Articles tagged with Cancer
A new study in Molecular Cell reveals that cellular aging is controlled by the ATM kinase response to withered telomeres. Cells grown under low oxygen conditions are more tolerant of short telomeres, while high oxygen accelerates cellular aging due to hyperactive ATM.
Researchers found that FOLFIRINOX improved progression-free and overall survival in patients with advanced biliary tract cancer. The treatment may offer a benefit as a second-line option after first-line chemotherapy failure, but toxicity remains a concern.
The study reveals a significant burden of metastatic disease in adolescents and young adults with cancer. The findings expand knowledge on metastatic recurrences, improving care for adolescent and young adult survivors.
Researchers at the University of Virginia Health System have developed a new treatment for acute myeloid leukemia, a deadly form of blood cancer. The FDA-approved medication works by disrupting cellular protein interactions that drive leukemia cell growth and survival, offering patients a potential cure.
A study published in JAMA Oncology found that shorter courses of androgen deprivation therapy can effectively control prostate cancer without increasing risks. The ideal duration of ADT depends on cancer risk, allowing for more personalized treatment plans.
The new system can reveal early cancers, lung disease, hidden material defects and changes in porosity without multiple exposures or complex mechanical movement. This method produces low-dose and faster images, lowering patients' radiation dose and making clinical translation feasible.
The SISAQOL-IMI consortium has published key guidelines for patient-reported outcomes in cancer clinical trials, providing a harmonised framework for designing, analysing, and interpreting PRO data. The new online toolkit offers practical resources to support implementation across the research and policy landscape.
Zanidatamab demonstrated significant efficacy in patients with HER2-positive biliary tract cancer, achieving response rates of up to 51.6% and improving symptoms such as pain levels. The trial's results support the emerging role of zanidatamab as a treatment paradigm for this rare and aggressive cancer.
Researchers have discovered that rhesus macaques shed TIGIT from immune cell surfaces when exposed to plasmin, a natural enzyme involved in blood clot breakdown. This creates a soluble form of TIGIT that can still bind anti-TIGIT monoclonal antibodies, potentially leading to misleading safety and efficacy data for human trials.
Researchers at the University of York have discovered a way to harness radiation from particle accelerator beam dumps to produce medical isotopes used in cancer diagnosis and treatment. Copper-67 is a rare isotope with limited global supplies, but this method could generate it without affecting main physics experiments.
A novel liver cancer vaccine has achieved responses in a rare disease affecting children and young adults, with 75% of patients experiencing disease control. Three patients are now believed to be cancer-free after receiving the therapy, including a 13-year-old patient who achieved a nearly complete response.
A population-based cohort study found that individuals following high-glycemic index diets had a 13% higher chance of developing lung cancer compared to those on low-GI diets. In contrast, those consuming high-glycemic load diets experienced a 28% lower risk of lung cancer.
A global survey led by UC Irvine researchers found that 70% of oncology professionals use or recommend integrative approaches to manage cancer symptoms. However, these services remain underused due to cost, lack of insurance coverage, and limited training opportunities, particularly in low-income countries.
The report emphasizes the importance of pairing research with policy partners and investing in mentorship and career advancement of Latino scientists and students. It also calls for implementing evidence-based practices, using telemedicine and AI equitably, and designing trauma-informed interventions that fit Latino family life.
A new review connects gut microbiome imbalances to obesity, metabolic syndrome, and colorectal cancer, highlighting the potential for diet and microbiome-based treatments. The study also explores racial and socioeconomic disparities in microbiome-related diseases, emphasizing the need for inclusive prevention strategies.
Research reveals that pleural cavity macrophages support lung tumor growth by suppressing anti-tumor immunity. Macrophage depletion leads to increased cytotoxic CD8 T cells, establishing their role as key drivers of tumor progression.
Recent advances reveal circadian rhythms modulate gut microbiota diversity and metabolic functions, affecting the tumor microenvironment and immune cell function. Gut microbial dysbiosis induced by circadian misalignment promotes an immunosuppressive TME and accelerates tumor growth.
Researchers discovered P. angustum selectively targets colorectal cancer, inducing direct tumor lysis and robust immune activation. The therapy promotes intratumoral infiltration of immune cells and enhances production of inflammatory cytokines, significantly prolonging survival in treated mice.
A study at Technical University of Munich found that AI-simplified CT reports reduced reading time to two minutes and improved patient comprehension. Patients rated the simplified texts as more helpful and informative, with 82% finding them easier to read and understand.
A recent study led by Dr. Leah Backhus found that lung cancer patients often receive inadequate posttreatment surveillance, which can lead to a substantial gap in care. The study estimated the true surveillance rates and predictors of guideline-concordant care in patients with early-stage non-small cell lung cancer.
A special issue of Cancer Biology & Medicine highlights scientific progress, policy innovations, and digital health tools to accelerate cervical cancer elimination. The collection provides a comprehensive resource for advancing women's health equity worldwide, tackling vast inequities in health resources and implementation capacity.
New research reveals VEGF(R) inhibitors induce arthritis through increased inflammatory responses and activation of pro-inflammatory pathways. The study provides important mechanistic insights into this treatment-related adverse event, ultimately enhancing oncology care safety.
A team at the University of Pennsylvania has solved the mechanism of action of hydralazine, revealing its potential to halt the growth of brain cancer cells. By blocking an oxygen-sensing enzyme, hydralazine can reduce intracellular calcium levels, causing blood vessels to relax and tumor cells to enter a dormant state.
Researchers at UC San Diego found that cancer cells use non-genetic mechanisms to regrow after targeted therapy, which could help prevent tumor recurrence. By blocking these signaling pathways, future treatments may be able to stop tumors from relapsing during therapy.
A new AI tool, SMMILe, can rapidly analyze complex cancer images and provide detailed information about tumor lesions, including their locations and proportions. This could lead to more accurate diagnoses and personalized treatment options for patients.
A new type of DNA damage, glutathionylated DNA adducts, accumulates at high levels in mitochondrial DNA, affecting energy production and stress response. The discovery sheds light on how cells sense and respond to stress, with potential implications for diseases like cancer and diabetes.
This study evaluates the long-term effects of IMRT on HNC patients' vision, patient well-being, and morbidity. A cohort study of adults with HNC treated with IMRT in Ghana will investigate visual outcomes and quality of life.
The review highlights the progress in gene-editing nucleases and delivery vectors for in vivo gene therapy, enabling targeted correction of genetic errors. Key examples include FDA-approved products targeting monogenic disorders and cancers, showcasing the therapeutic promise of combining genome editors with advanced delivery platforms.
Researchers found a significant link between type 1 diabetes and an increased risk of bladder cancer, with people being 4.29 times more likely to develop the disease. The new analysis controlled for tobacco smoking, a factor that obscured the heightened risk in earlier studies.
Linda Bulone, a Queens Cancer Center Oncology nurse, received the 2025 Alliance Clinical Research Professionals Research Integrity Service Excellence (CRP RISE) Award. She has significantly increased clinical trial participation, expanded early screening efforts, and supported reductions in late-stage diagnoses.
Researchers at Virginia Tech's Fralin Biomedical Research Institute are studying how fluid flow contributes to the spread of glioblastoma tumors. They will use focused ultrasound and advanced MRI techniques to build a map of fluid flow in the whole brain and test the effectiveness of drug delivery.
The study reveals that mutated and unmutated CLL subtypes originate from distinct stages of B cell development. New molecular biomarkers, including genes LPL, ZNF667, and ZNF667-AS1, have been identified for more precise patient stratification.
Scientists have created a complex tissue model of human bone marrow using only human cells, replicating the cellular complexity of the body's 'blood factory'. This breakthrough reduces the need for animal experiments in blood cancer research and potentially enables personalized therapies.
A new study has discovered that cancer cells use different strategies to move through tight tissue gaps, with fibrosarcoma cells being more flexible and deformable. This flexibility allows them to squeeze through narrow gaps more efficiently, but does not affect the direction of their movement.
The 2025 Tata Transformation Prize recognizes Padubidri V. Shivaprasad's epigenetic engineering for climate-resilient rice, Balasubramanian Gopal's sustainable bio-manufacturing platform using E. coli bacteria, and Ambarish Ghosh's cancer-targeting magnetic nanorobots.
Researchers found that bifidobacterium can boost cancer treatment by regulating the immune system, reducing inflammation, and supporting anti-tumor responses. The probiotic also helps detoxify carcinogens and convert food-based substances into cancer-fighting agents, offering a promising natural ally for cancer prevention and treatment.
The new department will drive the next generation of discovery and patient-centered care through advanced imaging and therapy. Key collaborations include UCLA Health, David Geffen School of Medicine, and UCLA Health Jonsson Comprehensive Cancer Center.
Researchers have identified a protein complex that drives T cell exhaustion in tumors and show that disrupting it can revive exhausted anti-tumor CTLs. The study's findings offer new hope for improving the efficacy of cancer immunotherapy.
Researchers at The University of Osaka have developed a novel Balloon-Assisted Bronchoscope Delivery (BDBD) technique, enabling safe access to small, early-stage lung cancers hidden in the peripheral lung fields. This innovation promises to revolutionize both early diagnosis and minimally invasive treatment.
Researchers identified a targeted drug that blocks a specific genetic pathway to reverse tumor-driving cellular interactions, potentially restoring DNA function and benefiting patients with synovial sarcoma. The study's findings endorse a promising strategy to improve outcomes for this rare but deadly cancer.
Dr. Sedrak receives King Hussein Cancer Research Award for innovative work on accelerated aging in cancer survivors, with a focus on developing new strategies to prevent or reverse age-related effects. His research aims to improve health span and quality of life for cancer patients, holding promise for other age-related diseases.
A new study finds that reducing arsenic levels in drinking water can decrease death rates from chronic diseases such as heart disease and cancer. Over a 20-year period, efforts to lower arsenic levels resulted in a 70% decrease in chemical levels, halving arsenic levels in urine among study participants.
Researchers developed an RNA-based therapeutic strategy targeting mutant KRAS genes, stimulating the immune system to attack tumours. The treatment, combining antisense oligonucleotides and immunomodulatory RNA, effectively killed cancer cells in laboratory studies, reducing tumour burden and extending survival.
Researchers are presenting groundbreaking findings at the Association for Molecular Pathology's annual meeting, including a novel technique to study ancient DNA and rapid detection of serious fungal pathogens. The Association for Molecular Pathology is providing press materials and resources for media coverage.
A new computational tool called DeepTarget predicts direct and indirect targets of cancer drugs, revealing that small molecules can have different targets and effects depending on the disease and cell type. The study demonstrates the tool's superior performance in real-world scenarios, highlighting its potential to accelerate drug deve...
A deep learning system developed by Incheon National University integrates images and clinical details to improve early skin cancer diagnosis. The model achieved 94.5% accuracy, outperforming popular image-only models.
Researchers have made significant advancements in diagnosing acute myeloid leukemia (AML), a common and aggressive form of blood cancer. Genetic testing can now predict relapse after stem cell transplant and detect hidden gene fusions that were previously undetectable.
The University of Texas MD Anderson Cancer Center has launched a historic $2.5 billion philanthropic campaign to end cancer, with an initial $1.9 billion raised. The campaign focuses on expanding reach, expediting breakthroughs, and elevating the patient experience.
Researchers from the University of Miami Miller School of Medicine and Sylvester Comprehensive Cancer Center will present their work on various hematological conditions at ASH 2025. These posters highlight recent findings in fields such as von Willebrand disease, multiple myeloma, and acute myeloid leukemia.
Lymphomas develop resistance to targeted therapies through various mechanisms, including loss of target antigens, reactivation of growth pathways, and changes in tumor microenvironment. Researchers explore new treatment approaches, such as dual-target therapies and biomarker-guided therapy, to overcome these challenges.
City of Hope researchers have made significant breakthroughs in cancer treatment, including a long-term survival boost for advanced prostate cancer patients, targeting IL-18 to improve immune function, and identifying a new target for pancreatic cancer therapy. These discoveries offer promising strategies for improving patient outcomes...
Researchers at Gladstone Institutes and UCSF have identified the genetic switches that regulate FOXP3 levels in human and mouse cells. In humans, multiple enhancers work together to keep FOXP3 active, while a repressor keeps it off in conventional T cells. This discovery has important implications for developing immune therapies.
Researchers at the University of Chicago discovered that YTHDF2 regulates RNA metabolism to suppress inflammatory responses, potentially preventing skin cancer. The study found that UV exposure triggers a decrease in YTHDF2 levels, leading to increased inflammation and tumorigenesis.
A study found that higher consumption of ultraprocessed foods is associated with an increased risk of developing early-onset colorectal cancer precursors. The research highlights the importance of improving dietary quality to mitigate the rising burden of early-onset colorectal cancer.
The ESMO Congress on Artificial Intelligence and Digital Oncology features a diverse range of presentations on multimodal AI for clinical decision support, AI-based biomarkers for precision oncology, and digital health in practice. The congress also explores ethics, regulation, and patient perspectives.
Researchers identified a new subtype of T-cells that do not respond to current treatments and could impact clinical care. A genetic marker, ZBTB16, was found to be switched on in these cells, which can be used to identify them.
Australian scientists have developed a new blood test that can identify women with ovarian cancer more likely to benefit from PARP inhibitor therapy, offering hope for more effective treatment. The test measures immune biomarkers and predicts which patients will respond to treatment.
A comprehensive review identifies exosomes as critical mediators in the process of obstructive sleep apnea (OSA)-related diseases. OSA-induced intermittent hypoxia and sleep fragmentation alter exosome secretion and content, disrupting cell function and leading to various comorbidities.
Researchers analyzed 29 new and 22 previously reported cases of PCNSL involving the ventricles, finding different clinical symptoms such as headache, dizziness, and vision impairment. The study suggests that despite its unusual location, ventricular PCNSL behaves like other forms of brain lymphoma, with a recommended treatment strategy...
A recent study using UK Biobank data found that greener environments may reduce the risk of postmenopausal breast cancer associated with air pollution. The researchers analyzed data from over 500,000 women to investigate the relationship between green spaces and air pollution on breast cancer risk.