Research on cancer as a disease, from cause to care. Covers tumor biology, small-cell lung cancer, cancer-linked stroke risk, and cancer center research.
A new study finds that high fasting glucose has surpassed tobacco use as the leading risk factor for pancreatic cancer in the US, while China faces a dual metabolic-tobacco burden. China recorded more absolute cases, but lower age-standardized rates, with a peak burden at ages 60-74.
A multidisciplinary approach is crucial for treating recurrent prostate cancer, combining advanced imaging, radiation, and systemic therapies to address microscopic disease. The case report follows Larry Hardesty, who underwent several clinical trials, including PSMA-targeted radioligand therapy, leading to undetectable PSA levels and ...
A study has identified a molecular pathway controlling TFEB activity, revealing new druggable targets for therapies in rare genetic diseases, cancer, and disorders linked to lysosomal dysfunction. Lysosomal stress triggers TFEB activation, which boosts cellular recycling and adapts to stress.
KRAS-driven cancer is a complex disease with multiple layers of post-translational control, including membrane localization, stability, activity, and signaling output. Post-translational modifications of KRAS offer new therapeutic opportunities by targeting PTM enzymes and modification-dependent regulatory networks.
A study by McGill researchers found that certain diets associated with obesity improve cancer treatment responses, suggesting a complex relationship between diet, gut microbiome, and the immune system. The findings aim to improve cancer treatment success by understanding the synergistic effect of diet and gut bacteria.
Researchers found distinct gut microbiome patterns in adults 50 or younger with colorectal and breast cancers compared to those diagnosed later in life. The study identified broad microbiome differences between cancer patients and healthy individuals, and pinpointed specific bacterial species associated with five cancer groups.
Extracellular vesicles (EVs) are key players in the pathogenesis of chronic lung diseases, modulating cellular senescence and immune-inflammatory responses. EVs facilitate aberrant intercellular communication, deliver pathogenic miRNAs and proteins, and promote chronic inflammation.
Bile genome sequencing detected tumour DNA in 73% of patients with initial pathological diagnosis of malignancy, including 82% of cholangiocarcinomas and 56% of pancreatic ductal adenocarcinomas. The test showed high specificity, identifying 96% of benign cases and 51% of initially indeterminate cases, outperforming serum CA19-9.
Researchers found implanting collagen tiles during brain surgery to deliver targeted radiation therapy improves tumor control, lowers recurrence risk, and increases overall survival. Patients treated with tile-based radiation therapy had a 1.3% rate of recurrence at the surgical site compared to 15.4% in the control group.
The new company will provide integrated advisory and lifecycle support services to help healthcare organizations develop and sustain successful proton therapy programs. Penn Medicine and IBA will combine their expertise to create a unique platform for delivering exceptional care to patients and building sustainable oncology programs.
A Phase III trial found that delivering focused radiation therapy over three to five sessions after surgery for a large brain metastasis reduced cancer recurrence at the surgical site. Fractionated stereotactic radiosurgery also showed a trend in controlling brain metastases that had not been removed surgically. Median overall survival...
A new study from the Max Planck Institute for the Science of Light reveals that physical processes in growing tumors and microbial biofilms play a crucial role in determining the optimal timing of treatment cycles. The researchers used a 'Real-To-Sim-To-Real' approach, combining microbial model systems and computer simulations, to show...
Mount Sinai researchers collaborate with Johnson & Johnson to evaluate a liquid radioembolic agent for treating brain tumors. The agent combines radiation delivery and embolization to target tumors, offering a new approach for managing difficult-to-remove tumors.
A phase 3 trial found that delivering focused radiation therapy over three to five sessions after surgery for a large brain metastasis reduced cancer recurrence and improved survival. Patients who received multi-session treatment lived nine months longer than those treated in a single session without significantly increasing side effects.
The UVA Weber Symposium will discuss the latest research and advancements in metastasis, a complex area of cancer research and care. The event will bring together top scientists and physicians to present findings on cancer metastasis, genetics, and treatment considerations.
The human microbiome may influence cancer development, treatment response, and emerging precision-oncology strategies. Dysbiosis, or an imbalance in microbial communities, has been associated with several cancers, while favorable gut microbial profiles may support responses to immune checkpoint inhibitors.
A large Medicare analysis found that depression is associated with higher cancer mortality, while psychotherapy soon after diagnosis reduces cancer risk. Patients with depression had a 21% lower risk of cancer-specific mortality after receiving psychotherapy within four weeks of their diagnosis.
Patients with small cell lung cancer and brain metastases lived 17.4 months with radiosurgery, compared to 8.6 months with whole brain treatment. Radiosurgery was associated with a 40% lower risk of death. The study challenges the long-standing reliance on whole brain treatment for SCLC brain metastases.
A study found that Acceptance and Commitment Therapy Plus (ACT+) helped cancer survivors reconnect with valued living, managing difficult thoughts and emotions through mindfulness practices and activities focused on
A multi-institutional trial found that ultra-low-dose radiation therapy relieved painful bone lesions from multiple myeloma for most patients, with 81% achieving pain control without additional radiation. Treatment side effects were limited to low-grade fatigue.
A large U.S. insurance claims analysis found that fewer than 30% of patients with hormone receptor-positive early-stage breast cancer remained adherent to endocrine therapy for five years after lumpectomy. Younger age and radiation therapy omission were associated with lower adherence rates.
Researchers have developed a laser-powered technology that accelerates antibody-antigen interactions to detect tiny amounts of a colorectal cancer biomarker within minutes. This technology has the potential to improve cancer diagnosis by increasing detection sensitivity and speed.
Studies on hypofractionated postmastectomy radiotherapy, proton therapy for hepatocellular carcinoma, and stereotactic body radiation therapy for Ewing sarcoma showcase improved patient outcomes. The findings also suggest potential benefits for short-course radiation therapy access and patient navigation in cancer centers.
Researchers at UT MD Anderson Cancer Center have made significant breakthroughs in cancer treatment, developing a targeted antibody that improves outcomes for patients with advanced lung cancer who have faced treatment resistance. The treatment, which combines ivonescimab with chemotherapy, has been shown to extend disease control and ...
A matched cohort study of over 30,000 patients found that appendectomy was associated with a 58% lower relative risk of colorectal cancer diagnosis. The exact mechanisms behind this association are unknown, but may be related to earlier detection of an underlying cancer and removal of a source of inflammation.
UCLA researchers present new radiotherapy research for prostate cancer, head and neck cancers, and personalized radiation therapy. A genetic test identifies men with prostate cancer at higher risk of urinary side effects after SBRT, suggesting personalized radiation treatment.
Researchers developed an AI approach to predict glioblastoma recurrence, allowing for targeted treatments before the cancer becomes visible on MRI. The tool uses microscopic images of fresh, unprocessed tissue and scored based on tumor infiltration, with an accuracy of predicting recurrence within 5-10 millimeters of the sampled tissue.
Researchers are exploring biomarker-guided patient selection and combination therapies to overcome glioblastoma's biological barriers. Agents targeting tumor metabolism, immunotherapies, and oncolytic viruses are being investigated.
A Chinese registry report presents real-world perioperative and survival outcomes for surgically treated pancreatic cancer patients, achieving high overall survival rates and encouraging surgical safety metrics. The study emphasizes the need for national-level benchmarks and standardized clinical protocols for pancreatic surgery in China.
Mayo Clinic researchers will present emerging technologies, precision treatments, and new radiation therapy techniques at ASTRO 2026. The meeting highlights include presentations on AI-driven automation in pelvic radiation therapy and novel therapies for glioblastoma.
A UCLA study found that a dietary supplement, Ca-αKG, reduced lung tumor growth in female mice, but increased tumor growth in male mice. The supplement activated genes associated with better outcomes in women with lung cancer, but had the opposite effect in men.
The Momentum conference brings together European cancer research leaders to discuss ways to accelerate the adoption of new cancer research advances and strengthen cross-border collaboration. The event aims to shorten the path from scientific discovery to clinical practice, ultimately benefiting patients sooner.
Researchers at MIT identified a cellular pathway necessary for colorectal cancer metastasis, controlled by protein YAP1, which promotes cell proliferation and migration. A high-fat diet triggers activation of this pathway, and drugs blocking ceramide production may help prevent metastasis.
Researchers at MIT have developed a handheld device to collect living cells from specific locations in patient samples, enabling early cancer detection and personalized medicine development. The device uses a microfluidic channel to gently detach living cells from tissue, allowing for targeted sampling and cultivation for diagnostics a...
Researchers developed an AI model that uses routine chest CT scans to identify patients at risk of pneumonitis, a potentially life-threatening form of lung inflammation. The model, called CIPHER, achieved high predictive power and maintained strong performance despite differences in patient populations and imaging protocols.
The National Comprehensive Cancer Network presents original research abstracts on tailoring cancer care for different regions during the 2026 World Cancer Congress. The research found that 61% of National Cancer Control Plans include references to existing national or international cancer treatment guidelines, highlighting the need for...
Researchers at the University of Maryland Baltimore County have identified USP15 as a promising new target for ovarian cancer treatment, which appears to rely on the enzyme for survival, division, and spread. Reducing USP15 levels makes cancer cells more sensitive to chemotherapy drugs, potentially leading to less harm to healthy cells.
A Phase 1 clinical trial found that an investigational CAR-T therapy, anito-cel, led to high response rates and durable benefits in patients with relapsed/refractory multiple myeloma. Serious side effects were uncommon, and no delayed neurological complications were reported.
Researchers found similar diarrhea outcomes among patients with low and normal fecal elastase levels, suggesting stool dilution is a possible cause. Fecal fat testing is recommended before enzyme therapy to confirm exocrine pancreatic insufficiency.
A new study by Silent Spring Institute identified hundreds of chemicals in pesticide products that may increase breast cancer risk, including inert ingredients that evade safety testing. The study highlights a regulatory blind spot and calls for stronger oversight of pesticide formulations.
Researchers analyzed exhaled breath to distinguish between cancerous and non-cancerous lung nodules, showing substantially better discrimination than standard clinical information alone. The study's findings support earlier lung cancer diagnosis and potentially reduce unnecessary procedures.
Virtual reality may help patients with cancer experience less pain and anxiety in the short term, according to a systematic review and meta-analysis. The research found that VR was associated with reduced pain and anxiety in patients, with effects being more consistent among pediatric patients.
A pharmacist-led medication review improved medication quality in older adults with cancer, with 29.9% fewer patients on potentially inappropriate prescriptions and 34.2% less medication overuse. The review also recommended 337 missing vaccinations.
Researchers at Bar-Ilan University and Weizmann Institute successfully engineered immune cells to recognize and attack cancer and viral targets. The enhanced T cells demonstrated stronger immune responses and greater cancer-killing ability, improving survival in mice.
A new, incisionless liver cancer treatment called histotripsy was associated with low rates of laboratory toxicity and procedural complications in a real-world review of 972 patients. However, the study found that 11% of patients died within 30 days, suggesting that advanced cancer and overall disease burden may be contributing factors.
A nationwide study in Denmark found that cancer incidence is 12% higher among men with type 2 diabetes and 22% higher among women with type 2 diabetes compared to those without diabetes. Obesity-related cancers, such as colorectal and postmenopausal breast cancer, are particularly prevalent among people with type 2 diabetes.
IMS Solutions launches with a £1.1 million Seed round to develop a stratification test for Polyendocrine Metabolic Ovarian Syndrome (PMOS) and a urine test for Adrenocortical Carcinoma (ACC), aiming to improve patient outcomes and reduce costs. The technology platform detects unique steroid signatures in urine and blood, offering a mor...
A large prospective study found that a multicancer blood test identified cancer signals across 17 broad cancer types, including ovarian, lung, and breast cancers. The test correctly predicted cancer diagnoses in 60.3% of cases, with 99.64% specificity.
A phase 2 clinical trial found that vitamin C supplements reduced the frequency of anemia, pneumonia, and internal bleeding in patients with pre-cancer blood disorders. The study suggests that vitamin C may improve outcomes in these patients, warranting further investigation in a phase 3 trial.
Researchers have mapped cellular differences between two similar bowel diseases, identifying hidden immune activity that may explain why one carries a much higher risk of colon cancer. The study found that patients with PSC-associated IBD had a distinct microbiome and higher levels of immune activity even in the absence of inflammation.
Researchers found that the loss of the Y chromosome in healthy-seeming tissue can serve as an early indicator of cancer development. The study analyzed 1,000 tissue samples from 405 men and discovered that Y chromosome loss increased in normal tissue adjacent to tumors, particularly in organs like the colon, rectum, and esophagus.
By creating virtual cells from 4D AI models and digital twins, researchers can predict how mitochondria respond to drug treatment, grouping cells that respond similarly together. This technology has the potential to speed up drug discovery and accelerate research for diseases such as cancer, diabetes, and Alzheimer's.
A new study found that a rare inherited genetic mutation, EGFR T790M, significantly increases lung cancer risk among non-smokers, 62 times higher than average. The mutation is most common in the Southern Appalachian region of the US, where it arrived with British and Irish settlers during the colonial era.
The Alliance for Clinical Trials in Oncology is hosting a public webinar highlighting key findings from Alliance and Alliance Foundation Trials studies presented at the 2026 ASCO Annual Meeting. The webinar will feature treatment advances for breast, lung, and prostate cancers, and will include patient representatives to provide insigh...
The new NCCN Guidelines for Patients with Cancer explain the importance of assessments to tailor cancer care to every person, regardless of age. The guidelines stress the need for support and validation for older adults, who face unique issues such as memory function and treatment interactions with other medications and conditions.
Researchers found that mindfulness-based cancer recovery and tai chi/qigong helped participants manage common challenges after cancer treatment, including fatigue, pain, and sleep difficulties. These mind-body interventions improved symptoms by targeting the psychological aspect of pain and promoting overall well-being.
A comprehensive review of 20 years of research involving over 80,000 carers found that many deprioritise and dismiss their own emotional needs, highlighting the need for psychological support-seeking among carers.
Researchers developed targeted fecal qPCR models that showed moderate discrimination for colorectal and pancreatic cancer, offering a potential non-invasive approach for early detection and risk assessment. The study's findings suggest that fecal qPCR could provide complementary information without invasive sampling.
Researchers found that mind-body interventions, including mindfulness-based cancer recovery and tai chi/qigong, improved symptoms such as pain, fatigue, and sleep problems in cancer survivors. The study, which included over 500 participants, highlights the value of a whole-person approach to cancer survivorship care.
For appropriately selected patients with muscle-invasive bladder cancer, preserving the bladder can be a curative treatment option, and trimodal therapy is recommended as an alternative to radical cystectomy. The guideline also provides guidance on radiation therapy after surgery and for patients with metastatic or symptomatic disease.