Research on cancer as a disease, from cause to care. Covers tumor biology, small-cell lung cancer, cancer-linked stroke risk, and cancer center research.
Researchers identified specific gene fusion patterns linked to more aggressive disease behavior and increased risk of metastasis in solitary fibrous tumors. The study suggests that these molecular differences could serve as potential biomarkers for predicting patient outcomes and guiding treatment decisions.
Researchers from Mass General Brigham Cancer Institute presented various studies on cancer treatments, including the efficacy of lung cancer drug neladalkib and a psychosocial digital app for patients with multiple myeloma. An electronic frailty index was also used to identify high-risk older adults receiving CAR-T cell therapy.
A new study reveals that nitrosylcobalamin, a vitamin B12 analog, selectively crosses the blood-brain barrier and targets glioblastoma tissue, demonstrating broad antitumor activity. The therapy also shows synergistic activity with existing treatments, offering a promising new strategy for treating this deadly brain cancer.
Researchers from Penn Medicine presented findings on the intersection of GLP-1s and breast cancer, gaps in patient-facing information about AI and cancer care, and updates from clinical trials in cancer genetics and CAR T cell therapy for glioblastoma. The studies suggest that GLP-1 usage is associated with a lower risk of breast cance...
Researchers discovered that overproduction of a DNA repair protein creates DNA damage mimicking BRCA mutations, which may respond to targeted treatments. Tumors with high levels of EXO1 protein exhibit characteristics similar to BRCA-mutant cells, suggesting personalized therapies could be effective.
Researchers have discovered that precursor lesions in the pancreas, often considered a step towards cancer, do not undergo malignant transformation if they lack a specific microenvironment. The team used advanced technologies to isolate and analyze single cells from over 150 donated pancreases, finding that the microenvironment surroun...
Researchers at UT MD Anderson Cancer Center have uncovered genetic and cell-state adaptive mechanisms that drive resistance to KRAS inhibitors in patients with KRAS-mutant colorectal cancer. Targeting early inflammatory responses by adding TBK1 blockade may be a promising combination strategy to overcome treatment resistance.
Dropping the cancer label from grade group (GG)1 prostate disease redefines it as a precancerous lesion, leading to a net reduction in estimated prostate cancer deaths. This relabeling strategy may have minimal impact on screening rates.
A new study replicated patient- and sex-specific hallmarks of Inflammatory Bowel Disease (IBD) in a human organ chip, identifying stromal fibroblasts as key drivers of inflammation, fibrosis, and enhanced cancer risk. The model also recapitulated the impact of pregnancy hormones on IBD severity in female patients.
The University of Texas MD Anderson Cancer Center has been awarded $19 million by CPRIT to support young cancer survivors, groundbreaking research, and faculty recruitment programs. The funding will enable UT MD Anderson to recruit world-class scientists and clinicians, pursue new discoveries, and accelerate cancer treatment advancements.
A Kaiser Permanente study found that HPV self-collection increased cervical cancer screening completion by 2.2% among over 95,000 members, with higher gains in diverse populations. The program also reduced clinician-performed pelvic exams and improved follow-up for high-risk HPV results.
The National Comprehensive Cancer Network has launched a new version of its Distress Thermometer and Problem List in over 70 languages to screen patients for mental, physical, social, or spiritual distress. The tool aims to enhance cancer care by identifying psychological distress and providing support.
Researchers found that increasing ADAR2 expression in osteosarcoma cells forces them to differentiate, slowing growth and invasive capacity. The treated cells began producing mineralized matrix, a hallmark of mature bone tissue. In mice, ADAR2-restored tumors were smaller and less invasive.
Researchers have discovered that errors in the final step of cell division can cause dramatic changes in developing brain cells, leading to abnormalities such as multiple nuclei and cilia. The study found that a protein called p53 acts as a guardian of brain development by triggering the self-destruction of abnormal cells.
Researchers at the Francis Crick Institute have developed a new method to enhance anti-cancer immunity by redirecting non-specialized immune cells to present a broader range of tumor antigens. This approach, leveraging understanding of dendritic cell biology, has shown promise in reducing tumour growth and amplifying responses in mice.
The LUNA-2 trial will pair immunotherapy with fecal microbiota transplantation (FMT) to boost treatment effectiveness in people with non-small cell lung cancer. If successful, it could provide new treatment options for those living with the disease, helping them live longer and with fewer side effects.
Dr. Michele Carbone received the 2026 Szent-Görgyi Prize for his groundbreaking discovery that mesothelioma can be transmitted through families in a Mendelian fashion, driven by inherited mutations in the BAP1 gene. His research has transformed how the disease is understood, diagnosed, treated and prevented worldwide.
Researchers from Harrington Discovery Institute provide a new understanding of cancer processes and identify promising targets for treatments. They uncover a class of therapeutic targets that may complement existing therapies.
A new study found that switching to a nicotine e-cigarette reduces toxicant exposure and improves quitting rates, with the nicotine group having a higher chance of quitting entirely. The study's results suggest that nicotine e-cigarettes could serve as an effective off-ramp for smokers seeking to reduce their tobacco use.
Dr. Sandra Orsulic has received two federal awards totaling nearly $2 million to advance research aimed at improving outcomes for women with ovarian cancer. Her team will examine the body's inflammatory response after surgery and develop AI-powered tools to guide personalized treatment.
A systematic review of AI models for meningioma segmentation reveals that better model architecture is the key driver of improved performance. The top models achieved high accuracy and efficiency, while future research focuses on making them more generalizable and efficient for real-world clinical settings.
Researchers have created a new molecule that stabilizes gold nanoparticles, preserving their shape and enhancing photothermal therapy's effectiveness. This breakthrough aims to control the function of these particles during medical treatments like cancer therapy.
Researchers found that a common asthma drug can help fight aggressive cancers by blocking the CysLTR1 molecule. The study used mouse models and human tissue samples to demonstrate its potential in treating triple-negative breast cancer and other tough tumors.
A new study found that chemotherapy can unintentionally reshape the immune system, allowing cancer to persist. Researchers discovered that a standard chemotherapy triggers pyroptosis, releasing inflammatory signals that inhibit tumor treatment.
A study published by the European Society for Radiotherapy and Oncology found that delivering radiotherapy in just two sessions over eight days is safe and effective for treating prostate cancer. The treatment had no additional side effects compared to the standard five doses, making it a convenient option for patients.
Researchers found that stereotactic body radiotherapy (SBRT) improved progression-free survival by 15.6 months, compared to 20.6 months without targeted therapy. The treatment also showed no significant impact on quality-of-life measures.
The University of Cologne's researchers will continue to work on innovative treatments for lymph node cancer and study plant responses to environmental changes. The Collaborative Research Centres have received a total of approximately €39 million in funding, highlighting the university's strength in collaborative research.
Research suggests that tumors with poor prognosis outcomes may be infected with bacteria, which can weaken treatment by altering local immunity and damaging tissue structure. The authors propose using familiar carrier-free antibiotic and chemotherapeutic drug combinations to restore treatment sensitivity in these tumors.
IEC-HS is a rare but potentially fatal complication of CAR-T therapy, characterized by sustained inflammatory response and distinct biochemical differences from CRS. Targeted therapies, such as interleukin-1 blockade, are gaining attention for its management.
Screening with a PSA blood test reduces prostate cancer deaths by approximately 2 for every 1,000 men screened. The review found that 500 men would need to be invited to screening to prevent one prostate cancer death.
The ASTRO Annual Meeting will take place in Boston from September 26-30, featuring research presentations, keynote addresses, and panel discussions on critical cancer care issues. The meeting aims to foster meaningful conversations about radiation therapy's value in advancing patient care.
A new study aims to make proton therapy available to more patients in Europe by planning five new centres across Romania, Greece, Italy, Northern Ireland, and Poland. Currently, 59% of European cancer patients have access to the treatment, but this can be increased to 87% with strategic location and expansion.
Researchers found that self-propelled particles can spontaneously form clusters when navigating a dense colony of dividing cells. The growing medium creates an environment that transforms the particles' behavior, making them behave like active Brownian particles and attracting them to each other without explicit interaction.
A rare case of esophageal adenocarcinoma is reported, where the tumor grew outside the esophagus and invaded the thoracic spine, causing spinal cord compression. The patient initially had normal endoscopic findings, highlighting the challenge in detecting rare extraluminal growth patterns.
Researchers conducted a meta-analysis of nine randomized clinical trials to evaluate the effectiveness of methylphenidate-type psychostimulants in reducing cancer-related fatigue. The study found significant improvements in fatigue scores, with benefits increasing over time.
New research links excessive weight gain across adulthood to increased risks of various obesity-related cancers, including liver and colon cancer. The study found that steeper weight gain was associated with higher incidence rates.
Researchers have developed a drug carrier that physically anchors itself to cancer cell membranes, improving drug retention and effectiveness. The technology maximizes tumor delivery of drugs while sparing normal tissues, resulting in safer and more effective therapies.
A new study suggests that ultrasound stimulation can bring about functionally meaningful changes in pain perception and brain connectivity. The research found a delayed analgesic effect, with participants reporting reduced pain intensity after 28-55 minutes following TUS application.
A team of Rice University bioengineers has developed a new way to create highly realistic mock patient samples that could help accelerate the development of faster and more accessible cervical cancer screening tests. The approach combines multiple factors, including viral DNA levels and cell counts, to mimic real clinical specimens.
Researchers created a new way to boost T-cell response to mRNA vaccines, yielding more powerful anti-cancer effects and stronger protection against infectious diseases. The innovation enabled the immune system to completely eradicate most tumors in mouse models.
Researchers at Winship Cancer Institute have administered the first investigational in vivo CAR-T cell therapy in the US for relapsed and refractory multiple myeloma, marking a significant milestone in next-generation cellular therapies. The therapy aims to streamline treatment processes and eliminate delays in care.
A new study suggests that medical imaging can capture the molecular activity of particularly aggressive head and neck tumors, opening new possibilities for more precise diagnosis and treatment planning. The research team found that tumors driven by activation of the Hedgehog signaling pathway exhibit distinct patterns on PET/CT scans.
Prescriptions for ivermectin and benzimidazole increased significantly following a high-profile podcast endorsement, with the highest rates among men, White patients, and those in the US South. The study raises concerns about celebrity endorsements influencing people to turn to unproven treatments.
Dr. Marcus Ruscetti receives the prize to study senescence and its impact on immune responses in cancer metastasis. The funding will help him develop novel treatments targeting senescent cells.
The PrecisionView device enables clinicians to visualize both subcellular structures and underlying blood vessels across large tissue areas without invasive biopsies. It generates detailed maps of tissue areas spanning several square centimeters and displays results in real-time.
A real-world study highlights higher overall irAE incidence in lung cancer (61.0%) compared to GI tumor patients (47.9%). Skin toxicity is more frequent in GI tumors, while thyroid dysfunction prevails in lung cancer patients.
A first-in-human trial demonstrates the potential of implantable cytokine factories for treating ovarian cancer, showing a favorable safety profile and encouraging disease stabilization in patients. The therapy successfully activated key immune cells without expanding regulatory T cells, revealing a promising mechanism of action.
A new national clinical trial investigates whether fewer invasive bladder exams can safely reduce discomfort and improve quality of life for patients with bladder cancer. Led by Dartmouth Cancer Center, the study aims to show that fewer procedures are just as effective at keeping patients healthy.
The PanAMP study assesses the impact of PanCystPro on clinicians' decision-making for patients with pancreatic cysts. The study aims to provide insights into surveillance and treatment strategies for those at higher risk for pancreatic cancer.
Researchers have developed nanoparticles that sequentially disable the cancer cell's drug-expulsion mechanism and then release anticancer drugs, combined with photothermal therapy. This approach overcomes multidrug resistance and achieves complete tumor elimination in a mouse model, with no detectable toxicity to normal tissues.
Glioblastoma is a highly aggressive brain tumor that has seen modest improvements in survival rates over the past decade. Researchers at UCLA's Jonsson Comprehensive Cancer Center are part of a national effort to develop more personalized approaches to care, combining advanced imaging and analysis of tumor tissue samples and blood test...
Researchers at Johns Hopkins Kimmel Cancer Center identified the missing link in how a common gut bacterium, B. fragilis, triggers colon cancer. The team found that BFT toxin binds to host receptor claudin-4 before causing damage, revealing a potential strategy for preventing colon damage and cancer.
A new research paper presents a practical diagnostic approach for detecting high-grade serous ovarian carcinoma using a low-cost, portable color sensor device. The method tracks inorganic phosphate generated during nucleic acid amplification, producing a visible green signal that correlates with the amount of amplified DNA.
A team of scientists has uncovered more than 1,700 new proteins known as peptideins, which are smaller than traditional proteins and may have unique biology. These proteins were found in the 'dark proteome', a section of DNA previously overlooked, and could have implications for human diseases like cancer.
Researchers at the University of Texas MD Anderson Cancer Center have identified specific blood-based genomic biomarkers that distinguish inflammatory breast cancer from other subtypes. The study used an improved method of RNA sequencing, called TGIRT sequencing, which allowed for a more comprehensive overview of all RNA types and amou...
The ERASur clinical trial is investigating whether total ablative therapy can improve overall survival in patients with newly diagnosed, limited metastatic colorectal cancer. The study has reached one-third patient accrual milestone, signaling strong momentum.
A new trial aims to test an AI-powered tool that detects signs of infection in children undergoing cancer treatment. The custom app, which utilizes Apple Watch data, may help clinicians intervene sooner and reduce hospital stays.
A study published in Cancer Medicine reveals that the same genes active in pancreatic cancer are also linked to obesity and diabetes, driving inflammatory and immune pathways. This discovery helps explain poorer cancer outcomes for those with metabolic disease and offers new avenues for targeted treatment.
A new CRISPR protein, Cas12a2, has shown potential for killing sick cells while leaving healthy ones untouched. Researchers have tested its effectiveness in destroying cancer cells and virus-infected cells with promising results.
A NIH-funded study discovered that testosterone may play a key role in limiting brain tumor growth in men by suppressing inflammation and stress hormone production. Analysis of over 1,300 men with glioblastoma found that supplemental testosterone was significantly associated with improved survival rates.