Researchers from the University of East Anglia have discovered 18 new bacterial species collected from prostate cancer patients, including previously linked species like Porphyromonas and Treponema. The study provides new insights into microbes in cancer patients and could uncover links that improve understanding of how cancer develops.
A review of nine international studies found that 71% of caregivers experienced anxiety, 50% depression, and almost all struggled to care for themselves, while social isolation and poor sleep were common. Healthcare services can play a vital role in supporting caregivers by delivering coordinated care that includes them in follow-up care.
Research in Ontario found that 23% of people with de novo metastatic breast cancer died within 6 months of diagnosis, with factors including older age, chronic illness, and housing marginalization contributing to early death. Access to a primary care provider was associated with lower odds of early death and improved outcomes.
Melanie Ott and Alex Marson, directors at Gladstone Institutes, have been elected to the National Academy of Medicine for their pioneering achievements in science and medicine. Their work focuses on understanding viral mechanisms, developing innovative treatments, and repurposing human immune cells to fight disease.
Breast cancer research is making progress through clinical trials, with 8 active trials currently open to patients and survivors. The trials aim to improve treatments and offer hope to millions of people affected by the disease.
Researchers developed AI tools to estimate biological age and predict cancer survival risk using facial photographs, with improved accuracy and robustness across photo variations, and lifestyle factors influencing facial aging, including smoking and heavy alcohol use.
Charles W.M. Roberts, MD, Ph.D., was elected to the National Academy of Medicine for his groundbreaking research on cancer epigenetics and its impact on developing novel therapies for children with cancer. As St. Jude president and CEO-elect, Roberts will continue to advance the field of pediatric oncology.
DS1025, a CD25-directed antibody drug conjugate, targets immunosuppressive regulatory T cells in the tumor microenvironment, aiming to reduce a mechanism that can limit the body's immune response against cancer. The trial is an international effort to investigate DS1025 in patients with advanced solid tumors.
Researchers developed a next-generation PET/CT scanner that produces diagnostic-quality images in as little as one minute, surpassing the performance of conventional scanners. The study showed that even 90% shorter scans maintained high image quality, making it a game-changer for cancer diagnosis and treatment.
Recent advances highlight glutamylation's regulatory mechanism in ciliogenesis, neurodevelopment, cell division, and cytoskeletal organization. The modification also modulates innate immunity, cell-fate determination, and hematopoietic homeostasis in non-tubulin substrates.
The Phase 1b FURTHER trial revealed that firmonertinib achieved durable antitumor activity in patients with EGFR PACC-mutated non-small cell lung cancer, with 43% and 68% objective response rates at 160mg and 240mg daily doses, respectively. Patients with complete clearance of EGFR PACC mutations from their blood experienced higher res...
A new study found that adding 3D goggles to deep-inspiratory breath-hold radiotherapy did not significantly reduce treatment time. However, setup time was longer when goggles were used, and treatment efficiency improved with repeated sessions.
Researchers analyzed data from 461,682 adults and found no association between overall ultra-processed food intake and colorectal cancer incidence, but found associations with whole grains and dairy products, and a 2% lower incidence with replacing 10% of UPF intake with minimally processed foods
The Montefiore Einstein Comprehensive Cancer Center has appointed senior leaders to advance research and programs in basic, translational, clinical, and population science. H. Dean Hosgood and Wenjun Guo will lead initiatives on population and community sciences and tumor microenvironment and metastasis, respectively.
Dr. LaBelle leads the pediatric cancer and blood diseases program at the Chicagoland Children's Health Alliance and UChicago Medicine, expanding clinical trials and integration of services. He brings expertise in stem cell transplant, cellular therapies, and cancer immunology to improve outcomes for children with cancer and sickle cell...
Researchers at UCLA Health Jonsson Comprehensive Cancer Center used CRISPR screen to identify key molecular pathway driving T-cell exhaustion in cancer-fighting immune cells. Disabling the pathway, CRL5, allowed engineered immune cells to stay active longer and fight solid tumors more effectively in preclinical studies.
The new website features a clean, intuitive architecture and interactive elements that streamline exploration of Gladstone's transformative discoveries. The site highlights the institute's core disease and technology areas, making complex scientific concepts more inviting for patients and the scientific community.
A review argues that a lack of analytically validated measurement systems is the primary obstacle to the clinical translation of RNA 5-methylcytosine (m5C) in cancer. Altered m5C pathways have been linked to tumor progression and therapeutic resistance, but only a small fraction of candidates have advanced toward clinically validated b...
A team of researchers has discovered how a protein linked to cancer activates silent DNA regions, a mechanism that contributes to tumour development. The study, conducted in fruit flies, identifies collaboration between two proteins as a key requirement for activation.
Scientists discover aberrant antibodies in children with cancer, targeting DNA repair proteins, which may hinder normal repair and lead to cancer. The findings suggest a potential mechanism for pediatric cancer development and may lead to early screening and prevention.
A new study from St. Jude Children's Research Hospital found that childhood cancer survivors living in socially or environmentally vulnerable neighborhoods are more likely to develop chronic health conditions. The study identified a doubled risk of overall chronic health condition burden compared to the least vulnerable neighborhoods.
Researchers identified fagopyrine, a naturally occurring compound in buckwheat, as a potential starting point for developing new AKT1-targeting drugs. The analysis revealed substantial variation in AKT1 expression across 33 cancer types, with increased expression linked to poorer outcomes in certain malignancies.
The American Society of Hematology has released new guidelines for managing myelofibrosis, a rare and life-threatening blood cancer. The guidelines recommend expanded molecular testing, early transplant referral, and appropriate use of JAK inhibitors to improve patient care and outcomes.
A recent study has identified unique genetic changes in brain tumors that recur after treatment, offering new insights into resistance to therapy. The research, conducted across 10 countries, found that different types of gliomas undergo distinct genetic changes, with some associated with poorer outcomes.
This comprehensive review synthesizes molecular mechanisms, current therapeutics, and emerging strategies in esophageal cancer. The findings highlight breakthroughs in immunotherapy and promising future directions in targeted therapies.
Researchers discovered that cancer cells under pressure trigger necroptosis, a type of programmed cell death, to stop spreading. Lower levels of MLKL protein may predict metastasis, leading to new biomarkers and treatments.
Japan has seen substantial reductions in HBV- and HCV-related disease burden and hepatocellular carcinoma mortality thanks to sustained national control measures. The prevalence of HBV and HCV has fallen drastically across Japan, with a significant shift in the relative distribution of liver cancer causes.
Researchers found that specific combinations of TP53 and CDKN2A mutations activate cGAS-STING-mediated immunity, delaying oral cancer progression. The immune activation was associated with delayed progression to invasive oral cancer.
Two UCLA-led studies reveal features of effective immune responses in glioblastoma and introduce a preclinical model that more closely mirrors the human disease. Long-term survivors showed evidence of a stronger immune response within their tumors, offering important clues for developing treatments.
Families of children with B-cell acute lymphoblastic leukemia (B-ALL) experience substantial and lasting challenges, including household employment changes and marital status changes, beginning early after diagnosis. These challenges persist throughout treatment and have significant financial, social, and emotional impacts on families.
Scientists at MIT have created a new method to reprogram natural killer immune cells to target diseased T cells, offering promise against diseases like lymphoma and autoimmune hepatitis. The technique uses lipid nanoparticles to deliver messenger RNA to NK cells, which are then programmed to seek and destroy dysfunctional T cells.
Researchers have identified a potential target for treating metastatic cancers: trapping DNA rings in micronuclei, which lose their activity. This process may help prevent cancer growth and improve treatment success rates.
A study published in the journal CANCER found that young women with breast cancer experience delays in care, with lower income and younger age being the most common factors. These delays can lead to later stages of disease and more extensive treatment, impacting quality of life.
A new UCLA study suggests that adding a targeted radioactive drug to stereotactic body radiation therapy may help delay the spread of recurrent prostate cancer. The treatment showed a 62% lower risk of progression or needing additional hormone therapy, and improved control of disease on conventional imaging.
A modified acupuncture needle enables minimally invasive sampling of lymph node-derived DNA for molecular profiling, offering a robust alternative to current clinical liquid biopsy approaches. The novel platform, His@PDA@Needle, is significantly less invasive than conventional lymph node biopsy and intended to complement histopathologi...
A study published in iMetaMed reveals a recurring association between convergent malignant-cell programs and coordinated immune dysfunction in bone metastases. Cancers of different origins exploit shared features of the bone microenvironment, including chromosomal instability and MYC-associated proliferation.
Researchers discovered a rare population of dendritic cells expressing the gene RORC in malignant ascites, a common problem across cancers, which may promote immune tolerance in cancer. This finding has potential implications for developing new therapies for patients with advanced solid tumors.
This study generates full-length transcriptomic profiles for 144 paired tumor-normal tissue sets, revealing two uncoupled layers of transcriptomic dysregulation. Gene expression levels show convergent transcriptional signatures linked to oncogenic dedifferentiation, while isoform-level remodeling is organ-restricted. Thousands of tumor...
Researchers developed a gene signature and patient-derived models to identify malignant neuroblastoma cells tied to poor prognosis. The findings provide a new framework and tools to study high-risk neuroblastoma.
JMIR Cancer invites original research, viewpoints, and clinical submissions on breast cancer digital health innovations, focusing on patient-centered strategies, technological advancements, and innovative treatments. The call aims to improve screening accuracy, treatment protocols, and survivorship outcomes.
Cysteine peptidases govern antigen-presenting cell function and antitumor immunity, with excessive activity leading to tumor immune evasion. Therapeutic targeting of cysteine peptidases holds promise for cancer immunotherapy, with combination therapies showing synergistic antitumor effects.
A rare case of high-grade serous ovarian carcinoma diagnosed during early gestation at 10 weeks of pregnancy was reported, highlighting the challenges of identifying ovarian malignancy during early pregnancy. The patient underwent surgical management and received adjuvant chemotherapy, and remained disease-free at one-year follow-up.
NCCN has published regional cancer treatment guidelines for the Philippines, tailored to the local setting and regulatory environment. The guidelines reflect collaborations with global organizations, including the International Gynecologic Cancer Society and the Philippine Society of Medical Oncology, to improve access to high-quality ...
Human stem cells from Adelaide University's Centre for Cancer Biology successfully travelled to the edge of space and back, providing new insights into cancer progression and early detection. The cells were exposed to microgravity for at least seven minutes, offering a unique opportunity to study their response.
Researchers found high CTDNEP1 expression linked to poorer survival in patients with clear cell renal cell carcinoma (ccRCC), but not in papillary renal cell carcinoma (pRCC). The study suggests CTDNEP1 may serve as a candidate prognostic biomarker in ccRCC, but further experimental and clinical validation is needed.
Nuclear medicine is experiencing rapid growth with over 50 million procedures performed worldwide each year. EANM'26 will present the latest advances in nuclear medicine, molecular imaging, and radiopharmaceuticals, including theranostics and next-generation imaging technology.
New research suggests that mitochondrial DNA (mtDNA) copy number affects cancer severity and therapy response. High mtDNA copy number is linked to the expression of genes that support tumor growth and survival. The study's findings could pave the way for new cancer management strategies.
A new device has been approved for a first human trial to treat cancer-related wasting, a severe and progressive syndrome affecting many patients with advanced cancer. The device, OnVagus, delivers noninvasive electrical stimulation to modulate the vagus nerve, aiming to preserve strength and quality of life during treatment.
Dr. Dennis Slamon, a pioneer in breast cancer research, has been awarded the 2026 Albany Prize for his groundbreaking work on targeted cancer treatments. His discovery of the HER2 protein and the development of Herceptin have transformed the understanding and treatment of breast cancer, saving millions of lives worldwide.
The National Comprehensive Cancer Network hosted a summit on cancer prevention and screening, focusing on policy solutions and equity, innovation, and access. Key findings include the need to address barriers to access, the potential of new screening technologies to transform cancer detection, and the importance of value-based care mod...
Researchers at Johns Hopkins Medicine have identified a distinct type of prostate cell concentrated in the transition zone of the prostate, where benign prostatic hyperplasia (BPH) commonly develops. The WIF1-positive basal cells may contribute to prostate enlargement and establish the unique biological environment of the transition zone.
Dr. Derek Janssens' lab will develop and apply new techniques for studying epigenetics, a relationship with vast implications for health. They will analyze blood samples from people with myelodysplastic syndrome and lupus to understand epigenetic changes that drive disease-related changes in the body.
A new study models C. diff transmission in oncology units, revealing that asymptomatic colonized patients are the primary source of new infections. The model provides a clearer picture of C. diff transmission events and could help inform protocols to prevent future disease transmission.
Theresa Werner, MD, has been appointed chief of the Division of Oncology at Huntsman Cancer Institute, overseeing clinical, research, and educational priorities. As a nationally recognized physician-scientist, she will advance innovative cancer care and research.
The review proposes co-designing oncolytic viruses and CAR cells to overcome solid tumor barriers, enabling a self-amplifying therapeutic system. Oncolytic viruses can be engineered to deliver payloads, expanding target recognition and maintaining CAR cell function.
Lukas Chavez and his team at Sanford Burnham Prebys will develop an AI-powered system called Leitstern to help clinicians analyze complex data from children with cancer and identify personalized treatment options more quickly
The 11th International Cell Senescence Association Conference brings together researchers worldwide to advance understanding of cellular senescence and its roles in aging, cancer, and disease. Aging supports the conference through a $200 cash poster prize recognizing outstanding scientific research.
Tony Hunter, PhD, receives the 2026 Albany Prize for his identification of tyrosine phosphorylation, a molecular switch that has been targeted to create over 100 cancer drugs. This discovery has saved millions of lives worldwide and transformed cancer biology and treatment.
A new urine test devised by researchers at Stanford Medicine can diagnose bladder cancer more accurately than current methods, capturing a tumor's behavior in addition to its presence. The test, called uRARE-seq, correctly identified 95% of people with localized bladder cancer and gave a clean bill of health to 90% of those who did not.
Chemotherapies like CarboTaxol enhance cancer vaccine responses by expanding a pool of T cells that express the factor TCF1, rejuvenating their life and functionality. This effect is further enhanced when combined with immunotherapy, showing potential for improved clinical trial outcomes.