Research on cancer as a disease, from cause to care. Covers tumor biology, small-cell lung cancer, cancer-linked stroke risk, and cancer center research.
A new trial aims to test an AI-powered tool that detects signs of infection in children undergoing cancer treatment. The custom app, which utilizes Apple Watch data, may help clinicians intervene sooner and reduce hospital stays.
A study published in Cancer Medicine reveals that the same genes active in pancreatic cancer are also linked to obesity and diabetes, driving inflammatory and immune pathways. This discovery helps explain poorer cancer outcomes for those with metabolic disease and offers new avenues for targeted treatment.
A new CRISPR protein, Cas12a2, has shown potential for killing sick cells while leaving healthy ones untouched. Researchers have tested its effectiveness in destroying cancer cells and virus-infected cells with promising results.
A NIH-funded study discovered that testosterone may play a key role in limiting brain tumor growth in men by suppressing inflammation and stress hormone production. Analysis of over 1,300 men with glioblastoma found that supplemental testosterone was significantly associated with improved survival rates.
Researchers at Trinity College Dublin have published a comprehensive review of pancreatic cancer, explaining why it's resistant to treatment and where new hope may emerge. The study identifies multiple biological systems interacting to drive the disease's growth and suggests combination-based treatments targeting multiple hallmarks of ...
Dr. Aparna Bhaduri receives $750k Pershing Square Sohn Cancer Prize for her innovative glioblastoma research. Her advanced human organoid models reveal how tumors interact with the immune system and brain cells, driving tumor aggressiveness.
A new study published in Genes & Diseases journal reveals that lncRNA ROLLCSC promotes ferroptosis resistance and metastasis in lung cancer by regulating lipid metabolism. The researchers identified ROLLCSC as a therapeutic target, suggesting potential treatments for advanced lung adenocarcinoma.
A new AI system, SPARK, enables autonomous scientific discovery in cancer pathology by generating biological hypotheses and translating them into analytical tools. The system identifies clinically relevant tissue markers linked to disease course, treatment response, and tumour progression.
Three young scientists in Israel have been awarded the prestigious Blavatnik Awards for their innovative research in chemistry, cancer biology, and astrophysics. Sergey Semenov, Uri Ben-David, and Paz Beniamini will each receive US$100,000 to advance their projects on complex materials, cancer treatments, and extreme cosmic events.
Researchers developed a hand-held device to differentiate tumors from healthy tissue using mechanical properties, reducing the need for future surgeries and delayed treatments. The wireless probe can aid surgeons in precise tumor removal during breast-conserving surgery.
A new study reveals that ALK mutations enhance tumor immunogenicity and predict favorable outcomes in immune checkpoint blockade. The presence of ALK mutations is an independent favorable predictor of overall survival, decreasing the risk of patient death by 31%.
The ASPIRE trial aims to enroll 1,200 participants with advanced prostate cancer and assess the impact of chemotherapy on overall survival and disease progression. Genetic profiling is included to identify patients who benefit most from intensified treatment.
Researchers at OHSU have developed a sophisticated blood test that can detect early signs of pancreatic cancer with a 97% accuracy rate, distinguishing it from benign conditions. The technique uses nanoparticles shed by tumors into blood, offering a non-invasive way to identify the disease.
The review highlights how retrieval-augmented generation can improve the accuracy, transparency, and clinical reliability of AI tools in cancer care. RAG-enhanced systems produced more accurate results than standard AI models across multiple studies.
Researchers discovered a small molecule, UNI418, that destabilizes key DNA repair proteins, making drug-resistant cancer cells vulnerable to PARP inhibitor therapy. This approach restores tumor sensitivity and improves treatment outcomes.
A new study reveals that impaired protein recycling is the key factor in T cell exhaustion, allowing researchers to develop a 'tag and sort' fix to restore normal proteostasis. This approach boosts the potency of cell therapy against cancer.
A new study found that targeted maternal screening can prevent adult T-cell leukemia/lymphoma, a rare and aggressive cancer caused by human T-cell leukemia virus type 1. The research identified high disease rates among non-Hispanic Caribbean-born US residents, particularly in Florida and New York.
A new study reveals that specific features of the human cerebral cortex are causally linked to multiple myeloma and chronic lymphocytic leukemia, differing between ancestries. Genetic variants favoring larger pars triangularis surface area and thicker frontal cortices are found in Western populations.
NCCN staff received awards and publications for advancing quality cancer care, including Dr. Alyssa Schatz's Leadership in Policy, Equity, and Advocacy award and Faviolla Baez-Cruz's publication on biochemical research. The National Comprehensive Cancer Network is recognized for its work to improve outcomes for people with cancer.
Researchers found that patients with high senescence burdens in their CD8+ T cells were more likely to fail treatment, while those with youthful profiles responded better. The study identified three transcription factors controlling the senescence program, which can be targeted to improve treatment outcomes.
A research consortium has developed mini-antibodies that can reactivate mutated p53, a key tumor suppressor protein. These DARPins bind selectively to p53 mutants, restoring stability and functionality, making them potentially useful against various types of tumors.
Researchers at King's College London uncover a timing mechanism in cells that allows them to ignore brief mechanical stimuli while reacting to sustained changes. This discovery has huge implications for disease treatment and could lead to the development of better therapies for cancer and fibrosis.
A new study found a clear shift in mortality trends in multiple myeloma closely parallels major therapeutic advances. Targeted therapies, including immunomodulatory drugs and CAR T-cell therapies, have significantly improved disease control and induced deep responses.
A study by University of Pittsburgh researchers found that eating creates a temporary metabolic state that influences T cell function, leading to improved responses to infection. The findings have particular relevance for cancer immunotherapy and may inform when immune cells are collected or activated.
Researchers at UIC developed an anti-cancer therapy using a bacterial protein called aurB, which prevents energy production in tumor cells' mitochondria. The treatment was tested in combination with radiation and showed highly effective results in animal models of prostate cancer, effectively shutting down tumor growth.
A new paradigm shift in cancer research defines valid primary study endpoints for oligometastatic disease, focusing on treatment-free time and minimal side effects. The consensus paper establishes two new metrics: STFS (Start or Switch of Systemic Therapy–Free Survival) and pPFS (polymetastatic Progression–Free Survival), which capture...
EGFR-TKIs have significantly improved OS and quality of life for EGFR-mutant NSCLC patients. However, ongoing research is needed to refine therapies for precise individualized treatment, addressing resistance mechanisms and optimal combination strategies.
A first-in-human clinical trial found that setidegrasib, a targeted therapy drug, demonstrated early antitumor activity in advanced lung and pancreatic cancers. The therapy shrank tumors and delayed disease progression in some patients, providing a potential new treatment approach for KRAS G12D-driven cancers.
Scientists have uncovered an unexpected way cancer cells generate cancer-driving proteins by cutting RNA into shorter fragments. This process, termed as RNA dicing, enables the production of a truncated form of the JAK1 protein that remains highly active and can promote tumor growth.
A recent CNIO study has identified a key mechanism in the development of liver fibrosis by targeting bile duct cells. The research reveals that these cells regulate liver health and form a barrier that prevents bile acid leakage and fibrosis, opening new avenues for personalized treatment.
Cancer cases are on the rise among younger adults in England, with a significant increase in bowel and ovarian cancer rates. The study found that excess weight is a key contributor, but it's unlikely to fully explain this trend, as trends in risk factors such as smoking and diet have been stable or improving over the past decade.
Researchers at Mayo Clinic have developed a blood-based method to detect germ cell tumors, the most common type of testicular cancer, including cases that do not show up on standard blood tests. The new test, GCT-iSIGN, identified 93% of individuals with germ cell tumors and correctly ruled out cancer in 99% of those without.
The new NCCN Guidelines for Patients: Prostate Cancer Screening provide a comprehensive guide to evidence-based recommendations for age-specific screening. The guidelines aim to balance the benefits of early detection with the risks of unnecessary procedures, emphasizing the importance of personalized care and monitoring.
A new study suggests that an AI tool analyzing facial changes can serve as a prognostic biomarker for cancer prognosis. The researchers found that patients with higher biological aging rates had lower chances of survival, and the effect was strongest when photos were taken over longer intervals.
Proteomics-driven precision oncology combines multi-omics integration to reveal tumor heterogeneity and functional regulatory networks. Emerging single-cell and spatial proteomics technologies with AI analysis facilitate clinically relevant biomarker discovery.
Researchers found a higher risk of acute lymphoblastic leukemia among children exposed to PFAS compounds at birth. The study suggests that early-life exposure may contribute to cancer risk in children and highlights the need for further research on PFAS contamination.
Researchers at the University of British Columbia have developed a new method to target intrinsically disordered proteins, which are difficult to treat with medication. The approach has shown promise in slowing prostate cancer growth and could lead to new treatments for various diseases.
A new study published in Circulation: Population Health and Outcomes journal links cardiovascular-kidney-metabolic syndrome to a higher risk of developing cancer. The study found that individuals with advanced heart, kidney, and metabolic disease face a sharper increase in cancer risk only in the later stages of CKM syndrome.
Researchers from UH, Baylor College of Medicine and MD Anderson Cancer Center propose a new treatment approach for Crohn's disease by targeting the stress signal that fuels inflammation. They found that repurposing two existing cancer medications can promote natural repair and regeneration of the intestinal lining.
Dr. Dennis Slamon, a renowned breast cancer researcher, has been elected to the Association of American Physicians (AAP) for his pioneering work in HER2 gene discovery and targeted therapies. His research led to significant improvements in survival rates and established the principle of targeted cancer treatment.
Scientists have developed a strategy to enhance the cancer-fighting power of natural killer cells by suppressing specific proteins. This approach effectively kills human cancer cells across several hard-to-treat tumour types, including leukemia and triple-negative breast cancer.
A new study from the University of Lausanne identifies a specific subset of fibroblasts that produce Ccl19, an 'attractant signal' for cytotoxic T lymphocytes, bringing them into contact with type 1 dendritic cells. This mechanism is essential for proper immune cell organization and function.
A study finds that rectal cancer mortality is increasing rapidly among adults under 45, with Hispanic and Western US populations experiencing the steepest rises. The study calls for earlier screening and increased awareness to combat this growing trend.
Research from Lund University reveals that stiffer tumor tissue triggers a chain of molecular events driving cancer cells to invade surrounding tissue. The studies identified key proteins and pathways involved in this process, offering new insights into the mechanical properties of tumor microenvironments.
Scientists discover that tRNA gene mutations can alter the reading of the genetic code, leading to increased protein synthesis errors. This phenomenon is linked to aging and cellular decline, with potential implications for neurodegenerative diseases like Alzheimer's.
Researchers found that restoring a young microbiome can reverse features of aging in the liver, including inflammation and DNA damage. The study suggests that a healthy gut microbiome plays a key role in preventing liver cancer.
A new targeted therapy has shown strong results in preclinical studies against aggressive childhood and adult cancers, eliminating tumours and stopping cancer spread. The therapy targets the IL1RAP protein, which is found on cancer cells but largely absent from normal tissues, allowing for precise delivery of treatment.
The Keck School of Medicine of USC and Tempus are creating a system-wide framework to integrate clinical care, clinical trials, and research through AI-powered precision medicine tools. The goal is to enhance patient care and accelerate research and innovation.
A study found that higher midlife cardiorespiratory fitness is strongly associated with later onset of chronic disease, lower overall disease burden, and longer life expectancy. Adults with higher fitness levels developed fewer chronic diseases and spent more years free from serious illness.
A USC-led team is working on a medical device that uses tears to monitor health, starting with dry eye disease. The device aims to provide continuous monitoring and automated medication delivery, improving patient comfort and treatment efficacy.
Researchers will build connections with Detroit's digital equity ecosystem and promote digital inclusion to link cancer patients, survivors, and caregivers with resources. The Digital Engagement and Cancer Outcomes (DECO) Center aims to advance interventions that improve outcomes at the individual level.
A new study from the University of Toronto links childhood sexual abuse to a significantly higher likelihood of cancer later in life. Researchers found that those who experienced childhood sexual abuse had about twice the odds of reporting a cancer diagnosis compared to the general population.
A phase 2 study led by NYU Langone Health showed that adding pembrolizumab to standard chemotherapy and radiation with surgery allowed 60% of patients to avoid bladder removal for up to two years post-treatment. This breakthrough treatment offers hope to patients with muscle-invasive urothelial cancer of the bladder.
The experimental drug DH20931 targets triple-negative breast cancer by triggering a surge in fat-like molecules called ceramides, overwhelming cancer cells with toxic fats. In lab experiments, the drug made standard chemotherapy more effective, reducing the dose needed to kill cancer cells by about fivefold.
Researchers at the University of Cape Town have identified a critical molecular switch that drives the formation of cancer-associated antigens. By understanding how enzymes relocate within a cell, they have uncovered key mechanisms for tumorigenesis.
A new study found that prostate cancer overdiagnosis increases with age, with low rates in younger men and high rates in older men. The study suggests that targeted PSA testing or screening policies for men in their 50s and early 60s may be more effective.
A rare case of mucinous ovarian carcinoma was reported in a postmenopausal woman, initially misdiagnosed as a pelvic abscess due to nonspecific symptoms and radiologic features. The diagnosis was confirmed after advanced imaging and tumor marker assessment. Early recognition is crucial for timely diagnosis and effective treatment of th...
Researchers found that tumor genetics alone did not explain which patients responded to combination therapy, but rather the tumor's immune environment. Patients with active networks of cancer-killing T cells were more likely to benefit from treatment, while those with dense clusters of plasma cells were less likely.
A new study found that high school students who perceive sun protection as inconvenient or uncomfortable are less likely to engage in sun-safe behaviors. Teens who view tanning as enhancing appearance or social appeal also tend to neglect UV radiation protection.
A study found that long-term exposure to wildfire smoke was significantly associated with an increased risk of developing lung, colorectal, breast, bladder, and blood cancer. The risk increased with every additional microgram per cubic meter of fine particulate matter in the air.