Research on cancer as a disease, from cause to care. Covers tumor biology, small-cell lung cancer, cancer-linked stroke risk, and cancer center research.
Researchers propose using a simple GKI test to track metabolic health in noncommunicable diseases like cancer and cardiovascular disease. The test measures glucose to ketone ratio and may help assess nutritional ketosis and adherence to metabolic interventions.
Researchers discovered a signaling pathway activated by acidic tumor environments that drives resistance to PARP inhibitors. Blocking the pathway resensitizes tumors, suggesting a potential new therapeutic strategy for overcoming acquired resistance.
Researchers from Virginia Commonwealth University have uncovered a protein, TRNAU1AP, that helps glioblastoma cells survive and multiply. Targeting this protein could make cancer cells more vulnerable to treatment, potentially leading to improved survival rates.
A new immunotherapy treatment has been shown to be effective in treating high-risk bladder cancer, allowing many patients to keep their bladder instead of having it surgically removed. The treatment, called cretostimogene grenadenorepvec, produced a complete response in 75% of patients, with most side effects being mild and temporary.
Researchers have developed spatialproteomics, an open-source software package that makes it easier to analyze complex tissue images. This framework guides users from raw microscopy images through cell segmentation, annotation, and spatial analysis, standardizing workflows and enabling more efficient and reproducible results.
Circulating circRNAs show high cell-type and tissue specificity, making them ideal for non-invasive cancer management. They can be detected in multiple body fluids and reflect treatment response, positioning them as functional drivers of therapy resistance.
Studies show that plant fibers and proteins, known as 'proteins imitating fiber,' reprogram microbial metabolism to produce beneficial phenol metabolites. These findings highlight the potential of diet in controlling the microbiome and its outputs.
Dr. Yi Li receives CPRIT funding to develop treatments for solitary fibrous tumor, a rare cancer driven by gene fusions. Researchers are working on novel therapies, including immunotherapy and antisense oligonucleotides, to reduce cancer-causing signal activity.
Researchers identified a rare genetic mutation, BTK A428D, that blocks both BTK inhibitors and next-generation BTK degraders. The study provides new insight into how cancers evolve under treatment pressure and may help develop strategies to overcome resistance in patients with chronic lymphocytic leukemia.
A three-year research award from Gabrielle’s Angel Foundation will support the study of transcutaneous auricular vagus nerve stimulation (taVNS) to manage chemotherapy-induced peripheral neuropathy symptoms. The goal is to improve quality of life for cancer patients with long-term effects of treatment.
Scientists found that inherited genes interact with acquired mutations to shape tumor evolution, influencing cancer risk and treatment responses. The study suggests a personalized approach to cancer prevention and screening strategies may be necessary.
Research reveals that patients' inherited genetic variants can impact the benefits and toxicity of CAR-T cell therapy for blood cancers. Variants in genes such as STXBP2, ADAMTSL3, and PTPN22 were found to correlate with treatment-related toxicity or enhanced therapeutic activity.
A research team led by Iowa State University's Raquel Espin Palazon identified two essential components — a pervasive protein and a crucial cellular signaling pathway — needed to make some types of blood cells. Adding these components to leukemia cells could potentially lead to new treatment options.
Researchers at the University of Chicago report a promising new strategy using BifidoSumIL-2, an engineered bacterial strain, to deliver an immune-stimulating therapy directly into pancreatic tumors. The treatment selectively activates cancer-fighting T cells and slows tumor growth, even when combined with chemotherapy or radiotherapy.
A randomized controlled trial in Singapore found that self-sampling increased high-risk HPV detection and overall screening uptake among previously unscreened women. Screening uptake also increased among women with regular screening history, particularly those who chose self-sampling.
By coating extracellular vesicles with metal ions, cells can recognize and capture their own vesicles more strongly, improving liquid biopsies and aiding in drug delivery, rejuvenation, and more. This technique amplifies signals indicating cancer cells by a factor of 10,000, making single cells detectable even in large samples.
A Rice University research team created prostate cancer cells that can survive high-force moments in the body, a process known as mechanoresistance. The study found that a gene called CALB2 plays a key role in this ability, with increased expression linked to metastatic cancer.
Researchers at Brown and U.T. Southwestern have identified a key mechanism underlying GPT2 deficiency, a rare genetic disease affecting brain development. Supplementing a metabolite called alpha-ketoglutarate may improve DNA structure and gene expression in the brain, potentially leading to new treatments.
Researchers discover how tumors hijack the thymus to evade immune surveillance by transporting tumor antigens there. Disrupting a specific chemokine receptor may enhance anti-tumor immunity and improve cancer treatment outcomes.
Cevostamab, a bispecific antibody targeting FcRH5, showed promise in treating multiple myeloma, with over 40% of patients experiencing cancer reduction. The fixed-duration approach provided a break from treatment for patients, reducing serious infections and adverse events.
Scientists at UVA have developed a new method to target glioblastoma, the most common and deadly brain cancer, by delivering microRNAs through the brain's natural barrier. The approach shows promise in slowing tumor growth and extending survival in animal models.
Researchers used advanced 3D genome mapping technology to study prostate cancer cells and discovered a new feature of gene control networks that could help fight cancer. The study found that enhancers work cooperatively in 3D networks, with some acting as central hubs that control many genes.
Researchers discovered specific microRNAs, including miR-16 and miR-140, which may help detect cancer-related muscle wasting in dogs. The study's findings have implications for human medicine, suggesting a potential new approach for earlier diagnosis and monitoring of cancer-related cachexia.
Researchers have identified a unique type of melanoma that spreads between catfish in Lake Memphremagog, behaving like parasites. The discovery sheds light on the spread of cancer in wild animals and raises questions about its origin and ecological impact.
A UMass Amherst-led team is developing a new approach to prevent bladder cancer recurrence by exfoliating the bladder lining. The technology uses irreversible electroporation to target premalignant cells, offering a potential alternative to surgical removal or aggressive treatments.
Researchers found that risk calculators used to estimate heart attack and stroke risk perform about as well for predicting certain cancers. The tools estimated cancer risk based on factors such as age, BMI, smoking status, and blood pressure, which are also linked to a higher risk of cancer.
Researchers at Sanford Burnham Prebys Medical Discovery Institute found significant sex-based protein differences in lung adenocarcinoma, with 901 proteins varying between male and female patient samples. This study contributes to understanding cancer biology and may benefit physicians and patients.
Researchers found that a new treatment regimen can slow cancer progression in patients with functional high-risk (FHR) multiple myeloma. The study defines FHR multiple myeloma as progressing within 36 months of starting treatment, indicating a survival prognosis of less than 2 years after progression.
Researchers at UIC identified KCNMB1, an ion channel protein that helps regulate cell movement. Activating this pathway increases cell stiffness, making cancerous cells more susceptible to immune attack. The discovery points to a promising new therapeutic target for metastatic cancer.
A Rutgers-led study of nearly 500,000 adults reveals that repeat testing is linked to earlier diagnoses and depends on primary care provider behaviors. The study found that health systems play a significant role in increasing patient consistency, with Kaiser Permanente having the highest adherence rate.
A new study published in Chinese Neurosurgical Journal found that real-time MRI and brain function monitoring during neurosurgery can improve the removal of tumors affecting the corpus callosum more effectively and safely. This multimodal approach gave patients about 30 extra months after treatment before the tumor grew back or worsene...
Researchers at Wayne State University and Indiana University have developed a new class of drugs that target the Ku70/80 DNA-binding complex, a critical enzyme in DNA damage response. This approach aims to sensitize cancer cells to radiation and improve radiotherapy outcomes for lung cancer patients.
Researchers developed a KRAS-targeted vaccine and found it generated significant immune responses in participants with a hereditary predisposition to pancreatic cancer. The vaccine was safe and produced memory T cells that persisted over time.
Daniel E. Sabath, a professor at UW Department of Laboratory Medicine and Pathology, has won the Association for Molecular Pathology's 2026 Meritorious Service Award for his dedication and effort over three decades. He is being honored for his leadership roles, scientific expertise, and collaborative spirit in advancing education and s...
A subset of cancers, known as microsatellite instability (MSI) and deficient DNA mismatch repair (dMMR) cancers, are more visible to the immune system than others. Researchers from the Keck School of Medicine of USC identified a biological feedback loop that helps activate the immune response against these types of cancer.
Researchers at UT MD Anderson Cancer Center have made significant progress in treating rare brain infections with a virus-specific T cell therapy, achieving an overall response rate of 56.8% in patients with progressive multifocal leukoencephalopathy (PML). The center also introduced a novel CAR T cell therapy for hard-to-treat kidney ...
Dr. Elaine S. Jaffe receives AMP's highest honor for pioneering contributions to lymphoma diagnosis and treatment. Dr. Laura J. Tafe is recognized for her leadership and service to the organization, while Dr. Daniel E. Sabath receives the Meritorious Service Award for his dedication to scientific excellence and organizational service.
The Association for Molecular Pathology recognizes Dartmouth Health medical director Laura J. Tafe for her exceptional leadership and dedication to the field of molecular diagnostics. She has been a member of the organization since 2007 and has held various positions, including president in 2023.
A study found that cancer care providers are more likely to be aware of the risks of cannabis use, but less comfortable discussing it with patients. In contrast, survivors feel more comfortable discussing cannabis with their care team and hold more positive attitudes towards its use.
The study found significant progress in reducing cancer mortality disparities for breast and uterine corpus cancers, but persistence in prostate cancer remains. The findings highlight the need for targeted interventions to accelerate progress in equitable cancer prevention and control.
Elaine S. Jaffe, a distinguished investigator at the NCI Center for Cancer Research, has transformed our understanding of lymphoid malignancies through her groundbreaking research. Her work has led to significant advancements in disease classifications, diagnosis, and treatment.
The ECOG-ACRIN ENDURANCE trial found that indefinite lenalidomide maintenance had no survival benefit and more toxicity compared to stopping treatment after 2 years in patients not undergoing a stem cell transplant. The study suggests that fixed duration treatment can significantly reduce healthcare costs.
A Johns Hopkins Medicine team created a computational model to forecast which patients with hepatocellular carcinoma (HCC) will benefit from combination treatment using immunotherapy and targeted therapy. The spatial QSP modeling platform accurately predicted response rates for virtual patients, demonstrating its potential to inform pe...
A buildup of bile acids caused by an unhealthy gut can drive breast cancer to other parts of the body, researchers reveal. The study found that replenishing beneficial bacteria or treating patients with FDA-approved bile acid sequestrants may reduce breast cancer metastasis.
Researchers at Texas A&M University have found a way to intervene early in traumatic brain injuries using a natural, gut-derived chemical that prevents post-traumatic epilepsy from taking root. The treatment reduced brain inflammation, improved memory and mood, protected brain cells, made seizures both rarer and harder to trigger.
A new study suggests that ketogenic diets can increase the risk of cancer in the small intestine, unlike their protective effect on colon cancer. The diet's effects are driven by fat metabolism rather than ketone bodies.
Researchers developed a nanoparticle system that uses cancer cells' own copper resources to activate cuproptosis, eliminating tumor cells while protecting healthy tissue. The targeted nanoparticles showed enhanced cellular uptake and were more lethal to breast cancer cells than non-targeted versions.
A study found that Black African and Caribbean women in the UK are less likely to attend breast cancer screening due to limited knowledge and trust issues with healthcare providers. Researchers recommend stronger links between GP practices, breast screening services, and community champions to improve awareness and attendance.
Scientists at MD Anderson Cancer Center have identified a previously unknown mechanism by which T cells attack and eliminate acute myeloid leukemia (AML) cells. The discovery reveals that AML cells use a CD64-dependent pathway to evade traditional MHC recognition, potentially explaining why AML is sensitive to immune-based treatments.
The meeting will explore breakthroughs in diabetes prevention and treatment, as well as innovative approaches to monitoring astronauts' health in space. Researchers will also discuss potential targets for slowing or preventing Alzheimer's disease in people with Down syndrome, and advancements in cervical cancer screening.
A study on the lemon frost gecko, a pet reptile prone to aggressive tumours, has identified genomic changes associated with cancer. The findings may provide insights into why some animals are more susceptible to cancer than others.
A new cancer drug has shown promising results in a mesothelioma trial, controlling disease progression in 67% of patients. The drug targets the cancer's energy system by inhibiting a specific enzyme, causing oxidative stress that kills tumor cells.
Researchers from the University of Nebraska-Lincoln have identified a specific gut bacterium, Bacteroides uniformis, and its metabolites that can positively impact the body's immune response to cancer. The study found that these metabolites can suppress tumor growth and boost anti-tumor immunity in mice.
Researchers propose using the glucose ketone index (GKI) to track metabolic health in non-communicable diseases, which cause three in four deaths worldwide. The GKI measures blood glucose and ketones and may indicate metabolic state, assess long-term nutritional adherence, and support mitochondrial function improvement.
Researchers developed nanoparticles that retain their protective coating in normal tissue but shed it upon reaching tumor tissue, releasing anticancer drugs. This technology reduces systemic side effects and enhances treatment efficacy.
A new study found that a virtual smoking cessation treatment program nearly doubled quit rates for cancer patients who currently smoke. The program, delivered at community oncology care settings, was both cost-effective and satisfying for patients. Participants who completed more sessions had a higher likelihood of quitting.
Researchers discovered a new epigenetic therapy that remained effective in treatment-resistant acute myeloid leukemia (AML) through activating the Hippo pathway, a tumor-suppressing pathway linked to cancer growth and drug resistance. The therapy, NTX-301, consistently reduced leukemia cell survival more effectively than existing hypom...
Artificial intelligence is enhancing cancer drug discovery by identifying optimal targets, screening compounds, and designing novel therapies. This technology combines various data types to uncover vulnerabilities in cancer cells, ultimately improving the development of effective treatments.
A new study found that simple weekly electronic symptom check-ins with care teams significantly improves the quality of life for individuals undergoing treatment for advanced cancer. The benefits were notable among patient groups that historically faced barriers to care, including Black patients and those with less formal education.
Researchers identified a potential new treatment strategy combining popular weight-loss medications with anti-inflammatory drugs to help patients with obesity-associated leukemia. The study found that obesity creates a state of chronic inflammation that accelerates the growth of mutated, leukemia-causing blood stem cells.