Articles tagged with Cancer
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Scientists at the University of Cambridge created a smarter way to activate the immune system against cancer by harnessing the STING pathway. The new two-part prodrug system triggers the immune response only in tumour tissues, reducing harm to healthy cells.
A growing body of research links environmental pollutants to worsened health and shorter life spans in childhood cancer survivors. The study found that only 25% of pediatric oncology providers felt comfortable discussing environmental pollutant impacts with patients.
A novel method combining biological experiments and information science techniques reveals cancer cells' preference for aerobic glycolysis despite sufficient oxygen availability. This research provides a powerful tool for identifying metabolic vulnerabilities in cancer cells, which could lead to more effective treatments.
Researchers from the Stowers Institute for Medical Research have identified a common process that powers the creation of protein formations that assemble like a 3D puzzle, triggering inflammation and cell death. This 'Catch-22' mechanism may be one of the fundamental reasons why we age.
A new study found that providing personalized colorectal cancer risk information to patients and their health care providers did not improve screening rates for the deadly ailment. Colorectal cancer is the second-most common cause of death from cancer in the United States, claiming nearly 55,000 lives annually.
A community-led study found elevated contaminants in animal food sources and rare cancers in local populations, highlighting the need for comprehensive studies on oil sands' health impacts. The authors call for rigorous research to address TRC commitments and protect Indigenous Peoples' environment and health.
Research from Edith Cowan University found that both resistance training and high-intensity interval training (HIIT) reduced breast cancer cell growth by 22-25%. Both types of exercise also increased lean muscle and decreased body fat after 12 weeks of training.
A new tool called Flexynesis uses deep neural networks to evaluate multi-modal data, enabling doctors to make better diagnoses and develop more precise treatment strategies for patients. The tool is designed to be flexible and accessible to non-experts, bridging the gap in precision cancer therapy.
A new study found that Black men often view their primary-care providers as gatekeepers for prostate cancer screening, but are frequently dismissed from getting PSA tests. The study's lead author notes that PSA testing can catch the disease earlier and reduce mortality rates by up to 30% if done in the 40s rather than the 50s.
Researchers have developed a new platform for investigating tumor metastasis using CTC-derived organoids. These organoids provide an in-depth model for analyzing CTC behavior, including interactions with the tumor microenvironment and drug resistance mechanisms.
A chemically modified STn glycoconjugate vaccine has been developed with enhanced antitumor immunity, demonstrating substantial resistance to enzymatic degradation and inducing potent T-cell responses. The vaccine induces functional antibodies capable of initiating both CDC and ADCC against STn-positive tumor cells.
American Indian and Alaska Native residents in Oklahoma face significant cancer disparities due to barriers in accessing lifesaving cancer care. A new care coordination and communication program aims to address these challenges by facilitating virtual huddles between healthcare teams.
A new study finds that women who have overcome cervical cancer are nearly twice as likely to develop anal cancer compared to the general population. The study highlights the need for updated screening guidelines for these patients.
A recent discovery reveals that microbes associated with tumours produce a molecule, which can control cancer progression and boost the effectiveness of chemotherapy. The molecule, 2-methylisocitrate (2-MiCit), was found to inhibit a key enzyme in cancer cells, leading to DNA damage and reducing cancer progression.
A consortium led by the University of Southampton aims to advance cutting-edge treatments for lung cancer, blood cancers, and chronic inflammation. The ON-TRACT project will train researchers in academic, industrial, and clinical settings to develop safer and more effective treatments.
Researchers at King's College London have discovered that cells use electricity to selectively target and eliminate the weakest neighbours, helping to maintain a balanced and healthy protective layer. This process, known as extrusion, is crucial for balancing cell division and death, and disrupting it can lead to disease.
Research by University of Pittsburgh scientists discovered that damaging telomeres can lead to dysfunctional T cell function. To combat this, they developed a targeted antioxidant approach that rescued T cell function, opening the door for novel therapies in cancer immunotherapies.
Researchers evaluated a tool based on NCCN Guidelines to identify high-risk medications and their association with frailty and outcomes in over 380,000 older adults diagnosed with cancer. The study found that each additional high-risk medication increased the odds of being mildly or moderately-to-severely frail by 66%.
High-grade endometrial cancer (HGEC) consists of aggressive variants with poor prognosis and resistance to conventional therapies. The article proposes a molecular-histologic integration framework using the Cancer Genome Atlas to refine diagnosis, guide clinical management, and inform targeted therapy.
A quicker and cheaper two-part MRI scan is just as effective as the current 30-40 minute scan in detecting prostate cancer. The PRIME trial confirms that this streamlined approach can diagnose cancer at the same rate as a full three-part scan, cutting scan time to 15-20 minutes and reducing costs.
A federally funded study found children with leukemia who were exposed to pesticides during their mother's pregnancy had a higher risk of death. The study, published in Cancers, examined over 800 children and showed pesticide exposure increased child mortality by up to 60%.
A clinical trial found that patients with mesothelioma who received combination immunotherapy drugs before surgery had successful surgeries and improved early outcomes. The study showed that tracking tumor DNA in the blood could help predict treatment benefit.
Researchers have developed a new technique to measure boron in individual cancer cells, enabling the study of how drugs interact with tumour cells. This breakthrough could lead to more effective treatments for head and neck cancers.
A new study from Mizzou's College of Veterinary Medicine analyzed the effects of radioactive iodine therapy on thyroid cancer in dogs. The research found that tailoring the dose of radiation more precisely for each dog could improve outcomes and potentially lead to more targeted care.
Experts weighed in on the current state of artificial intelligence (AI) in cancer care, noting both its potential for improving efficiency and its challenges. Many expressed excitement over AI's possibilities for helping support an overburdened oncology workforce and accelerating the pursuit of new cures.
Researchers create nanoparticles shaped like bottlebrushes with antibodies guiding them to tumor sites, delivering a large range of chemotherapy drugs directly to cancer cells. This approach reduces the need for potent drugs and enhances customizability of treatment options.
Children undergoing cancer treatment often lose skeletal muscle at a time when they should be rapidly gaining it, which can increase treatment complications and raise the risk of long-term health problems. Muscle loss makes children more vulnerable to heart and metabolic issues like high blood sugar and insulin resistance.
Oral mucositis increases infection risks in stem cell transplant patients by nearly four times, according to new research. A superior AI tool has been introduced to accurately predict these risks, enabling targeted oral care before transplants and reducing complications.
Adult fibrosarcoma is a rare and highly aggressive malignancy requiring precise diagnosis and multimodal treatment. The case report emphasizes the need for early detection, complete surgical removal, and tailored postoperative care to improve outcomes in patients with this type of tumor.
Researchers at Indiana University School of Medicine have developed a novel candidate drug that shifts the behavior of immunosuppressive regulatory T cells, turning them from cancer protectors into tumor fighters. The study shows promising results in clearing triple-negative breast cancer tumors and treating other aggressive cancers.
A team of scientists has identified rogue DNA rings as early drivers of glioblastoma growth, suggesting a window of opportunity for earlier detection and treatment. The study suggests that targeting these DNA rings could lead to more effective treatments.
A clinical study suggests that immunotherapy can be effective in treating mesothelioma, a rare cancer affecting the lining of the lungs. The trial found improvements in time to tumor growth and overall length of survival for patients with operable diffuse pleural mesothelioma.
Researchers found that frail patients with residual intra-abdominal bacteria or fungi are at a higher risk of developing postoperative ileus and infections. The study suggests that incorporating frailty assessment and prehabilitation programs into surgical planning may help reduce complications.
The Lung Cancer Genetics Study has launched an open-source data platform, offering no-cost access to de-identified data from consenting participants. Researchers can conduct analyses on germline genotyping, self-reported health and exposure data, and cancer-causing driver mutations, with longitudinal datasets to be added over time.
Researchers harness AlphaFold 3 to predict how T cells recognize peptides, opening avenues for precision immunotherapy and vaccine design. The approach enables in silico identification of immunogenic epitopes that could serve as vaccine targets.
A new study published in the American Cancer Society's journal reveals that nearly 1 in 10 patients undergoing surgery for early-stage cancer will initiate opioid prescriptions long-term. The research found that those with a prior history of chronic pain, comorbidities, and lower socioeconomic status were at higher risk.
Dr. Steven B. Heymsfield joins an elite group of scholars recognized for advancing knowledge and transforming their fields. He has authored over 1,300 scientific publications with nearly 79,000 citations, placing him among the top 500 most-cited researchers globally.
Researchers have developed an immunotherapy drug STF-1623 that safely prevents cancer cells from hiding from the immune system's first responders. The drug works by inhibiting ENPP1 proteins that destroy cGAMP, allowing it to trigger a broader immune response and suppress tumor growth.
Researchers have identified a potential new strategy for treating glioblastoma multiforme (GBM), the most common and aggressive type of adult brain cancer. Disabling a protein called ADAR1 can stall GBM cell proliferation while reprogramming the tumor microenvironment to an anti-tumoral state.
Researchers have identified two molecular targets, HER2 and CD24, as promising candidates for new nuclear diagnostics and therapeutics for endometrial cancer. These targets may help clinicians identify patients likely to respond to targeted therapies, offering new hope for those with disseminated or recurrent disease.
Scientists discovered that human melanoma cancer cells behave like stem cells when forced through channels narrower than 10 micrometres, gaining traits to survive, spread, and form new tumours. Researchers created a biomedical device to simulate blood flow through narrow blood vessels, showing the mechanical pressure makes cancer cells...
Researchers at Sanford Burnham Prebys Medical Discovery Institute found that using a drug as a blocker to outcompete the SUMO2 protein may be a winning strategy against synovial sarcoma. This approach aims to reverse aberrant epigenetic rewiring driven by the SS18::SSX fusion oncoproteins and impair sarcomagenesis.
The ASTRO's 2025 Annual Meeting will feature pivotal studies in radiation medicine, highlighting advances in radiopharmaceutical therapy and new indications for low-dose radiation therapy. The meeting will also explore cutting-edge techniques for prostate, breast, lung, and other common cancers.
Researchers uncover how cerebrospinal fluid dynamics drive tumour spread, identifying a way to target this process to inhibit metastasis. The study provides new insights into the role of fluid shear stress in shaping cancer behaviour and offers a promising therapeutic approach for medulloblastoma.
Researchers have created a human vascularized liver cancer-on-a-chip model to evaluate vessel remodeling and cell death in response to embolic agents. This innovative platform replicates the microenvironment of liver tumors, providing unprecedented insight into how tumors respond to embolization.
Researchers at the University of Mississippi have developed a new method to deliver cancer therapies directly to triple-negative breast cancer cells. The sugar-coated nanoparticles effectively target this aggressive cancer, which affects young women and disproportionately impacts Black women. The discovery holds promise for treating no...
A team of scientists has developed a protein-based therapeutic tool called Crunch to target and remove specific living cells, such as cancer cells or overactive immune cells. The new system uses the body's natural waste removal system to clear out unwanted cells, offering hope for improved treatments.
Researchers at SMART Alliance for Research and Technology developed a powerful tool to scan thousands of biological samples and detect transfer ribonucleic acid (tRNA) modifications, which help control cell growth and response to diseases. The tool opens up new possibilities for disease research, diagnostics, and treatment development.
Researchers discovered that breast cancer cells co-opt iron-recycling immune cells in bone marrow to acquire essential minerals, disrupting red blood cell production. This adaptation enables cancer cells to survive in low-oxygen environments and proliferate, ultimately leading to anemia and poor patient outcomes.
Researchers developed a high-volume method to rapidly build and test large numbers of antibodies at once, accelerating antibody research and treatment development. The oPool+ display platform has potential applications in influenza vaccination research, infectious disease treatment, and cancer research.
Researchers found a unique microbial signature in colorectal cancer samples that can accurately distinguish them from other types of cancer. This discovery has the potential to improve diagnosis and treatment outcomes for patients with colorectal cancer.
A new study assesses ChatGPT 3.5's performance on hematology-oncology tasks, revealing its strengths and limitations in providing accurate information for patients. The study highlights the importance of physician oversight when using AI-generated medical information.
Prostate cancer incidence rates have reversed from a decline to an increase, with advanced-stage diagnoses rising by 4.6-4.8% per year. Meanwhile, mortality declines slowed from 3-4% per year in the 1990s and 2000s to 0.6% over the past decade. The study highlights wide disparities, with Black men facing twice the risk of death compare...
Scientists have found a way to stop brain cancer cells from spreading by 'freezing' hyaluronic acid molecules in place. This approach could lead to a new type of treatment for glioblastoma, the most aggressive form of brain cancer.
Researchers have developed a novel urine-based test to identify prostate cancer using biomarkers TTC3, H4C5, and EPCAM. The three-biomarker panel accurately detected prostate cancer 91% of the time and ruled out non-cancerous conditions 84% of the time in validation studies.
Researchers at Northwestern University have developed a new CRISPR delivery system that triples efficiency using DNA-wrapped nanoparticles, improving safety and effectiveness. The new system, called LNP-SNAs, targets specific cells and tissues, reducing toxicity and boosting gene-editing efficiency by threefold.
A recent study found that menin promotes bladder cancer malignancy by enhancing TFAP2C/β-catenin signaling, suggesting its potential as a therapeutic target and prognostic marker. Menin upregulates TFAP2C expression, which regulates β-catenin gene transcription via binding to its proximal promoter.
Researchers at Lund University identify genetic toolkit to program dendritic cell subtypes for targeted cancer treatment. The discovery could lead to more precise and powerful immunotherapies by supplying patients with tailored dendritic cells.
A subanalysis of the LoDoCo2 trial found that low-dose colchicine slows the growth of clonal hematopoiesis, a common acquired gene mutation linked to cardiovascular disease and cancer. Colchicine was associated with significantly attenuated clonal growth in TET2-mutated CH.
A recent survey by Ohio State University Comprehensive Cancer Center found that 80% of Americans are unaware of the lack of noticeable symptoms in early-stage prostate cancer. The disease is treatable if caught early, and regular screening is crucial.