Articles tagged with Cancer
A new computational tool called DeepTarget predicts direct and indirect targets of cancer drugs, revealing that small molecules can have different targets and effects depending on the disease and cell type. The study demonstrates the tool's superior performance in real-world scenarios, highlighting its potential to accelerate drug deve...
City of Hope researchers have made significant breakthroughs in cancer treatment, including a long-term survival boost for advanced prostate cancer patients, targeting IL-18 to improve immune function, and identifying a new target for pancreatic cancer therapy. These discoveries offer promising strategies for improving patient outcomes...
Researchers at Gladstone Institutes and UCSF have identified the genetic switches that regulate FOXP3 levels in human and mouse cells. In humans, multiple enhancers work together to keep FOXP3 active, while a repressor keeps it off in conventional T cells. This discovery has important implications for developing immune therapies.
Researchers at the University of Chicago discovered that YTHDF2 regulates RNA metabolism to suppress inflammatory responses, potentially preventing skin cancer. The study found that UV exposure triggers a decrease in YTHDF2 levels, leading to increased inflammation and tumorigenesis.
A study found that higher consumption of ultraprocessed foods is associated with an increased risk of developing early-onset colorectal cancer precursors. The research highlights the importance of improving dietary quality to mitigate the rising burden of early-onset colorectal cancer.
Researchers from the University of Miami Miller School of Medicine and Sylvester Comprehensive Cancer Center will present their work on various hematological conditions at ASH 2025. These posters highlight recent findings in fields such as von Willebrand disease, multiple myeloma, and acute myeloid leukemia.
Lymphomas develop resistance to targeted therapies through various mechanisms, including loss of target antigens, reactivation of growth pathways, and changes in tumor microenvironment. Researchers explore new treatment approaches, such as dual-target therapies and biomarker-guided therapy, to overcome these challenges.
Researchers identified a new subtype of T-cells that do not respond to current treatments and could impact clinical care. A genetic marker, ZBTB16, was found to be switched on in these cells, which can be used to identify them.
Australian scientists have developed a new blood test that can identify women with ovarian cancer more likely to benefit from PARP inhibitor therapy, offering hope for more effective treatment. The test measures immune biomarkers and predicts which patients will respond to treatment.
A comprehensive review identifies exosomes as critical mediators in the process of obstructive sleep apnea (OSA)-related diseases. OSA-induced intermittent hypoxia and sleep fragmentation alter exosome secretion and content, disrupting cell function and leading to various comorbidities.
Researchers analyzed 29 new and 22 previously reported cases of PCNSL involving the ventricles, finding different clinical symptoms such as headache, dizziness, and vision impairment. The study suggests that despite its unusual location, ventricular PCNSL behaves like other forms of brain lymphoma, with a recommended treatment strategy...
A recent study using UK Biobank data found that greener environments may reduce the risk of postmenopausal breast cancer associated with air pollution. The researchers analyzed data from over 500,000 women to investigate the relationship between green spaces and air pollution on breast cancer risk.
Researchers at Stanford University found that very old mice are less prone to cancer, with significantly fewer lung tumors than younger animals. This contradicts the long-held assumption that cancer risk increases with age, suggesting a deeper biological cause.
A team of researchers led by Dr. Michele Ardolino is bridging scientific fields to unlock the mechanisms behind effective immune responses in cancer patients. They will study the interactions between the immune system, nervous system, and gut microbiome to design more personalized treatment strategies.
Researchers at UC Riverside and City of Hope have developed a novel Pin1 degrading compound that suppresses pancreatic cancer peritoneal metastases. The treatment targets not only cancer cells but also tumor-supporting cells, potentially overcoming treatment resistance.
The ESMO Congress on Artificial Intelligence and Digital Oncology features a diverse range of presentations on multimodal AI for clinical decision support, AI-based biomarkers for precision oncology, and digital health in practice. The congress also explores ethics, regulation, and patient perspectives.
Researchers identified a cholesterol metabolite called hydroxycholesterol that suppresses the immune system's ability to attack cancer, leading to increased metastasis. The team discovered a line of communication used by immune cells and cancer cells that stimulates breast cancer progression.
A recent study found that team-based clinic participants perceived significant improvements in patient care, whereas technology-based clinic participants saw limited benefits. The study highlights the importance of human interaction and values-centered care in supportive cancer care.
The new clinical cancer research center will support lung and genitourinary cancers, serving as a central hub for seven VA medical centers. The grant aims to improve access to precision oncology trials and patient care for veterans diagnosed at later stages.
Researchers developed a new approach combining genetic ancestry, lifestyle, and social determinants of health to identify individuals with skin cancer. The AI model achieved 89% accuracy in identifying skin cancer across all populations, with 90% accuracy for European ancestry and 81% accuracy for non-European ancestry.
Researchers at Sanford Burnham Prebys Medical Discovery Institute found that aging accelerates pancreatic cancer progression, leading to faster tumor growth and metastasis. By understanding the impact of age on the tumor microenvironment, they developed a new approach to treating this disease in frail patients.
Researchers at the University of Cincinnati have developed a new technique to treat cancer by altering the physical structure of subcellular organelles, specifically lipid droplets. By grouping and locking up lipid droplets, they can starve cancer cells of energy, slowing tumor progression.
Experts warn that new drugs for advanced breast cancer are unaffordable and may lead to unequal treatment access worldwide. The consensus panel recommended prioritizing most effective treatments and using next-generation sequencing for personalized medicine.
This study analyzed the temporal evolution of three LLMs in oncology, finding that subjective questions degrade faster over time than objective queries. The results highlight the need for ongoing performance monitoring and strategies to integrate up-to-date clinical data for safe and reliable AI deployment in cancer care.
Researchers analyzed 52,980 single cells from 11 patients with HPV-positive penile cancer, revealing distinct immune remodeling associated with viral status. HPV-positive tumors contained fewer proliferative macrophages and less exhausted CD8+ T cells, along with stronger chemokine signaling.
Steatotic liver disease, caused by metabolic dysfunction-associated steatosis, alcohol-related liver disease, and more, affects over 30% of adults worldwide. Emerging genetic variants like PNPLA3, TM6SF2, and MBOAT7 modulate susceptibility to SLD, which progresses to cancer through cumulative genomic instability and immune dysregulation.
The University of Freiburg is witnessing a surge in interdisciplinary research success with the recent awarding of four Synergy Grants from the European Research Council. Prof. Dr. Stefan Glunz's project aims to develop resource-efficient photovoltaic technologies, while Prof. Dr. Claudine Kraft's project investigates the degradation o...
Researchers uncover tandem allosteric effect enabling efficient deacetylation of proteins by Sir2, a key enzyme for biological processes. This finding reveals new target for modulating Sir2, potentially leading to novel cancer treatments and therapeutic applications.
A study reveals how colorectal tumors use TGF-β to prevent immune cells from reaching and attacking the tumor. The researchers suggest strategies to improve immunotherapy efficacy by blocking this dual barrier and identifying new therapeutic targets.
Recent research in pathological foundation models has demonstrated robust representation learning capabilities and generalization performance. These models enable multi-task transfer with minimal data, significantly enhancing clinical utility and generalizability.
Despite progress in controlling stomach, liver, and esophageal cancers, China's total cancer deaths continue to rise, projected to reach 2.4 million by 2030. Population aging and unequal access to healthcare drive these increases, with rural areas lagging behind urban regions.
Dr. Lovly brings nearly two decades of experience in clinical care, research and academic leadership to her new role, shaping the modern landscape of lung cancer care. Her expertise in precision medicine will be instrumental in accelerating progress for patients with lung cancer across the country.
The study found that a nine-month programme of supervised exercise improved muscle mass and strength, particularly in the arms and legs, and physical performance in patients with breast cancer that had spread to other parts of the body. Muscle mass increased by an average of 0.79 kg after three months and 0.32 kg after six months compa...
Researchers from Università Cattolica del Sacro Cuore develop hybrid endoscopes combining diagnostic and therapeutic functions. The MULTIPROBE project aims to revolutionize cancer care by providing a combined diagnostic and therapeutic tool using innovative endoscopic systems and cold plasma therapy.
Researchers from Arc Institute, UCSF, and Fred Hutchinson Cancer Center identified PTGES3 as a key regulator of the androgen receptor in prostate cancer. The study found that PTGES3 contributes to tumor growth and suggests it could be a promising new target for treating aggressive prostate cancers.
A study of over 60,000 US patients with advanced breast cancer found average survival times increased by six to seven months since 2011. Researchers attribute the improvement to more effective treatments, wider diagnosis, and quality of care advancements.
A new case report describes the successful treatment of a 37-year-old woman with HER2-positive breast cancer that had spread to the membranes surrounding the brain and spinal cord. Trastuzumab deruxtecan, an antibody-drug conjugate, improved the patient's neurological symptoms and reduced cancer growth.
The ABC Global Decade Report 2015-2025 reveals significant advances in breast cancer care for some patients globally. However, persistent inequalities leave many behind. The report's findings drive the creation of the ABC Global Charter 2025-2035, aiming to improve equitable progress and transform care for everyone with ABC.
Researchers have discovered a new way to understand cancer and its vulnerabilities by targeting FSP1, a protein that helps cancer cells survive. The study found that FSP1 inhibitors can effectively reduce the growth of metastatic melanoma cells in lymph nodes.
A recent study published in The FEBS Journal found that specific gut bacteria can efficiently metabolize different forms of nitrogen, preventing carcinogenic nitrosamine formation. This process is critical for maintaining intestinal and systemic health, potentially decreasing the risk of certain cancers.
A global survey of nearly 4,000 young women with advanced breast cancer found that nearly half have children under 18 and face significant hardship. The study also revealed delays in seeking care, unmet psychosocial needs, and limited access to precision diagnostics.
Researchers at University of Miami Miller School of Medicine have developed a new combination therapy that shrinks tumors, reduces cancer stem cells and reprograms immune environment to combat hormone-resistant breast cancer. The triple therapy approach targets tumor-associated macrophages, which act like bodyguards for cancer cells.
Scientists at Wake Forest University School of Medicine have discovered a new way to kill cancer cells by blocking their ability to clean up harmful waste. By inhibiting peroxiredoxin-3, researchers found that toxic levels of hydrogen peroxide overwhelm cancer cells, destroying them.
A large global study of 23,000 people found that proton pump inhibitors (PPIs) used for indigestion and heartburn were associated with poorer overall survival and a higher risk of severe side effects in patients with breast cancer. Statins and metformin showed no significant impact on either survival or adverse events.
A new editorial highlights the importance of primary care in preventing heart disease in breast cancer survivors. The study found that most women do not go on to develop serious cardiac disease, but those with higher-risk chemotherapy, older age, or multiple cardiovascular risk factors may benefit from closer monitoring.
Researchers at Syracuse University have developed a novel method using ultrasound to trigger chemotherapy drugs in targeted areas, minimizing damage to healthy tissues. The approach could lead to safer and more effective cancer treatment, potentially reducing side effects and improving patient outcomes.
The National Comprehensive Cancer Network (NCCN) has expanded access to cancer treatment in Sub-Saharan Africa with new international adaptations. The adaptations reflect significant progress in cancer care delivery, including increased access to imaging techniques and biomarker testing.
The DEFEND study aims to assess whether virtual exercise sessions can be successfully delivered to patients with cancer receiving chemotherapy. Researchers will evaluate the impact on physical function, fatigue, and disability.
MIT researchers use messenger RNA to activate an immune pathway in nearby immune cells, triggering the destruction of tumors. The approach combines existing immunotherapy drugs and avoids side effects associated with large doses of STING activators.
Researchers at Mass General Brigham have developed a strategy to promote antitumor immunity by inducing cancer cells to produce an immune-activating molecule. This approach was shown to reduce tumor growth and improve survival in mouse models of aggressive melanoma, with potential applications beyond cancer therapies.
A UC Merced biologist found that activating neural signals can selectively remove cancer symptoms in planarian flatworms, which could change how doctors treat cancer and age-related diseases. The study may also shed light on degenerative conditions linked to aging.
Researchers have identified a new histone variant, macroH2A1.1, as a potential therapeutic target for treating Acute Myeloid Leukaemia. The study found that targeting this variant is safe for patients and may lead to new treatment options.
Researchers at Texas A&M University found that indoor hydroponic gardening significantly improves mental well-being, reduces depression levels, and enhances overall quality of life in cancer patients. Participants experienced improvements in emotional and social functioning after just eight weeks of gardening.
A UT Dallas team developed an electrochemical biosensor that accurately identifies eight volatile organic compounds linked to thoracic cancers. AI analysis enhances the accuracy of breath samples, showing promise for early lung cancer detection and improved patient outcomes.
Researchers at TUM have discovered a new regulatory mechanism that controls apoptosis, with potential applications in cancer treatment and neurodegenerative diseases. The study found that the protein VDAC1 can bind to Bcl-xL, promoting apoptosis.
Research suggests m⁶A modification regulates oncogenic pathways, immune evasion, and metabolic reprogramming in cancer. Dysregulation of m⁶A drives cancer hallmarks like uncontrolled proliferation and metastasis.
A UCLA study finds that DNA copy-number changes enable melanoma cells to resist immune attacks, leading to tumor relapse. The researchers suggest a strategy to make tumors more prone to self-destruction after immune attacks, potentially extending the effectiveness of immunotherapy.
MIT researchers have developed new nanoparticles that deliver the immune-stimulating molecule IL-12 directly to ovarian tumors, eliciting a strong response and clearing tumors in over 80% of mice. This treatment combines with checkpoint inhibitors to launch an attack on cancer cells without causing side effects.
Researchers found that baseline Anti-Mullerian Hormone (AMH) levels between 2.1-2.8 ng/ml correspond to 35-42% of live birth rates in women with cancer using fertility preservation. The study aims to improve prediction and standardization for fertility treatments.
A new study from UC San Diego found that clinical pharmacists can play a crucial role in helping people with cancer and diabetes better manage their blood sugar. The study showed that patients referred to a diabetes management and education clinic led by pharmacists saw meaningful improvements in blood sugar levels over time.