Articles tagged with Cancer
Researchers aim to build a cohort of 2,000 AYA cancer survivors in NYC to study the short- and long-term effects of newer cancer treatments. The study will focus on challenges such as fertility and sexual health concerns, as well as financial stress.
The MIT researchers developed a new sensor that can detect biomarkers produced by bladder cancer cells in the bladder, allowing for earlier detection. This approach is nearly 50,000 times more sensitive than traditional urinalysis and can image tumor location in tissue.
Researchers developed a nanofiber drug delivery system that uses electrospun fiber membranes to deliver multiple drugs in concert, demonstrating improved efficacy against glioblastoma. The system enables localized long-term delivery of drugs directly at the tumor site after surgery.
Researchers from Ohio State University Comprehensive Cancer Center present new findings on a hospital program that redistributes unused oral cancer drugs donated by patients. The program helps patients avoid treatment delays caused by insurance issues, shipping problems or cost, and has been shown to reduce drug delays by six days.
Researchers discovered lung cancer cells change identity to resist treatment by reactivating a process involved in early lung development. This could help doctors predict which patients respond well to treatment and provide personalized care.
A comprehensive long-term study has demonstrated the efficacy of molecular blood tests in influencing leukemia course. The study found that early intervention based on molecular markers can have a significant impact on disease progression.
The National Comprehensive Cancer Network (NCCN) has launched a new free service providing weekly email updates on changes to evidence-based guidelines for cancer prevention, screening, treatment, and supportive care. The service aims to keep healthcare providers up-to-date with rapidly evolving evidence-based recommendations.
Research highlights the dual role of eosinophils in cancer, with higher counts associated with reduced risk and improved treatment response to immunotherapy. The immune-activating effects of eosinophils may help predict treatment outcomes and anticipate complications.
A study by Harvard T.H. Chan School of Public Health found that gut microbiome alterations persist even after adenoma removal, increasing the risk of colorectal cancer. The researchers discovered that diet and physical activity were closely tied to CRC-associated gut microbes, suggesting lifestyle habits may contribute to sustained risk.
The American Cancer Society has endorsed two new types of stool tests and recommends limiting the use of blood tests for colorectal cancer screening. The guidelines aim to encourage people to get screened while improving detection rates.
Researchers will present over 30 studies on precision oncology, early cancer detection and AI-powered personalized care. Featured topics include biomarker-driven treatments for bladder and lung cancers, new approaches for triple-negative breast cancer and AI-enabled analysis of tumor microenvironment in colon cancer.
Dr. Sharon Giordano and Dr. Eduardo Vilar-Sanchez receive ASCO Special Awards for their transformative work in breast cancer research and prevention, respectively. Their contributions advance understanding of cancer and improve patient outcomes.
Researchers at UC San Diego have identified a naturally occurring peptide that significantly slows melanoma growth, reduces tumor spread, and restores sensitivity in drug-resistant cells. The findings suggest CST could serve as the foundation for a new class of peptide-based therapies against advanced and therapy-resistant melanoma.
Researchers found that a vitamin D analog reduced fibroblast activation and increased T cell infiltration in pancreatic tumors, improving chemotherapy responses and progression-free survival. Patients with high vitamin D receptor expression also had longer overall survival.
A new AI model, MutationProjector, analyzes tumor DNA to predict immunotherapy and chemotherapy outcomes in various cancers. The model identifies biomarkers associated with treatment responses and provides insights into why predictions are made.
The PERCS initiative aims to develop and test interventions promoting comprehensive survivorship care for adult cancer survivors. Four randomized controlled trials will improve how primary care clinicians deliver survivorship care to over 18 million US cancer survivors.
Researchers found that smaller tetraploid cancer cells are more aggressive and tumorigenic, associated with worse prognosis and lower survival rates in several cancer types. This discovery challenges the conventional understanding of tetraploidy's role in cancer progression.
Researchers discover that kinases play a crucial role in moving cholesterol to activate a growth pathway in aggressive cancers. Without these enzymes, cancer cells are blocked from fueling tumor growth. The study highlights the importance of targeting lipid enzymes as a potential treatment strategy for cancers with TP53 mutations.
The Oncodarwinian Hypothesis proposes cancer as a potential immunoadaptive response, reframing uncontrolled division as an adaptive immune response. AI-based 3D printed p53 superproteins may accelerate tumor suppression and guide cancer treatment.
Researchers identified four distinct mutational clusters in oral cancers lacking traditional risk factors, with two linked to endogenous processes and unique driver gene mutations. The study suggests a potential role of the oral microbiome in tumor development and highlights opportunities for precision medicine approaches.
Researchers identified specific gene fusion patterns linked to more aggressive disease behavior and increased risk of metastasis in solitary fibrous tumors. The study suggests that these molecular differences could serve as potential biomarkers for predicting patient outcomes and guiding treatment decisions.
Researchers from Mass General Brigham Cancer Institute presented various studies on cancer treatments, including the efficacy of lung cancer drug neladalkib and a psychosocial digital app for patients with multiple myeloma. An electronic frailty index was also used to identify high-risk older adults receiving CAR-T cell therapy.
A new study reveals that nitrosylcobalamin, a vitamin B12 analog, selectively crosses the blood-brain barrier and targets glioblastoma tissue, demonstrating broad antitumor activity. The therapy also shows synergistic activity with existing treatments, offering a promising new strategy for treating this deadly brain cancer.
Researchers from Penn Medicine presented findings on the intersection of GLP-1s and breast cancer, gaps in patient-facing information about AI and cancer care, and updates from clinical trials in cancer genetics and CAR T cell therapy for glioblastoma. The studies suggest that GLP-1 usage is associated with a lower risk of breast cance...
Researchers discovered that overproduction of a DNA repair protein creates DNA damage mimicking BRCA mutations, which may respond to targeted treatments. Tumors with high levels of EXO1 protein exhibit characteristics similar to BRCA-mutant cells, suggesting personalized therapies could be effective.
Researchers have discovered that precursor lesions in the pancreas, often considered a step towards cancer, do not undergo malignant transformation if they lack a specific microenvironment. The team used advanced technologies to isolate and analyze single cells from over 150 donated pancreases, finding that the microenvironment surroun...
Researchers at UT MD Anderson Cancer Center have uncovered genetic and cell-state adaptive mechanisms that drive resistance to KRAS inhibitors in patients with KRAS-mutant colorectal cancer. Targeting early inflammatory responses by adding TBK1 blockade may be a promising combination strategy to overcome treatment resistance.
Dropping the cancer label from grade group (GG)1 prostate disease redefines it as a precancerous lesion, leading to a net reduction in estimated prostate cancer deaths. This relabeling strategy may have minimal impact on screening rates.
A new study replicated patient- and sex-specific hallmarks of Inflammatory Bowel Disease (IBD) in a human organ chip, identifying stromal fibroblasts as key drivers of inflammation, fibrosis, and enhanced cancer risk. The model also recapitulated the impact of pregnancy hormones on IBD severity in female patients.
The LUNA-2 trial will pair immunotherapy with fecal microbiota transplantation (FMT) to boost treatment effectiveness in people with non-small cell lung cancer. If successful, it could provide new treatment options for those living with the disease, helping them live longer and with fewer side effects.
Dr. Michele Carbone received the 2026 Szent-Görgyi Prize for his groundbreaking discovery that mesothelioma can be transmitted through families in a Mendelian fashion, driven by inherited mutations in the BAP1 gene. His research has transformed how the disease is understood, diagnosed, treated and prevented worldwide.
The University of Texas MD Anderson Cancer Center has been awarded $19 million by CPRIT to support young cancer survivors, groundbreaking research, and faculty recruitment programs. The funding will enable UT MD Anderson to recruit world-class scientists and clinicians, pursue new discoveries, and accelerate cancer treatment advancements.
A Kaiser Permanente study found that HPV self-collection increased cervical cancer screening completion by 2.2% among over 95,000 members, with higher gains in diverse populations. The program also reduced clinician-performed pelvic exams and improved follow-up for high-risk HPV results.
The National Comprehensive Cancer Network has launched a new version of its Distress Thermometer and Problem List in over 70 languages to screen patients for mental, physical, social, or spiritual distress. The tool aims to enhance cancer care by identifying psychological distress and providing support.
Researchers found that increasing ADAR2 expression in osteosarcoma cells forces them to differentiate, slowing growth and invasive capacity. The treated cells began producing mineralized matrix, a hallmark of mature bone tissue. In mice, ADAR2-restored tumors were smaller and less invasive.
Researchers have discovered that errors in the final step of cell division can cause dramatic changes in developing brain cells, leading to abnormalities such as multiple nuclei and cilia. The study found that a protein called p53 acts as a guardian of brain development by triggering the self-destruction of abnormal cells.
Researchers at the Francis Crick Institute have developed a new method to enhance anti-cancer immunity by redirecting non-specialized immune cells to present a broader range of tumor antigens. This approach, leveraging understanding of dendritic cell biology, has shown promise in reducing tumour growth and amplifying responses in mice.
Researchers from Harrington Discovery Institute provide a new understanding of cancer processes and identify promising targets for treatments. They uncover a class of therapeutic targets that may complement existing therapies.
A new study found that switching to a nicotine e-cigarette reduces toxicant exposure and improves quitting rates, with the nicotine group having a higher chance of quitting entirely. The study's results suggest that nicotine e-cigarettes could serve as an effective off-ramp for smokers seeking to reduce their tobacco use.
Dr. Sandra Orsulic has received two federal awards totaling nearly $2 million to advance research aimed at improving outcomes for women with ovarian cancer. Her team will examine the body's inflammatory response after surgery and develop AI-powered tools to guide personalized treatment.
A systematic review of AI models for meningioma segmentation reveals that better model architecture is the key driver of improved performance. The top models achieved high accuracy and efficiency, while future research focuses on making them more generalizable and efficient for real-world clinical settings.
Researchers have created a new molecule that stabilizes gold nanoparticles, preserving their shape and enhancing photothermal therapy's effectiveness. This breakthrough aims to control the function of these particles during medical treatments like cancer therapy.
Researchers found that a common asthma drug can help fight aggressive cancers by blocking the CysLTR1 molecule. The study used mouse models and human tissue samples to demonstrate its potential in treating triple-negative breast cancer and other tough tumors.
A new study found that chemotherapy can unintentionally reshape the immune system, allowing cancer to persist. Researchers discovered that a standard chemotherapy triggers pyroptosis, releasing inflammatory signals that inhibit tumor treatment.
A study published by the European Society for Radiotherapy and Oncology found that delivering radiotherapy in just two sessions over eight days is safe and effective for treating prostate cancer. The treatment had no additional side effects compared to the standard five doses, making it a convenient option for patients.
Researchers found that stereotactic body radiotherapy (SBRT) improved progression-free survival by 15.6 months, compared to 20.6 months without targeted therapy. The treatment also showed no significant impact on quality-of-life measures.
A team of Rice University bioengineers has developed a new way to create highly realistic mock patient samples that could help accelerate the development of faster and more accessible cervical cancer screening tests. The approach combines multiple factors, including viral DNA levels and cell counts, to mimic real clinical specimens.