two methods of sharing genetic test results with close relatives, with the goal of learning which approach helps more family members get necessary genetic testing.
A study found that only 9% of older adults with advanced cancer prioritize extending survival over maintaining quality of life. The lack of responsiveness of the current oncology care delivery system to patient preference may be a significant issue. This highlights the need for care system changes to prioritize patient needs.
Researchers from Dresden University Medicine developed a new treatment approach for relapsed acute myeloid leukemia (AML), combining standard therapy with the BCL2 inhibitor venetoclax. The innovative combination therapy has shown promising efficacy, increasing remission rates to 75% and improving patients' chances of recovery.
A team led by Paul Bastard aims to discover antibodies that open new avenues for early detection, prevention and treatment of cancer. Ludwig Institute scientists will employ novel protein profiling technologies to capture telltale patterns linking antibody repertoires and disease states.
Researchers from Johns Hopkins Medicine have created the open-source AstroID database to organize and analyze clinical and genetic data from cancer patients. The database allows for the study of multiple tumor types and longitudinal patient experiences, streamlining data collection and analysis.
A team of researchers led by Rice University bioengineer Omid Veiseh is developing a first-of-its-kind regenerative treatment aimed at restoring damaged lymphatic vessels and potentially curing lymphedema. The therapy, called ELIXIR, uses engineered human retinal pigment epithelial cells to rebuild broken lymphatic vessels.
Researchers found that interactions with healthy cells determine a tumor's ability to survive, grow, and progress. The team discovered a 'distress signal' sent by the tumor to nearby fibroblasts creates a supportive micro-environment that shelters the tumor from being cleared.
The novel approach outperforms standard CAR-T cell therapy in preclinical studies using mouse models of glioblastoma and ovarian cancer. Armored CAR-T cells eliminate tumors, reshape the tumor environment, and boost immune-cell activity.
Cancer cell-derived small extracellular vesicles can be excreted into urine, according to researchers who tracked their journey in mouse models. The study reveals that glomerular cells actively transport sEVs across the filtration barrier, supporting their use in emerging urine-based cancer diagnostics.
A team of scientists discovered that the mannose pathway plays a crucial role in regulating cell fate decisions in low glucose environments, particularly in cancer cells. They found that reducing mannose pathway activity led to impaired N-glycan biosynthesis and activated pro-survival signals, which can contribute to cancer progression.