Articles tagged with Cancer
Melanie Rutkowski's pioneering research may lead to novel immunotherapy treatments for ovarian cancer by understanding how faulty cellular signaling interacts with the microbiome. The grant aims to enhance immune system's ability to kill cancer cells and improve patient outcomes.
A clinical trial by UC San Diego School of Medicine found that personalizing cancer treatments using molecular testing improves treatment success. The study used advanced genomic sequencing to identify unique tumor DNA profiles and developed personalized treatment plans, resulting in better treatment results for patients.
A global review of COVID-19 vaccination and infection cases found associations between the two and certain types of cancer. The study analyzed 69 publications and identified potential biological mechanisms, including immune responses and inflammation.
Researchers have developed a new way to boost the immune system's response to cancer by using specially engineered antibodies. The antibodies work by clustering multiple immune cell receptors, amplifying the signal that tells T cells to attack cancer cells.
This study explores the feasibility of preoperative VEGFR-TKI plus ICI therapy for advanced renal cell carcinoma, finding improved cNSS rates and preservation of renal function. The therapy also induces robust immune activation through increased CD8⁺/CD20⁺ infiltration and tumor microenvironment remodeling.
A study of 105,260 adults found associations between higher intakes of certain preservatives and increased risks of breast, prostate, and other cancers. Researchers call for re-evaluation of regulations governing food industry use of additives to protect consumer health.
Researchers found that pitavastatin directly inhibits the anti-apoptotic protein Mcl-1, a key driver of survival and resistance in TNBC cells. The study showed pitavastatin effectively eliminates cancer stem-like cell populations and reduces tumor growth, angiogenesis, and lung metastasis.
Researchers found that children and young adult cancer survivors age faster and experience accelerated cognitive decline due to treatment effects. The study suggests that quitting smoking, exercising, and improving nutrition can help reverse these aging changes.
A new nanodrug called Nano-273 could offer improved survival for patients with pancreatic and lung cancers by activating the immune system and blocking tumor growth. The drug, developed by University of Houston researcher Wei Gao, has shown promising results in early studies.
A recent study published in Gut journal revealed that Streptococcus anginosus produces methionine metabolites, which significantly contribute to the development of gastric cancer. The research opens new paths for microbiota-targeted prevention strategies.
Researchers created an AI model to design peptides targeted by proteases, which are overactive in cancer cells. The peptides can be detected in urine, revealing specific types of cancer. This technology could lead to at-home tests for various cancers.
A new study maps breast cancer vulnerabilities, identifying two major classes of weaknesses: gene addiction and synthetic lethality. The analysis highlights key metabolic and signaling dependencies that distinguish different subtypes, revealing actionable targets for precision treatment strategies.
A team of researchers has developed a method for preparing supramolecular prodrug assemblies to enhance chemodynamic therapy efficacy by consuming glutathione (GSH) and inhibiting its synthesis. The approach allows for the simultaneous release of dual functional molecules from self-assemblies, amplifying cellular oxidative stress.
Researchers found that ovarian cancer transforms the omentum into an environment that favors tumor spread. The study analyzed tissue samples from 15 patients and created a cell atlas of the omentum in diseased and healthy states.
A new clinical trial, RECIPROCAL, seeks to optimize targeted radiation therapy for men with advanced prostate cancer by adjusting treatment based on individual PSA levels. The trial aims to minimize side effects while preserving survival benefits.
Researchers at Columbia University developed an inhalable nanotherapy called BEAT that delivers two therapeutic proteins to the lungs to target cancer cells. The treatment showed better retention in the lungs and dramatically suppressed tumor growth compared to a systemically delivered approach.
Researchers discover Vitamin A metabolite retinoic acid compromises anti-cancer immune response, but develop inhibitor KyA33 to restore DC maturation and function. The compound boosts efficacy of dendritic cell vaccines in preclinical studies.
A large-scale international study has deciphered a mechanism enabling breast cancer to metastasize to the brain. Researchers identified a specific chromosomal alteration predicting high likelihood of brain metastases and found that the absence of functional p53 gene impairs brain environment adaptation.
Two studies found that elevated bacteria levels in tumors weaken immune response, driving resistance to immunotherapy. Researchers are now exploring how to identify patients most likely to benefit from immunotherapy and develop targeted interventions to restore its effectiveness.
Leukemia prevalence increased by 28.0% globally from 1990 to 2021, alongside a 16.2% decline in disability-adjusted life years (DALYs). Chronic lymphocytic leukemia (CLL) is the most prevalent subtype, while acute myeloid leukemia (AML) contributes the largest proportion of DALYs.
Polysaccharide-based microneedles have been shown to effectively deliver anti-cancer agents directly into the skin, targeting rich networks of immune cells. The microneedle matrix itself can also modulate these immune cells, creating a powerful dual-action therapy.
Researchers at Kanazawa University have developed a new combination therapy that combines CAR-T cell therapy with a SUMOylation inhibitor, which effectively suppresses MYC activity and slows the growth of Burkitt's lymphoma cells. The approach extends survival rates in mouse models by up to 80%.
Researchers discovered a mechanism allowing melanoma cancer cells to paralyze immune cells by secreting extracellular vesicles, which can disrupt immune cell activity and even kill them. This breakthrough has promising therapeutic implications, enabling strengthening of immune cells and blocking molecules that enable vesicle adhesion.
A new study from Texas A&M University reveals that circadian disruptions change the structure of mammary glands, weaken immune defenses, and fuel aggressive breast cancer. Disabling an immune checkpoint molecule called LILRB4 helps restore the immune system's ability to fight back.
Early gastric cancer cells become self-sufficient by producing WNT7B, creating a self-sustaining loop and activating WNT signaling internally. This mechanism is triggered by MAPK signaling activation and has been validated in genetically engineered mouse models and human patient-derived organoids.
A new study validates OVCAR3 as a reliable model for high-grade serous ovarian carcinoma, providing insights into disease behavior and potential therapeutic targets. The research also explores the effects of repurposed drugs on ovarian cancer cells, revealing promising results for treatment responses.
A large comparative study found that even low daily alcohol intake increases mouth cancer risk by 50% in India, with locally brewed drinks posing the greatest threat. Chewing tobacco use is also a major contributor to this risk, accounting for up to 62% of cases.
The 2024 report shows improved care quality and accessibility across China, with a rise in early gastrointestinal cancer detection and improved colonoscopy quality indicators. Despite progress, regional disparities persist and costly treatments for IBD remain a challenge.
The study reveals that MCL1 directly influences the mTORC1 complex, controlling bioenergetics and tumorigenesis in cancer cells. Genetic analyses also show that MCL1 inhibitors inhibit mTOR signaling, addressing a previously unresolved problem in cancer therapy.
Researchers at Johns Hopkins Kimmel Cancer Center developed a new treatment that selectively targets TRBC2-positive T-cell cancers, preserving approximately 40%–60% of normal T cells. The therapy, an antibody-drug conjugate, provides a long-sought therapeutic option for half of T-cell lymphomas and leukemias.
A new MIT study shows that high-fat diets cause liver cells to revert to an immature state, making them more susceptible to cancer-causing mutations. This reversion is driven by genes that help the cells survive stressful conditions, but ultimately increases their likelihood of becoming cancerous.
A new study by researchers from the Germans Trias i Pujol Research Institute provides a comparative analysis of the impact of BRAF gene mutations in melanoma and colorectal cancer. The review highlights molecular, cellular, and tumour microenvironment factors that explain the therapeutic dichotomy between the two tumour types.
Researchers at Lund University have discovered a cell's protective mechanism against excessive hydrogen peroxide, a key free radical. The study shows that the channel in the cell membrane closes automatically when high concentrations of hydrogen peroxide are detected, preventing damage and cell death.
A deep learning framework called PRTS accurately predicts single-cell-resolution spatial transcriptomics from H&E-stained histology images. The model identifies 21 cell subtypes in mouse brain and maintains prediction accuracy in human breast and lung cancer tissues.
Researchers will investigate how HIV and cancer drugs damage brain cells over time, identifying potential early biomarkers of neurotoxicity. They will use human brain organoids grown in the lab to mimic brain physiology.
CORAL accurately predicts genetic subtypes and patient outcomes in multiple myeloma without costly genomic tests. The technology could be applied to other cancers, opening the door to personalized, faster and widely accessible cancer care.
A systematic review found that pancreatic cancer surgery significantly increases the risk of new-onset diabetes mellitus (NODM), particularly in patients with known risk factors. The study analyzed 45 studies and found an overall incidence of NODM of 24.5%, with a higher rate in those who underwent distal pancreatectomy.
A new approach integrates multimodal data, AI, and insights from traditional Chinese medicine to predict cancer risk and identify early biomarkers. This 'pan-cancer exceedingly-early' strategy offers a promising avenue for personalized early prevention.
Researchers at Kyoto University identified five molecular subtypes of colorectal cancer stem cells and developed a practical prognostic indicator, the general colorectal cancer signature (GCS), to predict patient outcomes. The GCS was validated with a novel orthotopic xenograft mouse model and showed promising clinical significance.
A new study has found that radioactive seed localization (RSL) is an effective and comfortable alternative to traditional wire localization for breast cancer surgery. Patients who received RSL reported less pain and anxiety, while surgeons rated the technique as more convenient and satisfying to perform.
A review of anti-diabetic medications reveals complex mechanisms influencing cancer progression through cell proliferation, immune function, and inflammation. The findings highlight potential therapeutic strategies and underscore the need for further research into diabetes treatments and cancer outcomes.
Researchers at EPFL have developed two bioengineering approaches that exploit extracellular vesicles to train dendritic cells to identify cancer cells without the need for tumor material. The approaches, published in Nature Communications and Science Translational Medicine, show promising results in enhancing cancer immunotherapy.
A new ultrasound technology developed at Johns Hopkins University can distinguish fluid from solid breast masses with near perfect accuracy, improving the diagnostic certainty of radiologists. In initial tests, doctors accurately identified masses 96% of the time, compared to 67% with traditional tools.
A virtual diet and exercise program has been shown to reduce treatment side effects and increase treatment retention, according to a Sylvester study presented at ASH 2025. Lifestyle interventions can also help patients with blood cancers such as MDS and large B-cell lymphoma receive more effective and less toxic treatments.
Researchers from MIT and Broad Institute develop temporary 'factory' in the liver to generate T-cell-stimulating signals, boosting immune response to vaccination and cancer immunotherapy treatments. Aged mice showed significant increases in T cell population size and function after treatment.
Researchers used machine learning to combine clinical data with biological markers, achieving 89.58% accuracy in predicting patient survival. The study identified key markers such as E2F8, WDR77, and hsa-miR-495-3p, which were associated with tumor growth and cancer development.
Chronic pain prevalence differs between rural and urban adult cancer survivors, with rural areas showing higher rates despite having fewer resources. Limited access to pain specialists and insurance challenges contribute to these disparities.
A new study led by Harvard Medical School researchers found that AI models analyzing pathology samples can infer demographic information, leading to biased diagnoses. The team developed a framework called FAIR-Path to reduce bias in these models, which showed improved performance across demographics.
Researchers developed a new way to stimulate the immune system to attack tumor cells by blocking an immune checkpoint. They created multifunctional molecules called AbLecs, which combine a lectin with a tumor-targeting antibody, and showed they could boost the immune response to cancer cells.
Researchers developed a new diagnostic chip that can detect tumor cells in blood, allowing for real-time monitoring of brain cancer treatment effectiveness. The GlioExoChip uses extracellular vesicles to assess treatment response, providing a quick and minimally invasive way to inform doctors about chemotherapy efficacy.
Researchers have developed a new strategy to target mRNA cancer vaccines by teaching the immune system to recognize and destroy tumors. The treatment uses chimeric nanobodies that bind to tumor surface proteins, releasing mRNA that stimulates an immune response against cancer cells.
Research from the UMBERTO Project found that adopting healthy lifestyles such as eating well, exercising regularly and maintaining a balanced weight significantly reduced cancer mortality. The study showed a strong link between traditional cardiovascular risk factors and survival in people with a history of cancer.
Researchers at the University of Houston have discovered a potential therapeutic strategy for counteracting muscle wasting in pancreatic cancer by blocking a specific cell pathway. Muscle wasting, also known as cachexia, is a debilitating syndrome affecting 60-85% of patients with pancreatic cancer.
Studies show that patients with advanced ovarian and metastatic breast cancer dedicate approximately 7 hours per week to cancer-related tasks. Most participants report performing these tasks daily, impacting their time burden. The use of a mobile app facilitated the collection of detailed time-use data.
Researchers at the University of Geneva have created a laboratory platform to rapidly evaluate the toxicity of new cancer treatments using human tissue-derived cell clusters. This approach allows for safer evaluation and could lead to personalized treatment options.
Researchers at The Hospital for Sick Children have identified a non-coding gene called CISTR-ACT that regulates cell size. By exploring its molecular mechanism, the team found that CISTR-ACT guides a protein called FOSL2 to bind to other genes, controlling cell growth and development.
The BRIDGE Program provides coordinated support across disease types to address the rising issue of early-onset cancer, offering fertility counseling, genomic testing, and community education. The program also fuels research into tumor biology and outcomes for younger patients affected by cancer.
Researchers have created an mRNA system that activates therapeutic genes in specific cell populations, potentially leading to safer and more precise cancer treatments. The system uses microRNAs to recognize cancer cells and shuts off the treatment if it's not needed, reducing toxicity and expanding mRNA therapy's reach.
A blood test may help doctors identify which patients with colon cancer can benefit from anti-inflammatory medication and chemotherapy after surgery. The test measures circulating tumor DNA levels, and high-risk patients who test positive see improved survival rates when taking celecoxib with chemotherapy.
Researchers discovered glioblastoma cells use PRDM9 to survive chemotherapy and regrow tumors. By blocking PRDM9 or cutting off cholesterol supply, persister cells can be wiped out, improving survival in mice. This breakthrough offers new strategies for treating the deadliest brain cancer.