China has more prevalent cases of pancreatic cancer (103,000 vs. 66,000), but lower age-standardized rates, compared to the US. The US has higher age-standardized rates of incidence, mortality, and disability-adjusted life years (DALYs), attributed to high fasting plasma glucose being the leading risk factor
Researchers developed a blood test that distinguishes between women with early-stage breast cancer and healthy women with 95% accuracy. The test also predicts the risk of recurrence after treatment, detecting aggressive cells with distinct epigenetic signatures.
Researchers explore earlier genetic diagnoses, improved cancer diagnostics, and genomic tracking of a deadly mpox outbreak in children. Studies demonstrate the potential to identify inherited conditions years before symptoms appear and improve childhood cancer testing.
A new study published in JNCCN found that comprehensive biomarker testing before treatment for advanced lung cancer was associated with patients living longer. Broad-based genomic sequencing helped identify a wider range of tumor biomarkers, guiding targeted treatment and improving survival outcomes.
Researchers at Linköping University developed an organ-on-chip model of head and neck cancer, demonstrating how tumours interact with surrounding structures and tissues. The model showed that cancer cells respond differently to the ECM material and blood vessels, and that nerves can influence tumour behaviour and pain.
A University of Houston researcher is developing a light-based technology to analyze tiny particles in the blood for molecular signs of liver cancer. The approach aims to detect the disease at its earliest stages and improve treatment options.
Two studies showcase molecular testing advancements in women's health, highlighting improved diagnosis and treatment for infectious diseases and cancer. The research reveals new insights into antimicrobial resistance, cancer recurrence risks, and tumor biology.
Scientists identify chimeric RNA molecules as essential in cellular health and disease, finding they play a wide variety of critical roles in vital cellular processes. Faulty chimeric RNA are often malfunctioning in breast cancer tumors, prompting new cancer treatments targeting specific chimeras.
Sylvester researchers presented findings on multiple myeloma, including biochemical progression, body mass index, and ultra-sensitive detection of systemic minimal residual disease. These studies aimed to improve understanding and treatment of the disease.
Researchers are developing a blood test to detect neuroblastoma via specific genetic changes in minute quantities. The goal is to identify the disease at an early stage and improve treatment options, increasing patients' chances of cure.
Researchers discovered how genetic mutations alter DNA organisation, changing gene activity and promoting cell proliferation in B-cell lymphomas. Disrupting BAF complex function led to CTCF binding, altering DNA folding and gene regulation.
A new tool, ASAP, rapidly and reversibly turns autophagy on and off, confirming suspected targets, revealing new ones, and suggesting a link between protein building and breakdown. ASAP also targets nuclear pore complexes and protein condensates, shedding light on autophagy's role in maintaining cellular health.
Researchers developed a new cancer therapeutic strategy that targets two proteins to improve efficacy and reduce side effects in prostate cancer. The approach demonstrated greater antitumor activity while sparing normal cells, offering a potential more effective treatment strategy.
Pseudogenes contribute to the adaptation of vertebrates to new environments by inactivating genes that are no longer necessary. This process, known as pseudogenization, has been observed in whales, naked mole-rats, and hummingbirds, where it has helped these species thrive in different ecological niches. For example, the loss of the TL...
Researchers used blood samples collected annually to reconstruct the development of acute myeloid leukemia (AML) over decades before diagnosis. In two-thirds of cases, the first cancer-driving mutation occurred before the age of 20, allowing for potential prevention strategies.
Reducing DUSP4 activity slows cancer cell proliferation, but related protein DUSP5 helps compensate and restore cell growth. Adaptive feedback mechanisms limit the therapeutic potential of DUSP4 in treating colorectal cancer.
Researchers at Hoag Memorial Hospital Presbyterian discovered a molecular warning signal in the blood that identifies serous tubal intraepithelial carcinoma, an early precancerous stage of ovarian cancer. The breakthrough may enable detection years earlier, transforming ovarian cancer surveillance and prevention.
The study found that Black children and teenagers have the lowest cancer survival rates, while certain leukemias and bone/soft tissue cancers have improved less than others. Advances in precision diagnostics and immunotherapies have improved survival among young patients, but disparities persist.
Researchers discovered a molecular pathway connecting lncRNA-encoded micropeptides, macrophage polarization, and tumor progression in liver cancer. The study found that the micropeptide CTXND1 suppresses mTORC1 signaling in macrophages, thereby limiting tumor growth.
A study by Fujita Health University found that watching a patient education video about surgery before consultation can reduce uncertainty and shorten doctor–patient discussion. The results showed a 40% reduction in consultation time, and a lower decisional conflict score in the video group.
Tracking hCG levels over time helps clinicians assess disease risk, guide treatment decisions, and detect possible relapse. Regular monitoring also supports early detection and timely intervention, even after treatment.
The study evaluated the combination of enzalutamide and talazoparib in patients with high-tumor-burden metastatic prostate cancer. The results showed that the combination delayed radiographic progression-free survival and reduced the time to PSA progression.
A new review examines the relationship between tumors and the nervous system, suggesting that psychedelics may be able to 'listen' to the system and provide relief from cancer-related symptoms. The review also explores the potential for psychedelics to modulate the immune system and reduce inflammation in cancer patients.
A new study suggests that DNA methylation patterns present at diagnosis could help predict which patients with myelodysplastic syndromes (MDS) will respond to azacitidine, a commonly used treatment. The study found that DNA methylation was more useful than gene activity alone in predicting treatment response, offering a potential path ...
Researchers propose that childhood cancers may spread aggressively by 'shape-shifting' into different cellular states, rather than accumulating genetic mutations. This process may be reversible, and understanding these transitions could lead to new treatment opportunities and potentially predict when cancers are preparing to spread
A new study reveals that participating in cancer clinical trials can cause financial burdens, with median reimbursement of $2,128. The study suggests that reimbursement programs can improve equitable access to and retention in trials, making cancer clinical trials more accessible.
A new treatment approach combining immunotherapy with targeted cancer drug enfortumab vedotin improves survival in patients with muscle-invasive bladder cancer. The treatment reduces the risk of death by 42% and cancer recurrence or progression by 49% in patients unable to receive standard chemotherapy.
Sylvester researchers made significant contributions to various oral presentations at the American Society of Hematology Annual Meeting, including results from phase 2 trials for multiple myeloma and lymphoma treatments. The studies showcased promising efficacy and safety profiles for novel immunotherapies.
Alliance Clinical Trials is advancing early detection, improving treatments, and enhancing survivorship for lung cancer patients. The organization is conducting seven active clinical trials focused on prevention, early detection, treatment, and survivorship.
Researchers discover E2F1's shortcut method to cell division, which can activate genes without physically unpacking DNA, and its potential role in cancer growth and development. The study's findings may lead to more precise and targeted treatments for cancer by understanding the mechanisms that drive cell proliferation.
Researchers have discovered how reprogrammed cancer cells can promote the formation of immune cells clusters that help coordinate the immune response, leading to better treatment outcomes for patients. The study's findings suggest that cell reprogramming could become a way to make tumors more responsive to immunotherapy.
A randomized controlled trial found that Tai Chi Qigong and an exercise class improved sleep quality in older male cancer survivors, with no significant difference between the two. While the changes were modest, the study suggests that a more diverse range of participants and future studies are needed to confirm the findings.
UT MD Anderson is expanding its cancer care facilities with a $2.5 billion project, adding nearly 2 million square feet of advanced patient care and radiation oncology facilities. The new facilities, Inspiration Tower and Prism, will serve as a benchmark for patient-centered and technology-driven care.
The Ludwig Institute and Keystone Symposia co-sponsor a meeting on cancer metabolism, focusing on the interactions between tumor and host metabolism. The event will explore how cancers exploit and engineer metabolic processes to support growth and resistance to therapy.
Simple automated text reminders and personalized telephone support increased bowel cancer screening uptake among non-responders in London, with 6.5% of initial non-responders completing their test kits. The interventions detected an additional 50 extra cancers annually, bridging the eight-percentage-point gap with the national average.
A new NIH study finds a higher incidence of estrogen receptor-negative breast cancer in women with higher blood plasma levels of PFAS, including PFOA and PFOS. The study suggests that these 'forever chemicals' may affect cancer risk through non-hormonal biologic pathways.
Researchers from Adelaide University have found a DNA switch that helps the body stop the growth of the most common form of breast cancer. The switch, known as HRRINT3, acts as an enhancer that helps the androgen receptor restrain cancer cell growth.
The National Comprehensive Cancer Network (NCCN) has signed an agreement with the Viet Nam National Cancer Hospital to expand cancer care resources in Vietnam. The collaboration aims to improve cancer care through the adaptation and use of evidence-based clinical practice guidelines.
A new study from UCLA found that most breast cancer recurrences after double mastectomy were detected through symptoms or clinical concerns, rather than routine screening. The study suggests that routine imaging may offer limited benefit for women with no symptoms after surgery.
A new study found associations between coagulation-related genes and lung cancer survival, with varying prognostic significance depending on mutation status and tumor location. The research identified four genes, F2, F5, PROS1, and SERPINC1, which may provide additional information for understanding lung cancer prognosis.
Researchers identified protein DUSP4 that helps maintain cancer-fighting T cells' anti-tumour function, potentially improving CAR-T therapy against colorectal cancer. Lower DUSP4 levels in patients correlate with poorer overall survival.
Researchers will analyze clinical data and tissue samples to investigate the mechanisms of early breast cancer relapse and identify new opportunities to predict and prevent recurrence. The study aims to detect early disseminated cancer cells and develop therapies to eliminate them before the cancer returns.
A Rutgers-led consortium has been awarded a $6.5 million grant to develop next-generation tools for tobacco control policies, improve lung cancer screening, and strengthen survivorship care. The research aims to provide policymakers with accurate tools to evaluate emerging tobacco products and their impact on population health.
Researchers at City of Hope have pioneered a new approach to preventing bloodstream infections in patients undergoing donor stem cell transplants for blood cancers. The therapy, called SER-155, uses 16 carefully selected beneficial bacteria to restore the microbiome and fight harmful pathogens.
JMIR Cancer is calling for research on prostate cancer, focusing on digital health innovations, patient perspectives, and AI advancements. Researchers and patients are encouraged to submit their work on topics such as teleoncology, mobile apps, and personalized treatment planning.
The Alliance for Clinical Trials in Oncology is highlighting eight ongoing clinical trials focused on improving cancer detection, treatment, and survivorship for men's cancers. These trials aim to enhance quality of life and support patients and their loved ones after treatment.
Researchers found genetic changes in childhood leukemia tumors that predict relapse risk and suggest personalized treatment approaches. Subtype-specific mutations were linked to increased relapse risk, with some subtypes showing distinct risk profiles.
Researchers found that immune cells, such as neutrophils and macrophages, create distinct neighborhoods around cancer cells, promoting metastasis. The molecular dialogue between these cells and cancer cells regulates EMT and metastatic dissemination.
Dr. El-Khoueiry is an international leader in liver cancer treatment and clinical trials. He will advance USC Norris' mission to translate scientific discoveries into new cancer prevention, diagnosis, and treatment approaches.
China's contributions to treating chronic hepatitis B focus on identifying patients most likely to benefit from shorter courses of therapy. Emerging treatments like bepirovirsen show promise, but durability and effectiveness remain uncertain.
Researchers at Vanderbilt-Ingram Cancer Center are investigating a novel approach to treating ovarian cancer by targeting proteins that help tumors evade the immune system. The grant supports development of an imaging approach to track treatment effectiveness and potentially identify patients most likely to benefit from treatment.
Researchers develop transdermal bioreactor patch to reprogram patient's own cells to fight disease or repair tissue, with potential applications in melanoma, diabetes, and autoimmune diseases. The technology aims to make advanced cell therapies faster, less costly, and available to more patients.
Researchers developed nanoparticles with a customized dose of cancer antigens that can provoke a strong immune response against tumors. By controlling the density of the antigens, they created a vaccine that prevents the development of colon tumors in mice, paving the way for personalized cancer vaccines.
Researchers have discovered a link between CDK1 protein activity and breast cancer response to CDK4/6 inhibitors. Higher CDK1 activity is associated with more aggressive cancer and poorer outcomes. The study suggests that tracking CDK1 activity could help doctors identify patients most likely to benefit from targeted therapy.
Researchers found that treatment reorganized immune cells and changed the behavior of macrophages, immune cells that can support or suppress an immune response. The study suggests that creating an environment where different immune cells can work together against cancer is crucial for effective immunotherapy.
Researchers found that hyperactive YAP and TAZ proteins increase PD-L2 expression, making cancer cells more recognizable to the immune system while also helping them evade immune attack. This combination may improve outcomes for patients treated with immune checkpoint inhibitors.
This study demonstrates that interleukin-33 alleviates the immunosuppressive tumor microenvironment in hepatocellular carcinoma, activating the STING/IRF axis and increasing functional CD8⁺ T cells. Combining IL-33 with anti-PD-L1 therapy synergistically reduces tumor burden and boosts anti-tumor immunity in vivo.
Fox Chase Cancer Center researchers have identified a potential new target for pancreatic cancer by blocking a protein called ANO6. ANO6 helps pancreatic cancer cells obtain nutrients from surrounding cells while suppressing the immune system's ability to fight tumors.
Eating a healthy diet is associated with reduced risk of heart disease and death among cancer survivors, with some dietary patterns showing stronger protective effects than others. The study found that participants with the highest adherence to a healthy diet increased life expectancy by up to 3.32 years.
A KAIST research team developed an antibody candidate that blocks a signal responsible for appetite suppression and weight loss in cancer cachexia. The candidate restored food intake and reduced muscle and fat loss in mouse experiments, demonstrating therapeutic effects.