Articles tagged with Cancer
Researchers suggest chemotherapy drugs may be responsible for 'chemo brain' symptoms, citing reduced lymphatic vessel growth and impaired cognitive function. The study highlights the need to consider long-term neurological side effects of cancer treatment on quality of life.
Researchers developed a new approach to overcome treatment resistance in aggressive cancers by activating macrophages, a type of immune cell abundant in advanced tumors. The custom anti-αvβ3 antibody triggers powerful anti-tumor responses and is highly selective, making it a potentially safer alternative.
Researchers developed a latex-based tissue adhesive to prevent seroma formation and prolonged lymphorrhea after axillary dissection. The study found that the adhesive significantly reduced wound exudate volume and allowed patients to be discharged earlier, with no complications reported.
Researchers have identified a novel biomarker, DKK1 to CALML5 ratio (DC score), predicting patient prognosis and response to immunotherapy in head and neck squamous cell carcinoma. The DC score also correlates with incomplete pathological response and poorer overall survival.
A special issue of Cancer Biology & Medicine brings together experts to accelerate cervical cancer elimination, highlighting scientific advances, policy innovations, and equity efforts. The journal's mission bridges oncology research with public health priorities.
Scientists at Institut Pasteur and Inserm developed a triple-therapy approach to treat blood cancers like lymphomas and leukemias. They induced necroptosis in malignant B cells, which activates the immune system to eliminate tumor cells.
Researchers at UT Austin have developed a new cancer treatment that uses LED light and SnOx nanoflakes to precisely target cancer cells without harming healthy ones. The treatment achieved remarkable effectiveness in neutralizing colorectal and skin cancer cells, with up to 92% kill rate in just 30 minutes of exposure.
Researchers identified a previously unknown gene, SMARCAL1, that increases the risk of developing osteosarcoma in children and young adults. The study found that approximately 2.6% of children with osteosarcoma carry inherited mutations in SMARCAL1, which may weaken DNA repair and promote tumor growth.
Researchers at UMass Amherst have developed a nanoparticle-based vaccine that prevents melanoma, pancreatic and triple-negative breast cancer in mice. The vaccine achieved remarkable survival rates, with up to 88% of vaccinated mice remaining tumor-free.
Researchers found that quitting smoking more than doubles survival time among patients with advanced cancers. The study shows the benefits of integrated smoking cessation interventions into cancer treatment plans.
A new study has mapped thousands of proteins in human blood to reveal unique molecular fingerprints for each individual. This atlas will enable blood tests to distinguish troubling signs from common ones, and provide a baseline for comparison that healthcare providers can use to flag early deviations.
Researchers found that patients with stage III or IV cancer who quit smoking lived significantly longer than those who continued smoking, with a two-fold lower rate of all-cause mortality. The study's findings emphasize the crucial role of smoking cessation support as part of standard cancer care.
A multi-institutional study found that serially testing tumor samples can detect immune system activation in recurrent glioblastoma even when traditional imaging measures cannot. The researchers used multi-omic analysis and integrated data from various sources to show positive changes in the tumor microenvironment over time.
Researchers found that Medicare patients receiving federal housing assistance were diagnosed at earlier stages with breast, colorectal, and non-small cell lung cancers compared to peer patients. Early cancer diagnosis is key to better prognoses and has saved millions of lives.
Joanna Wardwell-Ozgo, a Kennesaw State assistant professor, received a $720,000 NIH grant to investigate the hormonal control of cancer. She aims to understand how hormones affect cellular growth and development, with potential implications for disease mechanisms.
Researchers are collecting toenail clippings from Canadians to estimate a person's lung-cancer risk based on long-term radon exposure. The study aims to provide critical data for early screening and diagnosis of lung cancer.
Scientists at Fralin Biomedical Research Institute are developing nanotechnology-based approaches to reprogram the immune system and overcome tumor defenses. Integrating nanomedicine with immunology promises more precise and effective therapies.
Researchers at MIT have developed a new way to engineer CAR-NK cells that are less likely to be rejected by the patient's immune system, making them a promising treatment for cancer. The cells can destroy most cancer cells while evading the host immune system, and may offer a better safety profile than traditional CAR-T cells.
Researchers found that smoking and biological sex shape how normal cells evolve in healthy bladder tissue, with certain mutations gaining an advantage to expand into clones. This study offers new insights into cancer risk and prevention by providing a way to understand tissue evolution and identify early warning signs.
The Association for Molecular Pathology has created a standardized biomarker report template to simplify complex molecular profiling data presentation to oncologists and healthcare providers. The template includes guidelines for clear formatting, therapeutic guidance, and references to clinical practice guidelines.
Paul Boutros, a pioneer in using AI and machine learning to analyze cancer data, is appointed as the new director of the National Cancer Institute-designated cancer center at Sanford Burnham Prebys. The cancer center will leverage computational tools to personalize therapies for cancer patients.
Researchers found that 27% of breast cancer cases have genetic features guiding personalized treatment immediately. The study identified over 8,300 cases suitable for future research, providing insights into prognosis and potential new treatments.
Research found that inflammatory markers are linked to different aspects of cancer-related fatigue, with some effects persisting after treatment. The study suggests targeting inflammation for developing treatments to alleviate this debilitating symptom.
The NCCN Guidelines Navigator now covers treatment for over a dozen cancer types, including hereditary risk assessment, providing seamless navigation and search capabilities. The new format aims to improve treatment decision-making based on the latest evidence and expert-consensus.
Researchers found microplastic exposure changes the human gut microbiome, with some shifts resembling patterns linked to diseases. Microplastic-induced changes in microbial composition may serve as a bacterial stress response, potentially affecting overall well-being.
The 2025 NFCR Global Summit will convene world-renowned experts in cancer research, entrepreneurship, and patient care. Keynote speakers include Monica Bertagnolli, Webster K. Cavenee, Lisa Coussens, Ronald DePinho, and Tony Hunter.
The ASPIRE trial is a Phase III clinical study investigating whether adding chemotherapy to standard treatments can extend survival in men with advanced prostate cancer. The trial aims to determine the effectiveness of combining docetaxel with hormone therapy and apalutamide.
Research presents evidence suggesting that metabolically active visceral fat is associated with more advanced stages of endometrial cancer and lymph node metastases. The study found no strong correlation between visceral fat volume and its metabolic activity.
A study of 42,451 patients found that those whose credit scores dropped after a cancer diagnosis faced a significantly higher risk of mortality. The researchers also identified high-risk demographics and socioeconomic factors associated with financial toxicity.
Researchers found that glioblastoma causes skull bone erosion, alters immune-cell balance in skull marrow, and interferes with the body's immune response. The cancer was found to be more aggressive when treated with drugs intended to inhibit skull-bone loss.
Researchers found that rectal bleeding increases the odds of a colorectal cancer diagnosis by 8.5 times in patients under 50, highlighting the need for symptom-driven care and lifestyle modifications to reduce the risk. The study analyzed 443 patients and identified no family history as a factor in early-onset colorectal cancers.
Researchers discovered that an enzyme called EZH2 drives triple negative breast cancer cells to divide abnormally, enabling them to spread. Inhibiting EZH2 with drugs like tazemetostat restored order to dividing cells and thwarted the spread of TNBC cells.
A new study found that untreated depression in cancer patients leads to poorer surgical outcomes, including longer hospital stays and higher mortality rates. However, treating depression with antidepressants can significantly improve post-surgical recovery and reduce healthcare costs.
Researchers at UCSB have created an algae-based gel as a platform for studying mammary epithelial cells, which can transform into cancer cells. The gel supports the development of normal mammary gland tissue and can be modified to direct cell growth, offering new insights into how cancer develops.
A study found that stereotactic body radiotherapy (SBRT) after prostate surgery is safe and effective in preventing cancer recurrence, with low side effects and manageable treatment. The results suggest SBRT may be a faster and simpler option for men at risk of recurrent prostate cancer.
Researchers at CNIO have created a 'human repairome', a catalogue of 20,000 DNA 'scars' that reveal how genes affect DNA repair. This information can help determine the best treatment for each cancer type and overcome resistance to therapy.
Researchers at MSK presented two clinical trials looking at the benefits of lowering radiation doses for patients with throat cancer. The studies found that reducing treatment can protect the immune system and help patients recover quickly. Additionally, a trial on breast cancer treatment showed that accelerated partial breast irradiat...
Researchers found that a protein linked to Alzheimer's disease also strengthens the immune system, offering insights into innovative treatments for cancer, aging and neurodegenerative diseases. The protein, amyloid beta, plays a dual role in the body by damaging brain cells while boosting T-cells' energy production.
A new study by Kaiser Permanente found that mailing human papillomavirus (HPV) self-sampling kits to patients increases cervical cancer screening completion rates. The study also shows that this approach is cost-effective, especially for health systems with a wide range of patient populations.
Researchers at the University of Vienna have developed fluorescent peptide tracers that can simultaneously visualize and activate the oxytocin receptor. This breakthrough has far-reaching implications for breast cancer diagnostics and therapy, as well as fundamental research into social behavior and health.
The Keck School of Medicine has been recognized for its commitment to partnering with local communities in Los Angeles to address their critical needs through outreach, education, and service. The institution's community agenda is defined in collaboration with the communities it serves.
The review highlights the critical roles of phospholipids in regulating immune cell migration, differentiation, and survival, as well as their regulatory effects on inflammation. Dysregulated phospholipid metabolism is linked to various diseases, including autoimmune disorders, cardiovascular disease, and cancer.
A groundbreaking study aims to improve genetic services for adolescent and young adult (AYA) cancer survivors by integrating digital tools and chatbot technology. Participants will receive tailored communication, digital education tools, and genetic testing, with the goal of increasing uptake of genetic counseling and testing.
A Virginia Tech oncologist is championing a precise approach to treating acute myeloid leukemia by tracking subtle molecular changes in patients. His work aims to identify signs of potential relapse and tailor treatment for each individual with this rare blood cancer.
A new study discovers a previously unknown long noncoding RNA, EUDAL, that helps oral cancer cells survive chemotherapy by permanently activating the epidermal growth factor receptor. This RNA molecule blocks the cellular tagging system, allowing EGFR to remain active and promote autophagy in cancer cells.
An AI model successfully automates lymph node segmentation and extranodal extension classification from pretreatment CT scans in HPV-associated oropharyngeal carcinoma. Predicted extranodal extension is independently associated with worse oncologic outcomes, highlighting the potential for improved treatment planning.
A groundbreaking study enrolls 465 AYA cancer patients to test if chatbot technology and digital education tools increase uptake of genetic counseling and improve patient outcomes. The trial aims to address longstanding gaps in genetic services for AYAs aged 18-39, who often receive care with limited access to genetic specialists.
A phase III trial comparing proton and photon radiation therapy for breast cancer found that patients report equally strong health-related quality of life with either treatment. Patients treated with protons were more likely to say they would recommend or choose it again, but overall patient-reported outcomes were similar.
A phase III trial suggests that post-operative radiation therapy can reduce cancer recurrence in patients with high-risk disease. Patients who received radiation experienced significantly fewer pelvic recurrences and improved locoregional recurrence-free survival compared to those who did not receive radiation.
A recent study suggests that the rise in early-onset cancer incidence in the US population may not be as significant as initially thought. Much of the increase is attributed to increased diagnostic scrutiny and over-diagnosis, rather than a genuine rise in clinically meaningful cancer cases.
A large phase III trial found that stereotactic body radiation therapy (SBRT) preserves quality of life, with fewer declines in bowel and urinary functioning. However, SBRT does not outperform standard radiation therapy for disease-free survival, with higher rates of biochemical failure and rising PSA after treatment.
Dr. Amar Kishan has been recognized for his groundbreaking research on radiation treatments for genitourinary system cancers. He is the recipient of the 2025 Steven A. Leibel Memorial Award, presented by ASTRO and ABR Foundation.
A Harvard Medical School-led research team developed an AI tool called PICTURE that can reliably tell apart glioblastoma and primary central nervous system lymphoma during surgery. The tool distinguishes between the two cancers with near-perfect accuracy, reducing errors in diagnosis and guiding critical treatment decisions.
Researchers have discovered myeloid cells in children's liver tumors that could be activated for treatment. This discovery provides new avenues for immunotherapy in childhood liver cancer.
Researchers at Fox Chase Cancer Center found adaptive radiation therapy can reduce radiation to healthy tissue by 21% while delivering higher doses to tumors. The study offers new hope for patients with previously untreatable cancers.
A new randomized study validates a predictive gene expression test that identifies patients with recurrent prostate cancer who will benefit from adding hormone therapy to radiation. The test, PAM50, groups tumors into molecular subtypes and predicts treatment outcomes.
A new PSMA-targeting radioligand therapy added to stereotactic body radiotherapy (SBRT) more than doubled progression-free survival in men with recurrent prostate cancer, delaying the start of hormone therapy by up to 24 months. The study found minimal side effects and identified biological markers that may predict treatment benefits.
Researchers developed a genomic model to tailor radiation doses to individual patients with HPV-positive throat cancer. The study found that higher scores on the Genomic Adjusted Radiation Dose (GARD) model were associated with improved survival outcomes, even when patients received the same radiation dose.
Researchers at UCLA Health Jonsson Comprehensive Cancer Center identify IGF2BP3 as a master switch linking cancer metabolism and RNA regulation in leukemia cells. The protein shifts energy breakdown and RNA modifications to support cell survival and multiplication.
Researchers from UCLA presented findings on targeted radioactive therapy, new SBRT approaches and advances in MRI- and 5DCT-guided imaging. The LUNAR clinical trial looked at adding a targeted therapy before ablative radiotherapy for men with recurrent prostate cancer.