Cancer
Articles tagged with Cancer
Bacteria may hold a cancer treatment clue
Recognizing and managing IEC-HS: A life-threatening complication of CAR-T therapy
Screening modestly reduces prostate cancer deaths
American Society for Radiation Oncology (ASTRO) to host Annual Meeting in Boston, September 26-30
Share proton therapy across national borders and plan five new centres in Romania, Greece, Italy, Northern Ireland and Poland to maximise access for patients in Europe
The hidden force of growth
Rare extraluminal esophageal cancer invades spine despite normal endoscopy
New analysis in JNCCN offers evidence for effective use of medication to combat fatigue in people with cancer
Study shows that people who gain the most weight are at more than double the risk of certain cancers
Molecular grappling hooks improve cancer drug targeting and effectiveness
Ultrasound has potential to alter how the brain responds to pain
Rice researchers develop realistic ‘mock’ samples to speed cervical cancer test development
A team of Rice University bioengineers has developed a new way to create highly realistic mock patient samples that could help accelerate the development of faster and more accessible cervical cancer screening tests. The approach combines multiple factors, including viral DNA levels and cell counts, to mimic real clinical specimens.
MIT-MGH team finds a new approach to cancer vaccination that yields more powerful T cells
Winship administers first U.S. dose of investigational in vivo CAR-T therapy in multiple myeloma trial
Researchers at Winship Cancer Institute have administered the first investigational in vivo CAR-T cell therapy in the US for relapsed and refractory multiple myeloma, marking a significant milestone in next-generation cellular therapies. The therapy aims to streamline treatment processes and eliminate delays in care.
Routine scans may reveal tumor aggressiveness in head and neck cancer – without additional tests
Ivermectin prescriptions more than doubled after a celebrity endorsed it as a cancer treatment on a high-profile podcast
Prescriptions for ivermectin and benzimidazole increased significantly following a high-profile podcast endorsement, with the highest rates among men, White patients, and those in the US South. The study raises concerns about celebrity endorsements influencing people to turn to unproven treatments.
UMass Chan scientist Marcus Ruscetti receives 2026 Pershing Square Sohn Cancer Prize
AI-powered handheld microscope aims to spot cancer earlier
How immune-related adverse events differ in elderly gastrointestinal vs. lung cancer patients
First-in-human trial demonstrates promise of implantable cytokine factories for ovarian cancer
Rethinking bladder cancer surveillance: Can fewer procedures be just as effective?
Amplified Sciences enrolls patients in PanAMP real-world, multicenter clinical utility study
Nanoparticles overcome drug-resistant cancer via sequential drug release and photothermal therapy
UCLA researchers help lead national effort to improve care for patients with glioblastoma
Glioblastoma is a highly aggressive brain tumor that has seen modest improvements in survival rates over the past decade. Researchers at UCLA's Jonsson Comprehensive Cancer Center are part of a national effort to develop more personalized approaches to care, combining advanced imaging and analysis of tumor tissue samples and blood test...
Scientists discover how gut bacteria toxin invades colon cells to trigger cancer
Low-cost color sensor device enables rapid detection of ovarian cancer biomarkers
Thousands of new proteins revealed in dark proteome
A team of scientists has uncovered more than 1,700 new proteins known as peptideins, which are smaller than traditional proteins and may have unique biology. These proteins were found in the 'dark proteome', a section of DNA previously overlooked, and could have implications for human diseases like cancer.
Scientists find blood-based biomarkers for inflammatory breast cancer
Researchers at the University of Texas MD Anderson Cancer Center have identified specific blood-based genomic biomarkers that distinguish inflammatory breast cancer from other subtypes. The study used an improved method of RNA sequencing, called TGIRT sequencing, which allowed for a more comprehensive overview of all RNA types and amou...
ERASur colorectal cancer trial reaches one-third patient accrual milestone
The ERASur clinical trial is investigating whether total ablative therapy can improve overall survival in patients with newly diagnosed, limited metastatic colorectal cancer. The study has reached one-third patient accrual milestone, signaling strong momentum.
Protecting children receiving cancer treatment from infections
A new trial aims to test an AI-powered tool that detects signs of infection in children undergoing cancer treatment. The custom app, which utilizes Apple Watch data, may help clinicians intervene sooner and reduce hospital stays.
Common inflammatory genes link pancreatic cancer with obesity and diabetes
A study published in Cancer Medicine reveals that the same genes active in pancreatic cancer are also linked to obesity and diabetes, driving inflammatory and immune pathways. This discovery helps explain poorer cancer outcomes for those with metabolic disease and offers new avenues for targeted treatment.
New kind of CRISPR could treat viral infection and cancer by shredding sick cells’ DNA
A new CRISPR protein, Cas12a2, has shown potential for killing sick cells while leaving healthy ones untouched. Researchers have tested its effectiveness in destroying cancer cells and virus-infected cells with promising results.
NIH-funded study suggests that testosterone suppresses brain tumor growth in males
A NIH-funded study discovered that testosterone may play a key role in limiting brain tumor growth in men by suppressing inflammation and stress hormone production. Analysis of over 1,300 men with glioblastoma found that supplemental testosterone was significantly associated with improved survival rates.
Trinity researchers publish ‘playbook’ for understanding pancreatic cancer, one of the deadliest cancers
Researchers at Trinity College Dublin have published a comprehensive review of pancreatic cancer, explaining why it's resistant to treatment and where new hope may emerge. The study identifies multiple biological systems interacting to drive the disease's growth and suggests combination-based treatments targeting multiple hallmarks of ...
Aparna Bhaduri awarded Pershing Square Sohn Cancer Prize for advancing glioblastoma research
Dr. Aparna Bhaduri receives $750k Pershing Square Sohn Cancer Prize for her innovative glioblastoma research. Her advanced human organoid models reveal how tumors interact with the immune system and brain cells, driving tumor aggressiveness.
lncRNA ROLLCSC: A prognostic marker and therapeutic target for lung adenocarcinoma
A new study published in Genes & Diseases journal reveals that lncRNA ROLLCSC promotes ferroptosis resistance and metastasis in lung cancer by regulating lipid metabolism. The researchers identified ROLLCSC as a therapeutic target, suggesting potential treatments for advanced lung adenocarcinoma.
Artificial intelligence in pathology enables a deeper understanding of cancer
A new AI system, SPARK, enables autonomous scientific discovery in cancer pathology by generating biological hypotheses and translating them into analytical tools. The system identifies clinically relevant tissue markers linked to disease course, treatment response, and tumour progression.
Announcing the 2026 Laureates of the Blavatnik Awards for Young Scientists in Israel
Three young scientists in Israel have been awarded the prestigious Blavatnik Awards for their innovative research in chemistry, cancer biology, and astrophysics. Sergey Semenov, Uri Ben-David, and Paz Beniamini will each receive US$100,000 to advance their projects on complex materials, cancer treatments, and extreme cosmic events.
Mapping cancerous tissue with a hand-held probe
Researchers developed a hand-held device to differentiate tumors from healthy tissue using mechanical properties, reducing the need for future surgeries and delayed treatments. The wireless probe can aid surgeons in precise tumor removal during breast-conserving surgery.
ALK mutation: A predictive biomarker for pan-cancer immunotherapy
A new study reveals that ALK mutations enhance tumor immunogenicity and predict favorable outcomes in immune checkpoint blockade. The presence of ALK mutations is an independent favorable predictor of overall survival, decreasing the risk of patient death by 31%.
Trial now enrolling seeks to answer key question: Does adding chemotherapy to hormone therapy improve survival for metastatic prostate cancer?
The ASPIRE trial aims to enroll 1,200 participants with advanced prostate cancer and assess the impact of chemotherapy on overall survival and disease progression. Genetic profiling is included to identify patients who benefit most from intensified treatment.
Promising new technique uses nanoparticles to detect pancreatic cancer
Researchers at OHSU have developed a sophisticated blood test that can detect early signs of pancreatic cancer with a 97% accuracy rate, distinguishing it from benign conditions. The technique uses nanoparticles shed by tumors into blood, offering a non-invasive way to identify the disease.
Retrieval-augmented AI may improve accuracy and trust in oncology applications
The review highlights how retrieval-augmented generation can improve the accuracy, transparency, and clinical reliability of AI tools in cancer care. RAG-enhanced systems produced more accurate results than standard AI models across multiple studies.
Scientists discover a new way to make drug-resistant cancer treatable again
Researchers discovered a small molecule, UNI418, that destabilizes key DNA repair proteins, making drug-resistant cancer cells vulnerable to PARP inhibitor therapy. This approach restores tumor sensitivity and improves treatment outcomes.
Researchers uncover strategy to help exhausted immune cells fight tumors
A new study reveals that impaired protein recycling is the key factor in T cell exhaustion, allowing researchers to develop a 'tag and sort' fix to restore normal proteostasis. This approach boosts the potency of cell therapy against cancer.
Targeted maternal screening could prevent rare, deadly leukemia in the US
A new study found that targeted maternal screening can prevent adult T-cell leukemia/lymphoma, a rare and aggressive cancer caused by human T-cell leukemia virus type 1. The research identified high disease rates among non-Hispanic Caribbean-born US residents, particularly in Florida and New York.
Why cell therapy cancer treatment sometimes fails
Researchers found that patients with high senescence burdens in their CD8+ T cells were more likely to fail treatment, while those with youthful profiles responded better. The study identified three transcription factors controlling the senescence program, which can be targeted to improve treatment outcomes.
Cancer Research: Mini-Antibodies Reactivate the Guardian of the Genome
A research consortium has developed mini-antibodies that can reactivate mutated p53, a key tumor suppressor protein. These DARPins bind selectively to p53 mutants, restoring stability and functionality, making them potentially useful against various types of tumors.
How cells decide when to react could shape future treatments for cancer and fibrosis
Researchers at King's College London uncover a timing mechanism in cells that allows them to ignore brief mechanical stimuli while reacting to sustained changes. This discovery has huge implications for disease treatment and could lead to the development of better therapies for cancer and fibrosis.
Targeted therapies drive long-term decline in multiple myeloma mortality in the US
A new study found a clear shift in mortality trends in multiple myeloma closely parallels major therapeutic advances. Targeted therapies, including immunomodulatory drugs and CAR T-cell therapies, have significantly improved disease control and induced deep responses.
How eating primes immune cells for future responses
A study by University of Pittsburgh researchers found that eating creates a temporary metabolic state that influences T cell function, leading to improved responses to infection. The findings have particular relevance for cancer immunotherapy and may inform when immune cells are collected or activated.
Brain structure differences may explain striking ancestry gaps in blood cancers
A new study reveals that specific features of the human cerebral cortex are causally linked to multiple myeloma and chronic lymphocytic leukemia, differing between ancestries. Genetic variants favoring larger pars triangularis surface area and thicker frontal cortices are found in Western populations.
New awards and publications showcase achievements from staff at the National Comprehensive Cancer Network
NCCN staff received awards and publications for advancing quality cancer care, including Dr. Alyssa Schatz's Leadership in Policy, Equity, and Advocacy award and Faviolla Baez-Cruz's publication on biochemical research. The National Comprehensive Cancer Network is recognized for its work to improve outcomes for people with cancer.
UIC scientists source anti-cancer treatment in bacteria
Researchers at UIC developed an anti-cancer therapy using a bacterial protein called aurB, which prevents energy production in tumor cells' mitochondria. The treatment was tested in combination with radiation and showed highly effective results in animal models of prostate cancer, effectively shutting down tumor growth.
Living longer with less burden of cancer treatment: new endpoints defined for cancer trials
A new paradigm shift in cancer research defines valid primary study endpoints for oligometastatic disease, focusing on treatment-free time and minimal side effects. The consensus paper establishes two new metrics: STFS (Start or Switch of Systemic Therapy–Free Survival) and pPFS (polymetastatic Progression–Free Survival), which capture...
26 Years of development of EGFR-TKIs for non-small cell lung cancer: Clinical application and resistance research progress
EGFR-TKIs have significantly improved OS and quality of life for EGFR-mutant NSCLC patients. However, ongoing research is needed to refine therapies for precise individualized treatment, addressing resistance mechanisms and optimal combination strategies.
Targeted therapy drug shows early promise against KRAS-driven lung and pancreatic cancers
A first-in-human clinical trial found that setidegrasib, a targeted therapy drug, demonstrated early antitumor activity in advanced lung and pancreatic cancers. The therapy shrank tumors and delayed disease progression in some patients, providing a potential new treatment approach for KRAS G12D-driven cancers.
A hidden way cancer cells rewrite genetic messages uncovered, revealing a new target for treatment
Scientists have uncovered an unexpected way cancer cells generate cancer-driving proteins by cutting RNA into shorter fragments. This process, termed as RNA dicing, enables the production of a truncated form of the JAK1 protein that remains highly active and can promote tumor growth.
CNIO study unlocks new avenues to personalise liver fibrosis treatment
A recent CNIO study has identified a key mechanism in the development of liver fibrosis by targeting bile duct cells. The research reveals that these cells regulate liver health and form a barrier that prevents bile acid leakage and fibrosis, opening new avenues for personalized treatment.