Articles tagged with Cancer
Research by Queen Mary University of London led to changes in NHS guidelines, allowing hundreds of people with advanced bladder cancer to receive fewer chemotherapy cycles. This results in reduced toxic side effects and a better quality of life during treatment.
Charles Swanton has described the evolution of tumors through genetic mutations, explaining why treatments often fail to eliminate them entirely. His discoveries could lead to more accurate diagnostics and improved cancer treatment.
A study from Lund University found that a climate-friendly diet rich in plant-based foods like wholegrains, legumes, fruit, and vegetables leads to better nutritional status compared to traditional diets. Despite lower meat consumption, most participants achieved sufficient amounts of key vitamins and minerals.
Lung cancer in never-smokers (LCINS) is a growing global health challenge with distinct biological and clinical characteristics. The authors emphasize the importance of identifying risk factors, developing better screening tests, and discovering more effective treatment approaches for LCINS.
Researchers developed a PD-L1-binding antigen presenter that redirects antiviral antibodies to target cancer cells, transforming virus-specific immune memory into precision anti-cancer weapons. This strategy has significant potential for treating hard-to-treat cancers and represents a lower-cost, safer avenue for tumor immunotherapy.
The FLOWERS trial demonstrates a significant enhancement in clinical outcomes for NSCLC patients with EGFR and MET mutations when treated with osimertinib plus savolitinib. Patients receiving the combination regimen showed extended progression-free survival and improved tumor response rates compared to those on osimertinib alone.
A case report investigates a woman's development of acute lymphoblastic leukemia and lymphoblastic lymphoma after receiving her second dose of the Pfizer-BioNTech COVID-19 mRNA vaccine, highlighting potential genetic and molecular mechanisms involved in disease pathogenesis.
A new review highlights the growing burden of lung cancer in never-smokers, emphasizing the need for dedicated research, screening, and clinical trials. The study argues that LCINS has distinct causes and biology requiring a different approach to diagnosis and treatment.
The Phase I/II multicenter international CADENZA trial found that 75% of patients with BPDCN treated with pivekimab sunirine achieved a complete response. The treatment delivered the therapeutic drug directly to cancer cells, resulting in rapid cancer cell death with limited targeting of healthy tissue.
Researchers identified a previously unrecognized metabolic defence mechanism in aggressive brain tumours: a sugar-rich shield that protects tumour cells from ferroptosis. The study found that the sugar shield and lipid droplet storage mechanisms cooperate to evade cell death.
The American Society of Hematology released guidelines for frontline and relapsed/refractory management of acute lymphoblastic leukemia (ALL) in adolescents and young adults (AYAs), outlining optimal approaches to treating high-risk patient populations. The guidelines highlight the need for additional research on immunotherapies and tr...
A new analysis found that rural cancer patients treated locally have similar surgical outcomes to those who traveled to urban facilities. The study used Surveillance, Epidemiology, and End Results data from Medicare-eligible patients with lung or colon cancer, aged 65 or older, residing in rural areas.
Researchers have discovered a new mechanism by which an existing cancer drug can block the loss of BCMA molecules on cancer cells, allowing CAR T cell therapy to become effective again in some patients. The study shows that carfilzomib can prevent the degradation of BCMA and restore its presence on the surface of malignant plasma cells.
A study by Silent Spring Institute identified dozens of hazardous chemicals in hair extensions, including products made from human hair. The analysis revealed chemicals linked to cancer, hormone disruption, and developmental problems, prompting calls for stronger oversight and policy change.
Researchers at City of Hope have made significant breakthroughs in cancer treatment, immune system regulation and early disease detection. A study found that subtle RNA changes can shape cancer behavior, opening new avenues for precision oncology. In contrast, combining immunotherapy with chemoradiation did not improve survival rates f...
Researchers used DNA barcoding to track cancer cells in solid and liquid biopsies, finding that tumour heterogeneity varies widely depending on necrosis and tumour burden. This study suggests that combining both strategies may provide a more accurate representation of the disease.
Researchers found that an experimental compound SB-216 reduced the growth of pancreatic ductal adenocarcinoma cells by inhibiting oncogenic microtubules and mitochondrial function. This approach may reduce cancer cell adaptation and survival.
A breakthrough study has discovered a genetic defect that weakens the esophageal lining, making it vulnerable to acid damage. The discovery offers new hope for esophageal cancer patients and provides a potential screening tool for family members at high risk of developing the condition.
Dr. David Gius, a renowned physician-scientist and radiation oncologist, has been appointed as the new director of the University of Cincinnati Cancer Center. He brings a robust research portfolio, including active clinical trials and NIH grants, to enhance regional access to superlative care.
A UCalgary study found that adding high doses of vitamin B3 to the treatment plan may help rejuvenate compromised immune cells to kill tumour cells. The clinical trial showed promising results, with 82% of participants free of cancer progression at six-months.
Scientists have identified the FOXO1-KLHL6 axis as a novel therapeutic target to enhance T cell-mediated immune response against tumors. The research found that persistent T cell receptor signaling suppresses the transcription factor FOXO1, leading to the downregulation of the E3 ubiquitin ligase KLHL6 and promoting T cell exhaustion.
A global study found that ropeginterferon alfa-2b controls essential thrombocythemia effectively, improves symptoms and reduces serious complications in patients who can't use hydroxyurea. The therapy is expected to be approved for treatment of high-risk blood cancer.
A cohort study found combined GLP-1RA and progestin therapy reduces endometrial cancer risk in women with benign uterine pathology or endometrial hyperplasia. The study suggests potential benefits of this treatment approach for nonmalignant uterine diseases.
A major study has shown that tumour stage at diagnosis is strongly linked to childhood cancer survival across six different cancers. Researchers analysed data from 9,883 children in 27 countries and found significant variation in three-year survival rates between regions, particularly in the UK and Ireland.
Researchers found that PSMA PET/CT scans can help guide treatment planning and improve long-term outcomes for patients with recurring prostate cancer. The study suggests that incorporating these scans into routine care may lead to better results and reduced side effects.
A study found that 60.8% of American women prefer in-clinic cervical cancer screening, while 20.4% opt for at-home self-sampling. Marginalized groups, including those with low income and distrust of healthcare systems, are more likely to choose at-home options.
Researchers at the University of Illinois have found that the ABCA1 protein plays a crucial role in directing how myeloid immune cells, particularly macrophages, behave. When ABCA1 is expressed, these cells become better at fighting cancer and supporting T cell function.
Advanced Cancer Research defines a platform for integrating molecular biology, genomics, immunology, engineering, and computational science to understand cancer as a complex disease. The journal prioritizes studies that provide mechanistic depth and bridge disciplinary boundaries.
A new study reveals the CDK12-FOXA1-MDM2-p53 signaling axis promotes prostate cancer development through FOXA1 modification. The study identifies S234 phosphorylation as a critical site, and a CDK12 inhibitor THZ531 effectively blocks this pathway, reducing tumor growth.
Scientists at UNIGE discovered that neutrophils, a type of immune cell, undergo reprogramming to produce chemokine CCL3, promoting cancer growth. This mechanism appears to be a major variable in tumour biology and could serve as an indicator of disease progression.
A new computational tool called PRISM (Precise Identification of Species of the Microbiome) has been developed to settle the controversy over whether microorganisms truly reside in tumors. The tool uses rapid screening and machine-learning models to distinguish genuine microbial signals from artifacts.
A recent cohort study found that individuals diagnosed with cancer in 2020 and 2021 experienced worse short-term survival rates compared to those diagnosed between 2015 and 2019. The study suggests substantial harms associated with cancer care disruptions during the COVID-19 pandemic.
Tumor-associated neutrophils assume multiple functional states, but one gene expression program supports cancer cell survival and tumor progression across tumor types. A biomarker called CCL3 functionally supports cancer growth by engaging a receptor on the surface of TANs to transmit signals that drive them toward an aged state.
Researchers developed BrainIAC, a robust AI foundation model that analyzes brain MRI datasets to identify key neurological health indicators. The tool outperformed conventional AI models in diverse tasks, including predicting dementia risk and detecting brain tumor mutations.
Engineered yeast cells can mimic real cancer cells and be used to test new cancer immunotherapies much faster and cheaper than before. This new technology enables researchers to assess which CAR T variants are most promising much more quickly, leading to safer and more targeted cancer treatments.
A new study reveals that the surrounding microenvironment plays a crucial role in driving basal cell development, leading to treatment failure. The study also discovers intermediate tumor subtypes that could lead to new therapeutic strategies.
Researchers at Salk Institute uncover two transcription factors, ZSCAN20 and JDP2, that determine T cell fate. Turning off these genes reverses T cell exhaustion and restores their ability to kill tumors without losing immune memory. The study challenges the long-standing belief of inevitable immune exhaustion.
Researchers at the University of Virginia Health System have identified a molecule that blocks the gene responsible for glioblastoma, a fast-growing and deadly brain cancer. The compound shows promise in preventing the invasive cancer from spreading through the brain without causing harm to healthy tissue.
A Mass General Brigham-led study found that integrating feedback and personalized palliative care can improve the quality of life for children with advanced cancer. The study showed significant improvements in symptoms and well-being for patients who received the intervention, highlighting the potential benefits of early palliative care.
A UCLA research team has identified the best design for a promising new type of immunotherapy that could be mass-produced to treat multiple solid tumors. The 4-1BB-containing CAR design emerged as superior, demonstrating strongest anti-tumor activity and persistence.
The National Comprehensive Cancer Network (NCCN) has committed to updating its robust information resources for cancer patients and caregivers annually, available in both English and Spanish. The updated resources will provide factual, trustworthy information to guide patients and caregivers towards their best possible outcome.
Researchers have established that Candida albicans fungus makes melanoma more aggressive by activating signaling pathways and creating conditions for malignant cells to acquire oxygen and energy. The study's findings suggest potential new avenues for cancer treatment using antifungal therapies.
Researchers at UCLA Health Jonsson Comprehensive Cancer Center developed a new zinc oxide formulation that significantly reduces the white, chalky cast associated with traditional mineral sunscreens. The tetrapod-shaped particles provide strong protection against UV radiation while staying evenly distributed in the sunscreen.
George Coukos directs the Ludwig Laboratory for Cell Therapy at Weill Cornell Medicine's Sandra and Edward Meyer Cancer Center. The lab focuses on developing personalized cellular immunotherapies to optimize cancer treatment strategies.
A new study suggests that women vaccinated against human papillomavirus (HPV) may only need cervical cancer screenings 2-3 times over a lifetime, without compromising health benefits. This approach could lead to cost-effectiveness and reduced unnecessary follow-up procedures.
Researchers at Johns Hopkins Kimmel Cancer Center have developed a novel liquid biopsy approach to identify early-stage cancers by measuring DNA methylation patterns. The Epigenetic Instability Index (EII) successfully distinguished patients with early-stage lung and breast cancers from healthy individuals, showing promise in detecting...
Researchers developed polygenic risk score models to predict breast cancer risk in women of African ancestry, improving accuracy and performance compared to existing models. The new tools could lead to earlier screening, tailored care, and increased survival rates for high-risk women.
Researchers created a miniaturized ultrasound system that can be used at home or in doctors' offices to scan people at high risk of breast cancer. The new system detects tumors earlier, increasing the chances of successful treatment.
Key cytokines in tumor microenvironment exhibit both protumor and antitumor effects, influencing immune response and tumor progression. Current research focuses on reducing toxicity while enhancing efficacy of cytokine therapies.
Breakthrough research recommends that more than one N1 node be removed and evaluated during surgery for non-small cell lung cancer (NSCLC). The study found that many cancers were identified in N1 nodes adjacent to the bronchi, highlighting the need for expanded lymph node evaluation.
Vinay Badhwar, MD, was elected President of The Society of Thoracic Surgeons with a three-part framework emphasizing daily practice excellence, data-driven science, and measurable impact. He aims to advance collaboration across surgical disciplines and integrate the specialty into the broader healthcare ecosystem.
Researchers identified a crucial factor that may help improve treatment for glioblastoma, one of the most aggressive and common forms of adult brain cancer. They discovered a small molecule called miR-181d acts like a master switch that controls how much MGMT is produced by each glioblastoma cell.
A review decodes the comprehensive role of GDF15 in prostate cancer metabolism, chemoresistance, and clinical applications, highlighting its involvement in cachexia, bone metastasis, and drug resistance. The study also explores the synergistic power of combining GDF15 with established markers for improved diagnosis and prognosis.
Biologist Douglas Hanahan proposes an updated framework to help understand the complexity of human cancer. The new framework, known as Hallmarks of Cancer, offers a four-dimensional approach to analyzing cancer development and progression.
A new clinical trial shows that treating desmoplastic melanoma with immunotherapy before surgery dramatically shrinks or eliminates tumors, improving quality of life for patients. The study found that 71% of patients had no detectable cancer remaining at the time of surgery.
Researchers have developed a four-marker panel that can detect early-stage pancreatic cancer with high accuracy, potentially improving survival rates. The new test distinguishes cancer patients from healthy individuals and those with non-cancerous conditions, such as pancreatitis.
A cross-sectional analysis of nationwide population data reveals that high-deductible health plans are associated with worse overall and cancer-specific survival among cancer survivors. The study suggests that financial disincentives for medical care may lead to delayed or foregone necessary care, ultimately worsening cancer outcomes.
Researchers found that certain gut bacteria can deplete amino acids, affecting tumor growth or activating immune cells. Tailoring diets and microbiome strategies may enhance anti-tumor activity and support personalized therapy.
A recent study found that low-dose aspirin use was not associated with incident cancer incidence in older adults, contrary to previous findings. However, the study revealed a significant elevation in cancer mortality risk during the randomized clinical trial period, which did not persist after the trial ended.
Researchers developed a new framework called SOLVE to overcome data challenges in precision cancer treatment. By jointly modeling known and unknown factors, SOLVE provides a robust tool for biomarker discovery and investigating tumor responses.